
Professor
P_Pharmaceutical Chemistry
+1 415 476-9679
Custom People Group
One research interest is in the de novo design, in which one designs proteins or drugs beginning from first principles. This approach critically tests our understanding of protein folding and function, while also laying the groundwork for the design of molecules with properties unprecedented in nature.
Publications
De novo design of semisynthetic protein nanopores.
bioRxiv : the preprint server for biology
Resolving fibrosis by stimulating HSC-dependent extracellular matrix degradation.
Science translational medicine
High-throughput discovery of fluoroprobes that recognize amyloid fibril polymorphs.
Nature chemistry
De novo designed bright, hyperstable rhodamine binders for fluorescence microscopy.
bioRxiv : the preprint server for biology
Antimicrobial Activity of Brilacidin against E. coli.
ACS infectious diseases
Rapid clearance of achiral small-molecule drugs using de novo-designed proteins and their cyclic and mirror-image variants.
Nature biomedical engineering
A Designed Zn2+ Sensor Domain Transmits Binding Information to Transmembrane Histidine Kinases.
Journal of the American Chemical Society
De novo design of porphyrin-containing proteins as efficient and stereoselective catalysts.
Science (New York, N.Y.)
ProBASS-a language model with sequence and structural features for predicting the effect of mutations on binding affinity.
Bioinformatics (Oxford, England)
Fibronectin-dependent integrin signaling drives EphA2 expression in vascular smooth muscle cells.
American journal of physiology. Cell physiology
Emergence of binding and catalysis from a designed generalist binding protein.
bioRxiv : the preprint server for biology
De Novo Design of Proteins That Bind Naphthalenediimides, Powerful Photooxidants with Tunable Photophysical Properties.
Journal of the American Chemical Society
Sequence-dependent scale for translocon-mediated insertion of interfacial helices in membranes.
Science advances
A Cooperative Model for Symmetric Ligand Binding to Protein Fibrils.
bioRxiv : the preprint server for biology
Design of a light and Ca2+ switchable organic-peptide hybrid.
Proceedings of the National Academy of Sciences of the United States of America
A designed Zn 2+ sensor domain transmits binding information to transmembrane histidine kinases.
bioRxiv : the preprint server for biology
Methods for high throughput discovery of fluoroprobes that recognize tau fibril polymorphs.
bioRxiv : the preprint server for biology
SuFEx Chemistry Enables Covalent Assembly of a 280-kDa 18-Subunit Pore-Forming Complex.
Journal of the American Chemical Society
IL-13 and IL-17A activate ß1 integrin through an NF-kB/Rho kinase/PIP5K1? pathway to enhance force transmission in airway smooth muscle.
Proceedings of the National Academy of Sciences of the United States of America
Zfp106 binds to G-quadruplex RNAs and inhibits RAN translation and formation of RNA foci caused by G4C2 repeats.
Proceedings of the National Academy of Sciences of the United States of America
ProBASS - a language model with sequence and structural features for predicting the effect of mutations on binding affinity.
bioRxiv : the preprint server for biology
IL-13 and IL-17A Activate β1 Integrin through an NF-kB/Rho kinase/PIP5K1γ pathway to Enhance Force Transmission in Airway Smooth Muscle.
bioRxiv : the preprint server for biology
De novo design of drug-binding proteins with predictable binding energy and specificity.
Science (New York, N.Y.)
De novo-designed transmembrane proteins bind and regulate a cytokine receptor.
Nature chemical biology
An enhanced broad-spectrum peptide inhibits Omicron variants in vivo.
Cell reports. Medicine
Docking for Molecules That Bind in a Symmetric Stack with SymDOCK.
Journal of chemical information and modeling
De novo design of drug-binding proteins with predictable binding energy and specificity.
bioRxiv : the preprint server for biology
De novo Design of Peptides that Bind Specific Conformers of α-Synuclein.
bioRxiv : the preprint server for biology
Docking for molecules that bind in a symmetric stack with SymDOCK.
bioRxiv : the preprint server for biology
Hexamethylene amiloride binds the SARS-CoV-2 envelope protein at the protein-lipid interface.
Protein science : a publication of the Protein Society
Patterning and folding of intestinal villi by active mesenchymal dewetting.
bioRxiv : the preprint server for biology
Transient water wires mediate selective proton transport in designed channel proteins.
Nature chemistry
Stacked binding of a PET ligand to Alzheimer's tau paired helical filaments.
Nature communications
A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi.
Nature communications
EMBER multidimensional spectral microscopy enables quantitative determination of disease- and cell-specific amyloid strains.
Proceedings of the National Academy of Sciences of the United States of America
Designed Transmembrane Proteins Inhibit the Erythropoietin Receptor in a Custom Binding Topology.
bioRxiv : the preprint server for biology
EMBER multi-dimensional spectral microscopy enables quantitative determination of disease- and cell-specific amyloid strains.
bioRxiv : the preprint server for biology
Aβ and Tau Prions Causing Alzheimer's Disease.
Methods in molecular biology (Clifton, N.J.)
Solution of the protein structure prediction problem at last: crucial innovations and next frontiers.
Faculty reviews
Quaternary structure independent folding of voltage-gated ion channel pore domain subunits.
Nature structural & molecular biology
Covalent labeling of a chromatin reader domain using proximity-reactive cyclic peptides.
Chemical science
The CD3ζ adaptor structure determines functional differences between human and mouse CD16 Fc receptor signaling.
The Journal of experimental medicine
Brilacidin, a COVID-19 drug candidate, demonstrates broad-spectrum antiviral activity against human coronaviruses OC43, 229E, and NL63 through targeting both the virus and the host cell.
Journal of medical virology
Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ.
Proceedings of the National Academy of Sciences of the United States of America
Multiscale Simulation of an Influenza A M2 Channel Mutant Reveals Key Features of Its Markedly Different Proton Transport Behavior.
Journal of the American Chemical Society
Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer's disease pathology in Down syndrome.
Acta neuropathologica communications
Behaviour and interactions of proteins and peptides with and within membranes; from simple models to cellular membranes: general discussion.
Faraday discussions
Spiers Memorial Lecture: Analysis and de novo design of membrane-interactive peptides.
Faraday discussions
Theoretical and experimental comparisons of simple peptide-membrane systems; towards defining the reaction space: general discussion.
Faraday discussions
Theoretical and experimental studies of complex peptide-membrane systems: general discussion.
Faraday discussions
Allosteric mechanism of signal transduction in the two-component system histidine kinase PhoQ.
eLife
De novo metalloprotein design.
