Aartik Sarma, MD

Assistant Adjunct Professor
Medicine

I am an Assistant Professor of Medicine at the University of California, San Francisco and Affiliate Faculty in the UCSF/UC Berkeley Joint Program in Computational Precision Health.

My research is motivated by two key questions I frequently encounter in my clinical practice as an intensive care physician and pulmonologist: 1) Why do patients with same disease have such different responses to the same treatments?; and 2) Why are so many promising preclinical treatments ineffective in large clinical trials?

To address these questions, I am building a research program to study critical illness syndromes using a variety of multi-omic and computational tools. My research spans a wide range of scientific domains from characterizing molecular features of preclinical disease models to predicting individualized treatment effects in ICU clinical trials and identifying algorithmic biases in large observational data sets.

I am supported by a K23 Career Development Award from the National Heart, Lung, and Blood Institute and received an Emerging Generation Award from the American Society for Clinical Investigation. I serve as co-chair for the American Thoracic Society's Workshop on research standards for respiratory tract sampling and contribute as a site investigator for multiple clinical studies. I am a strong proponent of interdisciplinary team science to advance human health, and work with researchers across disciplines from cell biology to labor economics - if you have ideas for potential collaboration, please send me a message!

Publications: 

Microbial dynamics and pulmonary immune responses in COVID-19 secondary bacterial pneumonia.

Nature communications

Spottiswoode N, Tsitsiklis A, Chu VT, Phan HV, DeVoe C, Love C, Ghale R, Bloomstein J, Zha BS, Maguire CP, Glascock A, Sarma A, Mourani PM, Kalantar KL, Detweiler A, Neff N, Haller SC, COMET Consortium, DeRisi JL, Erle DJ, Hendrickson CM, Kangelaris KN, Krummel MF, Matthay MA, Woodruff PG, Calfee CS, Langelier CR

Distinct pulmonary and systemic effects of dexamethasone in severe COVID-19.

Nature communications

Neyton LPA, Patel RK, Sarma A, UCSF COMET Consortium, Willmore A, Haller SC, Kangelaris KN, Eckalbar WL, Erle DJ, Krummel MF, Hendrickson CM, Woodruff PG, Langelier CR, Calfee CS, Fragiadakis GK

Biological effects of corticosteroids on pneumococcal pneumonia in Mice-translational significance.

Critical care (London, England)

Taenaka H, Wick KD, Sarma A, Matsumoto S, Ghale R, Fang X, Maishan M, Gotts JE, Langelier CR, Calfee CS, Matthay MA

Rapidly improving ARDS differs clinically and biologically from persistent ARDS.

Critical care (London, England)

Valda Toro PL, Willmore A, Wu NE, Delucchi KL, Jauregui A, Sinha P, Liu KD, Hendrickson CM, Sarma A, Neyton LPA, Leligdowicz A, Langelier CR, Zhuo H, Jones C, Kangelaris KN, Gomez AD, Matthay MA, Calfee CS

Host and Microbe Blood Metagenomics Reveals Key Pathways Characterizing Critical Illness Phenotypes.

American journal of respiratory and critical care medicine

Neyton LPA, Sinha P, Sarma A, Mick E, Kalantar K, Chen S, Wu N, Delucchi K, Zhuo H, Bos LDJ, Jauregui A, Gomez A, Hendrickson CM, Kangelaris KN, Leligdowicz A, Liu KD, Matthay MA, Langelier CR, Calfee CS

Molecular Phenotypes of ARDS in the ROSE Trial have Differential Outcomes and Gene Expression Patterns That Differ at Baseline and Longitudinally Over Time.

American journal of respiratory and critical care medicine

Sinha P, Neyton L, Sarma A, Wu N, Jones C, Zhuo H, Liu KD, Sanchez Guerrero E, Ghale R, Love C, Mick E, Delucchi KL, Langelier CR, Thompson BT, Matthay MA, Calfee CS, NHLBI PETAL Network

Research Bronchoscopy Standards and the Need for Noninvasive Sampling of the Failing Lungs.

