Ma Somsouk, MD, MAS

Professor
Medicine
[email protected]
+1 628 206-6480

1. Programmatic implementation of population-based colorectal cancer screening and follow-up of abnormal screening results. We embrace big data and technology to design, develop, and deliver economic and effective services for patients and health systems.

2. Use of human gut samples to study HIV, Covid-19, barrier function, systemic inflammation, inflammatory bowel disease, and microbiome. Approaches employed: organoid models, isolation of epithelial cells and lymphocytes, single cell, spatial transcriptomic analysis, microbial profiling, and blood-based profiling.

Publications: 

Multilevel intervention for follow-up of abnormal FIT in the safety-net: IMProving Adherence to Colonoscopy through Teams and Technology (IMPACTT).

Contemporary clinical trials

Wang K, Wong J, Avilez L, Olazo K, Olanrewaju S, McCulloch CE, Pasick R, Patel S, Somsouk M, Sarkar U

Tissue-based T cell activation and viral RNA persist for up to 2 years after SARS-CoV-2 infection.

Science translational medicine

Peluso MJ, Ryder D, Flavell RR, Wang Y, Levi J, LaFranchi BH, Deveau TM, Buck AM, Munter SE, Asare KA, Aslam M, Koch W, Szabo G, Hoh R, Deswal M, Rodriguez AE, Buitrago M, Tai V, Shrestha U, Lu S, Goldberg SA, Dalhuisen T, Vasquez JJ, Durstenfeld MS, Hsue PY, Kelly JD, Kumar N, Martin JN, Gambhir A, Somsouk M, Seo Y, Deeks SG, Laszik ZG, VanBrocklin HF, Henrich TJ

Colorectal Cancer Screening: A Multicomponent Intervention to Increase Uptake in Patients Aged 45-49.

Journal of the American Board of Family Medicine : JABFM

McClellan SP, Patel S, Uy-Smith E, Gregory B, Neuhaus JM, Potter MB, Somsouk M

The effect of mailed outreach on FIT completion among patients aged 45-50 in a safety net healthcare system.

Cancer causes & control : CCC

McClellan SP, Khan T, Rafferty H, Wong J, La S, Patel S, Somsouk M

Electronic coding for abnormal fecal immunochemical test is associated with increased colonoscopy completion.

The American journal of gastroenterology

Burns S, Griffith M, Patel S, Sarkar U, Somsouk M

Assessing the Impact of COVID-19 on IBD Outcomes Among Vulnerable Patient Populations in a Large Metropolitan Center.

Inflammatory bowel diseases

Odufalu FD, Sewell JL, Rudrapatna V, Somsouk M, Mahadevan U

Intestinal Metaplasia Associated with Symptoms of Dyspepsia.

Research square

Viramontes O, Martinez D, Somsouk M

Delivering High-Quality, Efficient Gastroenterology Care to Vulnerable and Underserved Populations: Special Considerations and Possible Solutions.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Patel S, Sewell JL, Bhuket T, Somsouk M

Multimodal Molecular Imaging Reveals Tissue-Based T Cell Activation and Viral RNA Persistence for Up to 2 Years Following COVID-19.

medRxiv : the preprint server for health sciences

Peluso MJ, Ryder D, Flavell R, Wang Y, Levi J, LaFranchi BH, Deveau TM, Buck AM, Munter SE, Asare KA, Aslam M, Koch W, Szabo G, Hoh R, Deswal M, Rodriguez A, Buitrago M, Tai V, Shrestha U, Lu S, Goldberg SA, Dalhuisen T, Durstenfeld MS, Hsue PY, Kelly JD, Kumar N, Martin JN, Gambir A, Somsouk M, Seo Y, Deeks SG, Laszik ZG, VanBrocklin HF, Henrich TJ

The human microbiome and gut-liver axis in people living with HIV.

Current HIV/AIDS reports

Duarte MJ, Tien PC, Somsouk M, Price JC

LOXL-2 and TNC-C are markers of liver fibrogenesis in HCV/HIV-, HIV- and HCV-infected patients.

Biomarkers in medicine

Altinbas A, Holmes JA, Salloum S, Lidofsky A, Alatrakchi N, Somsouk M, Hunt P, Deeks S, Chew KW, Lauer G, Kruger A, Lin W, Chung RT

Extent of Follow-Up on Abnormal Cancer Screening in Multiple California Public Hospital Systems: A Retrospective Review.

