Emmanuelle Waubant, MD, PhD

Professor
Neurology
+1 415 514-2468
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Dr Waubant trained as a neurologist in Toulouse, France. She continued her training as a neuroimmunology fellow in Dr Stephen Hauser’s UCSF laboratory, focusing on matrix metalloproteinases (MMP) and their tissue inhibitors (TIMP), and their role in migration of lymphocytes through equivalents of the blood-brain barrier. In 1994, Dr Waubant returned to Toulouse to complete her 2-year junior faculty/chief residency in neurology. Dr Waubant later returned as a clinical research fellow at the UCSF MS Center with Dr Donald Goodkin. During that 3-year period, she furthered her in vitro MMP work to the study in the human disease that helped to understand the role of MMP-9 and TIMP-1 in patients with MS and their relationship to disease activity. After completing her clinical research training at the UCSF MS center, Dr Waubant returned to France to lead a clinical research center at Salpetriere Hospital in Paris for 2 years. She returned to the UCSF MS center in September 2001 as a faculty. She is also the Race to Erase MS Medical Director and coordinates clinical research collaborations between 8 American MS Centers of Excellence. With the support of the National MS Society, she has started a regional pediatric MS clinic at UCSF in January 2006 that she directs and has since seen over 500 patients with pediatric MS, NMO, MOG-associated disease or related disorders. She is the editor of the first text book on Pediatric MS and related disorders. In 2018, Dr Waubant funded an international group to foster diversity and visibility of women and minorities in the field of MS (International Women in MS, iwims.world). In March 2025, Dr Waubant became the president of the Americas Committee on Treatment and Research in MS (ACTRIMS, actrims.org). She is a member of the U.S. Pediatric MS Steering Committee. She is also chairing the international Clinical Trial Task Force for pediatric MS.
Dr Waubant’s specific interests include the translation of promising agents from the bench to the bedside, understanding factors that predict the response to MS therapies, and risk factors for pediatric MS susceptibility and disease modification. She is the lead investigator for a trial of neuroprotection with N-acetyl cystein in progressive MS funded by the Department of Defense. Dr. Waubant is also a very active mentor for junior investigators.

Publications

Epigenetic Aging in Pediatric-Onset Multiple Sclerosis.

Neurology

Goyne C, Fair AE, Yilmaz D, Race J, Schuette A, Caillier SJ, Aaen GS, Abrams AW, Benson LA, Casper TC, Chitnis T, Gorman MP, Lotze TE, Krupp LB, Mar SS, Ness JM, Rensel M, Rodriguez M, Rose JW, Schreiner TL, Tillema JM, Waldman AT, Wheeler YS, Barcellos LF, Waubant E, Graves JS, as the US Network of Pediatric MS Centers

Distinct plasma lipids predict axonal injury and multiple sclerosis activity.

Journal of neurology, neurosurgery, and psychiatry

Schoeps VA, Bhargava P, Virupakshaiah A, Ladakis DC, Moseley C, Chong J, Aaen G, Graves JS, Benson L, Gorman MP, Rensel M, Abrams A, Mar S, Lotze TE, Chitnis T, Waldman A, Krupp L, Rodriguez M, Tillema JM, Rose J, Schreiner T, Qureshi F, Peterson S, Barcellos LF, Casper TC, Newman J, Borkowski K, Waubant E, US Network of Pediatric MS Centers

Early Adversity and Socioeconomic Factors in Pediatric Multiple Sclerosis: A Case-Control Study.

Neurology(R) neuroimmunology & neuroinflammation

Jensen SKG, Camposano S, Berens A, Waltz M, Krupp LB, Charvet L, Belman AL, Aaen GS, Benson LA, Candee M, Casper TC, Chitnis T, Graves J, Wheeler YS, Kahn I, Lotze TE, Mar SS, Rensel M, Rodriguez M, Rose JW, Rubin JP, Tillema JM, Waldman AT, Weinstock-Guttman B, Barcellos LF, Waubant E, Gorman MP, US Network of Pediatric Multiple Sclerosis Centers

Therapeutic Response in Pediatric Neuromyelitis Optica Spectrum Disorder.

Neurology

Umeton RP, Waltz M, Aaen GS, Benson L, Gorman M, Goyal M, Graves JS, Harris Y, Krupp L, Lotze TE, Shukla NM, Mar S, Ness J, Rensel M, Schreiner T, Tillema JM, Roalstad S, Rodriguez M, Rose J, Waubant E, Weinstock-Guttman B, Casper C, Chitnis T, and the U.S. Network of Pediatric MS Centers

MOG and AQP4 Antibodies among Children with Multiple Sclerosis and Controls.

