Assoc Professor In Residence
M_MED-CORE-PULM
[email protected]
+1 415 476-9456
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UCSF Microbiome Researchers

I am a physician-scientist with an interest in airway epithelial dysfunction in asthma. Specifically, my lab focuses on understanding how genetic risk variants that are associated with asthma at a population level, actually confer risk of disease at a molecular level. We use novel techniques such as conditionally reprogrammed primary airway epithelial cells, CRISPR gene deletion, and biospecimens from large numbers of human subjects to discover the function of genes associated with asthma and elucidate the causal single nucleotide polymorphism. These efforts are designed to uncover novel drug targets and define the subpopulation of asthmatics most likely to benefit from therapy.

Publications

A common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma.

Nature communications

Everman JL, Sajuthi SP, Liegeois MA, Jackson ND, Collet EH, Peters MC, Chioccioli M, Moore CM, Patel BB, Dyjack N, Powell R, Rios C, Montgomery MT, Eng C, Elhawary JR, Mak ACY, Hu D, Huntsman S, Salazar S, Feriani L, Fairbanks-Mahnke A, Zinnen GL, Michel CR, Gomez J, Zhang X, Medina V, Chu HW, Cicuta P, Gordon ED, Zeitlin P, Ortega VE, Reisdorph N, Dunican EM, Tang M, Elicker BM, Henry TS, Bleecker ER, Castro M, Erzurum SC, Israel E, Levy BD, Mauger DT, Meyers DA, Sumino K, Gierada DS, Hastie AT, Moore WC, Denlinger LC, Jarjour NN, Schiebler ML, Wenzel SE, Woodruff PG, Rodriguez-Santana J, Pearson CG, Burchard EG, Fahy JV, Seibold MA

Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.

The Journal of clinical investigation

Dunican EM, Elicker BM, Gierada DS, Nagle SK, Schiebler ML, Newell JD, Raymond WW, Lachowicz-Scroggins ME, Di Maio S, Hoffman EA, Castro M, Fain SB, Jarjour NN, Israel E, Levy BD, Erzurum SC, Wenzel SE, Meyers DA, Bleecker ER, Phillips BR, Mauger DT, Gordon ED, Woodruff PG, Peters MC, Fahy JV, National Heart Lung and Blood Institute (NHLBI) Severe Asthma Research Program (SARP)