Christopher Hernandez, PhD

Professor In Res
Orthopaedic Surgery
[email protected]

I am a mechanical engineer and bioengineer. My laboratory studies interactions between microbes, musculoskeletal tissues and materials. We are currently studying the effects of the gut microbiome on the musculoskeletal system and the success of orthopaedic surgery. Additionally we are studying mechanobiology of bacteria and advancing the new field of Engineered Living Materials.

Publications: 

Microbiome-induced Increases and Decreases in Bone Matrix Strength can be Initiated After Skeletal Maturity.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Liu C, Cyphert EL, Stephen SJ, Wang B, Morales AL, Nixon JC, Natsoulas NR, Garcia M, Carmona PB, Vill AC, Donnelly E, Brito IL, Vashishth D, Hernandez CJ

Effects of high dose aspartame-based sweetener on the gut microbiota and bone strength in young and aged mice.

JBMR plus

Cyphert EL, Liu C, Morales AL, Nixon JC, Blackford E, Garcia M, Cevallos N, Turnbaugh PJ, Brito IL, Booth SL, Hernandez CJ

Combinatorial characterization of bacterial taxa-driven differences in the microbiome of oyster reefs.

bioRxiv : the preprint server for biology

Cyphert EL, Nand S, Franco G, Hajkowski M, Soto L, Lee DM, Ferner M, Zabin C, Blumenthal J, Deck A, Boyer K, Burrus K, Hernandez CJ, Anand A

Determining the Young's Modulus of the Bacterial Cell Envelope.

ACS biomaterials science & engineering

Lee J, Jha K, Harper CE, Zhang W, Ramsukh M, Bouklas N, Dörr T, Chen P, Hernandez CJ

Effects of long-term high dose aspartame on body mass, bone strength, femoral geometry, and microbiota composition in a young and aged cohort of male and female mice.

bioRxiv : the preprint server for biology

Cyphert EL, Liu C, Morales AL, Nixon JC, Blackford E, Garcia M, Cevallos N, Turnbaugh PJ, Brito IL, Booth SL, Hernandez CJ

The 2023 Orthopaedic Research Society's International Consensus Meeting on musculoskeletal infection: Summary from the host immunity section.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Schwarz EM, Archer NK, Atkins GJ, Bentley KLM, Botros M, Cassat JE, Chisari E, Coraça-Huber DC, Daiss JL, Gill SR, Goodman SB, Harro J, Hernandez CJ, Ivashkiv LB, Kates SL, Marques CNH, Masters EA, Muthukrishnan G, Owen JR, Raafat D, Saito M, Veis DJ, Xie C

Mechanical stimuli activate gene expression via a cell envelope stress sensing pathway.

Scientific reports

Harper CE, Zhang W, Lee J, Shin JH, Keller MR, van Wijngaarden E, Chou E, Wang Z, Dörr T, Chen P, Hernandez CJ

Fragile X Messenger Ribonucleoprotein 1 (FMR1), a novel inhibitor of osteoblast/osteocyte differentiation, regulates bone formation, mass, and strength in young and aged male and female mice.

Bone research

Deosthale P, Balanta-Melo J, Creecy A, Liu C, Marcial A, Morales L, Cridlin J, Robertson S, Okpara C, Sanchez DJ, Ayoubi M, Lugo JN, Hernandez CJ, Wallace JM, Plotkin LI

Suppression of Remodeling and Bone Fragility.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Hernandez CJ

Multiple Dietary Vitamin K Forms Are Converted to Tissue Menaquinone-4 in Mice.

The Journal of nutrition

Ellis JL, Fu X, Karl JP, Hernandez CJ, Mason JB, DeBose-Boyd RA, Booth SL

Animal Models of Bone Marrow Lesions in Osteoarthritis.

JBMR plus

Bowen A, Shamritsky D, Santana J, Porter I, Feldman E, Pownder SL, Koff MF, Hayashi K, Hernandez CJ

Distributions of Microdamage Are Altered Between Trabecular Rods and Plates in Cancellous Bone From Men With Type 2 Diabetes Mellitus.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Sacher SE, Hunt HB, Lekkala S, Lopez KA, Potts J, Heilbronner AK, Stein EM, Hernandez CJ, Donnelly E

In Their Own Words: How Trans Women Acquired HIV Infection.

