Andrei Goga, MD, PhD

Professor
Cell and Tissue Biology
+1 415 353-7070
Publications: 

Tumor Cell Spatial Organization Directs EGFR/RAS/RAF Pathway Primary Therapy Resistance through YAP Signaling.

bioRxiv : the preprint server for biology

Nakagawa R, Beardsley A, Durney S, Hayward MK, Subramanyam V, Meyer NP, Wismer H, Goodarzi H, Weaver VM, Van de Mark D, Goga A

Single-cell analysis of breast cancer metastasis reveals epithelial-mesenchymal plasticity signatures associated with poor outcomes.

The Journal of clinical investigation

Winkler J, Tan W, Diadhiou CM, McGinnis CS, Abbasi A, Hasnain S, Durney S, Atamaniuc E, Superville D, Awni L, Lee JV, Hinrichs JH, Wagner PS, Singh N, Hein MY, Borja M, Detweiler AM, Liu SY, Nanjaraj A, Sitarama V, Rugo HS, Neff N, Gartner ZJ, Oliveira Pisco A, Goga A, Darmanis S, Werb Z

The temporal progression of lung immune remodeling during breast cancer metastasis.

Cancer cell

McGinnis CS, Miao Z, Superville D, Yao W, Goga A, Reticker-Flynn NE, Winkler J, Satpathy AT

Respiratory complex I regulates dendritic cell maturation in explant model of human tumor immune microenvironment.

Journal for immunotherapy of cancer

Turpin R, Liu R, Munne PM, Peura A, Rannikko JH, Philips G, Boeckx B, Salmelin N, Hurskainen E, Suleymanova I, Aung J, Vuorinen EM, Lehtinen L, Mutka M, Kovanen PE, Niinikoski L, Meretoja TJ, Mattson J, Mustjoki S, Saavalainen P, Goga A, Lambrechts D, Pouwels J, Hollmén M, Klefström J

The oncogene cyclin D1 promotes bipolar spindle integrity under compressive force.

PloS one

Sutanto R, Neahring L, Serra Marques A, Jacobo Jacobo M, Kilinc S, Goga A, Dumont S

An inflamed tumor cell subpopulation promotes chemotherapy resistance in triple negative breast cancer.

Scientific reports

Jacobo Jacobo M, Donnella HJ, Sobti S, Kaushik S, Goga A, Bandyopadhyay S

The oncogene cyclin D1 promotes bipolar spindle integrity under compressive force.

bioRxiv : the preprint server for biology

Sutanto R, Neahring L, Marques AS, Kilinc S, Goga A, Dumont S

An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus.

Nature cell biology

Navickas A, Asgharian H, Winkler J, Fish L, Garcia K, Markett D, Dodel M, Culbertson B, Miglani S, Joshi T, Yin K, Nguyen P, Zhang S, Stevers N, Hwang HW, Mardakheh F, Goga A, Goodarzi H

Author Correction: Combinatorial immunotherapies overcome MYC-driven immune evasion in triple negative breast cancer.

Nature communications

Lee JV, Housley F, Yau C, Nakagawa R, Winkler J, Anttila JM, Munne PM, Savelius M, Houlahan KE, Van de Mark D, Hemmati G, Hernandez GA, Zhang Y, Samson S, Baas C, Kok M, Esserman LJ, van 't Veer LJ, Rugo HS, Curtis C, Klefstr?m J, Matloubian M, Goga A

Host and gut bacteria share metabolic pathways for anti-cancer drug metabolism.

Nature microbiology

Spanogiannopoulos P, Kyaw TS, Guthrie BGH, Bradley PH, Lee JV, Melamed J, Malig YNA, Lam KN, Gempis D, Sandy M, Kidder W, Van Blarigan EL, Atreya CE, Venook A, Gerona RR, Goga A, Pollard KS, Turnbaugh PJ

Combinatorial immunotherapies overcome MYC-driven immune evasion in triple negative breast cancer.

Nature communications

Lee JV, Housley F, Yau C, Nakagawa R, Winkler J, Anttila JM, Munne PM, Savelius M, Houlahan KE, Van de Mark D, Hemmati G, Hernandez GA, Zhang Y, Samson S, Baas C, Esserman LJ, van 't Veer LJ, Rugo HS, Curtis C, Klefström J, Matloubian M, Goga A

Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability.

