Joseph Cuschieri, MD, FACS

Professor In Residence
Surgery

Joseph Cuschieri M.D. earned his Bachelor of Science Degree in Biochemistry from the University of Michigan, and his Medical Degree from Wayne State University School of Medicine. He completed his general surgery residence and surgical critical care fellowship at Henry Ford Hospital in Detroit, Michigan. Upon completion of his clinical training, he completed a 2-year NIH T32 Fellowship in the field of Trauma/Burn/Inflammation.

Dr. Cuschieri is certified by the American Board of Surgery in General Surgery with subspecialty certification in Surgical Critical Care.

Upon completion of his fellowship in 2002, Dr. Cuschieri joined the faculty at the University of Cincinnati School of Medicine. After a couple of years he left Cincinnati and returned to Seattle, joining the faculty at the University of Washington School of Medicine where he served as the Medical Director of Surgical Critical Care, Interim Associate Medical Director of Critical Care, Associate Medical Director of Surgical Services, and Program Director of Surgical Critical Care. Dr. Cuschieri left Washington and came to UCSF in 2021 to join the faculty in the Department of Surgery as Professor and Trauma Medical Director at the Zuckerberg San Francisco General Hospital and Trauma Center.

Dr. Cuschieri currently serves as Principal Investigator, Co-Principle investigator, or Co-Investigator on 3 federally funded grants and has authored or co-authored over 170 peer-reviewed articles and more than 10 book chapters. His national service includes active participation in major trauma, critical care, and surgical societies including the American Association for the Surgery of Trauma and the Society of Surgical Critical Care Program Directors. He also serves on the Editorial Board for the Journal of Trauma and Acute Care Surgery.

Publications: 

The Epidemiology of Genitourinary Self-Inflicted Injuries: Analysis of the National Trauma Databank.

Urology

Hakam N, Ghaffar U, Abbasi B, Li KD, Fernandez A, Patel HV, Cuschieri J, Breyer BN

Multiple organ failure: What you need to know.

The journal of trauma and acute care surgery

Brakenridge S, Kornblith L, Cuschieri J

Regulation of vascular endothelial integrity by mesenchymal stem cell extracellular vesicles after hemorrhagic shock and trauma.

Journal of translational medicine

Barry M, Trivedi A, Miyazawa B, Vivona LR, Shimmin D, Pathipati P, Keane C, Cuschieri J, Pati S

Antibiotic prophylaxis in injury: an American Association for the Surgery of Trauma Critical Care Committee clinical consensus document.

Trauma surgery & acute care open

Appelbaum RD, Farrell MS, Gelbard RB, Hoth JJ, Jawa RS, Kirsch JM, Mandell S, Nohra EA, Rinderknecht T, Rowell S, Cuschieri J, Stein DM

Fever and infections in surgical intensive care: an American Association for the Surgery of Trauma Critical Care Committee clinical consensus document.

Trauma surgery & acute care open

Nohra E, Appelbaum RD, Farrell MS, Carver T, Jung HS, Kirsch JM, Kodadek LM, Mandell S, Nassar AK, Pathak A, Paul J, Robinson B, Cuschieri J, Stein DM

Surgical and procedural antibiotic prophylaxis in the surgical ICU: an American Association for the Surgery of Trauma Critical Care Committee clinical consensus document.

Trauma surgery & acute care open

Farrell MS, Agapian JV, Appelbaum RD, Filiberto DM, Gelbard R, Hoth J, Jawa R, Kirsch J, Kutcher ME, Nohra E, Pathak A, Paul J, Robinson B, Cuschieri J, Stein DM

Scanning the aged to minimize missed injury: An EAST multicenter study.

The journal of trauma and acute care surgery

Ho VP, Kishawi SK, Hill H, O'Brien J, Ratnasekera A, Seng SS, Ton TH, Butts CA, Muller A, Diaz BF, Baltazar GA, Petrone P, Pacheco TBS, Morrissey S, Chung T, Biller J, Jacobson LE, Williams JM, Nebughr CS, Udekwu PO, Tann K, Piehl C, Veatch JM, Capasso TJ, Kuncir EJ, Kodadek LM, Miller SM, Altan D, Mentzer C, Damiano N, Burke R, Earley A, Doris S, Villa E, Wilkinson MC, Dixon JK, Wu E, Moncrief ML, Palmer B, Herzing K, Egodage T, Williams J, Haan J, Lightwine K, Colling KP, Harry ML, Nahmias J, Tay-Lasso E, Cuschieri J, Hinojosa CJ, Claridge JA

Balanced resuscitation: the role during non-massive hemorrhage.

