Michael Rosenblum, MD, PhD

Associate Professor
Laboratory Medicine
+1 415 353-7891

Dr. Michael Rosenblum is a dermatologist who specializes in caring for patients with inflammatory and autoimmune skin diseases.

One of the world's leading skin immunologists, Rosenblum's research has led to a better understanding of how immune responses are regulated in tissues. He also studies how to use this knowledge to develop better treatments for autoimmune disorders.

After completing a doctorate in immunology at the Medical College of Wisconsin, Rosenblum earned his medical degree from the same institution. He completed a residency in dermatology at UCSF.

Rosenblum is a member of the American Association of Immunologists, Society for Investigative Dermatology, American Academy of Dermatology and Federation of Clinical Immunology Societies. He has co-founded multiple biotech companies that are developing new treatments for autoimmune diseases.

Publications: 

Interleukin-2-induced skin inflammation.

European journal of immunology

Sommer C, Cohen JN, Dehmel S, Neuhaus V, Schaudien D, Braun A, Sewald K, Rosenblum MD

Tertiary lymphoid structures sustain cutaneous B cell activity in hidradenitis suppurativa.

JCI insight

Lowe MM, Cohen JN, Moss MI, Clancy S, Adler JP, Yates AE, Naik HB, Yadav R, Pauli M, Taylor I, McKay A, Harris H, Kim E, Hansen SL, Rosenblum MD, Moreau JM

Regulatory T cells in skin mediate immune privilege of the hair follicle stem cell niche.

Science immunology

Cohen JN, Gouirand V, Macon CE, Lowe MM, Boothby IC, Moreau JM, Gratz IK, Stoecklinger A, Weaver CT, Sharpe AH, Ricardo-Gonzalez RR, Rosenblum MD

Tertiary Lymphoid Structures Sustain Cutaneous B cell Activity in Hidradenitis Suppurativa.

bioRxiv : the preprint server for biology

Lowe MM, Cohen JN, Moss MI, Clancy S, Adler J, Yates A, Naik HB, Pauli M, Taylor I, McKay A, Harris H, Kim E, Hansen SL, Rosenblum MD, Moreau JM

Immunopathogenesis of hidradenitis suppurativa and response to anti-TNF-a?? therapy.

JCI insight

Lowe MM, Naik HB, Clancy S, Pauli M, Smith KM, Bi Y, Dunstan R, Gudjonsson JE, Paul M, Harris H, Kim E, Shin US, Ahn R, Liao W, Hansen SL, Rosenblum MD

Xenograft Skin Model to Manipulate Human Immune Responses In Vivo.

Journal of visualized experiments : JoVE

Moss MI, Pauli M, Moreau JM, Cohen JN, Rosenblum MD, Lowe MM

Transforming growth factor-ß1 in regulatory T cell biology.

Science immunology

Moreau JM, Velegraki M, Bolyard C, Rosenblum MD, Li Z

MTHFD2, metabolic mastermind of CD4+ T cell destiny.

Science immunology

Gouirand V, Rosenblum MD

Identifying and antagonizing the interactions between layilin and glycosylated collagens.

Cell chemical biology

Glasgow JE, Byrnes JR, Barbee SD, Moreau JM, Rosenblum MD, Wells JA

Author Correction: Transcriptional landscape of epithelial and immune cell populations revealed through FACS-seq of healthy human skin.

Scientific reports

Ahn RS, Taravati K, Lai K, Lee KM, Nititham J, Gupta R, Chang DS, Arron ST, Rosenblum M, Liao W

Transcriptomic Profiling of Plaque Psoriasis and Cutaneous T-Cell Subsets during Treatment with Secukinumab.

JID innovations : skin science from molecules to population health

Liu J, Chang HW, Grewal R, Cummins DD, Bui A, Beck KM, Sekhon S, Yan D, Huang ZM, Schmidt TH, Yang EJ, Sanchez IM, Nakamura M, Bhattarai S, Thibodeaux Q, Ahn R, Pauli M, Bhutani T, Rosenblum MD, Liao W

Early-life inflammation primes a T helper 2 cell-fibroblast niche in skin.

Nature

Boothby IC, Kinet MJ, Boda DP, Kwan EY, Clancy S, Cohen JN, Habrylo I, Lowe MM, Pauli M, Yates AE, Chan JD, Harris HW, Neuhaus IM, McCalmont TH, Molofsky AB, Rosenblum MD

Tregs and inflammation-bring it on!