Nature chemical biology

Li Z, Ferguson L, Deol KK, Roberts MA, Magtanong L, Hendricks JM, Mousa GA, Kilinc S, Schaefer K, Wells JA, Bassik MC, Goga A, Dixon SJ, Ingolia NT, Olzmann JA

NCI's publication affiliation conundrum: Reframing innovation to incentivize an equitable path for advocate representation.

Translational oncology

Samson S, Northey JJ, Acerbi I, Goga A, Flink CL, Weaver VM, LaBarge MA

Evaluation of disseminated tumor cells and circulating tumor cells in patients with breast cancer receiving adjuvant zoledronic acid.

NPJ breast cancer

Vidula N, Greenberg S, Petrillo L, Hwang J, Melisko M, Goga A, Moasser M, Magbanua M, Park JW, Rugo HS

Oncogene-regulated release of extracellular vesicles.

Developmental cell

Kilinc S, Paisner R, Camarda R, Gupta S, Momcilovic O, Kohnz RA, Avsaroglu B, L'Etoile ND, Perera RM, Nomura DK, Goga A

In Vivo Optical Metabolic Imaging of Long-Chain Fatty Acid Uptake in Orthotopic Models of Triple-Negative Breast Cancer.

Cancers

Madonna MC, Duer JE, Lee JV, Williams J, Avsaroglu B, Zhu C, Deutsch R, Wang R, Crouch BT, Hirschey MD, Goga A, Ramanujam N

MicroRNA-342-3p is a potent tumour suppressor in hepatocellular carcinoma.

Journal of hepatology

Komoll RM, Hu Q, Olarewaju O, von Döhlen L, Yuan Q, Xie Y, Tsay HC, Daon J, Qin R, Manns MP, Sharma AD, Goga A, Ott M, Balakrishnan A

MYC Dysregulates Mitosis, Revealing Cancer Vulnerabilities.

Cell reports

Rohrberg J, Van de Mark D, Amouzgar M, Lee JV, Taileb M, Corella A, Kilinc S, Williams J, Jokisch ML, Camarda R, Balakrishnan S, Shankar R, Zhou A, Chang AN, Chen B, Rugo HS, Dumont S, Goga A

Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer.

Nature medicine

Shah KN, Bhatt R, Rotow J, Rohrberg J, Olivas V, Wang VE, Hemmati G, Martins MM, Maynard A, Kuhn J, Galeas J, Donnella HJ, Kaushik S, Ku A, Dumont S, Krings G, Haringsma HJ, Robillard L, Simmons AD, Harding TC, McCormick F, Goga A, Blakely CM, Bivona TG, Bandyopadhyay S

Cancer cells exploit an orphan RNA to drive metastatic progression.

Nature medicine

Fish L, Zhang S, Yu JX, Culbertson B, Zhou AY, Goga A, Goodarzi H

microRNA 193a-5p Regulates Levels of Nucleolar- and Spindle-Associated Protein 1 to Suppress Hepatocarcinogenesis.

Gastroenterology

Roy S, Hooiveld GJ, Seehawer M, Caruso S, Heinzmann F, Schneider AT, Frank AK, Cardenas DV, Sonntag R, Luedde M, Trautwein C, Stein I, Pikarsky E, Loosen S, Tacke F, Ringelhan M, Avsaroglu SK, Goga A, Buendia MA, Vucur M, Heikenwalder M, Zucman-Rossi J, Zender L, Roderburg C, Luedde T

Kinome rewiring reveals AURKA limits PI3K-pathway inhibitor efficacy in breast cancer.

Nature chemical biology

Donnella HJ, Webber JT, Levin RS, Camarda R, Momcilovic O, Bayani N, Shah KN, Korkola JE, Shokat KM, Goga A, Gordan JD, Bandyopadhyay S

Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity.

Nature communications

Nguyen QH, Pervolarakis N, Blake K, Ma D, Davis RT, James N, Phung AT, Willey E, Kumar R, Jabart E, Driver I, Rock J, Goga A, Khan SA, Lawson DA, Werb Z, Kessenbrock K

New Horizons in Advocacy Engaged Physical Sciences and Oncology Research.