Annals of the American Thoracic Society

Bain W, Bastarache JA, Sarma A, McElvaney NG, Baron RM, McVerry BJ, Kitsios GD

A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling.

iScience

Hackney JA, Shivram H, Vander Heiden J, Overall C, Orozco L, Gao X, Kim E, West N, Qamra A, Chang D, Chakrabarti A, Choy DF, Combes AJ, Courau T, Fragiadakis GK, Rao AA, Ray A, Tsui J, Hu K, Kuhn NF, Krummel MF, Erle DJ, Kangelaris K, Sarma A, Lyon Z, Calfee CS, Woodruff PG, Ghale R, Mick E, Byrne A, Zha BS, Langelier C, Hendrickson CM, van der Wijst MGP, Hartoularos GC, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Ye CJ, UCSF COMET Consortium, Ramalingam T, McBride JM, Cai F, Teterina A, Bao M, Tsai L, Rosas IO, Regev A, Kapadia SB, Bauer RN, Rosenberger CM

Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials.

The Lancet. Respiratory medicine

Sinha P, Kerchberger VE, Willmore A, Chambers J, Zhuo H, Abbott J, Jones C, Wickersham N, Wu N, Neyton L, Langelier CR, Mick E, He J, Jauregui A, Churpek MM, Gomez AD, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Delucchi KL, Liu KD, Russell JA, Matthay MA, Walley KR, Ware LB, Calfee CS

Distinct pulmonary and systemic effects of dexamethasone in severe COVID-19.

Research square

Fragiadakis G, Neyton L, Patel R, Sarma A, Consortium UC, Willmore A, Haller SC, Kangelaris K, Eckalbar W, Erle D, Krummel M, Hendrickson C, Woodruff P, Langelier C, Calfee C

Aerosolized nicotine from e-cigarettes alters gene expression, increases lung protein permeability, and impairs viral clearance in murine influenza infection.

Frontiers in immunology

Maishan M, Sarma A, Chun LF, Caldera S, Fang X, Abbott J, Christenson SA, Langelier CR, Calfee CS, Gotts JE, Matthay MA

NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes.

JCI insight

Calabrese DR, Tsao T, Magnen M, Valet C, Gao Y, Mallavia B, Tian JJ, Aminian EA, Wang KM, Shemesh A, Punzalan EB, Sarma A, Calfee CS, Christenson SA, Langelier CR, Hays SR, Golden JA, Leard LE, Kleinhenz ME, Kolaitis NA, Shah RJ, Venado A, Lanier LL, Greenland JR, Sayah DM, Ardehali A, Kukreja J, Weigt SS, Belperio JA, Singer JP, Looney MR

Integrated host-microbe plasma metagenomics for sepsis diagnosis in a prospective cohort of critically ill adults.

Nature microbiology

Kalantar KL, Neyton L, Abdelghany M, Mick E, Jauregui A, Caldera S, Serpa PH, Ghale R, Albright J, Sarma A, Tsitsiklis A, Leligdowicz A, Christenson SA, Liu K, Kangelaris KN, Hendrickson C, Sinha P, Gomez A, Neff N, Pisco A, Doernberg SB, Derisi JL, Matthay MA, Calfee CS, Langelier CR

Impact of e-cigarette aerosol on primary human alveolar epithelial type 2 cells.

American journal of physiology. Lung cellular and molecular physiology

Wick KD, Fang X, Maishan M, Matsumoto S, Spottiswoode N, Sarma A, Simoneau C, Khakoo M, Langelier C, Calfee CS, Gotts JE, Matthay MA

Hyperinflammatory ARDS is characterized by interferon-stimulated gene expression, T-cell activation, and an altered metatranscriptome in tracheal aspirates

medRxiv

Aartik Sarma, Stephanie A. Christenson, Beth Shoshana Zha, Angela Oliveira Pisco, Lucile P.A. Neyton, Eran Mick, Pratik Sinha, Jennifer G. Wilson, Farzad Moazed, Aleksandra Leligdowicz, Manoj V. Maddali, Emily R. Siegel, Zoe Lyon, Hanjing Zhou, Alejandra Jauregui, Rajani Ghale, Saharai Caldera, Paula Hayakawa Serpa, Thomas Deiss, Christina Love, Ashley Byrne, Katrina L. Kalantar, Joseph L. DeRisi, David J. Erle, Matthew F. Krummel, Kirsten N. Kangelaris, Carolyn M. Hendrickson, Prescott G. Woodruff, Michael A. Matthay, COMET Consortium, Charles R. Langelier, Carolyn S. Calfee

Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis.

