
Assistant Professor
Medicine
+1 415 502-4444
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As an Assistant Professor in the Division of GI at UCSF, I am interested in the molecular underpinnings of intestinal inflammation and Inflammatory Bowel Disease (IBD). We employ a variety of tools to study intestinal epithelial cells and death signaling pathways in mouse models, patient-derived biopsies, and organoids.
Publications
Mo1835: POST-VACCINATION SARS-COV-2 NEUTRALIZING ANTIBODIES IN A COHORT OF PREGNANT WOMEN RECEIVING BIOLOGICS FOR INFLAMMATORY BOWEL DISEASE.
Gastroenterology
Symptomatic and Sonographic Improvement of Immune Checkpoint Inhibitor Enterocolitis With Risankizumab.
Inflammatory bowel diseases
Single-cell spatial transcriptomics of fixed, paraffin-embedded biopsies reveals colitis-associated cell networks.
bioRxiv : the preprint server for biology
Mo1866 REAL WORLD EFFICACY OF RISANKIZUMAB IN CROHN'S DISEASE PATIENTS WITH PRIOR EXPOSURE TO USTEKINUMAB.
Gastroenterology
Tu1756 TWO SPATIAL TRANSCRIPTOMIC PLATFORMS IDENTIFIED POTENTIAL PATHWAYS LINKED TO VEDOLIZUMAB RESPONSIVENESS IN ULCERATIVE COLITIS.
Gastroenterology
Dysregulation of CD4+ and CD8+ resident memory T, myeloid, and stromal cells in steroid-experienced, checkpoint inhibitor colitis.
Journal for immunotherapy of cancer
Single-cell and spatial multi-omics highlight effects of anti-integrin therapy across cellular compartments in ulcerative colitis.
Nature communications
VEDOLIZUMAB RESPONSE AND NON-RESPONSE IN ULCERATIVE COLITIS: INSIGHTS FROM SPATIAL TRANSCRIPTOMICS.
Gastroenterology
VEDOLIZUMAB RESPONSE AND NON-RESPONSE IN ULCERATIVE COLITIS: INSIGHTS FROM SPATIAL TRANSCRIPTOMICS.
Inflammatory bowel diseases
Single-cell and spatial multi-omics identify innate and stromal modules targeted by anti-integrin therapy in ulcerative colitis.
bioRxiv : the preprint server for biology
630 SINGLE-CELL AND SPATIAL MULTI-OMICS IDENTIFY INNATE AND STROMAL MODULES TARGETED BY ANTI-INTEGRIN THERAPY IN ULCERATIVE COLITIS.
Gastroenterology
A20 Restricts NOS2 Expression and Intestinal Tumorigenesis in a Mouse Model of Colitis-Associated Cancer.
Gastro Hep Advances
Vedolizumab Antagonizes MAdCAM-1-Dependent Human Placental Cytotrophoblast Adhesion and Invasion In Vitro.
Inflammatory bowel diseases
Intestinal inflammation alters the antigen-specific immune response to a skin commensal.
Cell reports
Tu1517: MICROBIAL SIGNALS, MYD88, AND LYMPHOTOXIN DRIVE TNFINDEPENDENT DEATH OF A20 AND ABIN-1 DEFICIENT EPITHELIUM.
Gastroenterology
Microbial signals, MyD88, and lymphotoxin drive TNF-independent intestinal epithelial tissue damage.
The Journal of clinical investigation
Importance of Not MSing Cerebral White Matter Disease in Patients with Inflammatory Bowel Disease.
Digestive diseases and sciences
Balancing the Checkpoint: Managing Colitis Associated with Dual Checkpoint Inhibitors and High-Dose Aspirin.
Digestive diseases and sciences
Correction: Anti-TNF and thiopurine therapy in pregnant IBD patients does not significantly alter a panel of B-cell and T-cell subsets in 1-year-old infants.
Clinical and translational gastroenterology
A20 and ABIN-1 synergistically preserve intestinal epithelial cell survival.