Journal of general internal medicine

Khoong EC, Rivadeneira NA, Pacca L, Schillinger D, Lown D, Babaria P, Gupta N, Pramanik R, Tran H, Whitezell T, Somsouk M, Sarkar U

Determinants of Colorectal Cancer Screening among South Asian Americans.

Journal of Asian health

Mukherjea A, Shariff-Marco S, Yang J, Tseng W, Palaniappan L, Li J, Ivey SL, Somsouk M, Gomez SL

From Cancer Epidemiology to Policy and Practice: the Role of a Comprehensive Cancer Center.

Current epidemiology reports

Hiatt RA, Sibley A, Venkatesh B, Cheng J, Dixit N, Fox R, Ling P, Nguyen T, Oh D, Palmer NR, Pasick RJ, Potter MB, Somsouk M, Vargas RA, Vijayaraghavan M, Ashworth A

Multiomic Analysis of the Gut Microbiome in Psoriasis Reveals Distinct Host?Microbe Associations.

JID innovations : skin science from molecules to population health

Chang HW, Yan D, Singh R, Bui A, Lee K, Truong A, Milush JM, Somsouk M, Liao W

A Root Cause Analysis of Barriers to Timely Colonoscopy in California Safety-Net Health Systems.

Journal of patient safety

Sharma AE, Lyson HC, Cherian R, Somsouk M, Schillinger D, Sarkar U

Asian American/Pacific Islander and Hispanic Ethnic Enclaves, Neighborhood Socioeconomic Status, and Hepatocellular Carcinoma Incidence in California: An Update.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Sangaramoorthy M, Yang J, Guan A, DeRouen MC, Tana MM, Somsouk M, Thompson CA, Gibbons J, Ho C, Chu JN, Cheng I, Gomez SL, Shariff-Marco S

Gag p24 is a Marker of HIV Expression in Tissues and Correlates with Immune Response.

The Journal of infectious diseases

Wu G, Zuck P, Goh SL, Milush JM, Vohra P, Wong JK, Somsouk M, Yukl SA, Shacklett BL, Chomont N, Haase AT, Hatano H, Schacker TW, Deeks SG, Hazuda DJ, Hunt PW, Howell BJ

Dual targeting of lymphocyte homing and retention through a4ß7 and aEß7 inhibition in inflammatory bowel disease.

Cell reports. Medicine

Dai B, Hackney JA, Ichikawa R, Nguyen A, Elstrott J, Orozco LD, Sun KH, Modrusan Z, Gogineni A, Scherl A, Gubatan J, Habtezion A, Deswal M, Somsouk M, Faubion WA, Chai A, Sharafali Z, Hassanali A, Oh YS, Tole S, McBride J, Keir ME, Yi T

Increased Colorectal Cancer Screening Sustained with Mailed Fecal Immunochemical Test Outreach.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Lee B, Keyes E, Rachocki C, Grimes B, Chen E, Vittinghoff E, Ladabaum U, Somsouk M

LINGO3 regulates mucosal tissue regeneration and promotes TFF2 dependent recovery from colitis.

Scandinavian journal of gastroenterology

Zullo KM, Douglas B, Maloney NM, Ji Y, Wei Y, Herbine K, Cohen R, Pastore C, Cramer Z, Wang X, Wei W, Somsouk M, Hung LY, Lengner C, Kohanski MH, Cohen NA, Herbert DR

Colorectal Cancer Screening and COVID-19.

The American journal of gastroenterology

Patel S, Issaka RB, Chen E, Somsouk M

Shared Mechanisms Govern HIV Transcriptional Suppression in Circulating CD103+ and Gut CD4+ T Cells.

Journal of virology

Yukl SA, Khan S, Chen TH, Trapecar M, Wu F, Xie G, Telwatte S, Fulop D, Pico AR, Laird GM, Ritter KD, Jones NG, Lu CM, Siliciano RF, Roan NR, Milush JM, Somsouk M, Deeks SG, Hunt PW, Sanjabi S

Mechanistic differences underlying HIV latency in the gut and blood contribute to differential responses to latency-reversing agents.

AIDS (London, England)

Telwatte S, Kim P, Chen TH, Milush JM, Somsouk M, Deeks SG, Hunt PW, Wong JK, Yukl SA

Phenotypic analysis of the unstimulated in vivo HIV CD4 T cell reservoir.

eLife

Neidleman J, Luo X, Frouard J, Xie G, Hsiao F, Ma T, Morcilla V, Lee A, Telwatte S, Thomas R, Tamaki W, Wheeler B, Hoh R, Somsouk M, Vohra P, Milush J, James KS, Archin NM, Hunt PW, Deeks SG, Yukl SA, Palmer S, Greene WC, Roan NR

Distinct viral reservoirs in individuals with spontaneous control of HIV-1.