Trends in cancer

Samson S, Northey JJ, Plaks V, Baas C, Dean I, LaBarge MA, Goga A, Van't Veer LJ, Weaver VM

Comprehensive analysis of normal adjacent to tumor transcriptomes.

Nature communications

Aran D, Camarda R, Odegaard J, Paik H, Oskotsky B, Krings G, Goga A, Sirota M, Butte AJ

Cancer recurrence monitoring using hyperpolarized [1-13C]pyruvate metabolic imaging in murine breast cancer model.

Magnetic resonance imaging

Shin PJ, Zhu Z, Camarda R, Bok RA, Zhou AY, Kurhanewicz J, Goga A, Vigneron DB

In vivo Reprogramming of Cancer Metabolism by MYC.

Frontiers in cell and developmental biology

Camarda R, Williams J, Goga A

Diverse regulation of mammary epithelial growth and branching morphogenesis through noncanonical Wnt signaling.

Proceedings of the National Academy of Sciences of the United States of America

Kessenbrock K, Smith P, Steenbeek SC, Pervolarakis N, Kumar R, Minami Y, Goga A, Hinck L, Werb Z

MYC-driven inhibition of the glutamate-cysteine ligase promotes glutathione depletion in liver cancer.

EMBO reports

Anderton B, Camarda R, Balakrishnan S, Balakrishnan A, Kohnz RA, Lim L, Evason KJ, Momcilovic O, Kruttwig K, Huang Q, Xu G, Nomura DK, Goga A

Development of high resolution 3D hyperpolarized carbon-13 MR molecular imaging techniques.

Magnetic resonance imaging

Milshteyn E, von Morze C, Reed GD, Shang H, Shin PJ, Zhu Z, Chen HY, Bok R, Goga A, Kurhanewicz J, Larson PE, Vigneron DB

PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression.

Nature medicine

Horiuchi D, Camarda R, Zhou AY, Yau C, Momcilovic O, Balakrishnan S, Corella AN, Eyob H, Kessenbrock K, Lawson DA, Marsh LA, Anderton BN, Rohrberg J, Kunder R, Bazarov AV, Yaswen P, McManus MT, Rugo HS, Werb Z, Goga A

Protein Sialylation Regulates a Gene Expression Signature that Promotes Breast Cancer Cell Pathogenicity.

ACS chemical biology

Kohnz RA, Roberts LS, DeTomaso D, Bideyan L, Yan P, Bandyopadhyay S, Goga A, Yosef N, Nomura DK

GSTP1 Is a Driver of Triple-Negative Breast Cancer Cell Metabolism and Pathogenicity.

Cell chemical biology

Louie SM, Grossman EA, Crawford LA, Ding L, Camarda R, Huffman TR, Miyamoto DK, Goga A, Weerapana E, Nomura DK

Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer.

Nature medicine

Camarda R, Zhou AY, Kohnz RA, Balakrishnan S, Mahieu C, Anderton B, Eyob H, Kajimura S, Tward A, Krings G, Nomura DK, Goga A

Fas-Activated Mitochondrial Apoptosis Culls Stalled Embryonic Stem Cells to Promote Differentiation.

Current biology : CB

Wang ES, Reyes NA, Melton C, Huskey NE, Momcilovic O, Goga A, Blelloch R, Oakes SA

Multiple breast cancer risk variants are associated with differential transcript isoform expression in tumors.

Human molecular genetics

Caswell JL, Camarda R, Zhou AY, Huntsman S, Hu D, Brenner SE, Zaitlen N, Goga A, Ziv E

Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells.

Nature

Lawson DA, Bhakta NR, Kessenbrock K, Prummel KD, Yu Y, Takai K, Zhou A, Eyob H, Balakrishnan S, Wang CY, Yaswen P, Goga A, Werb Z

Biogenesis, delivery, and function of extracellular RNA.

