
Professor
M_Neurology
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Publications
Germline analysis of an international cohort of pediatric diffuse midline glioma patients.
Neuro-oncology
Measles Oncolytic Virus as an Immunotherapy for Recurrent/Refractory Pediatric Medulloblastoma and Atypical Teratoid/Rhabdoid Tumor: Results from PNOC005.
Clinical cancer research : an official journal of the American Association for Cancer Research
Imaging Clusters of Pediatric Low-Grade Glioma Are Associated with Distinct Molecular Characteristics.
AJNR. American journal of neuroradiology
Applications of artificial intelligence and advanced imaging in pediatric diffuse midline glioma.
Neuro-oncology
Author Correction: The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial.
Nature medicine
Deep learning volumetrics reveal distinct clinical trajectories for pediatric low-grade gliomas under surveillance: A multicenter study.
Neuro-oncology advances
Dual treatment with Val-083 and AZD1775 shows potent anti-tumor activity in diffuse midline glioma models.
NPJ precision oncology
cIMPACT-NOW update 10: Recommendations for defining new types for central nervous system tumor classification.
Brain pathology (Zurich, Switzerland)
PNOC009: Convection-enhanced delivery of liposomal irinotecan in patients with newly diagnosed diffuse intrinsic pontine glioma.
Neuro-oncology advances
Gross tumor volume increase and need for adaptive radiotherapy in pediatric-type diffuse high-grade glioma of the midline structures.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Current clinical trials for craniopharyngiomas: what's on the horizon?
Journal of neuro-oncology
Correction: Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways.
Cancer discovery
Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions.
Clinical cancer research : an official journal of the American Association for Cancer Research
Paediatric strategy forum for medicinal product development in diffuse midline gliomas in children and adolescents ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration.
European journal of cancer (Oxford, England : 1990)
Multimodal deep learning improves recurrence risk prediction in pediatric low-grade gliomas.
Neuro-oncology
cIMPACT-NOW update 9: Recommendations on utilization of genome-wide DNA methylation profiling for central nervous system tumor diagnostics.
Neuro-oncology advances
Multiparametric MRI along with machine learning predicts prognosis and treatment response in pediatric low-grade glioma.
Nature communications
A foundation model for generalized brain MRI analysis.
medRxiv : the preprint server for health sciences
Editor's Note: BRAF Status in Personalizing Treatment Approaches for Pediatric Gliomas.
Clinical cancer research : an official journal of the American Association for Cancer Research
Retrospective Comparison of Targeted Anticancer Drugs Predicted by the CNS-TAP Tool Versus Those Selected by a Molecularly Driven Tumor Board in Children With DIPG.
Journal of pediatric hematology/oncology
Marrow-ablative consolidation chemotherapy and molecular targeted therapy delivered in a risk-adapted manner for newly diagnosed children with choroid plexus carcinoma: A work in progress.
Neuro-oncology advances
Stepwise Transfer Learning for Expert-level Pediatric Brain Tumor MRI Segmentation in a Limited Data Scenario.
Radiology. Artificial intelligence
Longitudinal risk prediction for pediatric glioma with temporal deep learning.
medRxiv : the preprint server for health sciences
A Standardized Nomenclature Design for Systematic Referencing and Identification of Animal Cellular Material.
Animals : an open access journal from MDPI
A review of current therapeutics targeting the mitochondrial protease ClpP in diffuse midline glioma, H3 K27-altered.
Neuro-oncology
ACTION: a randomized phase 3 study of ONC201 (dordaviprone) in patients with newly diagnosed H3 K27M-mutant diffuse glioma.
Neuro-oncology
Rational combination platform trial design for children and young adults with diffuse midline glioma: A report from PNOC.
Neuro-oncology
Author Correction: The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial.
Nature medicine
Noninvasive Molecular Subtyping of Pediatric Low-Grade Glioma with Self-Supervised Transfer Learning.
Radiology. Artificial intelligence
Comparison of Volumetric and 2D Measurements and Longitudinal Trajectories in the Response Assessment of BRAF V600E-Mutant Pediatric Gliomas in the Pacific Pediatric Neuro-Oncology Consortium Clinical Trial.