Nature reviews. Chemistry
Rimantadine Binds to and Inhibits the Influenza A M2 Proton Channel without Enantiomeric Specificity.
Biochemistry
Elucidation of the molecular interactions that enable stable assembly and structural diversity in multicomponent immune receptors.
Proceedings of the National Academy of Sciences of the United States of America
Integrin α2β1 regulates collagen I tethering to modulate hyperresponsiveness in reactive airway disease models.
The Journal of clinical investigation
Inclusion of the C-Terminal Domain in the β-Sheet Core of Heparin-Fibrillized Three-Repeat Tau Protein Revealed by Solid-State Nuclear Magnetic Resonance Spectroscopy.
Journal of the American Chemical Society
Constructing ion channels from water-soluble α-helical barrels.
Nature chemistry
Protein design-scapes generated by microfluidic DNA assembly elucidate domain coupling in the bacterial histidine kinase CpxA.
Proceedings of the National Academy of Sciences of the United States of America
Acyl Transfer Catalytic Activity in De Novo Designed Protein with N-Terminus of α-Helix As Oxyanion-Binding Site.
Journal of the American Chemical Society
De Novo Design, Solution Characterization, and Crystallographic Structure of an Abiological Mn-Porphyrin-Binding Protein Capable of Stabilizing a Mn(V) Species.
Journal of the American Chemical Society
Allosteric cooperation in a de novo-designed two-domain protein.
Proceedings of the National Academy of Sciences of the United States of America
Platform to Discover Protease-Activated Antibiotics and Application to Siderophore-Antibiotic Conjugates.
Journal of the American Chemical Society
Dual antagonists of α5β1/αvβ1 integrin for airway hyperresponsiveness.
Bioorganic & medicinal chemistry letters
Influenza A M2 Inhibitor Binding Understood through Mechanisms of Excess Proton Stabilization and Channel Dynamics.
Journal of the American Chemical Society
Prion biology: implications for Alzheimer's disease therapeutics.
The Lancet. Neurology
A defined structural unit enables de novo design of small-molecule-binding proteins.
Science (New York, N.Y.)
Robust Sequence Determinants of α-Synuclein Toxicity in Yeast Implicate Membrane Binding.
ACS chemical biology
Deep mutational scanning reveals the structural basis for α-synuclein activity.
Nature chemical biology
De novo protein design, a retrospective.
Quarterly reviews of biophysics
A disease-associated mutation in fibrillin-1 differentially regulates integrin-mediated cell adhesion.
The Journal of biological chemistry
In vitro 0N4R tau fibrils contain a monomorphic β-sheet core enclosed by dynamically heterogeneous fuzzy coat segments.
Proceedings of the National Academy of Sciences of the United States of America
Modulating Integrin αIIbβ3 Activity through Mutagenesis of Allosterically Regulated Intersubunit Contacts.
Biochemistry
Proton-Induced Conformational and Hydration Dynamics in the Influenza A M2 Channel.
Journal of the American Chemical Society
X-ray Crystal Structure of the Influenza A M2 Proton Channel S31N Mutant in Two Conformational States: An Open and Shut Case.
Journal of the American Chemical Society
Unique transmembrane domain interactions differentially modulate integrin αvβ3 and αIIbβ3 function.
Proceedings of the National Academy of Sciences of the United States of America
Genetically Introducing Biochemically Reactive Amino Acids Dehydroalanine and Dehydrobutyrine in Proteins.
Journal of the American Chemical Society
Aβ and tau prion-like activities decline with longevity in the Alzheimer's disease human brain.
Science translational medicine
Synthesis and application of the blue fluorescent amino acid l-4-cyanotryptophan to assess peptide-membrane interactions.
Chemical communications (Cambridge, England)
Glutamine Side Chain 13C═18O as a Nonperturbative IR Probe of Amyloid Fibril Hydration and Assembly.
Journal of the American Chemical Society
De Novo Design of Four-Helix Bundle Metalloproteins: One Scaffold, Diverse Reactivities.
Accounts of chemical research
Packing of apolar side chains enables accurate design of highly stable membrane proteins.
Science (New York, N.Y.)
SNAC-tag for sequence-specific chemical protein cleavage.
Nature methods
Exposing the Nucleation Site in α-Helix Folding: A Joint Experimental and Simulation Study.
The journal of physical chemistry. B
4-Cyanoindole-2'-deoxyribonucleoside as a Dual Fluorescence and Infrared Probe of DNA Structure and Dynamics.
Molecules (Basel, Switzerland)
Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations.
Cancer cell
Proximity-enhanced SuFEx chemical cross-linker for specific and multitargeting cross-linking mass spectrometry.
Proceedings of the National Academy of Sciences of the United States of America
Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters.
Journal of the American Chemical Society
Spectroscopic and metal binding properties of a de novo metalloprotein binding a tetrazinc cluster.
Biopolymers
Building and Breaking Bonds via a Compact S-Propargyl-Cysteine to Chemically Control Enzymes and Modify Proteins.
Angewandte Chemie (International ed. in English)
Designed peptides that assemble into cross-α amyloid-like structures.
Nature chemical biology
Structure and Function of the Transmembrane Domain of NsaS, an Antibiotic Sensing Histidine Kinase in Staphylococcus aureus.
Journal of the American Chemical Society
De novo designed transmembrane peptides activating the α5β1 integrin.
Protein engineering, design & selection : PEDS
Design of a Short Thermally Stable α-Helix Embedded in a Macrocycle.
Chembiochem : a European journal of chemical biology
De Novo Design of Tetranuclear Transition Metal Clusters Stabilized by Hydrogen-Bonded Networks in Helical Bundles.
Journal of the American Chemical Society
Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America
Spontaneous and specific chemical cross-linking in live cells to capture and identify protein interactions.
Nature communications
Self-assembling dipeptide antibacterial nanostructures with membrane disrupting activity.
Nature communications
De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures.
Proceedings of the National Academy of Sciences of the United States of America
XFEL structures of the influenza M2 proton channel: Room temperature water networks and insights into proton conduction.
Proceedings of the National Academy of Sciences of the United States of America
De novo design of a hyperstable non-natural protein-ligand complex with sub-Å accuracy.
Nature chemistry
Design of self-assembling transmembrane helical bundles to elucidate principles required for membrane protein folding and ion transport.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Zinc-binding structure of a catalytic amyloid from solid-state NMR.