Journal of extracellular vesicles

Patton JG, Franklin JL, Weaver AM, Vickers K, Zhang B, Coffey RJ, Ansel KM, Blelloch R, Goga A, Huang B, L'Etoille N, Raffai RL, Lai CP, Krichevsky AM, Mateescu B, Greiner VJ, Hunter C, Voinnet O, McManus MT

Identification of Chemical Inhibitors of ß-Catenin-Driven Liver Tumorigenesis in Zebrafish.

PLoS genetics

Evason KJ, Francisco MT, Juric V, Balakrishnan S, Lopez Pazmino Mdel P, Gordan JD, Kakar S, Spitsbergen J, Goga A, Stainier DY

Direct and indirect targeting of MYC to treat acute myeloid leukemia.

Cancer chemotherapy and pharmacology

Brondfield S, Umesh S, Corella A, Zuber J, Rappaport AR, Gaillard C, Lowe SW, Goga A, Kogan SC

Activity-Based Protein Profiling of Oncogene-Driven Changes in Metabolism Reveals Broad Dysregulation of PAFAH1B2 and 1B3 in Cancer.

ACS chemical biology

Kohnz RA, Mulvihill MM, Chang JW, Hsu KL, Sorrentino A, Cravatt BF, Bandyopadhyay S, Goga A, Nomura DK

CDK1 inhibition targets the p53-NOXA-MCL1 axis, selectively kills embryonic stem cells, and prevents teratoma formation.

Stem cell reports

Huskey NE, Guo T, Evason KJ, Momcilovic O, Pardo D, Creasman KJ, Judson RL, Blelloch R, Oakes SA, Hebrok M, Goga A

Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map.

Cancer discovery

Martins MM, Zhou AY, Corella A, Horiuchi D, Yau C, Rakhshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji AF, Schreiber SL, Krogan NJ, Shokat KM, McCormick F, Goga A, Bandyopadhyay S

Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphoma.

Blood

Hoellein A, Fallahi M, Schoeffmann S, Steidle S, Schaub FX, Rudelius M, Laitinen I, Nilsson L, Goga A, Peschel C, Nilsson JA, Cleveland JL, Keller U

Inositol phosphate recycling regulates glycolytic and lipid metabolism that drives cancer aggressiveness.

ACS chemical biology

Benjamin DI, Louie SM, Mulvihill MM, Kohnz RA, Li DS, Chan LG, Sorrentino A, Bandyopadhyay S, Cozzo A, Ohiri A, Goga A, Ng SW, Nomura DK

Phase I dose-escalation study of 5-day intermittent oral lapatinib therapy in patients with human epidermal growth factor receptor 2-overexpressing breast cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Chien AJ, Munster PN, Melisko ME, Rugo HS, Park JW, Goga A, Auerback G, Khanafshar E, Ordovas K, Koch KM, Moasser MM

Taking on challenging targets: making MYC druggable.

American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting

Horiuchi D, Anderton B, Goga A

Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targets.

Cancer discovery

Balko JM, Giltnane JM, Wang K, Schwarz LJ, Young CD, Cook RS, Owens P, Sanders ME, Kuba MG, Sánchez V, Kurupi R, Moore PD, Pinto JA, Doimi FD, Gómez H, Horiuchi D, Goga A, Lehmann BD, Bauer JA, Pietenpol JA, Ross JS, Palmer GA, Yelensky R, Cronin M, Miller VA, Stephens PJ, Arteaga CL

MicroRNA-494 within an oncogenic microRNA megacluster regulates G1/S transition in liver tumorigenesis through suppression of mutated in colorectal cancer.

Hepatology (Baltimore, Md.)

Lim L, Balakrishnan A, Huskey N, Jones KD, Jodari M, Ng R, Song G, Riordan J, Anderton B, Cheung ST, Willenbring H, Dupuy A, Chen X, Brown D, Chang AN, Goga A

A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis.

eLife

Olive V, Sabio E, Bennett MJ, De Jong CS, Biton A, McGann JC, Greaney SK, Sodir NM, Zhou AY, Balakrishnan A, Foth M, Luftig MA, Goga A, Speed TP, Xuan Z, Evan GI, Wan Y, Minella AC, He L

Endogenous nuclear RNAi mediates behavioral adaptation to odor.

Cell

Juang BT, Gu C, Starnes L, Palladino F, Goga A, Kennedy S, L'Etoile ND

Quantitative measurement of cancer metabolism using stimulated echo hyperpolarized carbon-13 MRS.