AJNR. American journal of neuroradiology
Diffusion deep learning for brain age prediction and longitudinal tracking in children through adulthood.
Imaging neuroscience (Cambridge, Mass.)
PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma.
The Journal of clinical investigation
Comparison of volumetric and 2D-based response methods in the PNOC-001 pediatric low-grade glioma clinical trial.
Neuro-oncology advances
Noninvasive molecular subtyping of pediatric low-grade glioma with self-supervised transfer learning.
medRxiv : the preprint server for health sciences
Everolimus for Children With Recurrent or Progressive Low-Grade Glioma: Results From the Phase II PNOC001 Trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial.
Nature medicine
Automated temporalis muscle quantification and growth charts for children through adulthood.
Nature communications
Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways.
Cancer discovery
Expert-level pediatric brain tumor segmentation in a limited data scenario with stepwise transfer learning.
medRxiv : the preprint server for health sciences
Evolution and implementation of radiographic response criteria in neuro-oncology.
Neuro-oncology advances
Pan-cancer atlas of somatic core and linker histone mutations.
NPJ genomic medicine
OpenPBTA: The Open Pediatric Brain Tumor Atlas.
Cell genomics
Translational considerations for immunotherapy clinical trials in pediatric neuro-oncology.
Neoplasia (New York, N.Y.)
ONC201 in Combination with Paxalisib for the Treatment of H3K27-Altered Diffuse Midline Glioma.
Cancer research
Cellular Therapy for Children with Central Nervous System Tumors: Mining and Mapping the Correlative Data.
Current oncology reports
ONC201 in combination with paxalisib for the treatment of H3K27-altered diffuse midline glioma.
Cancer research
Precision based approach to tailoring radiotherapy in the multidisciplinary management of pediatric central nervous system tumors.
Journal of the National Cancer Center
Evaluating preclinical evidence for clinical translation in childhood brain tumours: Guidelines from the CONNECT, PNOC, and ITCC brain networks.
Frontiers in oncology
Correspondence on 'H3.3K27M mutation is not a suitable target for immunotherapy in HLA-A2+ patients with diffuse midline glioma' by Immisch et al.
Journal for immunotherapy of cancer
Indigenous peoples and inclusion in clinical and genomic research: Understanding the history and navigating contemporary engagement.
Neoplasia (New York, N.Y.)
Past, present and future of Focused Ultrasound as an adjunct or complement to DIPG/DMG therapy: A consensus of the 2021 FUSF DIPG meeting.
Neoplasia (New York, N.Y.)
Retrospective dataset and survey analyses identify gaps in data collection for craniopharyngioma and priorities of patients and families affected by the disease.
Neoplasia (New York, N.Y.)
Advances and Clinical Trials Update in the Treatment of Diffuse Intrinsic Pontine Gliomas.
Pediatric neurosurgery
Response and resistance to BRAFV600E inhibition in gliomas: Roadblocks ahead?
Frontiers in oncology
Pediatric low-grade glioma: Targeted therapeutics and clinical trials in the molecular era.
Neoplasia (New York, N.Y.)
Outcomes of Infants and Young Children With Relapsed Medulloblastoma After Initial Craniospinal Irradiation-Sparing Approaches: An International Cohort Study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Interdisciplinary care of children with diffuse midline glioma.
Neoplasia (New York, N.Y.)
The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science.
Neoplasia (New York, N.Y.)
Real-time drug testing of paediatric diffuse midline glioma to support clinical decision making: The Zurich DIPG/DMG centre experience.
European journal of cancer (Oxford, England : 1990)
Upfront Biology-Guided Therapy in Diffuse Intrinsic Pontine Glioma: Therapeutic, Molecular, and Biomarker Outcomes from PNOC003.
Clinical cancer research : an official journal of the American Association for Cancer Research
Phase I dose escalation and expansion trial of single agent ONC201 in pediatric diffuse midline gliomas following radiotherapy.
Neuro-oncology advances
Functional network alterations in young brain tumor patients with radiotherapy-induced memory impairments and vascular injury.
Frontiers in neurology
Circulating tumor DNA sequencing provides comprehensive mutation profiling for pediatric central nervous system tumors.
NPJ precision oncology
Imipridones affect tumor bioenergetics and promote cell lineage differentiation in diffuse midline gliomas.
