Joel Babdor, PhD

Postdoc
Otolaryngology

Joel Babdor, PhD, is a postdoctoral researcher in the Spitzer lab. He uses high-throughput, high-dimensional technologies and computational methods to study the interactions between the human immune system and the microbiome at the systems level. He focuses on human research in healthy populations and in pathological settings where the immune system plays an important role (cancer, autoimmunity and organ transplantation).

One of the main projects Joel has developed in the Spitzer lab is the ImmunoMicrobiome Study, an IRB-approved human research protocol, which successfully enrolled 111 healthy individuals, to perform a comprehensive analysis of the peripheral immune system, the gut/oral/skin microbiome, and the metabolome. His study is designed to assess variations of the immune system and the microbiome across time and explore the interactions between these biological compartments. As "it takes a village", Joel is collaboratively developing novel, integrative computational strategies to analyze the ImmunoMicrobiome multi-OMIC dataset.

Publications: 

Neuropilin-1 cooperates with PD-1 in CD8+ T cells predicting outcomes in melanoma patients treated with anti-PD1.

iScience

Rossignol J, Belaid Z, Fouquet G, Guillem F, Rignault R, Milpied P, Renand A, Coman T, D'Aveni M, Dussiot M, Colin E, Levy J, Carvalho C, Goudin N, Cagnard N, Côté F, Babdor J, Bhukhai K, Polivka L, Bigorgne AE, Halse H, Marabelle A, Mouraud S, Lepelletier Y, Maciel TT, Rubio MT, Heron D, Robert C, Girault I, Lebeherec D, Scoazec JY, Moura I, Condon L, Weimershaus M, Pages F, Davoust J, Gross D, Hermine O

Mass cytometry reveals single-cell kinetics of cytotoxic lymphocyte evolution in CMV-infected renal transplant patients.

Proceedings of the National Academy of Sciences of the United States of America

Ishiyama K, Arakawa-Hoyt J, Aguilar OA, Damm I, Towfighi P, Sigdel T, Tamaki S, Babdor J, Spitzer MH, Reed EF, Sarwal MM, Lanier LL, CMV Systems Immunobiology Group

Black In Immuno: harnessing social media and digital platforms to connect the dots.

Nature reviews. Immunology

Babdor J, Fan AC, Wane M, Mbiribindi B, Mobley AS, Noel JC, Kouame E

Comprehensive Immune Monitoring of Clinical Trials to Advance Human Immunotherapy.

Cell reports

Hartmann FJ, Babdor J, Gherardini PF, Amir ED, Jones K, Sahaf B, Marquez DM, Krutzik P, O'Donnell E, Sigal N, Maecker HT, Meyer E, Spitzer MH, Bendall SC

Innate Immune Signals Induce Anterograde Endosome Transport Promoting MHC Class I Cross-Presentation.

Cell reports

Weimershaus M, Mauvais FX, Saveanu L, Adiko C, Babdor J, Abramova A, Montealegre S, Lawand M, Evnouchidou I, Huber KJ, Chadt A, Zwick M, Vargas P, Dussiot M, Lennon-Dumenil AM, Brocker T, Al-Hasani H, van Endert P

Human CD4- invariant NKT lymphocytes regulate graft versus host disease.

Oncoimmunology

Coman T, Rossignol J, D'Aveni M, Fabiani B, Dussiot M, Rignault R, Babdor J, Bouillé M, Herbelin A, Coté F, Moura IC, Hermine O, Rubio MT

Impaired Transferrin Receptor Palmitoylation and Recycling in Neurodegeneration with Brain Iron Accumulation.

American journal of human genetics

Drecourt A, Babdor J, Dussiot M, Petit F, Goudin N, Garfa-Traoré M, Habarou F, Bole-Feysot C, Nitschké P, Ottolenghi C, Metodiev MD, Serre V, Desguerre I, Boddaert N, Hermine O, Munnich A, Rötig A

IRAP+ endosomes restrict TLR9 activation and signaling.

Nature immunology

Babdor J, Descamps D, Adiko AC, Tohmé M, Maschalidi S, Evnouchidou I, Vasconcellos LR, De Luca M, Mauvais FX, Garfa-Traore M, Brinkmann MM, Chignard M, Manoury B, Saveanu L

Post-paralysis tyrosine kinase inhibition with masitinib abrogates neuroinflammation and slows disease progression in inherited amyotrophic lateral sclerosis.

Journal of neuroinflammation

Trias E, Ibarburu S, Barreto-Núñez R, Babdor J, Maciel TT, Guillo M, Gros L, Dubreuil P, Díaz-Amarilla P, Cassina P, Martínez-Palma L, Moura IC, Beckman JS, Hermine O, Barbeito L

Intracellular Transport Routes for MHC I and Their Relevance for Antigen Cross-Presentation.

Frontiers in immunology

Adiko AC, Babdor J, Gutiérrez-Martínez E, Guermonprez P, Saveanu L

Insulin-regulated aminopeptidase and its compartment in dendritic cells.

Molecular immunology

Saveanu L, Babdor J, Lawand M, van Endert P

Irap is required for normal phagosome and endosome maturation in dendritic cells.

Molecular immunology

Loredana Saveanu, Joel Babdor, Mira Tohme, Sophia Maschalidi, Benedicte Manoury, Peter van Endert