Trauma surgery & acute care open

Garber K, Kornblith L, Cuschieri J

Early Cold Stored Platelet Transfusion Following Severe Injury: A Randomized Clinical Trial.

Annals of surgery

Sperry JL, Guyette FX, Rosario-Rivera BL, Kutcher ME, Kornblith LZ, Cotton BA, Wilson CT, Inaba K, Zadorozny EV, Vincent LE, Harner AM, Love ET, Doherty JE, Cuschieri J, Kornblith AE, Fox EE, Bai Y, Hoffman MK, Seger CP, Hudgins J, Mallett-Smith S, Neal MD, Leeper CM, Spinella PC, Yazer MH, Wisniewski SR, Cold Stored Platelet for Hemorrhagic Shock (CRISP-HS) study group

Regulation of Vascular Endothelial Integrity by Mesenchymal Stem Cell Extracellular Vesicles after Hemorrhagic Shock and Trauma.

Research square

Barry M, Trivedi A, Miyazawa B, Vivona L, Shimmin D, Pathipati P, Keane C, Cuschieri J, Pati S

Insights from CTTACC: immune system reset by cellular therapies for chronic illness after trauma, infection, and burn.

Cytotherapy

Bertram K, Cox C, Alam H, Lowell C, Cuschieri J, Parekkadan B, Pati S

Effect of Aspirin Versus Low-Molecular-Weight Heparin Thromboprophylaxis on Medication Satisfaction and Out-of-Pocket Costs: A Secondary Analysis of a Randomized Clinical Trial.

The Journal of bone and joint surgery. American volume

O'Hara NN, Frey KP, Stein DM, Levy JF, Slobogean GP, Castillo R, Firoozabadi R, Karunakar MA, Gary JL, Obremskey WT, Seymour RB, Cuschieri J, Mullins CD, O'Toole RV, METRC

Risk-stratified thromboprophylaxis effects of aspirin versus low-molecular-weight heparin in orthopaedic trauma patients: a secondary analysis of the PREVENT CLOT trial.

The journal of trauma and acute care surgery

O'Hara NN, O'Toole RV, Frey KP, Castillo RC, Cuschieri J, Haut ER, Slobogean GP, Firoozabadi R, Christmas A, Obremskey WT, Carlini AR, Gaski G, Kutcher ME, Marvel D, Stein DM, Major Extremity Trauma Research Consortium (METRC)

Screening for Intimate Partner Violence in Trauma: Results of a Quality Improvement Project.

The Journal of surgical research

Decker H, Schwab M, Shao S, Kaki D, Melhado C, Cuschieri J, Bongiovanni T

The Injured Monocyte: The Link to Chronic Critical Illness and Mortality Following Injury.

The journal of trauma and acute care surgery

Cuschieri J, Kornblith L, Pati S, Piliponsky A

Trial Participation and Outcomes Among English-Speaking and Spanish-Speaking Patients With Appendicitis Randomized to Antibiotics: A Secondary Analysis of the CODA Randomized Clinical Trial.

JAMA surgery

Serrano E, Voldal EC, Machado-Aranda D, DeUgarte DA, Kao L, Drake T, Winchell R, Cuschieri J, Krishnadasan A, Talan DA, Siparsky N, Ayoung-Chee P, Self WH, McGonagill P, Mandell KA, Liang MK, Dodwad SJ, Thompson CM, Padilla RM, Fleischman R, Price TP, Jones A, Bernardi K, Garcia L, Evans HL, Sanchez SE, Odom S, Comstock BA, Heagerty PJ, Lawrence SO, Monsell SE, Fannon EEC, Kessler LG, Flum DR, Davidson GH, Writing Group for the CODA Collaborative

Organ donation in the surgical ICU: an American Association for the Surgery of Trauma Critical Care Committee clinical consensus document.

Trauma surgery & acute care open

Seshadri A, Cuschieri J, Kaups KL, Knowlton LM, Kutcher ME, Pathak A, Rappold J, Rinderknecht T, Stein DM, Young J, Michetti CP

Developing a National Trauma Research Action Plan (NTRAP): Results from the Long-term Outcomes Research Gap Delphi Survey.

The journal of trauma and acute care surgery

Herrera-Escobar JP, Reidy E, Phuong J, Brasel KJ, Cuschieri J, Fallat M, Potter BK, Price MA, Bulger EM, Haider AH, NTRAP Long-term Outcomes Panel

Management of Decompensated Cirrhosis in the Surgical ICU: an American Association for the Surgery of Trauma Critical Care Committee Clinical Consensus Document.