AIDS and behavior

Wilson EC, Hernandez CJ, Arayasirikul S, Scheer S, Trujillo D, Sicro S, Turner CM, McFarland W

Butyrate Inhibits Osteoclast Activity In Vitro and Regulates Systemic Inflammation and Bone Healing in a Murine Osteotomy Model Compared to Antibiotic-Treated Mice.

Mediators of inflammation

Wallimann A, Magrath W, Pugliese B, Stocker N, Westermann P, Heider A, Gehweiler D, Zeiter S, Claesson MJ, Richards RG, Akdis CA, Hernandez CJ, O'Mahony L, Thompson K, Moriarty TF

Improved PrEP Awareness and Use among Trans Women in San Francisco, California.

AIDS and behavior

Wilson EC, Hernandez CJ, Scheer S, Trujillo D, Arayasirikul S, Sicro S, McFarland W

The microbiome: A heritable contributor to bone morphology?

Seminars in cell & developmental biology

Hernandez CJ, Moeller AH

Impaired Bone Matrix: The Key to Fragility in Type 2 Diabetes?

The Journal of clinical endocrinology and metabolism

Hernandez CJ, Stein EM, Donnelly E

Components of the Gut Microbiome That Influence Bone Tissue-Level Strength.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Luna M, Guss JD, Vasquez-Bolanos LS, Castaneda M, Rojas MV, Strong JM, Alabi DA, Dornevil SD, Nixon JC, Taylor EA, Donnelly E, Fu X, Shea MK, Booth SL, Bicalho R, Hernandez CJ

Musculoskeletal Microbiology: The Microbiome in Orthopaedic Biomechanics.

Current opinion in biomedical engineering

Hernandez CJ

Alterations to the gut microbiome impair bone tissue strength in aged mice.

Bone reports

Castaneda M, Smith KM, Nixon JC, Hernandez CJ, Rowan S

High hepatitis C virus seropositivity, viremia, and associated risk factors among trans women living in San Francisco, California.

PloS one

Hernandez CJ, Trujillo D, Sicro S, Meza J, Bella M, Daza E, Torres F, McFarland W, Turner CM, Wilson EC

Dietary vitamin K is remodeled by gut microbiota and influences community composition.

Gut microbes

Ellis JL, Karl JP, Oliverio AM, Fu X, Soares JW, Wolfe BE, Hernandez CJ, Mason JB, Booth SL

Musculoskeletal microbiology: The utility of the microbiome in orthopedics.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Hernandez CJ

The Gut Microbiome and Bone Strength.

Current osteoporosis reports

Castaneda M, Strong JM, Alabi DA, Hernandez CJ

Obesity and load-induced posttraumatic osteoarthritis in the absence of fracture or surgical trauma.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Luna M, Guss JD, Vasquez-Bolanos LS, Alepuz AJ, Dornevil S, Strong J, Alabi D, Shi Q, Pannellini T, Otero M, Brito IL, van der Meulen MCH, Goldring SR, Hernandez CJ

The importance of diversity, equity, and inclusion in orthopedic research.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Alliston T, Foucher KC, Frederick B, Hernandez CJ, Iatridis JC, Kozloff KM, Lewis KJ, Liu XS, Mercer DM, Ochia R, Queen RM, Rimnac CM, van der Meulen MCH, Westendorf JJ

Improving Treatment Efficacy of In Situ Forming Implants via Concurrent Delivery of Chemotherapeutic and Chemosensitizer.

Scientific reports

Jeganathan S, Budziszewski E, Hernandez C, Dhingra A, Exner AA

Reply to Zadpoor: Fatigue mechanisms observed in bone provide insight to microarchitectured materials.

Proceedings of the National Academy of Sciences of the United States of America

Hernandez CJ, Zavattieri PD, Trikanad AA, Rimnac CM

Inhibition of the histone demethylase, KDM5B, directly induces re-expression of tumor suppressor protein HEXIM1 in cancer cells.

Breast cancer research : BCR

Montano MM, Yeh IJ, Chen Y, Hernandez C, Kiselar JG, de la Fuente M, Lawes AM, Nieman MT, Kiser PD, Jacobberger J, Exner AA, Lawes MC

Bone-inspired microarchitectures achieve enhanced fatigue life.

Proceedings of the National Academy of Sciences of the United States of America

Torres AM, Trikanad AA, Aubin CA, Lambers FM, Luna M, Rimnac CM, Zavattieri P, Hernandez CJ

Disruption of the Gut Microbiome Increases the Risk of Periprosthetic Joint Infection in Mice.