Annals of neurology

Gaudioso CM, Mar S, Casper TC, Codden R, Nguyen A, Aaen G, Benson L, Chitnis T, Francisco C, Gorman MP, Goyal MS, Graves J, Greenberg BM, Hart J, Krupp L, Lotze T, Narula S, Pittock SJ, Rensel M, Rodriguez M, Rose J, Schreiner T, Tillema JM, Waldman A, Weinstock-Guttman B, Wheeler Y, Waubant E, Flanagan EP, United States Network of Pediatric Multiple Sclerosis Centers

A new look at cognitive functioning in pediatric MS.

Multiple sclerosis (Houndmills, Basingstoke, England)

Krupp LB, Waubant E, Waltz M, Casper TC, Belman A, Wheeler Y, Ness J, Graves J, Gorman M, Benson L, Mar S, Goyal M, Schreiner T, Weinstock-Guttman B, Rodriguez M, Tillema JM, Lotze T, Aaen G, Rensel M, Rose J, Chitinis T, George A, Charvet LE, and the US Network of Pediatric MS Centers

Reply to "Spinal cord atrophy is a preclinical marker of progressive MS".

Annals of neurology

Bischof A, Papinutto N, Keshavan A, Rajesh A, Kirkish G, Zhang X, Mallott JM, Asteggiano C, Sacco S, Gundel TJ, Zhao C, Stern WA, Caverzasi E, Zhou Y, Gomez R, Ragan NR, Santaniello A, Zhu AH, Juwono J, Bevan CJ, Bove RM, Crabtree E, Gelfand JM, Goodin DS, Graves JS, Green AJ, Oksenberg JR, Waubant E, Wilson MR, Zamvil SS, University of CaliforniaSan Francisco MS-EPIC Team, Cree BA, Hauser SL, Henry RG

Spinal cord atrophy predicts progressive disease in relapsing multiple sclerosis.

Annals of neurology

Bischof A, Papinutto N, Keshavan A, Rajesh A, Kirkish G, Zhang X, Mallott JM, Asteggiano C, Sacco S, Gundel TJ, Zhao C, Stern WA, Caverzasi E, Zhou Y, Gomez R, Ragan NR, Santaniello A, Zhu AH, Juwono J, Bevan CJ, Bove RM, Crabtree E, Gelfand JM, Goodin DS, Graves JS, Green AJ, Oksenberg JR, Waubant E, Wilson MR, Zamvil SS, University of California, San Francisco MS-EPIC Team, Cree BA, Hauser SL, Henry RG

The gut microbiota in pediatric multiple sclerosis and demyelinating syndromes.

Annals of clinical and translational neurology

Tremlett H, Zhu F, Arnold D, Bar-Or A, Bernstein CN, Bonner C, Forbes JD, Graham M, Hart J, Knox NC, Marrie RA, Mirza AI, O'Mahony J, Van Domselaar G, Yeh EA, Zhao Y, Banwell B, Waubant E, US Network of Pediatric MS Centers, the Canadian Pediatric Demyelinating Disease Network

Association Between Time Spent Outdoors and Risk of Multiple Sclerosis.

Neurology

Sebastian P, Cherbuin N, Barcellos LF, Roalstad S, Casper C, Hart J, Aaen GS, Krupp L, Benson L, Gorman M, Candee M, Chitnis T, Goyal M, Greenberg B, Mar S, Rodriguez M, Rubin J, Schreiner T, Waldman A, Weinstock-Guttman B, Graves J, Waubant E, Lucas R, US Network of Pediatric Multiple Sclerosis Centers

Myelin-oligodendrocyte glycoprotein antibody-associated disease.

The Lancet. Neurology

Marignier R, Hacohen Y, Cobo-Calvo A, Pröbstel AK, Aktas O, Alexopoulos H, Amato MP, Asgari N, Banwell B, Bennett J, Brilot F, Capobianco M, Chitnis T, Ciccarelli O, Deiva K, De Sèze J, Fujihara K, Jacob A, Kim HJ, Kleiter I, Lassmann H, Leite MI, Linington C, Meinl E, Palace J, Paul F, Petzold A, Pittock S, Reindl M, Sato DK, Selmaj K, Siva A, Stankoff B, Tintore M, Traboulsee A, Waters P, Waubant E, Weinshenker B, Derfuss T, Vukusic S, Hemmer B

Gut microbiome is associated with multiple sclerosis activity in children.

