Jody Baron, MD, PhD

Hepatitis C virus infects and perturbs liver stem cells.

mBio

Meyers NL, Ashuach T, Lyons DE, Khalid MM, Simoneau CR, Erickson AL, Bouhaddou M, Nguyen TT, Kumar GR, Taha TY, Natarajan V, Baron JL, Neff N, Zanini F, Mahmoudi T, Quake SR, Krogan NJ, Cooper S, McDevitt TC, Yosef N, Ott M

Cyclone: an accessible pipeline to analyze, evaluate, and optimize multiparametric cytometry data.

Frontiers in immunology

Patel RK, Jaszczak RG, Im K, Carey ND, Courau T, Bunis DG, Samad B, Avanesyan L, Chew NW, Stenske S, Jespersen JM, Publicover J, Edwards AW, Naser M, Rao AA, Lupin-Jimenez L, Krummel MF, Cooper S, Baron JL, Combes AJ, Fragiadakis GK

Modelling T-cell immunity against hepatitis C virus with liver organoids in a microfluidic coculture system.

Open biology

Natarajan V, Simoneau CR, Erickson AL, Meyers NL, Baron JL, Cooper S, McDevitt TC, Ott M

A tumor-specific mechanism of Treg enrichment mediated by the integrin αvβ8.

Science immunology

Seed RI, Kobayashi K, Ito S, Takasaka N, Cormier A, Jespersen JM, Publicover J, Trilok S, Combes AJ, Chew NW, Chapman J, Krummel MF, Lou J, Marks J, Cheng Y, Baron JL, Nishimura SL

Cryo-EM Reveals Integrin-Mediated TGF-ß Activation without Release from Latent TGF-ß.

Cell

Campbell MG, Cormier A, Ito S, Seed RI, Bondesson AJ, Lou J, Marks JD, Baron JL, Cheng Y, Nishimura SL

Structural Studies avß8 Integrin by Single Particle Cryo-EM.

Microscopy and Microanalysis

Melody G. Campbell, Anthony Cormier, Saburo Ito, Shenping Wu, Jianlong Lou, James Marks, Jody L. Baron, Stephen L. Nishimura, Yifan Cheng

Integrin avß8-expressing tumor cells evade host immunity by regulating TGF-ß activation in immune cells.

JCI insight

Takasaka N, Seed RI, Cormier A, Bondesson AJ, Lou J, Elattma A, Ito S, Yanagisawa H, Hashimoto M, Ma R, Levine MD, Publicover J, Potts R, Jespersen JM, Campbell MG, Conrad F, Marks JD, Cheng Y, Baron JL, Nishimura SL

Cryo-EM structure of the avß8 integrin reveals a mechanism for stabilizing integrin extension.

Nature structural & molecular biology

Cormier A, Campbell MG, Ito S, Wu S, Lou J, Marks J, Baron JL, Nishimura SL, Cheng Y

An OX40/OX40L interaction directs successful immunity to hepatitis B virus.

Science translational medicine

Publicover J, Gaggar A, Jespersen JM, Halac U, Johnson AJ, Goodsell A, Avanesyan L, Nishimura SL, Holdorf M, Mansfield KG, Judge JB, Koshti A, Croft M, Wakil AE, Rosenthal P, Pai E, Cooper S, Baron JL

CD18 deficiency improves liver injury in the MCD model of steatohepatitis.

PloS one

Pierce AA, Duwaerts CC, Siao K, Mattis AN, Goodsell A, Baron JL, Maher JJ

Specific Macronutrients Exert Unique Influences on the Adipose-Liver Axis to Promote Hepatic Steatosis in Mice.

Cellular and molecular gastroenterology and hepatology

Duwaerts CC, Amin AM, Siao K, Her C, Fitch M, Beysen C, Turner SM, Goodsell A, Baron JL, Grenert JP, Cho SJ, Maher JJ

Role of IL-17A in murine models of COPD airway disease.

American journal of physiology. Lung cellular and molecular physiology

Yanagisawa H, Hashimoto M, Minagawa S, Takasaka N, Ma R, Moermans C, Ito S, Araya J, Budelsky A, Goodsell A, Baron JL, Nishimura SL

Liver capsule: Age-influenced hepatic immune priming determines HBV infection fate: Implications from mouse to man.

Hepatology (Baltimore, Md.)

Publicover J, Jespersen JM, Johnson AJ, Nishimura SL, Goodsell A, Wakil AE, Rosenthal P, Pai E, Avanesyan L, Cooper S, Baron JL

TGF-ß-Dependent Dendritic Cell Chemokinesis in Murine Models of Airway Disease.

Journal of immunology (Baltimore, Md. : 1950)

Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Ma R, Murray LA, Tsui P, Lou J, Marks JD, Baron JL, Krummel MF, Nishimura SL

Transforming Growth Factor-ß and Interleukin-1ß Signaling Pathways Converge on the Chemokine CCL20 Promoter.

The Journal of biological chemistry

Brand OJ, Somanath S, Moermans C, Yanagisawa H, Hashimoto M, Cambier S, Markovics J, Bondesson AJ, Hill A, Jablons D, Wolters P, Lou J, Marks JD, Baron JL, Nishimura SL

A critical role for dendritic cells in the evolution of IL-1ß-mediated murine airway disease.

Journal of immunology (Baltimore, Md. : 1950)

Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Goodsell A, Ma R, Moermans C, McKnelly KJ, Baron JL, Krummel MF, Nishimura SL

Selective targeting of TGF-ß activation to treat fibroinflammatory airway disease.

