
Professor In Res
M_Ortho-Gen Ortho-Core
Custom People Group
I am a mechanical engineer and bioengineer. My laboratory studies interactions between microbes, musculoskeletal tissues and materials. We are currently studying the effects of the gut microbiome on the musculoskeletal system and the success of orthopaedic surgery. Additionally we are studying mechanobiology of bacteria and advancing the new field of Engineered Living Materials.
Publications
Combinatorial characterization of bacterial taxa-driven differences in the microbiome of oyster beds.
Sustainable microbiology
Dietary Menaquinone-9 Supplementation Does Not Influence Bone Tissue Quality or Bone Mineral Density in Mice.
bioRxiv : the preprint server for biology
High interest for long-acting injectable PrEP among men who have sex with men at most risk for HIV in San Francisco, 2021.
Sexual health
Microbiome-induced Increases and Decreases in Bone Matrix Strength can be Initiated After Skeletal Maturity.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Combinatorial characterization of bacterial taxa-driven differences in the microbiome of oyster reefs.
bioRxiv : the preprint server for biology
Determining the Young's Modulus of the Bacterial Cell Envelope.
ACS biomaterials science & engineering
Effects of long-term high dose aspartame on body mass, bone strength, femoral geometry, and microbiota composition in a young and aged cohort of male and female mice.
bioRxiv : the preprint server for biology
The 2023 Orthopaedic Research Society's International Consensus Meeting on musculoskeletal infection: Summary from the host immunity section.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
A Pilot Study of the Gut Microbiota in Spine Fusion Surgery Patients.
HSS journal : the musculoskeletal journal of Hospital for Special Surgery
Mechanical stimuli activate gene expression via a cell envelope stress sensing pathway.
Scientific reports
Suppression of Remodeling and Bone Fragility.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Multiple Dietary Vitamin K Forms Are Converted to Tissue Menaquinone-4 in Mice.
The Journal of nutrition
Distributions of Microdamage Are Altered Between Trabecular Rods and Plates in Cancellous Bone From Men With Type 2 Diabetes Mellitus.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
In Their Own Words: How Trans Women Acquired HIV Infection.
AIDS and behavior
Butyrate Inhibits Osteoclast Activity In Vitro and Regulates Systemic Inflammation and Bone Healing in a Murine Osteotomy Model Compared to Antibiotic-Treated Mice.
Mediators of inflammation
Recent Advances in the Evaluation of Antimicrobial Materials for Resolution of Orthopedic Implant-Associated Infections In Vivo.
ACS infectious diseases
The microbiome: A heritable contributor to bone morphology?
Seminars in cell & developmental biology
Impaired Bone Matrix: The Key to Fragility in Type 2 Diabetes?
The Journal of clinical endocrinology and metabolism
Components of the Gut Microbiome That Influence Bone Tissue-Level Strength.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Musculoskeletal Microbiology: The Microbiome in Orthopaedic Biomechanics.
Current opinion in biomedical engineering
Characterization of Ultralow Density Cellular Solids: Lessons from 30 years of Bone Biomechanics Research.
Advanced engineering materials
Musculoskeletal microbiology: The utility of the microbiome in orthopedics.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
The Gut Microbiome and Bone Strength.
Current osteoporosis reports
Obesity and load-induced posttraumatic osteoarthritis in the absence of fracture or surgical trauma.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
The importance of diversity, equity, and inclusion in orthopedic research.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Improving Treatment Efficacy of In Situ Forming Implants via Concurrent Delivery of Chemotherapeutic and Chemosensitizer.
Scientific reports
Reply to Zadpoor: Fatigue mechanisms observed in bone provide insight to microarchitectured materials.
Proceedings of the National Academy of Sciences of the United States of America
Inhibition of the histone demethylase, KDM5B, directly induces re-expression of tumor suppressor protein HEXIM1 in cancer cells.
Breast cancer research : BCR
Bone-inspired microarchitectures achieve enhanced fatigue life.
Proceedings of the National Academy of Sciences of the United States of America
Disruption of the Gut Microbiome Increases the Risk of Periprosthetic Joint Infection in Mice.
Clinical orthopaedics and related research
Contrast enhanced ultrasound imaging by nature-inspired ultrastable echogenic nanobubbles.
Nanoscale
Altered Tissue Composition, Microarchitecture, and Mechanical Performance in Cancellous Bone From Men With Type 2 Diabetes Mellitus.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Enhancing Tumor Drug Distribution With Ultrasound-Triggered Nanobubbles.
Journal of pharmaceutical sciences
Immunomodulatory nanogels overcome restricted immunity in a murine model of gut microbiome-mediated metabolic syndrome.
Science advances
Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1).
Journal of medicinal chemistry
Bone marrow lesions in osteoarthritis: What lies beneath.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Current Options and Emerging Biomaterials for Periprosthetic Joint Infection.
Current rheumatology reports
The Microbiome and Bone and Joint Disease.
Current rheumatology reports
Cryo-EM Visualization of Lipid and Polymer-Stabilized Perfluorocarbon Gas Nanobubbles - A Step Towards Nanobubble Mediated Drug Delivery.
Scientific reports
An in vivo model of a mechanically-induced bone marrow lesion.
Journal of biomechanics
Ultrasound molecular imaging of ovarian cancer with CA-125 targeted nanobubble contrast agents.
Nanomedicine : nanotechnology, biology, and medicine
Mechanically induced bone formation is not sensitive to local osteocyte density in rat vertebral cancellous bone.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Predicting in vivo behavior of injectable, in situ-forming drug-delivery systems.
Therapeutic delivery
Alterations to the Gut Microbiome Impair Bone Strength and Tissue Material Properties.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Romosozumab Treatment Converts Trabecular Rods into Trabecular Plates in Male Cynomolgus Monkeys.
Calcified tissue international
Understanding Bone Strength Is Not Enough.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Macroporous acrylamide phantoms improve prediction of in vivo performance of in situ forming implants.
Journal of controlled release : official journal of the Controlled Release Society
LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates.
Bioorganic & medicinal chemistry letters
Improving performance of nanoscale ultrasound contrast agents using N,N-diethylacrylamide stabilization.
Nanomedicine : nanotechnology, biology, and medicine
Links Between the Microbiome and Bone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Material heterogeneity in cancellous bone promotes deformation recovery after mechanical failure.
Proceedings of the National Academy of Sciences of the United States of America
Validation of Ultrasound Elastography Imaging for Nondestructive Characterization of Stiffer Biomaterials.
Annals of biomedical engineering
Ultrasound imaging beyond the vasculature with new generation contrast agents.
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
The effects of tensile-compressive loading mode and microarchitecture on microdamage in human vertebral cancellous bone.
Journal of biomechanics
Nanobubble ultrasound contrast agents for enhanced delivery of thermal sensitizer to tumors undergoing radiofrequency ablation.
Pharmaceutical research
Biomechanical effects of simulated resorption cavities in cancellous bone across a wide range of bone volume fractions.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Irradiation does not modify mechanical properties of cancellous bone under compression.
Clinical orthopaedics and related research
Three-dimensional dynamic bone histomorphometry.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Ectopic expression of SOX9 in osteoblasts alters bone mechanical properties.
Calcified tissue international
Near-terminal creep damage does not substantially influence fatigue life under physiological loading.
Journal of biomechanics
Trabecular microarchitecture of hominoid thoracic vertebrae.
Anatomical record (Hoboken, N.J. : 2007)
A biomechanical analysis of the effects of resorption cavities on cancellous bone strength.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Genetic background influences cortical bone response to ovariectomy.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research