Annals of clinical and translational neurology

Horton MK, McCauley K, Fadrosh D, Fujimura K, Graves J, Ness J, Wheeler Y, Gorman MP, Benson LA, Weinstock-Guttman B, Waldman A, Rodriguez M, Tillema JM, Krupp L, Belman A, Mar S, Rensel M, Chitnis T, Casper TC, Rose J, Hart J, Shao X, Tremlett H, Lynch SV, Barcellos LF, Waubant E, U.S. Network of Pediatric MS Centers

Familial History of Autoimmune Disorders Among Patients With Pediatric Multiple Sclerosis.

Neurology(R) neuroimmunology & neuroinflammation

Greenberg BM, Casper TC, Mar SS, Ness JM, Plumb P, Liang S, Goyal M, Weinstock-Guttman B, Rodriguez M, Aaen GS, Belman A, Barcellos LF, Rose JW, Gorman MP, Benson LA, Candee M, Chitnis T, Harris YC, Kahn IL, Roalstad S, Hart J, Lotze TE, Rensel M, Rubin JP, Schreiner TL, Tillema JM, Waldman AT, Krupp L, Graves J, Drake K, Waubant E

Pediatric Multiple Sclerosis Severity Score in a Large U.S. Cohort.

Neurology

Santoro JD, Waltz M, Aaen G, Belman A, Benson L, Gorman M, Goyal MS, Graves JS, Harris Y, Krupp L, Lotze T, Mar S, Moodley M, Ness J, Rensel M, Rodriguez M, Schreiner T, Tillema JM, Waubant E, Weinstock-Guttman B, Hurtubise BF, Roalstad S, Rose J, Casper TC, Chitnis T

miRNA contributions to pediatric-onset multiple sclerosis inferred from GWAS.

Annals of clinical and translational neurology

Rhead B, Shao X, Graves JS, Chitnis T, Waldman AT, Lotze T, Schreiner T, Belman A, Krupp L, Greenberg BM, Weinstock-Guttman B, Aaen G, Tillema JM, Rodriguez M, Hart J, Caillier S, Ness J, Harris Y, Rubin J, Candee MS, Gorman M, Benson L, Mar S, Kahn I, Rose J, Casper TC, Quach H, Quach D, Schaefer C, Waubant E, Barcellos LF

Vitamin D genes influence MS relapses in children.

Multiple sclerosis (Houndmills, Basingstoke, England)

Graves JS, Barcellos LF, Krupp L, Belman A, Shao X, Quach H, Hart J, Chitnis T, Weinstock-Guttman B, Aaen G, Benson L, Gorman M, Greenberg B, Lotze T, Soe M, Ness J, Rodriguez M, Rose J, Schreiner T, Tillema JM, Waldman A, Casper TC, Waubant E

Several household chemical exposures are associated with pediatric-onset multiple sclerosis.

Annals of clinical and translational neurology

Mar S, Liang S, Waltz M, Casper TC, Goyal M, Greenberg B, Weinstock-Guttman B, Rodriguez M, Aaen G, Belman A, Barcellos LF, Rose J, Gorman M, Benson L, Candee M, Chitnis T, Harris Y, Kahn I, Roalsted S, Hart J, Lotze T, Moodley M, Ness J, Rensel M, Rubin J, Schreiner T, Tillema JM, Waldman A, Krupp L, Graves JS, Waubant E

Urban air quality and associations with pediatric multiple sclerosis.

Annals of clinical and translational neurology

Lavery AM, Waubant E, Casper TC, Roalstad S, Candee M, Rose J, Belman A, Weinstock-Guttman B, Aaen G, Tillema JM, Rodriguez M, Ness J, Harris Y, Graves J, Krupp L, Charvet L, Benson L, Gorman M, Moodley M, Rensel M, Goyal M, Mar S, Chitnis T, Schreiner T, Lotze T, Greenberg B, Kahn I, Rubin J, Waldman AT

Heterogeneity in association of remote herpesvirus infections and pediatric MS.

Annals of clinical and translational neurology

Nourbakhsh B, Rutatangwa A, Waltz M, Rensel M, Moodley M, Graves J, Casper TC, Waldman A, Belman A, Greenberg B, Goyal M, Harris Y, Kahn I, Lotze T, Mar S, Schreiner T, Aaen G, Hart J, Ness J, Rubin J, Tillema JM, Krupp L, Gorman M, Benson L, Rodriguez M, Chitnis T, Rose J, Candee M, Weinstock-Guttman B, Shao X, Barcellos L, James J, Waubant E

Editors' Welcome.

Multiple sclerosis and related disorders

Hawkes CH, Giovannoni G, Levy M, Waubant E

Editors' Welcome.