Science immunology

Gouirand V, Rosenblum MD

Layilin Anchors Regulatory T Cells in Skin.

Journal of immunology (Baltimore, Md. : 1950)

Mehta P, Gouirand V, Boda DP, Zhang J, Gearty SV, Zirak B, Lowe MM, Clancy S, Boothby I, Mahuron KM, Fries A, Krummel MF, Mankoo P, Chang HW, Liu J, Moreau JM, Scharschmidt TC, Daud A, Kim E, Neuhaus IM, Harris HW, Liao W, Rosenblum MD

Regulatory T cells promote innate inflammation after skin barrier breach via TGF-ß activation.

Science immunology

Moreau JM, Dhariwala MO, Gouirand V, Boda DP, Boothby IC, Lowe MM, Cohen JN, Macon CE, Leech JM, Kalekar LA, Scharschmidt TC, Rosenblum MD

Regulatory T Cells and Inflammatory Mediators in Autoimmune Disease.

The Journal of investigative dermatology

Gouirand V, Habrylo I, Rosenblum MD

Integrin αvβ8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy.

Cell reports

Dodagatta-Marri E, Ma HY, Liang B, Li J, Meyer DS, Chen SY, Sun KH, Ren X, Zivak B, Rosenblum MD, Headley MB, Pinzas L, Reed NI, Del Cid JS, Hann BC, Yang S, Giddabasappa A, Noorbehesht K, Yang B, Dal Porto J, Tsukui T, Niessen K, Atakilit A, Akhurst RJ, Sheppard D

T-Cell Adhesion in Healthy and Inflamed Skin.

JID innovations

Moreau JM, Gouirand V, Rosenblum MD

Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment.

The Journal of experimental medicine

Pauken KE, Shahid O, Lagattuta KA, Mahuron KM, Luber JM, Lowe MM, Huang L, Delaney C, Long JM, Fung ME, Newcomer K, Tsai KK, Chow M, Guinn S, Kuchroo JR, Burke KP, Schenkel JM, Rosenblum MD, Daud AI, Sharpe AH, Singer M

TregGF-ß: Deletion of TGF-ß in Tregs revisited.

Science immunology

Boothby IC, Rosenblum MD

Histologic Progression of Acne inversa/hidradenitis suppurativa: Implications for future Investigations and therapeutic intervention.

Experimental dermatology

Dunstan RW, Salte KM, Todorovic V, Lowe M, Wetter JB, Harms PW, Burney RE, Scott VE, Smith KM, Rosenblum M, Gudjonsson JE, Honore P

Single cell RNA-seq of psoriatic skin identifies pathogenic Tc17 subsets and reveals distinctions between CD8+ T cells in autoimmunity and cancer.

The Journal of allergy and clinical immunology

Liu J, Chang HW, Huang ZM, Nakamura M, Sekhon S, Ahn R, Munoz-Sandoval P, Bhattarai S, Beck KM, Sanchez IM, Yang E, Pauli M, Arron ST, Fung-Leung WP, Munoz E, Liu X, Bhutani T, North J, Fourie AM, Rosenblum MD, Liao W

Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature.

Cell reports. Medicine

Dhariwala MO, Karthikeyan D, Vasquez KS, Farhat S, Weckel A, Taravati K, Leitner EG, Clancy S, Pauli M, Piper ML, Cohen JN, Ashouri JF, Lowe MM, Rosenblum MD, Scharschmidt TC

Cutting Edge: Tissue Antigen Expression Levels Fine-Tune T Cell Differentiation Decisions In Vivo.

Journal of immunology (Baltimore, Md. : 1950)

Pinheiro DF, Szenes-Nagy AB, Maurano MM, Lietzenmayer M, Klicznik MM, Holly R, Kirchmeier D, Kitzmueller S, Achatz-Straussberger G, Rosenblum MD, Thalhamer J, Abbas AK, Gratz IK

Contribution of plasma cells and B-cells to hidradenitis suppurativa pathogenesis.

JCI insight

Gudjonsson JE, Tsoi LC, Ma F, Billi AC, van Straalen KR, Vossen AR, Zee HH, Harms PW, Wasikowski R, Yee CM, Rizvi SM, Xing X, Xing E, Plazyo O, Zeng C, Patrick MT, Lowe MM, Burney RE, Kozlow JH, Cherry-Bukowiec JR, Jiang Y, Kirma J, Weidinger S, Cushing KC, Rosenblum MD, Berthier CC, MacLeod AS, Voorhees JJ, Wen F, Kahlenberg JM, Maverakis E, Modlin RL, Prens EP

Immunopathogenesis of hidradenitis suppurativa and response to anti-TNFa therapy.