Nature

Jiang C, Lian X, Gao C, Sun X, Einkauf KB, Chevalier JM, Chen SMY, Hua S, Rhee B, Chang K, Blackmer JE, Osborn M, Peluso MJ, Hoh R, Somsouk M, Milush J, Bertagnolli LN, Sweet SE, Varriale JA, Burbelo PD, Chun TW, Laird GM, Serrao E, Engelman AN, Carrington M, Siliciano RF, Siliciano JM, Deeks SG, Walker BD, Lichterfeld M, Yu XG

Advanced Notification Calls Prior to Mailed Fecal Immunochemical Test in Previously Screened Patients: a Randomized Controlled Trial.

Journal of general internal medicine

Lee B, Patel S, Rachocki C, Issaka R, Vittinghoff E, Shapiro JA, Ladabaum U, Somsouk M

Changes in gastrointestinal microbial communities influence HIV-specific CD8+ T-cell responsiveness to immune checkpoint blockade.

AIDS (London, England)

SahBandar IN, Chew GM, Corley MJ, Pang APS, Tsai N, Hanks N, Khadka VS, Klatt NR, Hensley-McBain T, Somsouk M, Vujkovic-Cvijin I, Chow DC, Shikuma CM, Ndhlovu LC

Obesity and metabolic outcomes in a safety-net health system.

Biodemography and social biology

Huynh MP, Bradshaw PT, Tana MM, Rachocki C, Somsouk M

Antiretroviral Therapy Concentrations Differ in Gut vs. Lymph Node Tissues and Are Associated With HIV Viral Transcription by a Novel RT-ddPCR Assay.

Journal of acquired immune deficiency syndromes (1999)

Lee SA, Telwatte S, Hatano H, Kashuba ADM, Cottrell ML, Hoh R, Liegler TJ, Stephenson S, Somsouk M, Hunt PW, Deeks SG, Yukl S, Savic RM

Standardized Workflows Improve Colonoscopy Follow-Up After Abnormal Fecal Immunochemical Tests in a Safety-Net System.

Digestive diseases and sciences

Issaka RB, Rachocki C, Huynh MP, Chen E, Somsouk M

Effectiveness and cost of organized outreach for colorectal cancer screening: A Randomized Controlled Trial.

Journal of the National Cancer Institute

Somsouk M, Rachocki C, Mannalithara A, Garcia D, Laleau V, Grimes B, Issaka RB, Chen E, Vittinghoff E, Shapiro JA, Ladabaum U

Human Immunodeficiency Virus (HIV)-Infected CCR6+ Rectal CD4+ T Cells and HIV Persistence On Antiretroviral Therapy.

The Journal of infectious diseases

Anderson JL, Khoury G, Fromentin R, Solomon A, Chomont N, Sinclair E, Milush JM, Hartogensis W, Bacchetti P, Roche M, Tumpach C, Gartner M, Pitman MC, Epling CL, Hoh R, Hecht FM, Somsouk M, Cameron PU, Deeks SG, Lewin SR

HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells.

Nature immunology

Wang Y, Lifshitz L, Gellatly K, Vinton CL, Busman-Sahay K, McCauley S, Vangala P, Kim K, Derr A, Jaiswal S, Kucukural A, McDonel P, Hunt PW, Greenough T, Houghton J, Somsouk M, Estes JD, Brenchley JM, Garber M, Deeks SG, Luban J

The impact of antiretroviral therapy duration on the HIV-1 infection of T-cells within anatomic sites.

Journal of virology

Lee E, von Stockenstrom S, Morcilla V, Odevall L, Hiener B, Shao W, Hartogensis W, Bacchetti P, Milush J, Liegler T, Sinclair E, Hatano H, Hoh R, Somsouk M, Hunt P, Boritz E, Douek D, Fromentin R, Chomont N, Deeks SG, Hecht FM, Palmer S

Disparities in Hepatocellular Carcinoma Incidence in California: An Update.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Sangaramoorthy M, Yang J, DeRouen MC, Ho C, Somsouk M, Tana MM, Thompson CA, Gibbons J, Gomez SL, Shariff-Marco S

TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths.

