
Assistant Professor
M_Path-Anatomic Path
Custom People Group
Publications
Persistent and progressive acute lung allograft dysfunction is linked to cell compositional and transcriptional changes in small airways.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Tumor cell heterogeneity drives spatial organization of the intratumoral immune response.
The Journal of experimental medicine
Single-cell omics technologies - Fundamentals on how to create single-cell looking glasses for reproductive health.
American journal of obstetrics and gynecology
Identification of a conserved subset of cold tumors responsive to immune checkpoint blockade.
Journal for immunotherapy of cancer
Lack of TGFβ signaling competency predicts immune poor cancer conversion to immune rich and response to checkpoint blockade.
bioRxiv : the preprint server for biology
Multimodal identification of rare potent effector CD8 T cells in solid tumors.
bioRxiv : the preprint server for biology
Coordinated variation in the immune systems and microbiomes of healthy humans is linked to tonic interferon states.
bioRxiv : the preprint server for biology
Targeting CD206+ macrophages disrupts the establishment of a key antitumor immune axis.
The Journal of experimental medicine
Single-cell spatial transcriptomics of fixed, paraffin-embedded biopsies reveals colitis-associated cell networks.
bioRxiv : the preprint server for biology
Proinflammatory immune cells disrupt angiogenesis and promote germinal matrix hemorrhage in prenatal human brain.
Nature neuroscience
Critical role of CD206+ macrophages in organizing anti-tumor immunity.
bioRxiv : the preprint server for biology
Dysregulation of CD4+ and CD8+ resident memory T, myeloid, and stromal cells in steroid-experienced, checkpoint inhibitor colitis.
Journal for immunotherapy of cancer
Single-cell and spatial multi-omics highlight effects of anti-integrin therapy across cellular compartments in ulcerative colitis.
Nature communications
Macrophage and CD8 T cell discordance are associated with acute lung allograft dysfunction progression.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Single-cell and spatial multi-omics identify innate and stromal modules targeted by anti-integrin therapy in ulcerative colitis.
bioRxiv : the preprint server for biology
Single cell proteomics characterization of bone marrow hematopoiesis with distinct Ras pathway lesions.
bioRxiv : the preprint server for biology
Cyclone: an accessible pipeline to analyze, evaluate, and optimize multiparametric cytometry data.
Frontiers in immunology
Tumor cell heterogeneity drives spatial organization of the intratumoral immune response in squamous cell skin carcinoma.
bioRxiv : the preprint server for biology
Defining and using immune archetypes to classify and treat cancer.
Nature reviews. Cancer
Transcriptional space-time mapping identifies concerted immune and stromal cell patterns and gene programs in wound healing and cancer.
Cell stem cell
Polyunsaturated fatty acid-bound alpha-fetoprotein promotes immune suppression by altering human dendritic cell metabolism.
Cancer research
High-dimensional immune cell profiling of cerebrospinal fluid from patients with metastatic breast cancer and leptomeningeal disease.
NPJ breast cancer
Cyclone: an accessible pipeline to analyze, evaluate and optimize multiparametric cytometry data.
bioRxiv : the preprint server for biology
SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants.
Stem cell reports
Distinct metabolic states guide maturation of inflammatory and tolerogenic dendritic cells.
Nature communications
Tumor-associated macrophage heterogeneity is driven by tissue territories in breast cancer.
Cell reports
Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer.
Cancer immunology research
The intersection of COVID-19 and autoimmunity.
The Journal of clinical investigation
Genetic and immunologic features of recurrent stage I lung adenocarcinoma.
Scientific reports
Archetypes of checkpoint-responsive immunity.
Trends in immunology
Active surveillance characterizes human intratumoral T cell exhaustion.
The Journal of clinical investigation
Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19.
Science translational medicine
Publisher Correction: Global absence and targeting of protective immune states in severe COVID-19.
Nature
SARS-CoV-2 infection studies in lung organoids identify TSPAN8 as novel mediator.
bioRxiv : the preprint server for biology
DNGR-1 limits Flt3L-mediated antitumor immunity by restraining tumor-infiltrating type I conventional dendritic cells.
Journal for immunotherapy of cancer
Transcriptomic analysis of immune cells in a multi-ethnic cohort of systemic lupus erythematosus patients identifies ethnicity- and disease-specific expression signatures.
Communications biology
A tumor-specific mechanism of Treg enrichment mediated by the integrin αvβ8.
Science immunology
Longitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19.
bioRxiv : the preprint server for biology
SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution.
Cell metabolism
Global Absence and Targeting of Protective Immune States in Severe COVID-19.
bioRxiv : the preprint server for biology
Lessons of COVID-19: A roadmap for post-pandemic science.
The Journal of experimental medicine
A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments.
Nature medicine
Guanabenz inhibits TLR9 signaling through a pathway that is independent of eIF2α dephosphorylation by the GADD34/PP1c complex.
Science signaling
BAD-LAMP controls TLR9 trafficking and signalling in human plasmacytoid dendritic cells.
Nature communications
MARCH9-mediated ubiquitination regulates MHC I export from the TGN.
Immunology and cell biology
Protein synthesis inhibition and GADD34 control IFN-β heterogeneous expression in response to dsRNA.
The EMBO journal
RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4.
The Journal of cell biology