JCI insight

Lowe MM, Naik HB, Clancy S, Pauli M, Smith KM, Bi Y, Dunstan R, Gudjonsson J, Paul M, Harris HW, Kim EA, Shin US, Ahn R, Liao W, Hansen SL, Rosenblum M

Layilin augments integrin activation to promote antitumor immunity.

The Journal of experimental medicine

Mahuron KM, Moreau JM, Glasgow JE, Boda DP, Pauli ML, Gouirand V, Panjabi L, Grewal R, Luber JM, Mathur AN, Feldman RM, Shifrut E, Mehta P, Lowe MM, Alvarado MD, Marson A, Singer M, Wells J, Jupp R, Daud AI, Rosenblum MD

Keepin' it regulatory: Foxp3 gets a BAFfling SWItch.

Science immunology

Kinet MJ, Rosenblum MD

Exhausted T cell signature predicts immunotherapy response in ER-positive breast cancer.

Nature communications

Terranova-Barberio M, Pawlowska N, Dhawan M, Moasser M, Chien AJ, Melisko ME, Rugo H, Rahimi R, Deal T, Daud A, Rosenblum MD, Thomas S, Munster PN

A novel humanized mouse model to study the function of human cutaneous memory T cells in vivo in human skin.

Scientific reports

Klicznik MM, Benedetti A, Gail LM, Varkhande SR, Holly R, Laimer M, Stoecklinger A, Sir A, Reitsamer R, Neuper T, Horejs-Hoeck J, Rosenblum MD, Campbell DJ, Murauer EM, Gratz IK

Tumor Immune Profiling-Based Neoadjuvant Immunotherapy for Locally Advanced Melanoma.

Annals of surgical oncology

Levine LS, Mahuron KM, Tsai KK, Wu C, Mattis DM, Pauli ML, Oglesby A, Lee JC, Spitzer MH, Krummel MF, Algazi AP, Rosenblum MD, Alvarado M, Daud AI

Phase II Trial of IL-12 Plasmid Transfection and PD-1 Blockade in Immunologically Quiescent Melanoma.

Clinical cancer research : an official journal of the American Association for Cancer Research

Algazi AP, Twitty CG, Tsai KK, Le M, Pierce R, Browning E, Hermiz R, Canton DA, Bannavong D, Oglesby A, Francisco M, Fong L, Pittet MJ, Arlauckas SP, Garris C, Levine LP, Bifulco C, Ballesteros-Merino C, Bhatia S, Gargosky S, Andtbacka RHI, Fox BA, Rosenblum MD, Daud AI

Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair.

Cell stem cell

Shook BA, Wasko RR, Mano O, Rutenberg-Schoenberg M, Rudolph MC, Zirak B, Rivera-Gonzalez GC, López-Giráldez F, Zarini S, Rezza A, Clark DA, Rendl M, Rosenblum MD, Gerstein MB, Horsley V

Sex drives Tregs into fat.

Science immunology

Habrylo I, Rosenblum MD

Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues.

JCI insight

Lowe MM, Boothby I, Clancy S, Ahn RS, Liao W, Nguyen DN, Schumann K, Marson A, Mahuron KM, Kingsbury GA, Liu Z, Munoz Sandoval P, Rodriguez RS, Pauli ML, Taravati K, Arron ST, Neuhaus IM, Harris HW, Kim EA, Shin US, Krummel MF, Daud A, Scharschmidt TC, Rosenblum MD

An Injectable Cytokine Trap for Local Treatment of Autoimmune Disease.

Biomaterials

Zamecnik CR, Levy ES, Lowe MM, Zirak B, Rosenblum MD, Desai TA

Regulatory T cells in skin are uniquely poised to suppress profibrotic immune responses.

Science immunology

Kalekar LA, Cohen JN, Prevel N, Sandoval PM, Mathur AN, Moreau JM, Lowe MM, Nosbaum A, Wolters PJ, Haemel A, Boin F, Rosenblum MD

Regulatory T cells in inflammatory skin disease: from mice to humans.

International immunology

Kalekar LA, Rosenblum MD

Human CD4+CD103+ cutaneous resident memory T cells are found in the circulation of healthy individuals.