Proceedings of the National Academy of Sciences of the United States of America
Blue fluorescent amino acid for biological spectroscopy and microscopy.
Proceedings of the National Academy of Sciences of the United States of America
Water Distribution, Dynamics, and Interactions with Alzheimer's β-Amyloid Fibrils Investigated by Solid-State NMR.
Journal of the American Chemical Society
Activation pH and Gating Dynamics of Influenza A M2 Proton Channel Revealed by Single-Molecule Spectroscopy.
Angewandte Chemie (International ed. in English)
A 31-residue peptide induces aggregation of tau's microtubule-binding region in cells.
Nature chemistry
Stapled Voltage-Gated Calcium Channel (CaV) α-Interaction Domain (AID) Peptides Act As Selective Protein-Protein Interaction Inhibitors of CaV Function.
ACS chemical neuroscience
The accommodation index measures the perturbation associated with insertions and deletions in coiled-coils: Application to understand signaling in histidine kinases.
Protein science : a publication of the Protein Society
Pharmacologic Blockade of αvβ1 Integrin Ameliorates Renal Failure and Fibrosis In Vivo.
Journal of the American Society of Nephrology : JASN
An M2-V27A channel blocker demonstrates potent in vitro and in vivo antiviral activities against amantadine-sensitive and -resistant influenza A viruses.
Antiviral research
Targeting integrin α5β1 ameliorates severe airway hyperresponsiveness in experimental asthma.
The Journal of clinical investigation
Acid activation mechanism of the influenza A M2 proton channel.
Proceedings of the National Academy of Sciences of the United States of America
Infrared and fluorescence assessment of the hydration status of the tryptophan gate in the influenza A M2 proton channel.
Physical chemistry chemical physics : PCCP
Exploring N-Arylsulfonyl-l-proline Scaffold as a Platform for Potent and Selective αvβ1 Integrin Inhibitors.
ACS medicinal chemistry letters
Structural Polymorphism of Alzheimer's β-Amyloid Fibrils as Controlled by an E22 Switch: A Solid-State NMR Study.
Journal of the American Chemical Society
Graphene Symmetry Amplified by Designed Peptide Self-Assembly.
Biophysical journal
Crystal structure of the drug-resistant S31N influenza M2 proton channel.
Protein science : a publication of the Protein Society
Photoactivatable protein labeling by singlet oxygen mediated reactions.
Bioorganic & medicinal chemistry letters
Protein-directed self-assembly of a fullerene crystal.
Nature communications
Directly Activating the Integrin αIIbβ3 Initiates Outside-In Signaling by Causing αIIbβ3 Clustering.
The Journal of biological chemistry
Designed metalloprotein stabilizes a semiquinone radical.
Nature chemistry
Discovery of Highly Potent Inhibitors Targeting the Predominant Drug-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel.
Journal of medicinal chemistry
High-density grids for efficient data collection from multiple crystals.
Acta crystallographica. Section D, Structural biology
High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction.
Proceedings of the National Academy of Sciences of the United States of America
Molecular-Level Insight into the Differential Oxidase and Oxygenase Reactivities of de Novo Due Ferri Proteins.
Journal of the American Chemical Society
Artificial Diiron Enzymes with a De Novo Designed Four-Helix Bundle Structure.
European journal of inorganic chemistry
The αvβ1 integrin plays a critical in vivo role in tissue fibrosis.
Science translational medicine
Signal transduction in histidine kinases: insights from new structures.
Structure (London, England : 1993)
The Tyrosine Kinase c-Src Specifically Binds to the Active Integrin αIIbβ3 to Initiate Outside-in Signaling in Platelets.
The Journal of biological chemistry
The membrane- and soluble-protein helix-helix interactome: similar geometry via different interactions.
Structure (London, England : 1993)
Computational design and experimental characterization of peptides intended for pH-dependent membrane insertion and pore formation.
ACS chemical biology
C-terminal juxtamembrane region of full-length M2 protein forms a membrane surface associated amphipathic helix.
Protein science : a publication of the Protein Society
De novo design of a transmembrane Zn²⁺-transporting four-helix bundle.
Science (New York, N.Y.)
Flipping in the pore: discovery of dual inhibitors that bind in different orientations to the wild-type versus the amantadine-resistant S31N mutant of the influenza A virus M2 proton channel.
Journal of the American Chemical Society
Specific aromatic foldamers potently inhibit spontaneous and seeded Aβ42 and Aβ43 fibril assembly.
The Biochemical journal
Hydrogen-bonded water molecules in the M2 channel of the influenza A virus guide the binding preferences of ammonium-based inhibitors.
The journal of physical chemistry. B
Proton release from the histidine-tetrad in the M2 channel of the influenza A virus.
The journal of physical chemistry. B
A real-time all-atom structural search engine for proteins.
PLoS computational biology
Cys-scanning disulfide crosslinking and bayesian modeling probe the transmembrane signaling mechanism of the histidine kinase, PhoQ.
Structure (London, England : 1993)
Catalytic efficiency of designed catalytic proteins.
Current opinion in structural biology
Distinct synthetic Aβ prion strains producing different amyloid deposits in bigenic mice.
Proceedings of the National Academy of Sciences of the United States of America
Easily accessible polycyclic amines that inhibit the wild-type and amantadine-resistant mutants of the M2 channel of influenza A virus.
Journal of medicinal chemistry
2D IR spectroscopy reveals the role of water in the binding of channel-blocking drugs to the influenza M2 channel.
The Journal of chemical physics
Comparative mechanistic studies of brilacidin, daptomycin, and the antimicrobial peptide LL16.
Antimicrobial agents and chemotherapy
Crystal structure of an amphiphilic foldamer reveals a 48-mer assembly comprising a hollow truncated octahedron.
Nature communications
Short peptides self-assemble to produce catalytic amyloids.
Nature chemistry
De novo design of self-assembling foldamers that inhibit heparin-protein interactions.
ACS chemical biology
Structural Stability and Binding Strength of a Designed Peptide-Carbon Nanotube Hybrid.
The journal of physical chemistry. C, Nanomaterials and interfaces
Mechanistic insights from functional characterization of an unnatural His37 mutant of the influenza A/M2 protein.
Biochimica et biophysica acta
Slow folding-unfolding kinetics of an octameric β-peptide bundle.
ACS chemical biology
Assessment of local friction in protein folding dynamics using a helix cross-linker.
The journal of physical chemistry. B
3-Azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant.