Nature communications

Belle NM, Ji Y, Herbine K, Wei Y, Park J, Zullo K, Hung LY, Srivatsa S, Young T, Oniskey T, Pastore C, Nieves W, Somsouk M, Herbert DR

Fecal Microbiota Transplantation in Pouchitis: Clinical, Endoscopic, Histologic, and Microbiota Results from a Pilot Study.

Digestive diseases and sciences

Selvig D, Piceno Y, Terdiman J, Zydek M, Umetsu SE, Balitzer D, Fadrosh D, Lynch K, Lamere B, Leith T, Kassam Z, Beck K, Lewin S, Ma A, Somsouk M, Lynch SV, El-Nachef N

CD32-RNA Co-localizes with HIV-RNA in CD3+ Cells Found within Gut Tissues from Viremic and ART-Suppressed Individuals.

Pathogens & immunity

Vásquez JJ, Aguilar-Rodriguez BL, Rodriguez L, Hogan LE, Somsouk M, McCune JM, Deeks SG, Laszik ZG, Hunt PW, Henrich TJ

Serum Bovine Immunoglobulins Improve Inflammation and Gut Barrier Function in Persons with HIV and Enteropathy on Suppressive ART.

Pathogens & immunity

Utay NS, Somasunderam A, Hinkle JE, Petschow BW, Detzel CJ, Somsouk M, Fichtenbaum CJ, Weaver EM, Shaw AL, Asmuth DM

Fecal microbiota transplant for Crohn disease: A study evaluating safety, efficacy, and microbiome profile.

United European gastroenterology journal

Gutin L, Piceno Y, Fadrosh D, Lynch K, Zydek M, Kassam Z, LaMere B, Terdiman J, Ma A, Somsouk M, Lynch S, El-Nachef N

Increased mucosal neutrophil survival is associated with altered microbiota in HIV infection.

PLoS pathogens

Hensley-McBain T, Wu MC, Manuzak JA, Cheu RK, Gustin A, Driscoll CB, Zevin AS, Miller CJ, Coronado E, Smith E, Chang J, Gale M, Somsouk M, Burgener AD, Hunt PW, Hope TJ, Collier AC, Klatt NR

Low Literacy Level Instructions and Reminder Calls Improve Patient Handling of Fecal Immunochemical Test Samples.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Wang A, Rachocki C, Shapiro JA, Issaka RB, Somsouk M

Gut and blood differ in constitutive blocks to HIV transcription, suggesting tissue-specific differences in the mechanisms that govern HIV latency.

PLoS pathogens

Telwatte S, Lee S, Somsouk M, Hatano H, Baker C, Kaiser P, Kim P, Chen TH, Milush J, Hunt PW, Deeks SG, Wong JK, Yukl SA

Macrophage Activation Marker Soluble CD163 Is a Dynamic Marker of Liver Fibrogenesis in Human Immunodeficiency Virus/Hepatitis C Virus Coinfection.

The Journal of infectious diseases

Lidofsky A, Holmes JA, Feeney ER, Kruger AJ, Salloum S, Zheng H, Seguin IS, Altinbas A, Masia R, Corey KE, Gustafson JL, Schaefer EA, Hunt PW, Deeks S, Somsouk M, Chew KW, Chung RT, Alatrakchi N

Colorectal Cancer Incidence Trends by Age, Stage, and Racial/Ethnic Group in California, 1990-2014.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Ellis L, Abrahão R, McKinley M, Yang J, Somsouk M, Marchand LL, Cheng I, Gomez SL, Shariff-Marco S

Race/ethnicity is an independent risk factor for autoimmune hepatitis among the San Francisco underserved.

Autoimmunity

Lee B, Holt EW, Wong RJ, Sewell JL, Somsouk M, Khalili M, Maher JJ, Tana MM

Yield of Colonoscopy After a Positive Result From a Fecal Immunochemical Test OC-Light.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Alsayid M, Singh MH, Issaka R, Laleau V, Day L, Lee J, Allison J, Somsouk M

A20 upregulation during treated HIV disease is associated with intestinal epithelial cell recovery and function.

PLoS pathogens

Chitre AS, Kattah MG, Rosli YY, Pao M, Deswal M, Deeks SG, Hunt PW, Abdel-Mohsen M, Montaner LJ, Kim CC, Ma A, Somsouk M, McCune JM

Increased HIV-1 transcriptional activity and infectious burden in peripheral blood and gut-associated CD4+ T cells expressing CD30.