Science immunology

Klicznik MM, Morawski PA, Höllbacher B, Varkhande SR, Motley SJ, Kuri-Cervantes L, Goodwin E, Rosenblum MD, Long SA, Brachtl G, Duhen T, Betts MR, Campbell DJ, Gratz IK

CD27 Promotes CD4+ Effector T Cell Survival in Response to Tissue Self-Antigen.

Journal of immunology (Baltimore, Md. : 1950)

Remedios KA, Meyer L, Zirak B, Pauli ML, Truong HA, Boda D, Rosenblum MD

Y'all comeback now.

Science immunology

Cohen JN, Rosenblum MD

Adaptive Immune Resistance Emerges from Tumor-Initiating Stem Cells.

Cell

Miao Y, Yang H, Levorse J, Yuan S, Polak L, Sribour M, Singh B, Rosenblum MD, Fuchs E

Treg-Cell Control of a CXCL5-IL-17 Inflammatory Axis Promotes Hair-Follicle-Stem-Cell Differentiation During Skin-Barrier Repair.

Immunity

Mathur AN, Zirak B, Boothby IC, Tan M, Cohen JN, Mauro TM, Mehta P, Lowe MM, Abbas AK, Ali N, Rosenblum MD

a-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by a-TGFß antibody to promote durable rejection and immunity in squamous cell carcinomas.

Journal for immunotherapy of cancer

Dodagatta-Marri E, Meyer DS, Reeves MQ, Paniagua R, To MD, Binnewies M, Broz ML, Mori H, Wu D, Adoumie M, Del Rosario R, Li O, Buchmann T, Liang B, Malato J, Arce Vargus F, Sheppard D, Hann BC, Mirza A, Quezada SA, Rosenblum MD, Krummel MF, Balmain A, Akhurst RJ

Adoptive Treg Cell Therapy in a Patient With Systemic Lupus Erythematosus.

Arthritis & rheumatology (Hoboken, N.J.)

Dall'Era M, Pauli ML, Remedios K, Taravati K, Sandova PM, Putnam AL, Lares A, Haemel A, Tang Q, Hellerstein M, Fitch M, McNamara J, Welch B, Bluestone JA, Wofsy D, Rosenblum MD

Inflammatory T cells maintain a healing disposition.

Science immunology

Moreau JM, Rosenblum MD

The TNFRSF members CD27 and OX40 coordinately limit TH17 differentiation in regulatory T cells.

Science immunology

Remedios KA, Zirak B, Sandoval PM, Lowe MM, Boda D, Henley E, Bhattrai S, Scharschmidt TC, Liao W, Naik HB, Rosenblum MD

Tissue-specific contributions of Tmem79 to atopic dermatitis and mast cell-mediated histaminergic itch.

Proceedings of the National Academy of Sciences of the United States of America

Emrick JJ, Mathur A, Wei J, Gracheva EO, Gronert K, Rosenblum MD, Julius D

Colitis interruptus: LAGing gut inflammation.

Science immunology

Mehta P, Rosenblum MD

Alteration of the cutaneous microbiome in psoriasis and potential role in Th17 polarization.

Microbiome

Chang HW, Yan D, Singh R, Liu J, Lu X, Ucmak D, Lee K, Afifi L, Fadrosh D, Leech J, Vasquez KS, Lowe MM, Rosenblum MD, Scharschmidt TC, Lynch SV, Liao W

RNA-seq and flow-cytometry of conventional, scalp, and palmoplantar psoriasis reveal shared and distinct molecular pathways.

Scientific reports

Ahn R, Yan D, Chang HW, Lee K, Bhattarai S, Huang ZM, Nakamura M, Singh R, Afifi L, Taravati K, Munoz-Sandoval P, Pauli M, Rosenblum MD, Liao W

A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments.

Nature medicine

Barry KC, Hsu J, Broz ML, Cueto FJ, Binnewies M, Combes AJ, Nelson AE, Loo K, Kumar R, Rosenblum MD, Alvarado MD, Wolf DM, Bogunovic D, Bhardwaj N, Daud AI, Ha PK, Ryan WR, Pollack JL, Samad B, Asthana S, Chan V, Krummel MF

Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity.

Cell reports

Wang D, Quiros J, Mahuron K, Pai CC, Ranzani V, Young A, Silveria S, Harwin T, Abnousian A, Pagani M, Rosenblum MD, Van Gool F, Fong L, Bluestone JA, DuPage M

Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus-like inflammation.