Clinical orthopaedics and related research

Hernandez CJ, Yang X, Ji G, Niu Y, Sethuraman AS, Koressel J, Shirley M, Fields MW, Chyou S, Li TM, Luna M, Callahan RL, Ross FP, Lu TT, Brito IL, Carli AV, Bostrom MPG

Contrast enhanced ultrasound imaging by nature-inspired ultrastable echogenic nanobubbles.

Nanoscale

de Leon A, Perera R, Hernandez C, Cooley M, Jung O, Jeganathan S, Abenojar E, Fishbein G, Sojahrood AJ, Emerson CC, Stewart PL, Kolios MC, Exner AA

The microbial metagenome and bone tissue composition in mice with microbiome-induced reductions in bone strength.

Bone

Guss JD, Taylor E, Rouse Z, Roubert S, Higgins CH, Thomas CJ, Baker SP, Vashishth D, Donnelly E, Shea MK, Booth SL, Bicalho RC, Hernandez CJ

Altered Tissue Composition, Microarchitecture, and Mechanical Performance in Cancellous Bone From Men With Type 2 Diabetes Mellitus.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Hunt HB, Torres AM, Palomino PM, Marty E, Saiyed R, Cohn M, Jo J, Warner S, Sroga GE, King KB, Lane JM, Vashishth D, Hernandez CJ, Donnelly E

Enhancing Tumor Drug Distribution With Ultrasound-Triggered Nanobubbles.

Journal of pharmaceutical sciences

Nittayacharn P, Yuan HX, Hernandez C, Bielecki P, Zhou H, Exner AA

Immunomodulatory nanogels overcome restricted immunity in a murine model of gut microbiome-mediated metabolic syndrome.

Science advances

Mosquera MJ, Kim S, Zhou H, Jing TT, Luna M, Guss JD, Reddy P, Lai K, Leifer CA, Brito IL, Hernandez CJ, Singh A

Sink or float? Characterization of shell-stabilized bulk nanobubbles using a resonant mass measurement technique.

Nanoscale

Hernandez C, Abenojar EC, Hadley J, de Leon AC, Coyne R, Perera R, Gopalakrishnan R, Basilion JP, Kolios MC, Exner AA

Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1).

Journal of medicinal chemistry

Chien HC, Colas C, Finke K, Springer S, Stoner L, Zur AA, Venteicher B, Campbell J, Hall C, Flint A, Augustyn E, Hernandez C, Heeren N, Hansen L, Anthony A, Bauer J, Fotiadis D, Schlessinger A, Giacomini KM, Thomas AA

Bone marrow lesions in osteoarthritis: What lies beneath.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Alliston T, Hernandez CJ, Findlay DM, Felson DT, Kennedy OD

Current Options and Emerging Biomaterials for Periprosthetic Joint Infection.

Current rheumatology reports

Levack AE, Cyphert EL, Bostrom MP, Hernandez CJ, von Recum HA, Carli AV

The Microbiome and Bone and Joint Disease.

Current rheumatology reports

Hernandez CJ

An in vivo model of a mechanically-induced bone marrow lesion.

Journal of biomechanics

Matheny JB, Goff MG, Pownder SL, Koff MF, Hayashi K, Yang X, Bostrom MPG, van der Meulen MCH, Hernandez CJ

Ultrasound molecular imaging of ovarian cancer with CA-125 targeted nanobubble contrast agents.

Nanomedicine : nanotechnology, biology, and medicine

Gao Y, Hernandez C, Yuan HX, Lilly J, Kota P, Zhou H, Wu H, Exner AA

Mechanically induced bone formation is not sensitive to local osteocyte density in rat vertebral cancellous bone.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Cresswell EN, Nguyen TM, Horsfield MW, Alepuz AJ, Metzger TA, Niebur GL, Hernandez CJ

Alterations to the Gut Microbiome Impair Bone Strength and Tissue Material Properties.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Guss JD, Horsfield MW, Fontenele FF, Sandoval TN, Luna M, Apoorva F, Lima SF, Bicalho RC, Singh A, Ley RE, van der Meulen MC, Goldring SR, Hernandez CJ

Romosozumab Treatment Converts Trabecular Rods into Trabecular Plates in Male Cynomolgus Monkeys.

Calcified tissue international

Matheny JB, Torres AM, Ominsky MS, Hernandez CJ

Understanding Bone Strength Is Not Enough.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Hernandez CJ, van der Meulen MC

Macroporous acrylamide phantoms improve prediction of in vivo performance of in situ forming implants.