PLoS pathogens

Hogan LE, Vasquez J, Hobbs KS, Hanhauser E, Aguilar-Rodriguez B, Hussien R, Thanh C, Gibson EA, Carvidi AB, Smith LCB, Khan S, Trapecar M, Sanjabi S, Somsouk M, Stoddart CA, Kuritzkes DR, Deeks SG, Henrich TJ

Hospitalizations for Autoimmune Hepatitis Disproportionately Affect Black and Latino Americans.

The American journal of gastroenterology

Wen JW, Kohn MA, Wong R, Somsouk M, Khalili M, Maher J, Tana MM

Differential Expression of CD8+ T Cell Cytotoxic Effector Molecules in Blood and Gastrointestinal Mucosa in HIV-1 Infection.

Journal of immunology (Baltimore, Md. : 1950)

Kiniry BE, Hunt PW, Hecht FM, Somsouk M, Deeks SG, Shacklett BL

Missed Opportunities in Colorectal Cancer Prevention in Patients With Inadequate Bowel Preparations.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Issaka RB, Singh MH, Rachocki C, Day LW, Horton C, Somsouk M

Colorectal Cancer Screening Among South Asians: Focus Group Findings on Attitudes, Knowledge, Barriers and Facilitators.

Journal of health care for the poor and underserved

Ivey SL, Mukherjea A, Patel A, Kapoor N, Rau S, Kazi E, Bhatia J, Somsouk M, Tseng W

The San Francisco Cancer Initiative: A Community Effort To Reduce The Population Burden Of Cancer.

Health affairs (Project Hope)

Hiatt RA, Sibley A, Fejerman L, Glantz S, Nguyen T, Pasick R, Palmer N, Perkins A, Potter MB, Somsouk M, Vargas RA, van 't Veer LJ, Ashworth A

Risk factors for postpolypectomy bleeding in patients receiving anticoagulation or antiplatelet medications.

Gastrointestinal endoscopy

Lin D, Soetikno RM, McQuaid K, Pham C, Doan G, Mou S, Shergill AK, Somsouk M, Rouse RV, Kaltenbach T

Detection of HIV-1-specific gastrointestinal tissue resident CD8+ T-cells in chronic infection.

Mucosal immunology

Kiniry BE, Li S, Ganesh A, Hunt PW, Somsouk M, Skinner PJ, Deeks SG, Shacklett BL

An Optimized and Validated Method for Isolation and Characterization of Lymphocytes from HIV+ Human Gut Biopsies.

AIDS research and human retroviruses

Trapecar M, Khan S, Roan NR, Chen TH, Telwatte S, Deswal M, Pao M, Somsouk M, Deeks SG, Hunt PW, Yukl S, Sanjabi S

Evaluation of oral serum-derived bovine immunoglobulins in HIV-infected patients with chronic idiopathic diarrhea.

HIV clinical trials

Asmuth DM, Hinkle JE, LaMarca A, Fichtenbaum CJ, Somsouk M, Utay NS, Shaw AL, Petschow BW, Detzel CJ, Weaver EM

A Randomized Controlled Trial of Lisinopril to Decrease Lymphoid Fibrosis in Antiretroviral-Treated, HIV-infected Individuals.

Pathogens & immunity

Cockerham LR, Yukl SA, Harvill K, Somsouk M, Joshi SK, Sinclair E, Liegler T, Hoh R, Lyons S, Hunt PW, Rupert A, Sereti I, Morcock DR, Rhodes A, Emson C, Hellerstein MK, Estes JD, Lewin S, Deeks SG, Hatano H

Circulating LOXL2 Levels Reflect Severity of Intestinal Fibrosis and GALT CD4+ T Lymphocyte Depletion in Treated HIV Infection.

Pathogens & immunity

Seang S, Somasunderam A, Nigalye M, Somsouk M, Schacker TW, Sanchez JL, Hunt PW, Utay NS, Lake JE

Limited engraftment of donor microbiome via one-time fecal microbial transplantation in treated HIV-infected individuals.

Gut microbes

Vujkovic-Cvijin I, Rutishauser RL, Pao M, Hunt PW, Lynch SV, McCune JM, Somsouk M

Human Immunodeficiency Virus Persistence and T-Cell Activation in Blood, Rectal, and Lymph Node Tissue in Human Immunodeficiency Virus-Infected Individuals Receiving Suppressive Antiretroviral Therapy.

