Barbara Bensing, PhD | The Benioff Center for Microbiome Medicine

Streptococcus Gordonii Binds VWF Via Its Sialoglycan-Binding Adhesins Under Shear to Initiate Infective Endocarditis.

Blood

Martha M.S. Sim, Ava Obenaus, Richard Maldonado, Jennie Le, Lesley Martínez Rodríguez, Barbara Bensing, Paul Sullam, Wendy Thomas, Nathan Sniadecki, Junmei Chen, Jose A. Lopez

HIV-1 interaction with an O-glycan-specific bacterial lectin enhances virus infectivity and resistance to neutralizing antibodies.

iScience

Heindel DW, Figueroa Acosta DM, Goff M, Yengo CK, Jan M, Liu X, Wang XH, Petrova MI, Zhang M, Sagar M, Barnette P, Pandey S, Hessell AJ, Chan KW, Kong XP, Chen BK, Mahal LK, Bensing BA, Hioe CE

Abstract 1982 Targeting Sialic Acids with Streptococcal Adhesin Proteins.

Journal of Biological Chemistry

KeAndreya Morrison, Barbara Bensing, Hai Yu, Xi Chen, Paul Sullam, T. Iverson

Molecular Insights into O-Linked Sialoglycans Recognition by the Siglec-Like SLBR-N (SLBRUB10712) of Streptococcus gordonii.

ACS central science

Di Carluccio C, Cerofolini L, Moreira M, Rosu F, Padilla-Cortés L, Gheorghita GR, Xu Z, Santra A, Yu H, Yokoyama S, Gray TE, St Laurent CD, Manabe Y, Chen X, Fukase K, Macauley MS, Molinaro A, Li T, Bensing BA, Marchetti R, Gabelica V, Fragai M, Silipo A

HIV-1 interaction with an O-glycan-specific bacterial lectin enhances virus infectivity and cell-to-cell viral transfer.

Research square

Heindel D, Acosta DF, Goff M, Jan M, Wang XH, Petrova M, Chan KW, Kong XP, Chen B, Mahal L, Bensing B, Hioe C

Development and applications of sialoglycan-recognizing probes (SGRPs) with defined specificities: exploring the dynamic mammalian sialoglycome.

Glycobiology

Srivastava S, Verhagen A, Sasmal A, Wasik BR, Diaz S, Yu H, Bensing BA, Khan N, Khedri Z, Secrest P, Sullam P, Varki N, Chen X, Parrish CR, Varki A

Origins of glycan selectivity in streptococcal Siglec-like adhesins suggest mechanisms of receptor adaptation.

Nature communications

Bensing BA, Stubbs HE, Agarwal R, Yamakawa I, Luong K, Solakyildirim K, Yu H, Hadadianpour A, Castro MA, Fialkowski KP, Morrison KM, Wawrzak Z, Chen X, Lebrilla CB, Baudry J, Smith JC, Sullam PM, Iverson TM

Biological Consequences of HIV-1 Interactions with Bacteria.

The FASEB Journal

Daniel W. Heindel, Kun-Wei Chan, Mariya I. Petrova, Xiang-Peng Kong, Sarah Lebeer, Barbara A. Bensing, Lara K. Mahal, Catarina E. Hioe

O-linked α2,3 sialylation defines stem cell populations in breast cancer.

Science advances

Walker MR, Goel HL, Mukhopadhyay D, Chhoy P, Karner ER, Clark JL, Liu H, Li R, Zhu JL, Chen S, Mahal LK, Bensing BA, Mercurio AM

Proteoglycan 4 (lubricin) is a highly sialylated glycoprotein associated with cardiac valve damage in animal models of infective endocarditis.

Glycobiology

Solakyildirim K, Li Y, Bayer AS, Sullam PM, Xiong YQ, Lebrilla CB, Bensing BA

Molecular recognition of sialoglycans by streptococcal Siglec-like adhesins: toward the shape of specific inhibitors.

RSC chemical biology

Di Carluccio C, Forgione RE, Bosso A, Yokoyama S, Manabe Y, Pizzo E, Molinaro A, Fukase K, Fragai M, Bensing BA, Marchetti R, Silipo A

Display of the human mucinome with defined O-glycans by gene engineered cells.

Nature communications

Nason R, Büll C, Konstantinidi A, Sun L, Ye Z, Halim A, Du W, Sørensen DM, Durbesson F, Furukawa S, Mandel U, Joshi HJ, Dworkin LA, Hansen L, David L, Iverson TM, Bensing BA, Sullam PM, Varki A, Vries E, de Haan CAM, Vincentelli R, Henrissat B, Vakhrushev SY, Clausen H, Narimatsu Y

Novel, non-invasive markers for detecting therapy induced neuroendocrine differentiation in castration-resistant prostate cancer patients.

Scientific reports

Bhagirath D, Liston M, Akoto T, Lui B, Bensing BA, Sharma A, Saini S

O-acetylation controls the glycosylation of bacterial serine-rich repeat glycoproteins.

