Dr. Li works on human genomics. The main theme of his research is large-scale analysis of disease genomes by integrating multi-omics data, evolutionary insights, electronic health records, as well as digitized clinical traits from imaging and wearable sensor readouts. The ultimate goal is to build a data-driven framework to detect diseases before symptoms emerge and to achieve precision health management.

People who experience traumatic or enduring psychological stress are more likely to develop psychiatric disorders as well as cardiovascular, autoimmune and neurodegenerative disorders. Our research is focused on revealing how psychological stress drives the development of mental and physical disorders. Specifically, we aim to identify the psychological and biological factors that account for the adverse effects of psychological stress, and ultimately to drive the development of targeted interventions to reduce such negative effects of stress.