The Journal of infectious diseases

Khoury G, Fromentin R, Solomon A, Hartogensis W, Killian M, Hoh R, Somsouk M, Hunt PW, Girling V, Sinclair E, Bacchetti P, Anderson JL, Hecht FM, Deeks SG, Cameron PU, Chomont N, Lewin SR

Replication of CMV in the gut of HIV-infected individuals and epithelial barrier dysfunction.

PLoS pathogens

Maidji E, Somsouk M, Rivera JM, Hunt PW, Stoddart CA

Mucosal stromal fibroblasts markedly enhance HIV infection of CD4+ T cells.

PLoS pathogens

Neidleman JA, Chen JC, Kohgadai N, Müller JA, Laustsen A, Thavachelvam K, Jang KS, Stürzel CM, Jones JJ, Ochsenbauer C, Chitre A, Somsouk M, Garcia MM, Smith JF, Greenblatt RM, Münch J, Jakobsen MR, Giudice LC, Greene WC, Roan NR

Urgent colonoscopy in patients with lower GI bleeding: a systematic review and meta-analysis.

Gastrointestinal endoscopy

Kouanda AM, Somsouk M, Sewell JL, Day LW

Inadequate Utilization of Diagnostic Colonoscopy Following Abnormal FIT Results in an Integrated Safety-Net System.

The American journal of gastroenterology

Issaka RB, Singh MH, Oshima SM, Laleau VJ, Rachocki CD, Chen EH, Day LW, Sarkar U, Somsouk M

Predominance of weakly cytotoxic, T-betLowEomesNeg CD8+ T-cells in human gastrointestinal mucosa: implications for HIV infection.

Mucosal immunology

Kiniry BE, Ganesh A, Critchfield JW, Hunt PW, Hecht FM, Somsouk M, Deeks SG, Shacklett BL

Bacteroides are associated with GALT iNKT cell function and reduction of microbial translocation in HIV-1 infection.

Mucosal immunology

Paquin-Proulx D, Ching C, Vujkovic-Cvijin I, Fadrosh D, Loh L, Huang Y, Somsouk M, Lynch SV, Hunt PW, Nixon DF, SenGupta D

Protective association of colonoscopy against proximal and distal colon cancer and patterns in interval cancer.

Gastrointestinal endoscopy

Shergill AK, Conners EE, McQuaid KR, Epstein S, Ryan JC, Shah JN, Inadomi J, Somsouk M

Longitudinal Genetic Characterization Reveals That Cell Proliferation Maintains a Persistent HIV Type 1 DNA Pool During Effective HIV Therapy.

The Journal of infectious diseases

von Stockenstrom S, Odevall L, Lee E, Sinclair E, Bacchetti P, Killian M, Epling L, Shao W, Hoh R, Ho T, Faria NR, Lemey P, Albert J, Hunt P, Loeb L, Pilcher C, Poole L, Hatano H, Somsouk M, Douek D, Boritz E, Deeks SG, Hecht FM, Palmer S

Gut epithelial barrier and systemic inflammation during chronic HIV infection.

AIDS (London, England)

Somsouk M, Estes JD, Deleage C, Dunham RM, Albright R, Inadomi JM, Martin JN, Deeks SG, McCune JM, Hunt PW

The immunologic effects of mesalamine in treated HIV-infected individuals with incomplete CD4+ T cell recovery: a randomized crossover trial.

PloS one

Somsouk M, Dunham RM, Cohen M, Albright R, Abdel-Mohsen M, Liegler T, Lifson J, Piatak M, Gorelick R, Huang Y, Wu Y, Hsue PY, Martin JN, Deeks SG, McCune JM, Hunt PW

Lymphoid fibrosis occurs in long-term nonprogressors and persists with antiretroviral therapy but may be reversible with curative interventions.

The Journal of infectious diseases

Sanchez JL, Hunt PW, Reilly CS, Hatano H, Beilman GJ, Khoruts A, Jasurda JS, Somsouk M, Thorkelson A, Russ S, Anderson J, Deeks SG, Schacker TW

The CD8? memory stem T cell (T(SCM)) subset is associated with improved prognosis in chronic HIV-1 infection.

Journal of virology

Ribeiro SP, Milush JM, Cunha-Neto E, Kallas EG, Kalil J, Somsouk M, Hunt PW, Deeks SG, Nixon DF, SenGupta D

HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality.