The Journal of clinical investigation

Mande P, Zirak B, Ko WC, Taravati K, Bride KL, Brodeur TY, Deng A, Dresser K, Jiang Z, Ettinger R, Fitzgerald KA, Rosenblum MD, Harris JE, Marshak-Rothstein A

Say it isn't pso: IL-25 drives skin inflammation.

Science immunology

Kalekar LA, Rosenblum MD

Skin-Resident T Cells Drive Dermal Dendritic Cell Migration in Response to Tissue Self-Antigen.

Journal of immunology (Baltimore, Md. : 1950)

Ali N, Zirak B, Truong HA, Maurano MM, Gratz IK, Abbas AK, Rosenblum MD

SJS/TEN 2017: Building Multidisciplinary Networks to Drive Science and Translation.

The journal of allergy and clinical immunology. In practice

White KD, Abe R, Ardern-Jones M, Beachkofsky T, Bouchard C, Carleton B, Chodosh J, Cibotti R, Davis R, Denny JC, Dodiuk-Gad RP, Ergen EN, Goldman JL, Holmes JH, Hung SI, Lacouture ME, Lehloenya RJ, Mallal S, Manolio TA, Micheletti RG, Mitchell CM, Mockenhaupt M, Ostrov DA, Pavlos R, Pirmohamed M, Pope E, Redwood A, Rosenbach M, Rosenblum MD, Roujeau JC, Saavedra AP, Saeed HN, Struewing JP, Sueki H, Sukasem C, Sung C, Trubiano JA, Weintraub J, Wheatley LM, Williams KB, Worley B, Chung WH, Shear NH, Phillips EJ

HDAC inhibition potentiates immunotherapy in triple negative breast cancer.

Oncotarget

Terranova-Barberio M, Thomas S, Ali N, Pawlowska N, Park J, Krings G, Rosenblum MD, Budillon A, Munster PN

Genomic analysis of atypical fibroxanthoma.

PloS one

Lai K, Harwood CA, Purdie KJ, Proby CM, Leigh IM, Ravi N, Mully TW, Brooks L, Sandoval PM, Rosenblum MD, Arron ST

Injectable Polymeric Cytokine-Binding Nanowires Are Effective Tissue-Specific Immunomodulators.

ACS nano

Zamecnik CR, Lowe MM, Patterson DM, Rosenblum MD, Desai TA

Chronic Helicobacter cinaedi cellulitis diagnosed by microbial polymerase chain reaction.

JAAD case reports

Matsumoto A, Yeh I, Schwartz B, Rosenblum M, Schmidt TH

Regulatory T cells in skin.

Immunology

Ali N, Rosenblum MD

Partially exhausted tumor-infiltrating lymphocytes predict response to combination immunotherapy.

JCI insight

Loo K, Tsai KK, Mahuron K, Liu J, Pauli ML, Sandoval PM, Nosrati A, Lee J, Chen L, Hwang J, Levine LS, Krummel MF, Algazi AP, Pampaloni M, Alvarado MD, Rosenblum MD, Daud AI

Skin-infiltrating, interleukin-22-producing T cells differentiate pediatric psoriasis from adult psoriasis.

Journal of the American Academy of Dermatology

Cordoro KM, Hitraya-Low M, Taravati K, Sandoval PM, Kim E, Sugarman J, Pauli ML, Liao W, Rosenblum MD

Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation.

Cell

Ali N, Zirak B, Rodriguez RS, Pauli ML, Truong HA, Lai K, Ahn R, Corbin K, Lowe MM, Scharschmidt TC, Taravati K, Tan MR, Ricardo-Gonzalez RR, Nosbaum A, Bertolini M, Liao W, Nestle FO, Paus R, Cotsarelis G, Abbas AK, Rosenblum MD

Transcriptional landscape of epithelial and immune cell populations revealed through FACS-seq of healthy human skin.

Scientific reports

Ahn RS, Taravati K, Lai K, Lee KM, Nititham J, Gupta R, Chang DS, Arron ST, Rosenblum M, Liao W

Liver Metastasis and Treatment Outcome with Anti-PD-1 Monoclonal Antibody in Patients with Melanoma and NSCLC.