Science translational medicine

Minagawa S, Lou J, Seed RI, Cormier A, Wu S, Cheng Y, Murray L, Tsui P, Connor J, Herbst R, Govaerts C, Barker T, Cambier S, Yanagisawa H, Goodsell A, Hashimoto M, Brand OJ, Cheng R, Ma R, McKnelly KJ, Wen W, Hill A, Jablons D, Wolters P, Kitamura H, Araya J, Barczak AJ, Erle DJ, Reichardt LF, Marks JD, Baron JL, Nishimura SL

Production of factor VIII by human liver sinusoidal endothelial cells transplanted in immunodeficient uPA mice.

PloS one

Fomin ME, Zhou Y, Beyer AI, Publicover J, Baron JL, Muench MO

S-3 Age-dependent hepatic lymphoid organization directs immune priming, cytokine production, and successful immunity to Hepatitis B virus.

Cytokine

Jean Publicover, Anuj Gaggar, Stephen Nishimura, Christine M. Van Horn, Amanda Goodsell, Marcus O. Muench, R. Lee Reinhardt, Nico van Rooijen, Adil E. Wakil Marion Peters, Jason G. Cyster, David J. Erle, Philip Rosenthal, Lia Avanesyan, Rosanne Spolski, Warren J. Leonard, Stewart Cooper, Jody L. Baron

Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B.

The Journal of clinical investigation

Publicover J, Gaggar A, Nishimura S, Van Horn CM, Goodsell A, Muench MO, Reinhardt RL, van Rooijen N, Wakil AE, Peters M, Cyster JG, Erle DJ, Rosenthal P, Cooper S, Baron JL

Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity.

Nature medicine

Zeissig S, Murata K, Sweet L, Publicover J, Hu Z, Kaser A, Bosse E, Iqbal J, Hussain MM, Balschun K, Röcken C, Arlt A, Günther R, Hampe J, Schreiber S, Baron JL, Moody DB, Liang TJ, Blumberg RS

742 Hepatitis B Virus Infection Leads to Alterations in the Repertoire of Self Lipid Antigens Presented by Hepatocytes and is Associated With Direct and Indirect Activation of Natural Killer T Cells.

Gastroenterology

Sebastian Zeissig, Kazumoto Murata, Lindsay Sweet, Jean Publicover, Zongyi Hu, Arthur Kaser, Alexander Arlt, Rainer Günther, Jochen Hampe, Stefan Schreiber, Jody Baron, D. Branch Moody, T Jake Liang, Richard S. Blumberg

Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin avß8-mediated activation of TGF-ß.

The Journal of clinical investigation

Kitamura H, Cambier S, Somanath S, Barker T, Minagawa S, Markovics J, Goodsell A, Publicover J, Reichardt L, Jablons D, Wolters P, Hill A, Marks JD, Lou J, Pittet JF, Gauldie J, Baron JL, Nishimura SL

Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumor in vivo.

Proceedings of the National Academy of Sciences of the United States of America

Cerwenka A, Baron JL, Lanier LL

The Benioff Center for Microbiome Medicine

Jody Baron, MD, PhD

Hepatitis C virus infects and perturbs liver stem cells.

Cyclone: an accessible pipeline to analyze, evaluate, and optimize multiparametric cytometry data.

Modelling T-cell immunity against hepatitis C virus with liver organoids in a microfluidic coculture system.

A tumor-specific mechanism of Treg enrichment mediated by the integrin αvβ8.

Cryo-EM Reveals Integrin-Mediated TGF-ß Activation without Release from Latent TGF-ß.

Structural Studies avß8 Integrin by Single Particle Cryo-EM.

Integrin avß8-expressing tumor cells evade host immunity by regulating TGF-ß activation in immune cells.

Cryo-EM structure of the avß8 integrin reveals a mechanism for stabilizing integrin extension.

An OX40/OX40L interaction directs successful immunity to hepatitis B virus.

CD18 deficiency improves liver injury in the MCD model of steatohepatitis.

Specific Macronutrients Exert Unique Influences on the Adipose-Liver Axis to Promote Hepatic Steatosis in Mice.

Role of IL-17A in murine models of COPD airway disease.

Liver capsule: Age-influenced hepatic immune priming determines HBV infection fate: Implications from mouse to man.

TGF-ß-Dependent Dendritic Cell Chemokinesis in Murine Models of Airway Disease.

Transforming Growth Factor-ß and Interleukin-1ß Signaling Pathways Converge on the Chemokine CCL20 Promoter.

A critical role for dendritic cells in the evolution of IL-1ß-mediated murine airway disease.

Selective targeting of TGF-ß activation to treat fibroinflammatory airway disease.

Production of factor VIII by human liver sinusoidal endothelial cells transplanted in immunodeficient uPA mice.

S-3 Age-dependent hepatic lymphoid organization directs immune priming, cytokine production, and successful immunity to Hepatitis B virus.

Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B.

Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity.

742 Hepatitis B Virus Infection Leads to Alterations in the Repertoire of Self Lipid Antigens Presented by Hepatocytes and is Associated With Direct and Indirect Activation of Natural Killer T Cells.

Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin avß8-mediated activation of TGF-ß.

IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B.

Blockade of NKG2D on NKT cells prevents hepatitis and the acute immune response to hepatitis B virus.

Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function.

Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo.

The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1.

Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumor in vivo.

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Jody Baron, MD, PhD