PLoS pathogens

Serrano-Villar S, Sainz T, Lee SA, Hunt PW, Sinclair E, Shacklett BL, Ferre AL, Hayes TL, Somsouk M, Hsue PY, Van Natta ML, Meinert CL, Lederman MM, Hatano H, Jain V, Huang Y, Hecht FM, Martin JN, McCune JM, Moreno S, Deeks SG

Esophageal varices on computed tomography and subsequent variceal hemorrhage.

Abdominal imaging

Somsouk M, To'o K, Ali M, Vittinghoff E, Yeh BM, Yee J, Monto A, Inadomi JM, Aslam R

Challenges and possible solutions to colorectal cancer screening for the underserved.

Journal of the National Cancer Institute

Gupta S, Sussman DA, Doubeni CA, Anderson DS, Day L, Deshpande AR, Elmunzer BJ, Laiyemo AO, Mendez J, Somsouk M, Allison J, Bhuket T, Geng Z, Green BB, Itzkowitz SH, Martinez ME

Discordance between peripheral and colonic markers of inflammation during suppressive ART.

Journal of acquired immune deficiency syndromes (1999)

Dunham RM, Vujkovic-Cvijin I, Yukl SA, Broadhurst MJ, Loke P, Albright RG, Wong JK, Lederman MM, Somsouk M, Hunt PW, Martin JN, Deeks SG, McCune JM

A comparison of methods for measuring rectal HIV levels suggests that HIV DNA resides in cells other than CD4+ T cells, including myeloid cells.

AIDS (London, England)

Yukl SA, Sinclair E, Somsouk M, Hunt PW, Epling L, Killian M, Girling V, Li P, Havlir DV, Deeks SG, Wong JK, Hatano H

Commentary: Towards an effective and safe treatment of small intestine bacterial overgrowth - Authors' reply.

Alimentary pharmacology & therapeutics

Sewell JL, Somsouk M, Shah SC, Day LW

The HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time.

Proceedings of the National Academy of Sciences of the United States of America

Josefsson L, von Stockenstrom S, Faria NR, Sinclair E, Bacchetti P, Killian M, Epling L, Tan A, Ho T, Lemey P, Shao W, Hunt PW, Somsouk M, Wylie W, Douek DC, Loeb L, Custer J, Hoh R, Poole L, Deeks SG, Hecht F, Palmer S

Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllers.

PLoS pathogens

Hatano H, Yukl SA, Ferre AL, Graf EH, Somsouk M, Sinclair E, Abdel-Mohsen M, Liegler T, Harvill K, Hoh R, Palmer S, Bacchetti P, Hunt PW, Martin JN, McCune JM, Tracy RP, Busch MP, O'Doherty U, Shacklett BL, Wong JK, Deeks SG

Helicobacter pylori: evidence-based review with a focus on immigrant populations.

Journal of general internal medicine

Siao D, Somsouk M

Comparison of HIV DNA and RNA in gut-associated lymphoid tissue of HIV-infected controllers and noncontrollers.

AIDS (London, England)

Hatano H, Somsouk M, Sinclair E, Harvill K, Gilman L, Cohen M, Hoh R, Hunt PW, Martin JN, Wong JK, Deeks SG, Yukl SA

Meta-analysis: antibiotic therapy for small intestinal bacterial overgrowth.

Alimentary pharmacology & therapeutics

Shah SC, Day LW, Somsouk M, Sewell JL

Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism.

Science translational medicine

Vujkovic-Cvijin I, Dunham RM, Iwai S, Maher MC, Albright RG, Broadhurst MJ, Hernandez RD, Lederman MM, Huang Y, Somsouk M, Deeks SG, Hunt PW, Lynch SV, McCune JM

The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD4+ T-cell recovery: a randomized trial.

Blood

Hunt PW, Shulman NS, Hayes TL, Dahl V, Somsouk M, Funderburg NT, McLaughlin B, Landay AL, Adeyemi O, Gilman LE, Clagett B, Rodriguez B, Martin JN, Schacker TW, Shacklett BL, Palmer S, Lederman MM, Deeks SG

Late presentation of colorectal cancer in a vulnerable population.

The American journal of gastroenterology

Ho C, Kornfield R, Vittinghoff E, Inadomi J, Yee H, Somsouk M

Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies.