Cancer immunology research

Tumeh PC, Hellmann MD, Hamid O, Tsai KK, Loo KL, Gubens MA, Rosenblum M, Harview CL, Taube JM, Handley N, Khurana N, Nosrati A, Krummel MF, Tucker A, Sosa EV, Sanchez PJ, Banayan N, Osorio JC, Nguyen-Kim DL, Chang J, Shintaku IP, Boasberg PD, Taylor EJ, Munster PN, Algazi AP, Chmielowski B, Dummer R, Grogan TR, Elashoff D, Hwang J, Goldinger SM, Garon EB, Pierce RH, Daud A

Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin.

Cell host & microbe

Scharschmidt TC, Vasquez KS, Pauli ML, Leitner EG, Chu K, Truong HA, Lowe MM, Sanchez Rodriguez R, Ali N, Laszik ZG, Sonnenburg JL, Millar SE, Rosenblum MD

Warfarin-Associated Nonuremic Calciphylaxis.

JAMA dermatology

Yu WY, Bhutani T, Kornik R, Pincus LB, Mauro T, Rosenblum MD, Fox LP

Tumor immune profiling predicts response to anti-PD-1 therapy in human melanoma.

The Journal of clinical investigation

Daud AI, Loo K, Pauli ML, Sanchez-Rodriguez R, Sandoval PM, Taravati K, Tsai K, Nosrati A, Nardo L, Alvarado MD, Algazi AP, Pampaloni MH, Lobach IV, Hwang J, Pierce RH, Gratz IK, Krummel MF, Rosenblum MD

Cutting Edge: Regulatory T Cells Facilitate Cutaneous Wound Healing.

Journal of immunology (Baltimore, Md. : 1950)

Nosbaum A, Prevel N, Truong HA, Mehta P, Ettinger M, Scharschmidt TC, Ali NH, Pauli ML, Abbas AK, Rosenblum MD

The distribution of cutaneous metastases correlates with local immunologic milieu.

Journal of the American Academy of Dermatology

Schulman JM, Pauli ML, Neuhaus IM, Sanchez Rodriguez R, Taravati K, Shin US, McCalmont TH, Rosenblum MD

Regulatory T cell memory.

Nature reviews. Immunology

Rosenblum MD, Way SS, Abbas AK

A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes.

Immunity

Scharschmidt TC, Vasquez KS, Truong HA, Gearty SV, Pauli ML, Nosbaum A, Gratz IK, Otto M, Moon JJ, Liese J, Abbas AK, Fischbach MA, Rosenblum MD

Mechanisms of human autoimmunity.

The Journal of clinical investigation

Rosenblum MD, Remedios KA, Abbas AK

COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis.

Nature genetics

Watkin LB, Jessen B, Wiszniewski W, Vece TJ, Jan M, Sha Y, Thamsen M, Santos-Cortez RL, Lee K, Gambin T, Forbes LR, Law CS, Stray-Pedersen A, Cheng MH, Mace EM, Anderson MS, Liu D, Tang LF, Nicholas SK, Nahmod K, Makedonas G, Canter DL, Kwok PY, Hicks J, Jones KD, Penney S, Jhangiani SN, Rosenblum MD, Dell SD, Waterfield MR, Papa FR, Muzny DM, Zaitlen N, Leal SM, Gonzaga-Jauregui C, Boerwinkle E, Eissa NT, Gibbs RA, Lupski JR, Orange JS, Shum AK

Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity.

Cancer cell

Broz ML, Binnewies M, Boldajipour B, Nelson AE, Pollack JL, Erle DJ, Barczak A, Rosenblum MD, Daud A, Barber DL, Amigorena S, Van't Veer LJ, Sperling AI, Wolf DM, Krummel MF

Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity.

Cancer cell

Broz ML, Binnewies M, Boldajipour B, Nelson AE, Pollack JL, Erle DJ, Barczak A, Rosenblum MD, Daud A, Barber DL, Amigorena S, Van't Veer LJ, Sperling AI, Wolf DM, Krummel MF

Melanoma immunotherapy.

Cancer biology & therapy

Sanlorenzo M, Vujic I, Posch C, Dajee A, Yen A, Kim S, Ashworth M, Rosenblum MD, Algazi A, Osella-Abate S, Quaglino P, Daud A, Ortiz-Urda S

A case of Wong-type dermatomyositis with concomitant anti-MDA5 features.

Journal of the American Academy of Dermatology

Canavan T, Sidorsky T, Doan LT, Ricardo-Gonzalez RR, Shen G, Rosenblum MD

Plaque-based sub-blistering dosimetry: Reaching PASI-75 after two treatments with 308-nm excimer laser in a generalized psoriasis patient.