Journal of medicinal chemistry
Template-constrained cyclic sulfopeptide HIV-1 entry inhibitors.
Organic & biomolecular chemistry
Asp44 stabilizes the Trp41 gate of the M2 proton channel of influenza A virus.
Structure (London, England : 1993)
Influenza virus A M2 protein generates negative Gaussian membrane curvature necessary for budding and scission.
Journal of the American Chemical Society
Computational de novo design and characterization of a protein that selectively binds a highly hyperpolarizable abiological chromophore.
Journal of the American Chemical Society
Nanosecond Dynamics of InfluenzaA/M2TM and an Amantadine Resistant Mutant Probed by Time-Dependent Red Shifts of a Native Tryptophan.
Chemical physics
Exploring Histidine Conformations in the M2 Channel Lumen of the Influenza A Virus at Neutral pH via Molecular Simulations.
The journal of physical chemistry letters
Nature-inspired design of motif-specific antibody scaffolds.
Nature biotechnology
Drug-induced conformational and dynamical changes of the S31N mutant of the influenza M2 proton channel investigated by solid-state NMR.
Journal of the American Chemical Society
Discovery of novel dual inhibitors of the wild-type and the most prevalent drug-resistant mutant, S31N, of the M2 proton channel from influenza A virus.
Journal of medicinal chemistry
Assembly of the transmembrane domain of E. coli PhoQ histidine kinase: implications for signal transduction from molecular simulations.
PLoS computational biology
Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus.
Proceedings of the National Academy of Sciences of the United States of America
Agrobacterium tumefaciens recognizes its host environment using ChvE to bind diverse plant sugars as virulence signals.
Proceedings of the National Academy of Sciences of the United States of America
Platelet factor 4 activity against P. falciparum and its translation to nonpeptidic mimics as antimalarials.
Cell host & microbe
Detection of drug-induced conformational change of a transmembrane protein in lipid bilayers using site-directed spin labeling.
Protein science : a publication of the Protein Society
Development of α-helical calpain probes by mimicking a natural protein-protein interaction.
Journal of the American Chemical Society
Structural basis for proton conduction and inhibition by the influenza M2 protein.
Protein science : a publication of the Protein Society
Knowledge-based potential for positioning membrane-associated structures and assessing residue-specific energetic contributions.
Structure (London, England : 1993)
Using thioamides to site-specifically interrogate the dynamics of hydrogen bond formation in β-sheet folding.
Journal of the American Chemical Society
Computational design of a protein crystal.
Proceedings of the National Academy of Sciences of the United States of America
Inhibition of integrin α2β1 ameliorates glomerular injury.
Journal of the American Society of Nephrology : JASN
Neutralizing epitopes in the membrane-proximal external region of HIV-1 gp41 are influenced by the transmembrane domain and the plasma membrane.
Journal of virology
Affinity of talin-1 for the β3-integrin cytosolic domain is modulated by its phospholipid bilayer environment.
Proceedings of the National Academy of Sciences of the United States of America
Capture and imaging of a prehairpin fusion intermediate of the paramyxovirus PIV5.
Proceedings of the National Academy of Sciences of the United States of America
A photon-free approach to transmembrane protein structure determination.
Journal of molecular biology
Antibacterial mechanism of action of arylamide foldamers.
Antimicrobial agents and chemotherapy
Exploring organosilane amines as potent inhibitors and structural probes of influenza a virus M2 proton channel.
Journal of the American Chemical Society
Computational design of a β-peptide that targets transmembrane helices.
Journal of the American Chemical Society
Molecular dynamics simulation directed rational design of inhibitors targeting drug-resistant mutants of influenza A virus M2.
Journal of the American Chemical Society
Environment- and sequence-dependence of helical type in membrane-spanning peptides composed of β3-amino acids.
Organic letters
Residue-specific vibrational echoes yield 3D structures of a transmembrane helix dimer.
Science (New York, N.Y.)
Computational design of virus-like protein assemblies on carbon nanotube surfaces.
Science (New York, N.Y.)
Exploring the Requirements for the Hydrophobic Scaffold and Polar Amine in inhibitors of M2 from Influenza A Virus.
ACS medicinal chemistry letters
Design of a switchable eliminase.
Proceedings of the National Academy of Sciences of the United States of America
Exploring the size limit of templates for inhibitors of the M2 ion channel of influenza A virus.
Journal of medicinal chemistry
Tidal surge in the M2 proton channel, sensed by 2D IR spectroscopy.
Proceedings of the National Academy of Sciences of the United States of America
Photoinduced electron transfer and fluorophore motion as a probe of the conformational dynamics of membrane proteins: application to the influenza a M2 proton channel.
Langmuir : the ACS journal of surfaces and colloids
Specific binding of adamantane drugs and direction of their polar amines in the pore of the influenza M2 transmembrane domain in lipid bilayers and dodecylphosphocholine micelles determined by NMR spectroscopy.
Journal of the American Chemical Society
Design of a three-helix bundle capable of binding heavy metals in a triscysteine environment.
Angewandte Chemie (International ed. in English)
Transmembrane orientation and possible role of the fusogenic peptide from parainfluenza virus 5 (PIV5) in promoting fusion.
Proceedings of the National Academy of Sciences of the United States of America
Structural and dynamic mechanisms for the function and inhibition of the M2 proton channel from influenza A virus.
Current opinion in structural biology
Transmembrane communication: general principles and lessons from the structure and function of the M2 proton channel, K⁺ channels, and integrin receptors.
Annual review of biochemistry
NMR analysis of the alphaIIb beta3 cytoplasmic interaction suggests a mechanism for integrin regulation.
Proceedings of the National Academy of Sciences of the United States of America
Lipid membranes supported on optically transparent nanosilicas: synthesis and application in characterization of protein-membrane interactions.
Journal of colloid and interface science
Selective incorporation of nitrile-based infrared probes into proteins via cysteine alkylation.
Biochemistry
De novo design and molecular assembly of a transmembrane diporphyrin-binding protein complex.
Journal of the American Chemical Society
A pH-dependent conformational ensemble mediates proton transport through the influenza A/M2 protein.
Biochemistry
Role of the conformational rigidity in the design of biomimetic antimicrobial compounds.
Angewandte Chemie (International ed. in English)
Structural biology. The flu's proton escort.
Science (New York, N.Y.)
Multiple Proton Confinement in the M2 Channel from the Influenza A Virus.
The journal of physical chemistry. C, Nanomaterials and interfaces
Computational design of a self-assembling β-peptide oligomer.
