Jean Publicover, PhD

Assistant Professor
Medicine
[email protected]
+1 415 476-3547

The goal of my research is to identify factors that influence the initiation of effective immune responses to HBV in the liver. Currently, my focus is on understanding the role of the liver as a site of immune priming to hepatotropic pathogens and the influence of commensal bacteria on the liver priming environment. I am also very interested visualizing of immune structures in the liver by immunofluorescent staining of liver tissue.

Publications: 

Cyclone: an accessible pipeline to analyze, evaluate, and optimize multiparametric cytometry data.

Frontiers in immunology

Patel RK, Jaszczak RG, Im K, Carey ND, Courau T, Bunis DG, Samad B, Avanesyan L, Chew NW, Stenske S, Jespersen JM, Publicover J, Edwards AW, Naser M, Rao AA, Lupin-Jimenez L, Krummel MF, Cooper S, Baron JL, Combes AJ, Fragiadakis GK

Cyclone: an accessible pipeline to analyze, evaluate and optimize multiparametric cytometry data.

bioRxiv : the preprint server for biology

Patel RK, Jaszczak RG, Kwok I, Carey ND, Courau T, Bunis D, Samad B, Avanesyan L, Chew NW, Stenske S, Jespersen JM, Publicover J, Edwards A, Naser M, Rao AA, Lupin-Jimenez L, Krummel MF, Cooper S, Baron J, Combes AJ, Fragiadakis GK

A tumor-specific mechanism of Treg enrichment mediated by the integrin αvβ8.

Science immunology

Seed RI, Kobayashi K, Ito S, Takasaka N, Cormier A, Jespersen JM, Publicover J, Trilok S, Combes AJ, Chew NW, Chapman J, Krummel MF, Lou J, Marks J, Cheng Y, Baron JL, Nishimura SL

Integrin avß8-expressing tumor cells evade host immunity by regulating TGF-ß activation in immune cells.

JCI insight

Takasaka N, Seed RI, Cormier A, Bondesson AJ, Lou J, Elattma A, Ito S, Yanagisawa H, Hashimoto M, Ma R, Levine MD, Publicover J, Potts R, Jespersen JM, Campbell MG, Conrad F, Marks JD, Cheng Y, Baron JL, Nishimura SL

An OX40/OX40L interaction directs successful immunity to hepatitis B virus.

Science translational medicine

Publicover J, Gaggar A, Jespersen JM, Halac U, Johnson AJ, Goodsell A, Avanesyan L, Nishimura SL, Holdorf M, Mansfield KG, Judge JB, Koshti A, Croft M, Wakil AE, Rosenthal P, Pai E, Cooper S, Baron JL

Liver capsule: Age-influenced hepatic immune priming determines HBV infection fate: Implications from mouse to man.

Hepatology (Baltimore, Md.)

Publicover J, Jespersen JM, Johnson AJ, Nishimura SL, Goodsell A, Wakil AE, Rosenthal P, Pai E, Avanesyan L, Cooper S, Baron JL

S-3 Age-dependent hepatic lymphoid organization directs immune priming, cytokine production, and successful immunity to Hepatitis B virus.

Cytokine

Jean Publicover, Anuj Gaggar, Stephen Nishimura, Christine M. Van Horn, Amanda Goodsell, Marcus O. Muench, R. Lee Reinhardt, Nico van Rooijen, Adil E. Wakil Marion Peters, Jason G. Cyster, David J. Erle, Philip Rosenthal, Lia Avanesyan, Rosanne Spolski, Warren J. Leonard, Stewart Cooper, Jody L. Baron

Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B.

The Journal of clinical investigation

Publicover J, Gaggar A, Nishimura S, Van Horn CM, Goodsell A, Muench MO, Reinhardt RL, van Rooijen N, Wakil AE, Peters M, Cyster JG, Erle DJ, Rosenthal P, Cooper S, Baron JL

Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity.

Nature medicine

Zeissig S, Murata K, Sweet L, Publicover J, Hu Z, Kaser A, Bosse E, Iqbal J, Hussain MM, Balschun K, Röcken C, Arlt A, Günther R, Hampe J, Schreiber S, Baron JL, Moody DB, Liang TJ, Blumberg RS

742 Hepatitis B Virus Infection Leads to Alterations in the Repertoire of Self Lipid Antigens Presented by Hepatocytes and is Associated With Direct and Indirect Activation of Natural Killer T Cells.

Gastroenterology

Sebastian Zeissig, Kazumoto Murata, Lindsay Sweet, Jean Publicover, Zongyi Hu, Arthur Kaser, Alexander Arlt, Rainer Günther, Jochen Hampe, Stefan Schreiber, Jody Baron, D. Branch Moody, T Jake Liang, Richard S. Blumberg

Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin avß8-mediated activation of TGF-ß.

The Journal of clinical investigation

Kitamura H, Cambier S, Somanath S, Barker T, Minagawa S, Markovics J, Goodsell A, Publicover J, Reichardt L, Jablons D, Wolters P, Hill A, Marks JD, Lou J, Pittet JF, Gauldie J, Baron JL, Nishimura SL

IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B.

The Journal of clinical investigation

Publicover J, Goodsell A, Nishimura S, Vilarinho S, Wang ZE, Avanesyan L, Spolski R, Leonard WJ, Cooper S, Baron JL

Hybrid alphavirus-rhabdovirus propagating replicon particles are versatile and potent vaccine vectors.

Proceedings of the National Academy of Sciences of the United States of America

Rose NF, Publicover J, Chattopadhyay A, Rose JK

Requirement for CD4 T cell help in maintenance of memory CD8 T cell responses is epitope dependent.

Journal of immunology (Baltimore, Md. : 1950)

Ramsburg EA, Publicover JM, Coppock D, Rose JK