Neuro-oncology
Multiplatform molecular analyses refine classification of gliomas arising in patients with neurofibromatosis type 1.
Acta neuropathologica
Serial H3K27M cell-free tumor DNA (cf-tDNA) tracking predicts ONC201 treatment response and progression in diffuse midline glioma.
Neuro-oncology
Mass cytometry detects H3.3K27M-specific vaccine responses in diffuse midline glioma.
The Journal of clinical investigation
Wee1 kinase inhibitor adavosertib with radiation in newly diagnosed diffuse intrinsic pontine glioma: A Children's Oncology Group phase I consortium study.
Neuro-oncology advances
Pediatric pineoblastoma: A pooled outcome study of North American and Australian therapeutic data.
Neuro-oncology advances
Review: Neurological Complications From Therapies for Pediatric Brain Tumors.
Frontiers in oncology
Intracranial mesenchymal tumors with FET-CREB fusion are composed of at least two epigenetic subgroups distinct from meningioma and extracranial sarcomas.
Brain pathology (Zurich, Switzerland)
Preclinical and clinical evaluation of German-sourced ONC201 for the treatment of H3K27M-mutant diffuse intrinsic pontine glioma.
Neuro-oncology advances
Diffuse hemispheric glioma, H3 G34-mutant: Genomic landscape of a new tumor entity and prospects for targeted therapy.
Neuro-oncology
Repurposing Vandetanib plus Everolimus for the Treatment of ACVR1-Mutant Diffuse Intrinsic Pontine Glioma.
Cancer discovery
Author Correction: Topographic correlates of driver mutations and endogenous gene expression in pediatric diffuse midline gliomas and hemispheric high-grade gliomas.
Scientific reports
Topographic correlates of driver mutations and endogenous gene expression in pediatric diffuse midline gliomas and hemispheric high-grade gliomas.
Scientific reports
Radiation in Combination With Targeted Agents and Immunotherapies for Pediatric Central Nervous System Tumors - Progress, Opportunities, and Challenges.
Frontiers in oncology
Multi-institutional analysis of treatment modalities in basal ganglia and thalamic germinoma.
Pediatric blood & cancer
Relationship between 7T MR-angiography features of vascular injury and cognitive decline in young brain tumor patients treated with radiation therapy.
Journal of neuro-oncology
Optimal therapeutic targeting by HDAC inhibition in biopsy-derived treatment-naïve diffuse midline glioma models.
Neuro-oncology
Standardization of the liquid biopsy for pediatric diffuse midline glioma using ddPCR.
Scientific reports
Mass cytometry detects H3.3K27M-specific vaccine responses in diffuse midline glioma.
The Journal of clinical investigation
Opportunities for the treatment of NF1-associated low-grade gliomas: how to decide on the best treatment options for patients?
Neuro-oncology
Everolimus improves the efficacy of dasatinib in PDGFRα-driven glioma.
The Journal of clinical investigation
Rate of radiation-induced microbleed formation on 7T MRI relates to cognitive impairment in young patients treated with radiation therapy for a brain tumor.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Comprehensive analysis of diverse low-grade neuroepithelial tumors with FGFR1 alterations reveals a distinct molecular signature of rosette-forming glioneuronal tumor.
Acta neuropathologica communications
Diffuse midline glioma: review of epigenetics.
Journal of neuro-oncology
Response to Letter by Walker et al.
Neuro-oncology practice
Response to Karajannis et al.
Neuro-oncology practice
Harmonization of postmortem donations for pediatric brain tumors and molecular characterization of diffuse midline gliomas.
Scientific reports
Response assessment in paediatric high-grade glioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group.
The Lancet. Oncology
Population Pharmacokinetics of Vemurafenib in Children With Recurrent/Refractory BRAF Gene V600E-Mutant Astrocytomas.
Journal of clinical pharmacology
Neurocognitive Outcomes in Children with Brain Tumors.
Seminars in neurology
Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors.
Nature medicine
Pediatric hemispheric high-grade glioma: targeting the future.
Cancer metastasis reviews
Introduction. Pediatric brain tumor.
Neurosurgical focus
Stroke impact on mortality and psychologic morbidity within the Childhood Cancer Survivor Study.