Organic letters
Identification of interacting hot spots in the beta3 integrin stalk using comprehensive interface design.
The Journal of biological chemistry
Probing designability via a generalized model of helical bundle geometry.
Journal of molecular biology
The effects of pK(a) tuning on the thermodynamics and kinetics of folding: design of a solvent-shielded carboxylate pair at the a-position of a coiled-coil.
Biophysical journal
Proton and cation transport activity of the M2 proton channel from influenza A virus.
Proceedings of the National Academy of Sciences of the United States of America
Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus.
Proceedings of the National Academy of Sciences of the United States of America
Orientation, dynamics, and lipid interaction of an antimicrobial arylamide investigated by 19F and 31P solid-state NMR spectroscopy.
Journal of the American Chemical Society
Specificity for homooligomer versus heterooligomer formation in integrin transmembrane helices.
Journal of molecular biology
Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay.
Antimicrobial agents and chemotherapy
Development of a rotamer library for use in beta-peptide foldamer computational design.
Journal of the American Chemical Society
Infrared signature and folding dynamics of a helical beta-peptide.
Journal of the American Chemical Society
Transmembrane polar interactions are required for signaling in the Escherichia coli sensor kinase PhoQ.
Proceedings of the National Academy of Sciences of the United States of America
Computational design and elaboration of a de novo heterotetrameric alpha-helical protein that selectively binds an emissive abiological (porphinato)zinc chromophore.
Journal of the American Chemical Society
Functional studies and modeling of pore-lining residue mutants of the influenza a virus M2 ion channel.
Biochemistry
De novo design of antimicrobial polymers, foldamers, and small molecules: from discovery to practical applications.
Accounts of chemical research
Consensus motif for integrin transmembrane helix association.
Proceedings of the National Academy of Sciences of the United States of America
Solid-supported membrane technology for the investigation of the influenza A virus M2 channel activity.
Pflugers Archiv : European journal of physiology
An artificial di-iron oxo-protein with phenol oxidase activity.
Nature chemical biology
A key role for the integrin alpha2beta1 in experimental and developmental angiogenesis.
The American journal of pathology
Experimental and computational evaluation of forces directing the association of transmembrane helices.
Journal of the American Chemical Society
Engineering and design: editorial overview.
Current opinion in structural biology
Molecular basis of ChvE function in sugar binding, sugar utilization, and virulence in Agrobacterium tumefaciens.
Journal of bacteriology
Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel.
Proceedings of the National Academy of Sciences of the United States of America
Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from influenza A virus.
Journal of the American Chemical Society
Engineered single- and multi-cell chemotaxis pathways in E. coli.
Molecular systems biology
Multiple approaches converge on the structure of the integrin alphaIIb/beta3 transmembrane heterodimer.
Journal of molecular biology
De novo design and in vivo activity of conformationally restrained antimicrobial arylamide foldamers.
Proceedings of the National Academy of Sciences of the United States of America
Using two fluorescent probes to dissect the binding, insertion, and dimerization kinetics of a model membrane peptide.
Journal of the American Chemical Society
Metal-binding dependent disruption of membranes by designed helices.
Journal of the American Chemical Society
A one-dimensional free energy surface does not account for two-probe folding kinetics of protein alpha(3)D.
The Journal of chemical physics
Molecular dynamics calculations suggest a conduction mechanism for the M2 proton channel from influenza A virus.
Proceedings of the National Academy of Sciences of the United States of America
Small-molecule inhibitors of integrin alpha2beta1 that prevent pathological thrombus formation via an allosteric mechanism.
Proceedings of the National Academy of Sciences of the United States of America
The role of hydrophobicity in the antimicrobial and hemolytic activities of polymethacrylate derivatives.
Chemistry (Weinheim an der Bergstrasse, Germany)
Functional analysis of the transmembrane domain in paramyxovirus F protein-mediated membrane fusion.
Journal of molecular biology
De novo designed synthetic mimics of antimicrobial peptides.
Current opinion in biotechnology
Investigation of an unnatural amino acid for use as a resonance Raman probe: Detection limits, solvent and temperature dependence of the νC≡N band of 4-cyanophenylalanine.
Journal of Raman spectroscopy : JRS
Using alpha-helical coiled-coils to design nanostructured metalloporphyrin arrays.
Journal of the American Chemical Society
Computationally designed peptide inhibitors of protein-protein interactions in membranes.
Biochemistry
New design of helix bundle peptide-polymer conjugates.
Biomacromolecules
Modest membrane hydrogen bonds deliver rich results.
Nature chemical biology
Protein-protein interactions in the membrane: sequence, structural, and biological motifs.
Structure (London, England : 1993)
The interplay of functional tuning, drug resistance, and thermodynamic stability in the evolution of the M2 proton channel from the influenza A virus.
Structure (London, England : 1993)
Oxygen reactivity of the biferrous site in the de novo designed four helix bundle peptide DFsc: nature of the "intermediate" and reaction mechanism.
Journal of the American Chemical Society
Determination of the physiological dimer interface of the PhoQ sensor domain.
Journal of molecular biology
Identification of the pore-lining residues of the BM2 ion channel protein of influenza B virus.
The Journal of biological chemistry
Solution NMR structure of a designed metalloprotein and complementary molecular dynamics refinement.
Structure (London, England : 1993)
Role of helix nucleation in the kinetics of binding of mastoparan X to phospholipid bilayers.
Biochemistry
Small molecule inhibitors of integrin alpha2beta1.
Journal of medicinal chemistry
Enthalpic and entropic stages in alpha-helical peptide unfolding, from laser T-jump/UV Raman spectroscopy.
Journal of the American Chemical Society
Site-specific hydration status of an amphipathic peptide in AOT reverse micelles.
Langmuir : the ACS journal of surfaces and colloids
De novo design of a single-chain diphenylporphyrin metalloprotein.
Journal of the American Chemical Society
Energy and electron transfer in enhanced two-photon-absorbing systems with triplet cores.
The journal of physical chemistry. A
Foldamers as versatile frameworks for the design and evolution of function.
Nature chemical biology
Determining the orientation of uniaxially rotating membrane proteins using unoriented samples: a 2H, 13C, AND 15N solid-state NMR investigation of the dynamics and orientation of a transmembrane helical bundle.
Journal of the American Chemical Society
Adhesion of MC3T3-E1 cells to RGD peptides of different flanking residues: detachment strength and correlation with long-term cellular function.
