
Assistant Professor
Pediatrics
+1 415 476-3685
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I study the pathobiology of critical illness, including organ dysfunction and infection, in children with cancer, immunodeficiencies, and those who have undergone hematopoietic stem cell transplantation.
Publications
Postoperative Infections and Antimicrobial Prophylaxis in the Pediatric Intensive Care Unit After Liver Transplantation in Children.
Pediatric transplantation
High Prevalence of Abnormal Baseline Lung Function in Pediatric and Young Adult Hematopoietic Stem Cell Transplant Recipients: A Report from the TRANSPIRE Study.
Pediatric blood & cancer
Biologic Mechanisms Underlying the Heterogeneous Response to Tight Glycemic Control among Differentially Inflamed Patients in the HALF-PINT Trial.
American journal of respiratory and critical care medicine
International expert consensus statement on PICU admission and early critical care management for paediatric patients following haematopoietic cell transplant and immune effector cell therapy.
The Lancet. Child & adolescent health
Comparative Transcriptome Analysis of BAL and Blood in Pediatric HCT Recipients.
American journal of respiratory and critical care medicine
Differential Correlation Network Analysis Illustrates Novel Biomarker Interactions Underlying Hyperinflammation in Pediatric ARDS.
American journal of respiratory and critical care medicine
Latent Profile Analyses of Circulatory Biomarkers Indicate Distinct Patterns of Inflammation in Response to Transfusion in Pediatric MODS.
American journal of respiratory and critical care medicine
Upper and Lower Respiratory Microbiome-Transcriptome Concordance in Pediatric Hematopoietic Stem Cell Transplant Patients.
American journal of respiratory and critical care medicine
Integrating Pulmonary and Systemic Transcriptomic Profiles to Characterize Lung Injury after Pediatric Hematopoietic Stem Cell Transplant.
medRxiv : the preprint server for health sciences
Defining the host dependencies and the transcriptional landscape of RSV infection and bystander activation.
bioRxiv : the preprint server for biology
Macrophage ferroptosis inhibits Aspergillus conidial killing in lung transplantation.
bioRxiv : the preprint server for biology
Multidisciplinary approach to treating complex immune dysregulation disorders: an adaptive model for institutional implementation.
Frontiers in immunology
The Pediatric Immunocompromised Critical Care Program: Getting Everyone in the Room.
Transplantation and cellular therapy
1196: CORRELATION OF BLOOD AND BAL TRANSCRIPTOMES IN LUNG INJURY AFTER PEDIATRIC STEM CELL TRANSPLANT.
Critical care medicine
1218: UPPER AND LOWER AIRWAY GENE EXPRESSION IN PEDIATRIC ACUTE LUNG INJURY AFTER BONE MARROW TRANSPLANT.
Critical care medicine
Assessing Clinical Improvement of Infants Hospitalized for Respiratory Syncytial Virus-Related Critical Illness.
The Journal of infectious diseases
Pre-existing Immunocompromising Conditions and Outcomes of Acute COVID-19 Patients Admitted for Pediatric Intensive Care.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Epidemiology of Diffuse Alveolar Hemorrhage in Pediatric Allogeneic Hematopoietic Cell Transplant Recipients.
Transplantation and cellular therapy
Pediatric Hematology and Oncology Patients on Extracorporeal Membrane Oxygenation: Outcomes in a Multicenter, Retrospective Cohort 2009-2021.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
An orbitocortical-thalamic circuit suppresses binge alcohol-drinking.
bioRxiv : the preprint server for biology
Pulmonary hypertension in the intensive care unit after pediatric allogeneic hematopoietic stem cell transplant: incidence, risk factors, and outcomes.
Frontiers in oncology
Pathobiological signatures of dysbiotic lung injury in pediatric patients undergoing stem cell transplantation.
Nature medicine
Durability of Original Monovalent mRNA Vaccine Effectiveness Against COVID-19 Omicron-Associated Hospitalization in Children and Adolescents - United States, 2021-2023.
MMWR. Morbidity and mortality weekly report
Diagnosing and Grading of Sinusoidal Obstructive Syndrome after Hematopoietic Stem Cell Transplant of Children, Adolescent and Young Adults treated in a Pediatric Institution with Pediatric Protocols.
Transplantation and cellular therapy
Healthcare Burden and Resource Utilization After Pediatric Acute Respiratory Distress Syndrome: A Secondary Analysis of the Collaborative Pediatric Critical Care Research Network Acute Respiratory Distress Syndrome Study.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Intensive Care Risk and Long-Term Outcomes in Pediatric Allogeneic Hematopoietic Cell Transplant Recipients.
Blood advances
Characteristics and Clinical Outcomes of Vaccine-Eligible US Children Under-5 Years Hospitalized for Acute COVID-19 in a National Network.
The Pediatric infectious disease journal
Whole blood transcriptomics identifies subclasses of pediatric septic shock.