The Journal of biological chemistry

Seepersaud R, Anderson AC, Bensing BA, Choudhury BP, Clarke AJ, Sullam PM

Structure based virtual screening identifies small molecule effectors for the sialoglycan binding protein Hsa.

The Biochemical journal

Agarwal R, Bensing BA, Mi D, Vinson PN, Baudry J, Iverson TM, Smith JC

Tandem sialoglycan-binding modules in a Streptococcus sanguinis serine-rich repeat adhesin create target dependent avidity effects.

The Journal of biological chemistry

Stubbs HE, Bensing BA, Yamakawa I, Sharma P, Yu H, Chen X, Sullam PM, Iverson TM

The Two Distinct Types of SecA2-Dependent Export Systems.

Miriam Braunstein, Barbara A. Bensing, Paul M. Sullam

Recognition of specific sialoglycan structures by oral streptococci impacts the severity of endocardial infection.

PLoS pathogens

Bensing BA, Li L, Yakovenko O, Wong M, Barnard KN, Iverson TM, Lebrilla CB, Parrish CR, Thomas WE, Xiong Y, Sullam PM

An Atlas of Human Glycosylation Pathways Enables Display of the Human Glycome by Gene Engineered Cells.

Molecular cell

Narimatsu Y, Joshi HJ, Nason R, Van Coillie J, Karlsson R, Sun L, Ye Z, Chen YH, Schjoldager KT, Steentoft C, Furukawa S, Bensing BA, Sullam PM, Thompson AJ, Paulson JC, Büll C, Adema GJ, Mandel U, Hansen L, Bennett EP, Varki A, Vakhrushev SY, Yang Z, Clausen H

Development of Sialoglycan Recognizing Probes (SGRPs) With Defined Specificities: Towards Exploring the Dynamic Mammalian Sialoglycome.

The Journal of Immunology

Saurabh Srivastava, Andrea Verhagen, Brian Wasik, Hai Yu, Aniruddha Sasmal, Barbara Bensing, Naazneen Khan, Zahra Khedri, Sandra Diaz, Paul Sullam, Nissi Varki, Xi Chen, Colin Parrish, Ajit Varki

The Two Distinct Types of SecA2-Dependent Export Systems.

Microbiology spectrum

Braunstein M, Bensing BA, Sullam PM

The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins.

Proceedings of the National Academy of Sciences of the United States of America

Malaker SA, Pedram K, Ferracane MJ, Bensing BA, Krishnan V, Pett C, Yu J, Woods EC, Kramer JR, Westerlind U, Dorigo O, Bertozzi CR

Membrane trafficking of the bacterial adhesin GspB and the accessory Sec transport machinery.

The Journal of biological chemistry

Spencer C, Bensing BA, Mishra NN, Sullam PM

Streptococcal Siglec-like adhesins recognize different subsets of human plasma glycoproteins: implications for infective endocarditis.

Glycobiology

Bensing BA, Li Q, Park D, Lebrilla CB, Sullam PM

Serine-Rich Repeat Adhesins Mediate Shear-Enhanced Streptococcal Binding to Platelets.

Infection and immunity

Yakovenko O, Nunez J, Bensing B, Yu H, Mount J, Zeng J, Hawkins J, Chen X, Sullam PM, Thomas W

Unraveling the sequence of cytosolic reactions in the export of GspB adhesin from Streptococcus gordonii.

The Journal of biological chemistry

Chen Y, Bensing BA, Seepersaud R, Mi W, Liao M, Jeffrey PD, Shajahan A, Sonon RN, Azadi P, Sullam PM, Rapoport TA

O-acetylation of the serine-rich repeat glycoprotein GspB is coordinated with accessory Sec transport.

PLoS pathogens

Seepersaud R, Sychantha D, Bensing BA, Clarke AJ, Sullam PM

Structures of the Streptococcus sanguinis SrpA Binding Region with Human Sialoglycans Suggest Features of the Physiological Ligand.

Biochemistry

Loukachevitch LV, Bensing BA, Yu H, Zeng J, Chen X, Sullam PM, Iverson TM

Oral streptococci utilize a Siglec-like domain of serine-rich repeat adhesins to preferentially target platelet sialoglycans in human blood.

PLoS pathogens

Deng L, Bensing BA, Thamadilok S, Yu H, Lau K, Chen X, Ruhl S, Sullam PM, Varki A

A Specific interaction between SecA2 and a region of the preprotein adjacent to the signal peptide occurs during transport via the accessory Sec system.

The Journal of biological chemistry

Bensing BA, Yen YT, Seepersaud R, Sullam PM

A structural model for binding of the serine-rich repeat adhesin GspB to host carbohydrate receptors.

PLoS pathogens

Pyburn TM, Bensing BA, Xiong YQ, Melancon BJ, Tomasiak TM, Ward NJ, Yankovskaya V, Oliver KM, Cecchini G, Sulikowski GA, Tyska MJ, Sullam PM, Iverson TM