Journal of biomedical materials research. Part A
Computational design of peptides that target transmembrane helices.
Science (New York, N.Y.)
Interactions of ADP-stimulated human platelets with PEGylated polystyrene substrates prepared by surface amidation.
Colloids and surfaces. B, Biointerfaces
The leech product saratin is a potent inhibitor of platelet integrin alpha2beta1 and von Willebrand factor binding to collagen.
The FEBS journal
Amide vibrations are delocalized across the hydrophobic interface of a transmembrane helix dimer.
Proceedings of the National Academy of Sciences of the United States of America
Modeling the charge distribution at metal sites in proteins for molecular dynamics simulations.
Journal of structural biology
Activation of platelet alphaIIbbeta3 by an exogenous peptide corresponding to the transmembrane domain of alphaIIb.
The Journal of biological chemistry
E(z), a depth-dependent potential for assessing the energies of insertion of amino acid side-chains into membranes: derivation and applications to determining the orientation of transmembrane and interfacial helices.
Journal of molecular biology
Helix-packing motifs in membrane proteins.
Proceedings of the National Academy of Sciences of the United States of America
The structure of a designed diiron(III) protein: implications for cofactor stabilization and catalysis.
Angewandte Chemie (International ed. in English)
Arylamide derivatives as allosteric inhibitors of the integrin alpha2beta1/type I collagen interaction.
Bioorganic & medicinal chemistry letters
Probing Membrane Insertion Activity of Antimicrobial Polymers via Coarse-grain Molecular Dynamics.
Journal of chemical theory and computation
Characterization of a membrane protein folding motif, the Ser zipper, using designed peptides.
Journal of molecular biology
Polar networks control oligomeric assembly in membranes.
Journal of the American Chemical Society
Controlling the shape and flexibility of arylamides: a combined ab initio, ab initio molecular dynamics, and classical molecular dynamics study.
The journal of physical chemistry. B
Characterization of nonbiological antimicrobial polymers in aqueous solution and at water-lipid interfaces from all-atom molecular dynamics.
Journal of the American Chemical Society
Computational design of heterochiral peptides against a helical target.
Journal of the American Chemical Society
Response of a designed metalloprotein to changes in metal ion coordination, exogenous ligands, and active site volume determined by X-ray crystallography.
Journal of the American Chemical Society
Spectroscopic and computational studies of the de novo designed protein DF2t: correlation to the biferrous active site of ribonucleotide reductase and factors that affect O2 reactivity.
Journal of the American Chemical Society
The design and evaluation of heparin-binding foldamers.
Angewandte Chemie (International ed. in English)
An atomic environment potential for use in protein structure prediction.
Journal of molecular biology
Artificial di-iron proteins: solution characterization of four helix bundles containing two distinct types of inter-helical loops.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry
T-jump infrared study of the folding mechanism of coiled-coil GCN4-p1.
Biophysical journal
Structural organization and interactions of transmembrane domains in tetraspanin proteins.
BMC structural biology
Empirical lipid propensities of amino acid residues in multispan alpha helical membrane proteins.
Proteins
X-ray structure of a water-soluble analog of the membrane protein phospholamban: sequence determinants defining the topology of tetrameric and pentameric coiled coils.
Journal of molecular biology
De novo design of a redox-active minimal rubredoxin mimic.
Journal of the American Chemical Society
Synergistic interactions between aqueous and membrane domains of a designed protein determine its fold and stability.
Journal of molecular biology
Amphiphilic polymethacrylate derivatives as antimicrobial agents.
Journal of the American Chemical Society
De novo design of a pentameric coiled-coil: decoding the motif for tetramer versus pentamer formation in water-soluble phospholamban.
The journal of peptide research : official journal of the American Peptide Society
Rotational orientation of monomers within a designed homo-oligomer transmembrane helical bundle.
Protein science : a publication of the Protein Society
The conformation of the pore region of the M2 proton channel depends on lipid bilayer environment.
Protein science : a publication of the Protein Society
Computational de novo design and characterization of a four-helix bundle protein that selectively binds a nonbiological cofactor.
Journal of the American Chemical Society
A push-pull mechanism for regulating integrin function.
Proceedings of the National Academy of Sciences of the United States of America
Sequence determinants of a transmembrane proton channel: an inverse relationship between stability and function.
Journal of molecular biology
Analysis and design of turns in alpha-helical hairpins.
Journal of molecular biology
Volatile anesthetic modulation of oligomerization equilibria in a hexameric model peptide.
FEBS letters
Simulated evolution of emergent chiral structures in polyalanine.
Journal of the American Chemical Society
Controlling the conformation of arylamides: computational studies of intramolecular hydrogen bonds between amides and ethers or thioethers.
Chemistry (Weinheim an der Bergstrasse, Germany)
Length Dependent Helix-Coil Transition Kinetics of Nine Alanine-Based Peptides.
The journal of physical chemistry. B
Association of a model transmembrane peptide containing gly in a heptad sequence motif.
Biophysical journal
De novo design of catalytic proteins.
Proceedings of the National Academy of Sciences of the United States of America
Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs.
Current opinion in structural biology
De novo design of a D2-symmetrical protein that reproduces the diheme four-helix bundle in cytochrome bc1.
Journal of the American Chemical Society
Structural basis for integrin alphaIIbbeta3 clustering.
Biochemical Society transactions
A new method for determining the local environment and orientation of individual side chains of membrane-binding peptides.
Journal of the American Chemical Society
Amino acid propensities are position-dependent throughout the length of alpha-helices.
Journal of molecular biology
Dimerization of the transmembrane domain of Integrin alphaIIb subunit in cell membranes.
The Journal of biological chemistry
Nontoxic membrane-active antimicrobial arylamide oligomers.
Angewandte Chemie (International ed. in English)
Computational design of water-soluble analogues of the potassium channel KcsA.
Proceedings of the National Academy of Sciences of the United States of America
Oligomerization of fusogenic peptides promotes membrane fusion by enhancing membrane destabilization.
Biophysical journal
Computational design and characterization of a monomeric helical dinuclear metalloprotein.
Journal of molecular biology
Ultrafast folding of alpha3D: a de novo designed three-helix bundle protein.
Proceedings of the National Academy of Sciences of the United States of America
Use of thiol-disulfide equilibria to measure the energetics of assembly of transmembrane helices in phospholipid bilayers.
Proceedings of the National Academy of Sciences of the United States of America
De novo design of a molecular switch: phosphorylation-dependent association of designed peptides.