Magnetic resonance in medicine

Swisher CL, Larson PE, Kruttwig K, Kerr AB, Hu S, Bok RA, Goga A, Pauly JM, Nelson SJ, Kurhanewicz J, Vigneron DB

HER3 signalling is regulated through a multitude of redundant mechanisms in HER2-driven tumour cells.

The Biochemical journal

Amin DN, Sergina N, Lim L, Goga A, Moasser MM

IRE1a cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.

Science (New York, N.Y.)

Upton JP, Wang L, Han D, Wang ES, Huskey NE, Lim L, Truitt M, McManus MT, Ruggero D, Goga A, Papa FR, Oakes SA

Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma.

Proceedings of the National Academy of Sciences of the United States of America

Cheng CK, Gustafson WC, Charron E, Houseman BT, Zunder E, Goga A, Gray NS, Pollok B, Oakes SA, James CD, Shokat KM, Weiss WA, Fan QW

Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways.

Proceedings of the National Academy of Sciences of the United States of America

Horiuchi D, Huskey NE, Kusdra L, Wohlbold L, Merrick KA, Zhang C, Creasman KJ, Shokat KM, Fisher RP, Goga A

MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition.

The Journal of experimental medicine

Horiuchi D, Kusdra L, Huskey NE, Chandriani S, Lenburg ME, Gonzalez-Angulo AM, Creasman KJ, Bazarov AV, Smyth JW, Davis SE, Yaswen P, Mills GB, Esserman LJ, Goga A

Investigating tumor perfusion and metabolism using multiple hyperpolarized (13)C compounds: HP001, pyruvate and urea.

Magnetic resonance imaging

von Morze C, Larson PE, Hu S, Yoshihara HA, Bok RA, Goga A, Ardenkjaer-Larsen JH, Vigneron DB

13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression.

Cell metabolism

Hu S, Balakrishnan A, Bok RA, Anderton B, Larson PE, Nelson SJ, Kurhanewicz J, Vigneron DB, Goga A

Switching Cdk2 on or off with small molecules to reveal requirements in human cell proliferation.

Molecular cell

Merrick KA, Wohlbold L, Zhang C, Allen JJ, Horiuchi D, Huskey NE, Goga A, Shokat KM, Fisher RP

Nanodiamond therapeutic delivery agents mediate enhanced chemoresistant tumor treatment.

Science translational medicine

Chow EK, Zhang XQ, Chen M, Lam R, Robinson E, Huang H, Schaffer D, Osawa E, Goga A, Ho D

Imaging of blood flow using hyperpolarized [(13)C]urea in preclinical cancer models.

Journal of magnetic resonance imaging : JMRI

von Morze C, Larson PE, Hu S, Keshari K, Wilson DM, Ardenkjaer-Larsen JH, Goga A, Bok R, Kurhanewicz J, Vigneron DB

miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma.

Nature medicine

Swarbrick A, Woods SL, Shaw A, Balakrishnan A, Phua Y, Nguyen A, Chanthery Y, Lim L, Ashton LJ, Judson RL, Huskey N, Blelloch R, Haber M, Norris MD, Lengyel P, Hackett CS, Preiss T, Chetcuti A, Sullivan CS, Marcusson EG, Weiss W, L'Etoile N, Goga A

Therapeutic potential of a synthetic lethal interaction between the MYC proto-oncogene and inhibition of aurora-B kinase.

Proceedings of the National Academy of Sciences of the United States of America

Yang D, Liu H, Goga A, Kim S, Yuneva M, Bishop JM

Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state.

Blood

den Hollander J, Rimpi S, Doherty JR, Rudelius M, Buck A, Hoellein A, Kremer M, Graf N, Scheerer M, Hall MA, Goga A, von Bubnoff N, Duyster J, Peschel C, Cleveland JL, Nilsson JA, Keller U

Nuclear entry of a cGMP-dependent kinase converts transient into long-lasting olfactory adaptation.