The Journal of dermatological treatment

Debbaneh MG, Levin E, Sanchez Rodriguez R, Leon A, Koo J, Rosenblum MD

Memory regulatory T cells reside in human skin.

The Journal of clinical investigation

Sanchez Rodriguez R, Pauli ML, Neuhaus IM, Yu SS, Arron ST, Harris HW, Yang SH, Anthony BA, Sverdrup FM, Krow-Lucal E, MacKenzie TC, Johnson DS, Meyer EH, Löhr A, Hsu A, Koo J, Liao W, Gupta R, Debbaneh MG, Butler D, Huynh M, Levin EC, Leon A, Hoffman WY, McGrath MH, Alvarado MD, Ludwig CH, Truong HA, Maurano MM, Gratz IK, Abbas AK, Rosenblum MD

Cutting edge: Self-antigen controls the balance between effector and regulatory T cells in peripheral tissues.

Journal of immunology (Baltimore, Md. : 1950)

Gratz IK, Rosenblum MD, Maurano MM, Paw JS, Truong HA, Marshak-Rothstein A, Abbas AK

An open-label study of anakinra for the treatment of moderate to severe hidradenitis suppurativa.

Journal of the American Academy of Dermatology

Leslie KS, Tripathi SV, Nguyen TV, Pauli M, Rosenblum MD

Cutting edge: ABIN-1 protects against psoriasis by restricting MyD88 signals in dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Callahan JA, Hammer GE, Agelides A, Duong BH, Oshima S, North J, Advincula R, Shifrin N, Truong HA, Paw J, Barrera J, DeFranco A, Rosenblum MD, Malynn BA, Ma A

Depleting tumor-specific Tregs at a single site eradicates disseminated tumors.

The Journal of clinical investigation

Marabelle A, Kohrt H, Sagiv-Barfi I, Ajami B, Axtell RC, Zhou G, Rajapaksa R, Green MR, Torchia J, Brody J, Luong R, Rosenblum MD, Steinman L, Levitsky HI, Tse V, Levy R

Cutting Edge: memory regulatory t cells require IL-7 and not IL-2 for their maintenance in peripheral tissues.

Journal of immunology (Baltimore, Md. : 1950)

Gratz IK, Truong HA, Yang SH, Maurano MM, Lee K, Abbas AK, Rosenblum MD

The life of regulatory T cells.

Annals of the New York Academy of Sciences

Gratz IK, Rosenblum MD, Abbas AK

In vivo cardiac phase response curve elucidates human respiratory heart rate variability.

Nature communications

Kralemann B, Frühwirth M, Pikovsky A, Rosenblum M, Kenner T, Schaefer J, Moser M

Treating human autoimmunity: current practice and future prospects.

Science translational medicine

Rosenblum MD, Gratz IK, Paw JS, Abbas AK

Response to self antigen imprints regulatory memory in tissues.

Nature

Rosenblum MD, Gratz IK, Paw JS, Lee K, Marshak-Rothstein A, Abbas AK

Erosive pustular dermatosis of the scalp: a review with a focus on dapsone therapy.

Journal of the American Academy of Dermatology

Broussard KC, Berger TG, Rosenblum M, Murase JE

Opposing functions of IL-2 and IL-7 in the regulation of immune responses.

Cytokine

Katzman SD, Hoyer KK, Dooms H, Gratz IK, Rosenblum MD, Paw JS, Isakson SH, Abbas AK

CD200, a "no danger" signal for hair follicles.

Journal of dermatological science

Rosenblum MD, Yancey KB, Olasz EB, Truitt RL

Characterization of CD 200-receptor expression in the murine epidermis.

The Journal of investigative dermatology

Rosenblum MD, Woodliff JE, Madsen NA, McOlash LJ, Keller MR, Truitt RL

Expression of CD200 on epithelial cells of the murine hair follicle: a role in tissue-specific immune tolerance?

The Journal of investigative dermatology

Rosenblum MD, Olasz EB, Yancey KB, Woodliff JE, Lazarova Z, Gerber KA, Truitt RL

Efficacy of alemtuzumab treatment for refractory T-cell large granular lymphocytic leukemia.

Blood

Rosenblum MD, LaBelle JL, Chang CC, Margolis DA, Schauer DW, Vesole DH

CD200 is a novel p53-target gene involved in apoptosis-associated immune tolerance.