Journal of molecular biology
Determination of membrane protein stability via thermodynamic coupling of folding to thiol-disulfide interchange.
Protein science : a publication of the Protein Society
Position-dependence of stabilizing polar interactions of asparagine in transmembrane helical bundles.
Biochemistry
Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations.
Science (New York, N.Y.)
How do helix-helix interactions help determine the folds of membrane proteins? Perspectives from the study of homo-oligomeric helical bundles.
Protein science : a publication of the Protein Society
Preorganization of molecular binding sites in designed diiron proteins.
Proceedings of the National Academy of Sciences of the United States of America
The hydration of amides in helices; a comprehensive picture from molecular dynamics, IR, and NMR.
Protein science : a publication of the Protein Society
Computational design of a water-soluble analog of phospholamban.
Protein science : a publication of the Protein Society
Sliding helix and change of coordination geometry in a model di-MnII protein.
Angewandte Chemie (International ed. in English)
Probing the configurational space of a metalloprotein core: an ab initio molecular dynamics study of Duo Ferro 1 binuclear Zn cofactor.
Journal of the American Chemical Society
Using nitrile-derivatized amino acids as infrared probes of local environment.
Journal of the American Chemical Society
Use of phage display to probe the evolution of binding specificity and affinity in integrins.
Protein engineering
Light-induced helix formation.
Journal of the American Chemical Society
Long-range interactions stabilize the fold of a non-natural oligomer.
Journal of the American Chemical Society
Cooperativity and specificity of association of a designed transmembrane peptide.
Biophysical journal
Computational de novo design, and characterization of an A(2)B(2) diiron protein.
Journal of molecular biology
Sequence determinants of the energetics of folding of a transmembrane four-helix-bundle protein.
Proceedings of the National Academy of Sciences of the United States of America
A hierarchic approach to the design of hexameric helical barrels.
Journal of molecular biology
De novo design of biomimetic antimicrobial polymers.
Proceedings of the National Academy of Sciences of the United States of America
Noncovalent self-assembly of a heterotetrameric diiron protein.
Proceedings of the National Academy of Sciences of the United States of America
Helix formation via conformation diffusion search.
Proceedings of the National Academy of Sciences of the United States of America
Toward the de novo design of a catalytically active helix bundle: a substrate-accessible carboxylate-bridged dinuclear metal center.
Journal of the American Chemical Society
Template-constrained somatostatin analogues: a biphenyl linker induces a type-V' turn.
Journal of the American Chemical Society
Time-resolved infrared study of the helix-coil transition using (13)C-labeled helical peptides.
Journal of the American Chemical Society
Oligomerization of the integrin alphaIIbbeta3: roles of the transmembrane and cytoplasmic domains.
Proceedings of the National Academy of Sciences of the United States of America
Introduction: protein design.
Chemical reviews
beta-Peptides: from structure to function.
Chemical reviews
Temperature-dependent helix-coil transition of an alanine based peptide.
Journal of the American Chemical Society
D(n)-symmetrical tertiary templates for the design of tubular proteins.
Journal of molecular biology
Dynamics of a de novo designed three-helix bundle protein studied by 15N, 13C, and 2H NMR relaxation methods.
Biochemistry
De novo design, synthesis, and characterization of antimicrobial beta-peptides.
Journal of the American Chemical Society
De novo design, synthesis and characterization of membrane-active peptides.
Biochemical Society transactions
De novo design of a monomeric helical beta-peptide stabilized by electrostatic interactions.
Journal of the American Chemical Society
Proton and metal ion-dependent assembly of a model diiron protein.
Protein science : a publication of the Protein Society
Fluorinated Coiled-Coil Proteins Prepared In Vivo Display Enhanced Thermal and Chemical Stability This work was supported by a grant from the U.S. Army Research Office. Y. Tang is supported by a Whitaker Graduate Research Fellowship. We thank Dr. Gary Hat
Angewandte Chemie (International ed. in English)
Fluorinated Coiled-Coil Proteins Prepared In Vivo Display Enhanced Thermal and Chemical Stability.
Angewandte Chemie (International ed. in English)
Design of three-dimensional domain-swapped dimers and fibrous oligomers.
Proceedings of the National Academy of Sciences of the United States of America
Polar side chains drive the association of model transmembrane peptides.
Proceedings of the National Academy of Sciences of the United States of America
Hydrophobic core malleability of a de novo designed three-helix bundle protein.
Journal of molecular biology
Evolution of binding affinity in a WW domain probed by phage display.
Protein science : a publication of the Protein Society
Dynamics and folding of single two-stranded coiled-coil peptides studied by fluorescent energy transfer confocal microscopy.
Proceedings of the National Academy of Sciences of the United States of America
pH-dependent tetramerization and amantadine binding of the transmembrane helix of M2 from the influenza A virus.
Biochemistry
De novo design of helical bundles as models for understanding protein folding and function.
Accounts of chemical research
Template-constrained cyclic peptide analogues of somatostatin: subtype-selective binding to somatostatin receptors and antiangiogenic activity.
Bioorganic & medicinal chemistry
The activation state of alphavbeta 3 regulates platelet and lymphocyte adhesion to intact and thrombin-cleaved osteopontin.
The Journal of biological chemistry
Retrostructural analysis of metalloproteins: application to the design of a minimal model for diiron proteins.
Proceedings of the National Academy of Sciences of the United States of America
A polar, solvent-exposed residue can be essential for native protein structure.
Structure (London, England : 1993)
Asparagine-mediated self-association of a model transmembrane helix.
Nature structural biology
The twists and turns of beta-peptides.
The journal of peptide research : official journal of the American Peptide Society
Tertiary templates for the design of diiron proteins.
Current opinion in structural biology
Centrosymmetric bilayers in the 0.75 A resolution structure of a designed alpha-helical peptide, D,L-Alpha-1.
Protein science : a publication of the Protein Society
Solution structure and dynamics of a de novo designed three-helix bundle protein.
Proceedings of the National Academy of Sciences of the United States of America
Rapid synthesis of RGD mimetics with isoxazoline scaffolds on solid phase: identification of alphavbeta3 antagonists lead compounds.
Bioorganic & medicinal chemistry letters
The two-dimensional IR nonlinear spectroscopy of a cyclic penta-peptide in relation to its three-dimensional structure.
Proceedings of the National Academy of Sciences of the United States of America
Cu(II) inhibition of the proton translocation machinery of the influenza A virus M2 protein.