PLoS pathogens

Eriksson S, Graf EH, Dahl V, Strain MC, Yukl SA, Lysenko ES, Bosch RJ, Lai J, Chioma S, Emad F, Abdel-Mohsen M, Hoh R, Hecht F, Hunt P, Somsouk M, Wong J, Johnston R, Siliciano RF, Richman DD, O'Doherty U, Palmer S, Deeks SG, Siliciano JD

Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection.

Blood

Leeansyah E, Ganesh A, Quigley MF, Sönnerborg A, Andersson J, Hunt PW, Somsouk M, Deeks SG, Martin JN, Moll M, Shacklett BL, Sandberg JK

Short communication: HIV+ viremic slow progressors maintain low regulatory T cell numbers in rectal mucosa but exhibit high T cell activation.

AIDS research and human retroviruses

Shaw JM, Hunt PW, Critchfield JW, McConnell DH, Garcia JC, Pollard RB, Somsouk M, Deeks SG, Shacklett BL

Adherence to colorectal cancer screening: a randomized clinical trial of competing strategies.

Archives of internal medicine

Inadomi JM, Vijan S, Janz NK, Fagerlin A, Thomas JP, Lin YV, Muñoz R, Lau C, Somsouk M, El-Nachef N, Hayward RA

Adverse events in older patients undergoing colonoscopy: a systematic review and meta-analysis.

Gastrointestinal endoscopy

Day LW, Kwon A, Inadomi JM, Walter LC, Somsouk M

Prevalence of gastric cancer versus colorectal cancer in Asians with a positive fecal occult blood test.

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology

Day LW, Cello JP, Somsouk M, Inadomi JM

Increased frequency of regulatory T cells accompanies increased immune activation in rectal mucosae of HIV-positive noncontrollers.

Journal of virology

Shaw JM, Hunt PW, Critchfield JW, McConnell DH, Garcia JC, Pollard RB, Somsouk M, Deeks SG, Shacklett BL

Moderate ascites identifies patients with low model for end-stage liver disease scores awaiting liver transplantation who have a high mortality risk.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

Somsouk M, Kornfield R, Vittinghoff E, Inadomi JM, Biggins SW

New model for end stage liver disease improves prognostic capability after transjugular intrahepatic portosystemic shunt.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Guy J, Somsouk M, Shiboski S, Kerlan R, Inadomi JM, Biggins SW

Understanding liver health using the National Center for Health Statistics.

Digestive diseases and sciences

Somsouk M, Yee HF, Biggins SW

A cost-utility analysis of ablative therapy for Barrett's esophagus.

Gastroenterology

Inadomi JM, Somsouk M, Madanick RD, Thomas JP, Shaheen NJ

Management of obscure occult gastrointestinal bleeding: a cost-minimization analysis.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Somsouk M, Gralnek IM, Inadomi JM

Actinomycosis mimicking a pancreatic head neoplasm diagnosed by EUS-guided FNA.

Gastrointestinal endoscopy

Somsouk M, Shergill AK, Grenert JP, Harris H, Cello JP, Shah JN

Proton pump inhibitors and hip fracture: cause for alarm?

Gastroenterology

Inadomi JM, Somsouk MA

Constitutive activation of Stat3 signaling pathway in human colorectal carcinoma.

World journal of gastroenterology

Ma XT, Wang S, Ye YJ, Du RY, Cui ZR, Somsouk M

Hepatitis C virus is independently associated with increased insulin resistance after liver transplantation.

Transplantation

Delgado-Borrego A, Casson D, Schoenfeld D, Somsouk M, Terella A, Jordan SH, Bhan A, Baid S, Cosimi AB, Pascual M, Chung RT

Critical elements of the immunoglobulin heavy chain gene enhancers for deregulated expression of bcl-2.

Cancer research

Heckman CA, Cao T, Somsouk L, Duan H, Mehew JW, Zhang CY, Boxer LM

Spontaneous resolution of chronic hepatitis C virus disease after withdrawal of immunosuppression.

Gastroenterology

Somsouk M, Lauer GM, Casson D, Terella A, Day CL, Walker BD, Chung RT

Promoter structure and cell cycle dependent expression of the human methylpurine-DNA glycosylase gene.

Mutation research

Bouziane M, Miao F, Bates SE, Somsouk L, Sang BC, Denissenko M, O'Connor TR

Partial functional deficiency of E160D flap endonuclease-1 mutant in vitro and in vivo is due to defective cleavage of DNA substrates.

The Journal of biological chemistry

Frank G, Qiu J, Somsouk M, Weng Y, Somsouk L, Nolan JP, Shen B