Critical care (London, England)
Pulmonary microbiome and transcriptome signatures reveal distinct pathobiologic states associated with mortality in two cohorts of pediatric stem cell transplant patients.
medRxiv : the preprint server for health sciences
Vascular thrombosis after pediatric liver transplantation: Is prevention achievable?
Journal of Liver Transplantation
Risk factors for health impairments in children after hospitalization for acute COVID-19 or MIS-C.
Frontiers in pediatrics
Effectiveness of Maternal mRNA COVID-19 Vaccination During Pregnancy Against COVID-19-Associated Hospitalizations in Infants Aged <6 Months During SARS-CoV-2 Omicron Predominance - 20 States, March 9, 2022-May 31, 2023.
MMWR. Morbidity and mortality weekly report
Critical Illness Risk and Long-Term Outcomes Following Intensive Care in Pediatric Hematopoietic Cell Transplant Recipients.
medRxiv : the preprint server for health sciences
Infants Admitted to US Intensive Care Units for RSV Infection During the 2022 Seasonal Peak.
JAMA network open
Diffuse alveolar hemorrhage after hematopoietic cell transplantation- response to treatments and risk factors for mortality.
Frontiers in oncology
Tight Glycemic Control, Inflammation, and the ICU: Evidence for Heterogeneous Treatment Effects in Two Randomized Controlled Trials.
American journal of respiratory and critical care medicine
Extracorporeal Membrane Oxygenation Characteristics and Outcomes in Children and Adolescents With COVID-19 or Multisystem Inflammatory Syndrome Admitted to U.S. ICUs.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Community-Onset Bacterial Coinfection in Children Critically Ill With Severe Acute Respiratory Syndrome Coronavirus 2 Infection.
Open forum infectious diseases
Factors associated with COVID-19 non-vaccination in adolescents hospitalized without COVID-19.
Journal of the Pediatric Infectious Diseases Society
BNT162b2 mRNA Vaccination Against COVID-19 is Associated with Decreased Likelihood of Multisystem Inflammatory Syndrome in U.S. Children Ages 5-18 Years.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Life-Threatening Complications of Influenza versus COVID-19 in U.S. Children.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Sociodemographic factors associated with tracheostomy and mortality in bronchopulmonary dysplasia.
Pediatric pulmonology
Changes in the Use of Invasive and Noninvasive Mechanical Ventilation in Pediatric Asthma: 2009-2019.
Annals of the American Thoracic Society
Prior COVID-19 infection may increase risk for developing endothelial dysfunction following hematopoietic cell transplantation.
Frontiers in oncology
NFKB2 haploinsufficiency identified via screening for IFNa2 autoantibodies in children and adolescents hospitalized with SARS-CoV-2-related complications.
The Journal of allergy and clinical immunology
DDX58 Is Associated With Susceptibility to Severe Influenza Virus Infection in Children and Adolescents.
The Journal of infectious diseases
Critical Care and Mechanical Ventilation Practices Surrounding Liver Transplantation in Children: A Multicenter Collaborative.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Measurement of SARS-CoV-2 antigens in plasma of pediatric patients with acute COVID-19 or MIS-C using an ultrasensitive and quantitative immunoassay.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Health Impairments in Children and Adolescents After Hospitalization for Acute COVID-19 or MIS-C.
Pediatrics
Author Correction: Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C.
Nature communications
Maternal Vaccination and Risk of Hospitalization for Covid-19 among Infants.
The New England journal of medicine
Should We Intubate Pediatric Hematopoietic Cell Transplant Patients With Respiratory Failure Sooner?
Critical care medicine
A Description of COVID-19-Directed Therapy in Children Admitted to US Intensive Care Units 2020.
Journal of the Pediatric Infectious Diseases Society
Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C.
Nature communications
Assessment of Patient Health-Related Quality of Life and Functional Outcomes in Pediatric Acute Respiratory Distress Syndrome.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
BNT162b2 Protection against the Omicron Variant in Children and Adolescents.
The New England journal of medicine
Lower respiratory tract infections in children requiring mechanical ventilation: a multicentre prospective surveillance study incorporating airway metagenomics.
The Lancet. Microbe
Pulmonary microbiome and gene expression signatures differentiate lung function in pediatric hematopoietic cell transplant candidates.
Science translational medicine
Candidacy for Extracorporeal Life Support in Children After Hematopoietic Cell Transplantation: A Position Paper From the Pediatric Acute Lung Injury and Sepsis Investigators Network's Hematopoietic Cell Transplant and Cancer Immunotherapy Subgroup.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Effectiveness of Maternal Vaccination with mRNA COVID-19 Vaccine During Pregnancy Against COVID-19-Associated Hospitalization in Infants Aged <6 Months - 17 States, July 2021-January 2022.
MMWR. Morbidity and mortality weekly report
Effectiveness of BNT162b2 Vaccine against Critical Covid-19 in Adolescents.