The Journal of experimental medicine
Effect of I-scan Electronic Chromoendoscopy on Detection of Adenomas During Colonoscopy.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Anti-TNF and thiopurine therapy in pregnant IBD patients does not significantly alter a panel of B-cell and T-cell subsets in 1-year-old infants.
Clinical and translational gastroenterology
A20 upregulation during treated HIV disease is associated with intestinal epithelial cell recovery and function.
PLoS pathogens
Ubiquitin-Modifying Enzymes and Regulation of the Inflammasome.
Journal of molecular biology
332e Multiparameter Flow Cytometry Reveals Differences in B Cells Subsets among Infants Born to Mothers being Treated for IBD.
Gastroenterology
P-285 A20 and ABIN-1 Cooperate to Preserve Intestinal Epithelial Homeostasis.
Inflammatory bowel diseases
Effect of Intense Exercise on Inflammatory Bowel Disease Activity.
The American journal of gastroenterology
245 A20 and ABIN-1 Cooperate to Restrict Intestinal Epithelial Cell Death and Maintain Mucosal Immune Homeostasis.
Gastroenterology
Confocal laser endomicroscopy for membrane-bound tumor necrosis factor predicts response to therapy in Crohn's disease.
Gastroenterology
Tetramers reveal IL-17-secreting CD4+ T cells that are specific for U1-70 in lupus and mixed connective tissue disease.
Proceedings of the National Academy of Sciences of the United States of America
Measurement of mast cell surface molecules by high-throughput immunophenotyping using transcription (HIT).
Methods in molecular biology (Clifton, N.J.)
Insights into the molecular pathophysiology of inflammatory bowel disease: ATG16L1 suppresses nod-driven inflammation.
Gastroenterology
Antigen Specific T Cells in Lupus Recognize U1-70 and Produce IL-17 by Tetramer Staining.
Clinical Immunology
The U1-snRNP complex: structural properties relating to autoimmune pathogenesis in rheumatic diseases.
Immunological reviews
Naive CD4 t cell proliferation is controlled by mammalian target of rapamycin regulation of GRAIL expression.
Journal of immunology (Baltimore, Md. : 1950)
OR.85. Regulation of GRAIL Expression by mTOR Controls Naive CD4 T Cell Proliferation.
Clinical Immunology
Differential regulation of chemokines by IL-17 in colonic epithelial cells.
Journal of immunology (Baltimore, Md. : 1950)
Protein microarrays with carbon nanotubes as multicolor Raman labels.
Nature biotechnology
HIT: a versatile proteomics platform for multianalyte phenotyping of cytokines, intracellular proteins and surface molecules.
Nature medicine
Cytokines secreted in response to Toll-like receptor ligand stimulation modulate differentiation of human Th17 cells.
Arthritis and rheumatism
Protein microarrays address the elephant in the room.
Clinical chemistry
OR.40. Cytokines Secreted in Response to TLR-ligand Stimulation Modulate Human Th17 Differentiation.
Clinical Immunology
Sa.12. Profiling Epigenetic Biomarkers for the Study and Treatment of Lupus.
Clinical Immunology
Sa.95. HIT: A Novel Protein Array Platform Identifies Down-regulation of CD26 on Regulatory T Cell Subsets.
Clinical Immunology
Free-solution oligonucleotide separation in nanoscale channels.
Analytical chemistry
Antibody-oligo Arrays for Multiplex Surface Marker Profiling of Immune Cells Subsets.
Clinical Immunology
Medicine on a need-to-know basis.
Nature immunology
Multiplexed protein array platforms for analysis of autoimmune diseases.
Annual review of immunology
Sa.127. A Novel Two-Color Fab Labeling Method for Autoantigen Protein Microarrays.
Clinical Immunology
Structure-based discovery of nonpeptidic small organic compounds to block the T cell response to myelin basic protein.
Journal of medicinal chemistry
Crystal structure of the human myeloid cell activating receptor TREM-1.
Structure (London, England : 1993)
Making sense of the diverse ligand recognition by NKG2D.
Journal of immunology (Baltimore, Md. : 1950)
Generating isomorphous heavy-atom derivatives by a quick-soak method. Part I: test cases.
Acta crystallographica. Section D, Biological crystallography