The Journal of biological chemistry
Exploration of the structural features defining the conduction properties of a synthetic ion channel.
Biophysical journal
De novo design and structural characterization of proteins and metalloproteins.
Annual review of biochemistry
Synthesis and antiplatelet effects of an isoxazole series of glycoprotein IIb/IIIa antagonists.
Bioorganic & medicinal chemistry letters
From synthetic coiled coils to functional proteins: automated design of a receptor for the calmodulin-binding domain of calcineurin.
Journal of molecular biology
The role of protonation and metal chelation preferences in defining the properties of mercury-binding coiled coils.
Journal of molecular biology
From coiled coils to small globular proteins: design of a native-like three-helix bundle.
Protein science : a publication of the Protein Society
Design and synthesis of cyclic inhibitors of matrix metalloproteinases and TNF-alpha production.
Journal of medicinal chemistry
Macrocyclic amino carboxylates as selective MMP-8 inhibitors.
Journal of medicinal chemistry
A functionally defined model for the M2 proton channel of influenza A virus suggests a mechanism for its ion selectivity.
Proceedings of the National Academy of Sciences of the United States of America
Proteins from scratch.
Science (New York, N.Y.)
Modeling transmembrane helical oligomers.
Current opinion in structural biology
Design, synthesis, and in vitro activities of benzamide-core glycoprotein IIb/IIIa antagonists: 2,3-diaminopropionic acid derivatives as surrogates of aspartic acid.
Bioorganic & medicinal chemistry
Agonist-activated alphavbeta3 on platelets and lymphocytes binds to the matrix protein osteopontin.
The Journal of biological chemistry
The crystal structure of the designed trimeric coiled coil coil-VaLd: implications for engineering crystals and supramolecular assemblies.
Protein science : a publication of the Protein Society
Novel nonpeptide antiplatelet glycoprotein IIb/IIIa receptor antagonist, DMP754: receptor binding affinity and specificity.
Coronary artery disease
Expression of de novo designed alpha-helical bundles.
Acta chemica Scandinavica (Copenhagen, Denmark : 1989)
Protein minimization: downsizing through mutation.
Proceedings of the National Academy of Sciences of the United States of America
In vitro evolution of thermodynamically stable turns.
Nature structural biology
Oral antiplatelet, antithrombotic efficacy of DMP 728, a novel platelet GPIIb/IIIa antagonist.
Circulation
De novo design of heterotrimeric coiled coils.
Biopolymers
Protein design: a hierarchic approach.
Science (New York, N.Y.)
Native-like and structurally characterized designed alpha-helical bundles.
Current opinion in structural biology
Design of two-stranded and three-stranded coiled-coil peptides.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Disulfide crosslinks to probe the structure and flexibility of a designed four-helix bundle protein.
Protein science : a publication of the Protein Society
Design and synthesis of simplified energy-converting proteins.
Biochemical Society transactions
A helical-dipole model describes the single-channel current rectification of an uncharged peptide ion channel.
Proceedings of the National Academy of Sciences of the United States of America
Identification of recognition sequences of adhesion molecules using phage display technology.
Methods in enzymology
Multiple oligomeric states regulate the DNA binding of helix-loop-helix peptides.
Proceedings of the National Academy of Sciences of the United States of America
Metal ion-dependent modulation of the dynamics of a designed protein.
Science (New York, N.Y.)
Crystal structure of a synthetic triple-stranded alpha-helical bundle.
Science (New York, N.Y.)
Crystallization of proton channel peptides.
Protein science : a publication of the Protein Society
X-ray grade crystals of a designed alpha-helical coiled coil.
Protein science : a publication of the Protein Society
Molecular characterization of helix-loop-helix peptides.
Science (New York, N.Y.)
A thermodynamic scale for the helix-forming tendencies of the commonly occurring amino acids.
Science (New York, N.Y.)
Phospholipid interactions of synthetic peptides representing the N-terminus of HIV gp41.
Biochemistry
Design of DNA-binding peptides based on the leucine zipper motif.
Science (New York, N.Y.)
Crystal structure of alpha 1: implications for protein design.
Science (New York, N.Y.)
How calmodulin binds its targets: sequence independent recognition of amphiphilic alpha-helices.
Trends in biochemical sciences
Photolabeling of calmodulin with basic, amphiphilic alpha-helical peptides containing p-benzoylphenylalanine.
The Journal of biological chemistry
Emil Thomas Kaiser 1938-1988.
Journal of molecular recognition : JMR
Protein design, a minimalist approach.
Science (New York, N.Y.)
Contributions of chemistry: biotechnology and materials science.
Science (New York, N.Y.)
Characterization of a helical protein designed from first principles.
Science (New York, N.Y.)
Synthetic amphiphilic peptide models for protein ion channels.
Science (New York, N.Y.)
Design of peptides and proteins.
Advances in protein chemistry
Fluorescence properties of calmodulin-binding peptides reflect alpha-helical periodicity.
Science (New York, N.Y.)
Membrane binding and conformational properties of peptides representing the NH2 terminus of influenza HA-2.
The Journal of biological chemistry
Recognition and characterization of calmodulin-binding sequences in peptides and proteins.
Methods in enzymology
The design of a four-helix bundle protein.
Cold Spring Harbor symposia on quantitative biology
p-Benzoyl-L-phenylalanine, a new photoreactive amino acid. Photolabeling of calmodulin with a synthetic calmodulin-binding peptide.
The Journal of biological chemistry
Nonidentical induction of the guanylate binding protein and the 56K protein by type I and type II interferons.
Journal of interferon research
A predicted structure of calmodulin suggests an electrostatic basis for its function.
Proceedings of the National Academy of Sciences of the United States of America
In vivo function and membrane binding properties are correlated for Escherichia coli lamB signal peptides.
Science (New York, N.Y.)
The interaction of calmodulin with amphiphilic peptides.
The Journal of biological chemistry
The design, synthesis, and characterization of tight-binding inhibitors of calmodulin.
Journal of cellular biochemistry
Antibodies to synthetic peptides of human interferon-beta. Use in biosynthetic studies.
The Journal of biological chemistry
Antibodies to human c-myc oncogene product: evidence of an evolutionarily conserved protein induced during cell proliferation.
Science (New York, N.Y.)
Purification and properties of thiol beta-lactamase. A mutant of pBR322 beta-lactamase in which the active site serine has been replaced with cysteine.
The Journal of biological chemistry
Posttranslational modification of human T-cell growth factor.
Biochemical and biophysical research communications