Cancer
Comparative Tumor RNA Sequencing Analysis for Difficult-to-Treat Pediatric and Young Adult Patients With Cancer.
JAMA network open
Recurrent non-canonical histone H3 mutations in spinal cord diffuse gliomas.
Acta neuropathologica
A systematic review and meta-analysis of outcomes in pediatric, recurrent ependymoma.
Journal of neuro-oncology
Brainstem Injury in Pediatric Patients Receiving Posterior Fossa Photon Radiation.
International journal of radiation oncology, biology, physics
Pediatric and adult H3 K27M-mutant diffuse midline glioma treated with the selective DRD2 antagonist ONC201.
Journal of neuro-oncology
Neuro-Oncology Practice Clinical Debate: targeted therapy vs conventional chemotherapy in pediatric low-grade glioma.
Neuro-oncology practice
Molecular profiling and targeted therapy in pediatric gliomas: review and consensus recommendations.
Neuro-oncology
Oncolytic Measles Virotherapy and Opposition to Measles Vaccination.
Mayo Clinic proceedings
Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids.
Journal of visualized experiments : JoVE
A pilot precision medicine trial for children with diffuse intrinsic pontine glioma-PNOC003: A report from the Pacific Pediatric Neuro-Oncology Consortium.
International journal of cancer
The genetic landscape of anaplastic pleomorphic xanthoastrocytoma.
Brain pathology (Zurich, Switzerland)
Clinically Relevant and Minimally Invasive Tumor Surveillance of Pediatric Diffuse Midline Gliomas Using Patient-Derived Liquid Biopsy.
Clinical cancer research : an official journal of the American Association for Cancer Research
Prospective feasibility and safety assessment of surgical biopsy for patients with newly diagnosed diffuse intrinsic pontine glioma.
Neuro-oncology
Reirradiation and PD-1 inhibition with nivolumab for the treatment of recurrent diffuse intrinsic pontine glioma: a single-institution experience.
Journal of neuro-oncology
The genetic landscape of gliomas arising after therapeutic radiation.
Acta neuropathologica
Abnormal Morphology of Select Cortical and Subcortical Regions in Neurofibromatosis Type 1.
Radiology
Clinical Applications of Quantitative 3-Dimensional MRI Analysis for Pediatric Embryonal Brain Tumors.
International journal of radiation oncology, biology, physics
The genetic landscape of ganglioglioma.
Acta neuropathologica communications
Dual HDAC and PI3K Inhibition Abrogates NFκB- and FOXM1-Mediated DNA Damage Response to Radiosensitize Pediatric High-Grade Gliomas.
Cancer research
Large Vessel Arteriopathy After Cranial Radiation Therapy in Pediatric Brain Tumor Survivors.
Journal of child neurology
Early detection of recurrent medulloblastoma: the critical role of diffusion-weighted imaging.
Neuro-oncology practice
Deep sequencing of WNT-activated medulloblastomas reveals secondary SHH pathway activation.
Acta neuropathologica
Pediatric low-grade gliomas: next biologically driven steps.
Neuro-oncology
Novel and shared neoantigen derived from histone 3 variant H3.3K27M mutation for glioma T cell therapy.
The Journal of experimental medicine
Survival outcomes in pediatric recurrent high-grade glioma: results of a 20-year systematic review and meta-analysis.
Journal of neuro-oncology
New therapeutic approaches for brainstem tumors: a comparison of delivery routes using nanoliposomal irinotecan in an animal model.
Journal of neuro-oncology
Case-based review: pediatric medulloblastoma.
Neuro-oncology practice
Therapeutic and Prognostic Implications of BRAF V600E in Pediatric Low-Grade Gliomas.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Pediatric high-grade glioma: current molecular landscape and therapeutic approaches.
Journal of neuro-oncology
Response to "Cognitive function, cerebral microbleeds, radiotherapy, and bevacizumab in survivors of paediatric brain tumors".
Neuro-oncology
Survival after chemotherapy and stem cell transplant followed by delayed craniospinal irradiation is comparable to upfront craniospinal irradiation in pediatric embryonal brain tumor patients.
Journal of neuro-oncology
Presence of cerebral microbleeds is associated with worse executive function in pediatric brain tumor survivors.