Proceedings of the National Academy of Sciences of the United States of America

Lee JI, O'Halloran DM, Eastham-Anderson J, Juang BT, Kaye JA, Scott Hamilton O, Lesch B, Goga A, L'Etoile ND

3D compressed sensing for highly accelerated hyperpolarized (13)C MRSI with in vivo applications to transgenic mouse models of cancer.

Magnetic resonance in medicine

Hu S, Lustig M, Balakrishnan A, Larson PE, Bok R, Kurhanewicz J, Nelson SJ, Goga A, Pauly JM, Vigneron DB

Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion.

The Journal of biological chemistry

Huang TH, Wu F, Loeb GB, Hsu R, Heidersbach A, Brincat A, Horiuchi D, Lebbink RJ, Mo YY, Goga A, McManus MT

Hepatic stem-like phenotype and interplay of Wnt/beta-catenin and Myc signaling in aggressive childhood liver cancer.

Cancer cell

Cairo S, Armengol C, De Reyniès A, Wei Y, Thomas E, Renard CA, Goga A, Balakrishnan A, Semeraro M, Gresh L, Pontoglio M, Strick-Marchand H, Levillayer F, Nouet Y, Rickman D, Gauthier F, Branchereau S, Brugières L, Laithier V, Bouvier R, Boman F, Basso G, Michiels JF, Hofman P, Arbez-Gindre F, Jouan H, Rousselet-Chapeau MC, Berrebi D, Marcellin L, Plenat F, Zachar D, Joubert M, Selves J, Pasquier D, Bioulac-Sage P, Grotzer M, Childs M, Fabre M, Buendia MA

Anti-oncomir suppression of tumor phenotypes.

Molecular interventions

Goga A, Benz C

Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC.

Nature medicine

Goga A, Yang D, Tward AD, Morgan DO, Bishop JM

Coordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA miR-125a or miR-125b.

The Journal of biological chemistry

Scott GK, Goga A, Bhaumik D, Berger CE, Sullivan CS, Benz CC

RNA interference (RNAi) with RNase III-prepared siRNAs.

Methods in molecular biology (Clifton, N.J.)

Yang D, Goga A, Bishop JM

Short RNA duplexes produced by hydrolysis with Escherichia coli RNase III mediate effective RNA interference in mammalian cells.

Proceedings of the National Academy of Sciences of the United States of America

Yang D, Buchholz F, Huang Z, Goga A, Chen CY, Brodsky FM, Bishop JM

A functional screen for regulators of the c-Abl protein tyrosine kinase.

Leukemia

Moro M, Walkenhorst J, Goga A, Witte ON, Superti-Furga G

Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia.

Molecular and cellular biology

Golub TR, Goga A, Barker GF, Afar DE, McLaughlin J, Bohlander SK, Rowley JD, Witte ON, Gilliland DG

Analysis of human c-Abl tyrosine kinase activity and regulation in S. pombe.

Oncogene

Walkenhorst J, Goga A, Witte ON, Superti-Furga G

Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene.

Cell

Goga A, McLaughlin J, Afar DE, Saffran DC, Witte ON

p53 dependent growth suppression by the c-Abl nuclear tyrosine kinase.

Oncogene

Goga A, Liu X, Hambuch TM, Senechal K, Major E, Berk AJ, Witte ON, Sawyers CL

Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinases.

Proceedings of the National Academy of Sciences of the United States of America

Cohen L, Mohr R, Chen YY, Huang M, Kato R, Dorin D, Tamanoi F, Goga A, Afar D, Rosenberg N

Differential complementation of Bcr-Abl point mutants with c-Myc.

Science (New York, N.Y.)

Afar DE, Goga A, McLaughlin J, Witte ON, Sawyers CL

The nuclear tyrosine kinase c-Abl negatively regulates cell growth.

Cell

Sawyers CL, McLaughlin J, Goga A, Havlik M, Witte O

Genetic approaches to defining signaling by the CML-associated tyrosine kinase BCR-ABL.

Cold Spring Harbor symposia on quantitative biology

Afar DE, Goga A, Cohen L, Sawyers CL, McLaughlin J, Mohr RN, Witte ON

Oncogenic activation of c-ABL by mutation within its last exon.

Molecular and cellular biology

Goga A, McLaughlin J, Pendergast AM, Parmar K, Muller A, Rosenberg N, Witte ON

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