Multiple sclerosis and related disorders

Hawkes C, Giovannoni G, Levy M, Waubant E

Editors' Welcome.

Multiple sclerosis and related disorders

Giovannoni G, Hawkes C, Levy M, Lublin F, Waubant E

Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria.

The Lancet. Neurology

Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, Correale J, Fazekas F, Filippi M, Freedman MS, Fujihara K, Galetta SL, Hartung HP, Kappos L, Lublin FD, Marrie RA, Miller AE, Miller DH, Montalban X, Mowry EM, Sorensen PS, Tintoré M, Traboulsee AL, Trojano M, Uitdehaag BMJ, Vukusic S, Waubant E, Weinshenker BG, Reingold SC, Cohen JA

Editors' Welcome.

Multiple sclerosis and related disorders

Waubant E, Giovannoni G, Hawkes C, Lublin F

Genetic risk factors for pediatric-onset multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England)

Gianfrancesco MA, Stridh P, Shao X, Rhead B, Graves JS, Chitnis T, Waldman A, Lotze T, Schreiner T, Belman A, Greenberg B, Weinstock-Guttman B, Aaen G, Tillema JM, Hart J, Caillier S, Ness J, Harris Y, Rubin J, Candee M, Krupp L, Gorman M, Benson L, Rodriguez M, Mar S, Kahn I, Rose J, Roalstad S, Casper TC, Shen L, Quach H, Quach D, Hillert J, Hedstrom A, Olsson T, Kockum I, Alfredsson L, Schaefer C, Barcellos LF, Waubant E

Editors' Welcome.

Multiple sclerosis and related disorders

Lublin F, Giovannoni G, Hawkes C, Waubant E

Examining the contributions of environmental quality to pediatric multiple sclerosis.

Multiple sclerosis and related disorders

Lavery AM, Waldman AT, Charles Casper T, Roalstad S, Candee M, Rose J, Belman A, Weinstock-Guttman B, Aaen G, Tillema JM, Rodriguez M, Ness J, Harris Y, Graves J, Krupp L, Benson L, Gorman M, Moodley M, Rensel M, Goyal M, Mar S, Chitnis T, Schreiner T, Lotze T, Greenberg B, Kahn I, Rubin J, Waubant E

Editors' Welcome.

Multiple sclerosis and related disorders

Hawkes C, Giovannoni G, Lublin F, Waubant E

Dietary factors and pediatric multiple sclerosis: A case-control study.

Multiple sclerosis (Houndmills, Basingstoke, England)

Pakpoor J, Seminatore B, Graves JS, Schreiner T, Waldman AT, Lotze TE, Belman A, Greenberg BM, Weinstock-Guttman B, Aaen G, Tillema JM, McDonald JC, Hart J, Ness JM, Harris Y, Rubin J, Candee M, Krupp L, Gorman M, Benson L, Rodriguez M, Chitnis T, Mar S, Kahn I, Rose J, Carmichael SL, Roalstad S, Waltz M, Casper TC, Waubant E

Editors' welcome.

Multiple sclerosis and related disorders

Waubant E, Giovannoni G, Hawkes C, Lublin F

Editors' Welcome.

Multiple sclerosis and related disorders

Lublin F, Giovannoni G, Hawkes C, Waubant E

Evidence for a causal relationship between low vitamin D, high BMI, and pediatric-onset MS.

Neurology

Gianfrancesco MA, Stridh P, Rhead B, Shao X, Xu E, Graves JS, Chitnis T, Waldman A, Lotze T, Schreiner T, Belman A, Greenberg B, Weinstock-Guttman B, Aaen G, Tillema JM, Hart J, Caillier S, Ness J, Harris Y, Rubin J, Candee M, Krupp L, Gorman M, Benson L, Rodriguez M, Mar S, Kahn I, Rose J, Roalstad S, Casper TC, Shen L, Quach H, Quach D, Hillert J, Bäärnhielm M, Hedstrom A, Olsson T, Kockum I, Alfredsson L, Metayer C, Schaefer C, Barcellos LF, Waubant E

Editors' Welcome.

Multiple sclerosis and related disorders

Hawkes C, Giovannoni G, Lublin F, Waubant E

Editors' Welcome.

Multiple sclerosis and related disorders

Giovannoni G, Hawkes C, Lublin F, Waubant E

Editors' Welcome.

Multiple sclerosis and related disorders

Hawkes C, Lublin F, Giovannoni G, Waubant E

A case-control study of dietary salt intake in pediatric-onset multiple sclerosis.