Neuro-oncology
Evaluation of Pre-Hematopoietic Cell Transplantation (HCT) Brain MRI and Neurologic Complications of Pediatric Patients Undergoing HCT for Hematologic Malignancies.
Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses
BRAF Status in Personalizing Treatment Approaches for Pediatric Gliomas.
Clinical cancer research : an official journal of the American Association for Cancer Research
IDH1 mutation can be present in diffuse astrocytomas and giant cell glioblastomas of young children under 10 years of age.
Acta neuropathologica
Inactivating MUTYH germline mutations in pediatric patients with high-grade midline gliomas.
Neuro-oncology
Erratum to: Survival advantage combining a BRAF inhibitor and radiation in BRAF V600E-mutant glioma.
Journal of neuro-oncology
MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism.
Nature genetics
Clinical outcome and prognostic factors for central neurocytoma: twenty year institutional experience.
Journal of neuro-oncology
Survival advantage combining a BRAF inhibitor and radiation in BRAF V600E-mutant glioma.
Journal of neuro-oncology
EAG2 potassium channel with evolutionarily conserved function as a brain tumor target.
Nature neuroscience
WEE1 Kinase As a Target for Cancer Therapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Late Effects of Treatment of Pediatric Central Nervous System Tumors.
Journal of child neurology
Posttranscriptional deregulation of signaling pathways in meningioma subtypes by differential expression of miRNAs.
Neuro-oncology
Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma.
Nature medicine
Pure germinomas of the central nervous system: treatment strategies and outcomes.
Journal of neuro-oncology
Rates and characteristics of radiographically detected intracerebral cavernous malformations after cranial radiation therapy in pediatric cancer patients.
Journal of child neurology
Germ-line and somatic DICER1 mutations in pineoblastoma.
Acta neuropathologica
The alternative lengthening of telomere phenotype is significantly associated with loss of ATRX expression in high-grade pediatric and adult astrocytomas: a multi-institutional study of 214 astrocytomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Radiation, atherosclerotic risk factors, and stroke risk in survivors of pediatric cancer: a report from the Childhood Cancer Survivor Study.
International journal of radiation oncology, biology, physics
Feasibility, safety, and indications for surgical biopsy of intrinsic brainstem tumors in children.
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
Risk of first and recurrent stroke in childhood cancer survivors treated with cranial and cervical radiation therapy.
International journal of radiation oncology, biology, physics
The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression.
Genes & development
PDGFRA amplification is common in pediatric and adult high-grade astrocytomas and identifies a poor prognostic group in IDH1 mutant glioblastoma.
Brain pathology (Zurich, Switzerland)
Poly (ADP-Ribose) polymerase inhibitor MK-4827 together with radiation as a novel therapy for metastatic neuroblastoma.
Anticancer research
Multidisciplinary care of patients with brain tumors.
Surgical oncology clinics of North America
Characterization of a diffuse intrinsic pontine glioma cell line: implications for future investigations and treatment.
Journal of neuro-oncology
PTEN promoter methylation and activation of the PI3K/Akt/mTOR pathway in pediatric gliomas and influence on clinical outcome.
Neuro-oncology
High-grade gliomas in children.
Neurosurgery clinics of North America
The superiority of conservative resection and adjuvant radiation for craniopharyngiomas.
Journal of neuro-oncology
Cooperation of the HDAC inhibitor vorinostat and radiation in metastatic neuroblastoma: efficacy and underlying mechanisms.
Cancer letters
Vorinostat increases expression of functional norepinephrine transporter in neuroblastoma in vitro and in vivo model systems.
Clinical cancer research : an official journal of the American Association for Cancer Research
Inhibition of PI3K/mTOR pathways in glioblastoma and implications for combination therapy with temozolomide.
Neuro-oncology
Effect of imaging and catheter characteristics on clinical outcome for patients in the PRECISE study.
Journal of neuro-oncology
Neuroblastoma: biology and staging.
Current oncology reports
T-cell lymphoproliferative disorder following mycophenolate treatment for myasthenia gravis.
Muscle & nerve
A case of paraneoplastic myelopathy associated with the neuromyelitis optica antibody.
Nature clinical practice. Neurology