The New England journal of medicine
Extracorporeal membrane oxygenation in children receiving haematopoietic cell transplantation and immune effector cell therapy: an international and multidisciplinary consensus statement.
The Lancet. Child & adolescent health
Measurement of SARS-CoV-2 antigens in plasma of pediatric patients with acute COVID-19 or MIS-C using an ultrasensitive and quantitative immunoassay.
medRxiv : the preprint server for health sciences
Hematopoietic Cell Transplant-Comorbidity Index Score is Correlated with Treatment Related Mortality and Overall Survival following Second Allogeneic Hematopoietic Cell Transplant in Children.
Transplantation and cellular therapy
Consensus-Based Guidelines for the Recognition, Diagnosis, and Management of Hemophagocytic Lymphohistiocytosis in Critically Ill Children and Adults.
Critical care medicine
Risk Factors for Noninvasive Ventilation Failure in Children Post-Hematopoietic Cell Transplant.
Frontiers in oncology
Delirium in Children Undergoing Hematopoietic Cell Transplantation: A Multi-Institutional Point Prevalence Study.
Frontiers in oncology
Effects of Hematopoietic Cell Transplantation on the Pulmonary Immune Response to Infection.
Frontiers in pediatrics
Outcomes of Children With Cystic Fibrosis Admitted to PICUs.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
How We Treat Fever and Hypotension in Pediatric Hematopoietic Cell Transplant Patients.
Frontiers in oncology
Investigating Transfusion-Related Sepsis using Culture-Independent Metagenomic Sequencing.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Acute hypoxaemic respiratory failure in immunocompromised patients: abandon bronchoscopy or make it better?
The European respiratory journal
Comprehensive Prognostication in Critically Ill Pediatric Hematopoietic Cell Transplant Patients: Results from Merging the Center for International Blood and Marrow Transplant Research (CIBMTR) and Virtual Pediatric Systems (VPS) Registries.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
Risk Factors for Mortality and Pre-ICU Fluid Balance Among Critically Ill Hematopoietic Stem Cell Transplant Patients.
Journal of intensive care medicine
Pulmonary Metagenomic Sequencing Suggests Missed Infections in Immunocompromised Children.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Positive Cumulative Fluid Balance Is Associated With Mortality in Pediatric Acute Respiratory Distress Syndrome in the Setting of Acute Kidney Injury.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Early Plasma Matrix Metalloproteinase Profiles. A Novel Pathway in Pediatric Acute Respiratory Distress Syndrome.
American journal of respiratory and critical care medicine
Miniaturization and optimization of 384-well compatible RNA sequencing library preparation.
PloS one
Integrating host response and unbiased microbe detection for lower respiratory tract infection diagnosis in critically ill adults.
Proceedings of the National Academy of Sciences of the United States of America
Cardiac arrest and pulmonary hypertension in scurvy: a case report.
Pulmonary circulation
Intensive Care Mortality Prognostic Model for Pediatric Pulmonary Hypertension.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
A multicenter investigation of respiratory syncytial viral infection in children with hematopoietic cell transplantation.
Transplant infectious disease : an official journal of the Transplantation Society
Metagenomic Sequencing Detects Respiratory Pathogens in Hematopoietic Cellular Transplant Patients.
American journal of respiratory and critical care medicine
Multicenter mortality and morbidity associated with pulmonary hypertension in the pediatric intensive care unit.
Pulmonary circulation
Pediatric Hematopoietic Cell Transplant Patients Who Survive Critical Illness Frequently Have Significant but Recoverable Decline in Functional Status.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
Pulmonary veno-occlusive disease in a pediatric hematopoietic stem cell transplant patient: a cautionary tale.
Leukemia & lymphoma
Extracorporeal life support survival in a pediatric hematopoietic cellular transplant recipient with presumed GvHD-related fulminant myocarditis.
Bone marrow transplantation
Incorporating Inflammation into Mortality Risk in Pediatric Acute Respiratory Distress Syndrome.
Critical care medicine
A Simple and Robust Bedside Model for Mortality Risk in Pediatric Patients With Acute Respiratory Distress Syndrome.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Safe and Effective Prophylaxis with Bimonthly Intravenous Pentamidine in the Pediatric Hematopoietic Stem Cell Transplant Population.
The Pediatric infectious disease journal
Elevated soluble thrombomodulin is associated with organ failure and mortality in children with acute respiratory distress syndrome (ARDS): a prospective observational cohort study.
Critical care (London, England)
Plasma angiopoietin-2 outperforms other markers of endothelial injury in prognosticating pediatric ARDS mortality.
American journal of physiology. Lung cellular and molecular physiology
New Insights Into Multicenter PICU Mortality Among Pediatric Hematopoietic Stem Cell Transplant Patients.
Critical care medicine
A review of pathogens causing lower respiratory tract infection in the pediatric hematopoietic stem cell transplant recipient.
Journal of pediatric intensive care