Journal of controlled release : official journal of the Controlled Release Society

Hernandez C, Gawlik N, Goss M, Zhou H, Jeganathan S, Gilbert D, Exner AA

LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates.

Bioorganic & medicinal chemistry letters

Zur AA, Chien HC, Augustyn E, Flint A, Heeren N, Finke K, Hernandez C, Hansen L, Miller S, Lin L, Giacomini KM, Colas C, Schlessinger A, Thomas AA

Improving performance of nanoscale ultrasound contrast agents using N,N-diethylacrylamide stabilization.

Nanomedicine : nanotechnology, biology, and medicine

Perera RH, Wu H, Peiris P, Hernandez C, Burke A, Zhang H, Exner AA

Links Between the Microbiome and Bone.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Hernandez CJ, Guss JD, Luna M, Goldring SR

Material heterogeneity in cancellous bone promotes deformation recovery after mechanical failure.

Proceedings of the National Academy of Sciences of the United States of America

Torres AM, Matheny JB, Keaveny TM, Taylor D, Rimnac CM, Hernandez CJ

Validation of Ultrasound Elastography Imaging for Nondestructive Characterization of Stiffer Biomaterials.

Annals of biomedical engineering

Zhou H, Goss M, Hernandez C, Mansour JM, Exner A

Ultrasound imaging beyond the vasculature with new generation contrast agents.

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

Perera RH, Hernandez C, Zhou H, Kota P, Burke A, Exner AA

The effects of tensile-compressive loading mode and microarchitecture on microdamage in human vertebral cancellous bone.

Journal of biomechanics

Lambers FM, Bouman AR, Tkachenko EV, Keaveny TM, Hernandez CJ

A microfluidic platform for profiling biomechanical properties of bacteria.

Lab on a chip

Sun X, Weinlandt WD, Patel H, Wu M, Hernandez CJ

Nanobubble ultrasound contrast agents for enhanced delivery of thermal sensitizer to tumors undergoing radiofrequency ablation.

Pharmaceutical research

Perera RH, Solorio L, Wu H, Gangolli M, Silverman E, Hernandez C, Peiris PM, Broome AM, Exner AA

Biomechanical effects of simulated resorption cavities in cancellous bone across a wide range of bone volume fractions.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Easley SK, Chang MT, Shindich D, Hernandez CJ, Keaveny TM

Irradiation does not modify mechanical properties of cancellous bone under compression.

Clinical orthopaedics and related research

Hernandez CJ, Ramsey DS, Dux SJ, Chu EH, Rimnac CM

Three-dimensional dynamic bone histomorphometry.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Slyfield CR, Tkachenko EV, Wilson DL, Hernandez CJ

Ectopic expression of SOX9 in osteoblasts alters bone mechanical properties.

Calcified tissue international

Liang B, Cotter MM, Chen D, Hernandez CJ, Zhou G

Human evolution and osteoporosis-related spinal fractures.

PloS one

Cotter MM, Loomis DA, Simpson SW, Latimer B, Hernandez CJ

Surface contaminants inhibit osseointegration in a novel murine model.

Bone

Bonsignore LA, Colbrunn RW, Tatro JM, Messerschmitt PJ, Hernandez CJ, Goldberg VM, Stewart MC, Greenfield EM

Near-terminal creep damage does not substantially influence fatigue life under physiological loading.

Journal of biomechanics

Stern LC, Brinkman JG, Furmanski J, Rimnac CM, Hernandez CJ

Trabecular microarchitecture of hominoid thoracic vertebrae.

Anatomical record (Hoboken, N.J. : 2007)

Cotter MM, Simpson SW, Latimer BM, Hernandez CJ

Voxel size and measures of individual resorption cavities in three-dimensional images of cancellous bone.

Bone

Tkachenko EV, Slyfield CR, Tomlinson RE, Daggett JR, Wilson DL, Hernandez CJ

A biomechanical analysis of the effects of resorption cavities on cancellous bone strength.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Hernandez CJ, Gupta A, Keaveny TM

Trabecular microfracture and the influence of pyridinium and non-enzymatic glycation-mediated collagen cross-links.

Bone

Hernandez CJ, Tang SY, Baumbach BM, Hwu PB, Sakkee AN, van der Ham F, DeGroot J, Bank RA, Keaveny TM

Genetic background influences cortical bone response to ovariectomy.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Li CY, Schaffler MB, Wolde-Semait HT, Hernandez CJ, Jepsen KJ

Custom People Group: 
UCSF Microbiome Researchers