Blood

Rosenblum MD, Olasz E, Woodliff JE, Johnson BD, Konkol MC, Gerber KA, Orentas RJ, Sandford G, Truitt RL

Phase I study of intraperitoneal recombinant human interleukin 12 in patients with Müllerian carcinoma, gastrointestinal primary malignancies, and mesothelioma.

Clinical cancer research : an official journal of the American Association for Cancer Research

Lenzi R, Rosenblum M, Verschraegen C, Kudelka AP, Kavanagh JJ, Hicks ME, Lang EA, Nash MA, Levy LB, Garcia ME, Platsoucas CD, Abbruzzese JL, Freedman RS

'Rings' of F-actin form around the nucleus in cultured human MCF7 adenocarcinoma cells upon exposure to both taxol and taxotere.

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP

Rosenblum MD, Shivers RR

Myeloablative chemotherapy with autologous bone marrow rescue in young children with recurrent malignant brain tumors.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Guruangan S, Dunkel IJ, Goldman S, Garvin JH, Rosenblum M, Boyett JM, Gardner S, Merchant TE, Gollamudi S, Finlay JL

High-dose carboplatin, thiotepa, and etoposide with autologous stem-cell rescue for patients with recurrent medulloblastoma. Children's Cancer Group.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Dunkel IJ, Boyett JM, Yates A, Rosenblum M, Garvin JH, Bostrom BC, Goldman S, Sender LS, Gardner SL, Li H, Allen JC, Finlay JL

Primary amyloidoma of the brain: CT and MR presentation.

AJNR. American journal of neuroradiology

Lee J, Krol G, Rosenblum M

Development of a non-selecting, non-perturbing method to study human brain tumor cell invasion in murine brain.

Journal of neuro-oncology

DeArmond SJ, Stowring L, Amar A, Coopersmith P, Dougherty D, Spencer D, Mikkelsen T, Rosenblum M

Hemorrhagic tumor necrosis during a pilot trial of tumor necrosis factor-alpha and anti-GD3 ganglioside monoclonal antibody in patients with metastatic melanoma.

Blood

Minasian LM, Szatrowski TP, Rosenblum M, Steffens T, Morrison ME, Chapman PB, Williams L, Nathan CF, Houghton AN

Microtubule aggregates in a clival chordoma.

Archives of pathology & laboratory medicine

Jeffrey PB, Davis RL, Biava C, Rosenblum M

Neoplastic meningitis as the presentation of occult primitive neuroectodermal tumors.

Journal of child neurology

Jennings MT, Slatkin N, D'Angelo M, Ketonen L, Johnson MD, Rosenblum M, Creasy J, Tulipan N, Walker R

Developmental regulation of annexin II (Lipocortin 2) in human brain and expression in high grade glioma.

Cancer research

Reeves SA, Chavez-Kappel C, Davis R, Rosenblum M, Israel MA

Phase I trial of an interleukin-2 (IL-2) fusion toxin (DAB486IL-2) in hematologic malignancies expressing the IL-2 receptor.

Blood

LeMaistre CF, Meneghetti C, Rosenblum M, Reuben J, Parker K, Shaw J, Deisseroth A, Woodworth T, Parkinson DR

Low dose rate radiotherapy for transplantable gliosarcoma in the rat brain.

Journal of neuro-oncology

Kim JH, Alfieri AA, Rosenblum M, Bravo S, Kim SH

AIDS-related vacuolar myelopathy is not associated with coinfection by human T-lymphotropic virus type I.

Annals of neurology

Brew BJ, Hardy W, Zuckerman E, Chien N, Paul M, Rosenblum M, Gadler H, Vahlne A, Gold J, Armstrong DA

Dissociation of AIDS-related vacuolar myelopathy and productive HIV-1 infection of the spinal cord.

Neurology

Rosenblum M, Scheck AC, Cronin K, Brew BJ, Khan A, Paul M, Price RW

Clinical and laboratory changes induced by alpha interferon in chronic lymphocytic leukemia--a pilot study.

American journal of hematology

Talpaz M, Rosenblum M, Kurzrock R, Reuben J, Kantarjian H, Gutterman J

Depression of murine natural killer cell cytotoxicity by isobutyl nitrite.

Cancer immunology, immunotherapy : CII

Lotzová E, Savary CA, Hersh EM, Khan AA, Rosenblum M