Multiple sclerosis and related disorders

McDonald J, Graves J, Waldman A, Lotze T, Schreiner T, Belman A, Greenberg B, Weinstock-Guttman B, Aaen G, Tillema JM, Hart J, Lulu S, Ness J, Harris Y, Rubin J, Candee M, Krupp LB, Gorman M, Benson L, Rodriguez M, Chitnis T, Mar S, Barcellos LF, Laraia B, Rose J, Roalstad S, Simmons T, Casper TC, Waubant E

Update on biomarkers in neuromyelitis optica.

Neurology(R) neuroimmunology & neuroinflammation

Melamed E, Levy M, Waters PJ, Sato DK, Bennett JL, John GR, Hooper DC, Saiz A, Bar-Or A, Kim HJ, Pandit L, Leite MI, Asgari N, Kissani N, Hintzen R, Marignier R, Jarius S, Marcelletti J, Smith TJ, Yeaman MR, Han MH, Aktas O, Apiwattanakul M, Banwell B, Bichuetti D, Broadley S, Cabre P, Chitnis T, De Seze J, Fujihara K, Greenberg B, Hellwig K, Iorio R, Jarius S, Klawiter E, Kleiter I, Lana-Peixoto M, O'Connor K, Palace J, Paul F, Prayoonwiwat N, Ruprecht K, Stuve O, Tedder T, Tenembaum S, Garrahan JP, Aires B, van Herle K, van Pelt D, Villoslada P, Waubant E, Weinshenker B, Wingerchuk D, Würfel J, Zamvil S

Use of Advanced Magnetic Resonance Imaging Techniques in Neuromyelitis Optica Spectrum Disorder.

JAMA neurology

Kremer S, Renard F, Achard S, Lana-Peixoto MA, Palace J, Asgari N, Klawiter EC, Tenembaum SN, Banwell B, Greenberg BM, Bennett JL, Levy M, Villoslada P, Saiz A, Fujihara K, Chan KH, Schippling S, Paul F, Kim HJ, de Seze J, Wuerfel JT, Cabre P, Marignier R, Tedder T, van Pelt D, Broadley S, Chitnis T, Wingerchuk D, Pandit L, Leite MI, Apiwattanakul M, Kleiter I, Prayoonwiwat N, Han M, Hellwig K, van Herle K, John G, Hooper DC, Nakashima I, Sato D, Yeaman MR, Waubant E, Zamvil S, Stüve O, Aktas O, Smith TJ, Jacob A, O'Connor K

Defining the clinical course of multiple sclerosis: the 2013 revisions.

Neurology

Lublin FD, Reingold SC, Cohen JA, Cutter GR, Sørensen PS, Thompson AJ, Wolinsky JS, Balcer LJ, Banwell B, Barkhof F, Bebo B, Calabresi PA, Clanet M, Comi G, Fox RJ, Freedman MS, Goodman AD, Inglese M, Kappos L, Kieseier BC, Lincoln JA, Lubetzki C, Miller AE, Montalban X, O'Connor PW, Petkau J, Pozzilli C, Rudick RA, Sormani MP, Stüve O, Waubant E, Polman CH

Consensus Guidelines for CSF and Blood Biobanking for CNS Biomarker Studies.

Multiple sclerosis international

Teunissen CE, Tumani H, Bennett JL, Berven FS, Brundin L, Comabella M, Franciotta D, Federiksen JL, Fleming JO, Furlan R, Hintzen RQ, Hughes SG, Jimenez CR, Johnson MH, Killestein J, Krasulova E, Kuhle J, Magnone MC, Petzold A, Rajda C, Rejdak K, Schmidt HK, van Pesch V, Waubant E, Wolf C, Deisenhammer F, Giovannoni G, Hemmer B

Pediatric multiple sclerosis.

Neurologic clinics

Chitnis T, Krupp L, Yeh A, Rubin J, Kuntz N, Strober JB, Chabas D, Weinstock-Guttmann B, Ness J, Rodriguez M, Waubant E

Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.

Human molecular genetics

Baranzini SE, Wang J, Gibson RA, Galwey N, Naegelin Y, Barkhof F, Radue EW, Lindberg RL, Uitdehaag BM, Johnson MR, Angelakopoulou A, Hall L, Richardson JC, Prinjha RK, Gass A, Geurts JJ, Kragt J, Sombekke M, Vrenken H, Qualley P, Lincoln RR, Gomez R, Caillier SJ, George MF, Mousavi H, Guerrero R, Okuda DT, Cree BA, Green AJ, Waubant E, Goodin DS, Pelletier D, Matthews PM, Hauser SL, Kappos L, Polman CH, Oksenberg JR