Professor
Cell and Tissue Biology
+1 415 353-7070
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As a physician-scientist and practicing breast medical oncologist, I have dedicated my career to understanding and treating aggressive breast cancers, with a particular focus on metastatic disease. In my dual role as Co-Leader of the UCSF Breast Oncology Program and Vice-Chair of the Cell & Tissue Biology Department, I bridge the gap between basic research and clinical practice, working to translate laboratory discoveries into meaningful treatments for patients. Our research program has made significant contributions to understanding the mechanisms of breast cancer metastasis, notably identifying the critical role of the MYC oncogene in driving metastasis in triple-negative breast cancers. Our laboratory has successfully discovered multiple therapeutic vulnerabilities, including cell cycle, metabolic, and immune pathways, with the goal of developing promising new therapies for metastatic cancer.

Publications

Biogenesis, delivery, and function of extracellular RNA.

Journal of extracellular vesicles

Patton JG, Franklin JL, Weaver AM, Vickers K, Zhang B, Coffey RJ, Ansel KM, Blelloch R, Goga A, Huang B, L'Etoille N, Raffai RL, Lai CP, Krichevsky AM, Mateescu B, Greiner VJ, Hunter C, Voinnet O, McManus MT

Hepatic stem-like phenotype and interplay of Wnt/beta-catenin and Myc signaling in aggressive childhood liver cancer.

Cancer cell

Cairo S, Armengol C, De Reyniès A, Wei Y, Thomas E, Renard CA, Goga A, Balakrishnan A, Semeraro M, Gresh L, Pontoglio M, Strick-Marchand H, Levillayer F, Nouet Y, Rickman D, Gauthier F, Branchereau S, Brugières L, Laithier V, Bouvier R, Boman F, Basso G, Michiels JF, Hofman P, Arbez-Gindre F, Jouan H, Rousselet-Chapeau MC, Berrebi D, Marcellin L, Plenat F, Zachar D, Joubert M, Selves J, Pasquier D, Bioulac-Sage P, Grotzer M, Childs M, Fabre M, Buendia MA