The Lancet. Respiratory medicine

Maddali MV, Churpek M, Pham T, Rezoagli E, Zhuo H, Zhao W, He J, Delucchi KL, Wang C, Wickersham N, McNeil JB, Jauregui A, Ke S, Vessel K, Gomez A, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Liu KD, Matthay MA, Ware LB, Laffey JG, Bellani G, Calfee CS, Sinha P, LUNG SAFE Investigators and the ESICM Trials Group

Impaired antibacterial immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.

medRxiv : the preprint server for health sciences

Tsitsiklis A, Zha BS, Byrne A, Devoe C, Levan S, Rackaityte E, Sunshine S, Mick E, Ghale R, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson S, Jones N, Wu B, Darmanis S, Matthay MA, Lynch SV, DeRisi JL, COMET Consortium+ , Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Rosenberg O, Calfee CS, Langelier CR

Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS.

Nature communications

Sarma A, Christenson SA, Byrne A, Mick E, Pisco AO, DeVoe C, Deiss T, Ghale R, Zha BS, Tsitsiklis A, Jauregui A, Moazed F, Detweiler AM, Spottiswoode N, Sinha P, Neff N, Tan M, Serpa PH, Willmore A, Ansel KM, Wilson JG, Leligdowicz A, Siegel ER, Sirota M, DeRisi JL, Matthay MA, COMET Consortium , Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Calfee CS, Langelier CR

Latent class analysis-derived subphenotypes are generalisable to observational cohorts of acute respiratory distress syndrome: a prospective study.

Thorax

Sinha P, Delucchi KL, Chen Y, Zhuo H, Abbott J, Wang C, Wickersham N, McNeil JB, Jauregui A, Ke S, Vessel K, Gomez A, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Liu KD, Matthay MA, Ware LB, Calfee CS

The sputum transcriptome better predicts COPD exacerbations after the withdrawal of inhaled corticosteroids than sputum eosinophils.

ERJ open research

Ditz B, Sarma A, Kerstjens HAM, Liesker JJW, Bathoorn E, Vonk JM, Bernal V, Horvatovich P, Guryev V, Caldera S, Langelier C, Faiz A, Christenson SA, van den Berge M

Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.

Research square

Tsitsiklis A, Zha B, Byrne A, DeVoe C, Levan S, Rackaityte E, Sunshine S, Mick E, Ghale R, Jauregui A, Neff N, Sarma A, Serpa P, Deiss T, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson S, Jones N, Wu B, Darmanis S, Matthay M, Lynch S, DeRisi J, Consortium C, Hendrickson C, Kangelaris K, Krummel M, Woodruff P, Erle D, Rosenberg O, Calfee C, Langelier C

Biomarkers and Precision Medicine: State of the Art.

Critical care clinics

Sarma A, Calfee CS, Ware LB

A Systems Approach to Healthcare Innovation Using the MIT Hacking Medicine Model.

Cell systems

Gubin TA, Iyer HP, Liew SN, Sarma A, Revelos A, Ribas J, Movassaghi B, Chu ZM, Khalid AN, Majmudar MD, Lee CX

A novel subtyping assay for detection of Clostridium difficile virulence genes.

The Journal of molecular diagnostics : JMD

Angione SL, Sarma AA, Novikov A, Seward L, Fieber JH, Mermel LA, Tripathi A

Abstract 344: Interoperator Variability and Physician Learning with Medical Devices: Experience with Three New Vascular Closure Devices.

Circulation Cardiovascular Quality and Outcomes

Aartik Sarma, Sharon-Lise T Normand, Laura A Hatfield, Michael E Matheny, Frederic S Resnic

THE LEARNING CURVE FOR MEDICAL DEVICES: EXPERIENCE WITH VASCULAR CLOSURE DEVICES IN MASSACHUSETTS.

Journal of the American College of Cardiology

Aartik Sarma, Sharon-Lise T. Normand, Laura A. Hatfield, Michael E. Matheny, Frederic S. Resnic

A simple method for amplifying RNA targets (SMART).

The Journal of molecular diagnostics : JMD

McCalla SE, Ong C, Sarma A, Opal SM, Artenstein AW, Tripathi A

Ligation with nucleic acid sequence-based amplification.

The Journal of molecular diagnostics : JMD

Ong C, Tai W, Sarma A, Opal SM, Artenstein AW, Tripathi A

The state of health policy education in U.S. medical schools.

The New England journal of medicine

Mou D, Sarma A, Sethi R, Merryman R

Early in vitro transcription termination in human H5 influenza viral RNA synthesis.

Applied biochemistry and biotechnology

Kerby MB, Sarma AA, Patel MS, Artenstein AW, Opal SM, Tripathi A

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