Trauma surgery & acute care open

Seshadri A, Appelbaum R, Carmichael SP, Cuschieri J, Hoth J, Kaups KL, Kodadek L, Kutcher ME, Pathak A, Rappold J, Rudnick SR, Michetti CP

Perception of Treatment Success and Impact on Function with Antibiotics or Appendectomy for Appendicitis: A Randomized Clinical Trial with an Observational Cohort.

Annals of surgery

Thompson CM, Voldal EC, Davidson GH, Sanchez SE, Ayoung-Chee P, Victory J, Guiden M, Bizzell B, Glaser J, Hults C, Price TP, Siparsky N, Ohe K, Mandell KA, DeUgarte DA, Kaji AH, Uribe L, Kao LS, Mueck KM, Farjah F, Self WH, Clark S, Drake FT, Fischkoff K, Minko E, Cuschieri J, Faine B, Skeete DA, Dhanani N, Liang MK, Krishnadasan A, Talan DA, Fannon E, Kessler LG, Comstock BA, Heagerty PJ, Monsell SE, Lawrence SO, Flum DR, Lavallee DC, Writing Group for the CODA Collaborative:

Analysis of Outcomes Associated With Outpatient Management of Nonoperatively Treated Patients With Appendicitis.

JAMA network open

Writing Group for the CODA Collaborative, Talan DA, Moran GJ, Krishnadasan A, Monsell SE, Faine BA, Uribe L, Kaji AH, DeUgarte DA, Self WH, Shapiro NI, Cuschieri J, Glaser J, Park PK, Price TP, Siparsky N, Sanchez SE, Machado-Aranda DA, Victory J, Ayoung-Chee P, Chiang W, Corsa J, Evans HL, Ferrigno L, Garcia L, Hatch Q, Horton MD, Johnson J, Jones A, Kao LS, Kelly A, Kim D, Kutcher ME, Liang MK, Maghami N, McGrane K, Minko E, Mohr C, Neufeld M, Patton JH, Rog C, Rushing A, Sabbatini AK, Salzberg M, Thompson CM, Tichter A, Wisler J, Bizzell B, Fannon E, Lawrence SO, Voldal EC, Lavallee DC, Comstock BA, Heagerty PJ, Davidson GH, Flum DR, Kessler LG

Self-selection vs Randomized Assignment of Treatment for Appendicitis.

JAMA surgery

Writing Group for the CODA Collaborative, Davidson GH, Monsell SE, Evans H, Voldal EC, Fannon E, Lawrence SO, Krishnadasan A, Talan DA, Bizzell B, Heagerty PJ, Comstock BA, Lavallee DC, Villegas C, Winchell R, Thompson CM, Self WH, Kao LS, Dodwad SJ, Sabbatini AK, Droullard D, Machado-Aranda D, Gibbons MM, Kaji AH, DeUgarte DA, Ferrigno L, Salzberg M, Mandell KA, Siparsky N, Price TP, Raman A, Corsa J, Wisler J, Ayoung-Chee P, Victory J, Jones A, Kutcher M, McGrane K, Holihan J, Liang MK, Cuschieri J, Johnson J, Fischkoff K, Drake FT, Sanchez SE, Odom SR, Kessler LG, Flum DR

Postinjury platelet aggregation and venous thromboembolism.

The journal of trauma and acute care surgery

Matthay ZA, Hellmann ZJ, Nunez-Garcia B, Fields AT, Cuschieri J, Neal MD, Berger JS, Luttrell-Williams E, Knudson MM, Cohen MJ, Callcut RA, Kornblith LZ

Developing a National Trauma Research Action Plan: Results from the acute resuscitation, initial patient evaluation, imaging, and management research gap Delphi survey.

The journal of trauma and acute care surgery

Costantini TW, Galante JM, Braverman MA, Phuong J, Price MA, Cuschieri J, Godat LN, Holcomb JB, Coimbra R, Bulger EM, NTRAP Acute Resuscitation Panel

Nonoperative Management in Blunt Splenic Trauma: Can Shock Index Predict Failure?

The Journal of surgical research

Senekjian L, Robinson BRH, Meagher AD, Gross JA, Maier RV, Bulger EM, Arbabi S, Cuschieri J

Patient Factors Associated With Appendectomy Within 30 Days of Initiating Antibiotic Treatment for Appendicitis.

JAMA surgery

Writing Group for the CODA Collaborative, Monsell SE, Voldal EC, Davidson GH, Fischkoff K, Coleman N, Bizzell B, Price T, Narayan M, Siparsky N, Thompson CM, Ayoung-Chee P, Odom SR, Sanchez S, Drake FT, Johnson J, Cuschieri J, Evans HL, Liang MK, McGrane K, Hatch Q, Victory J, Wisler J, Salzberg M, Ferrigno L, Kaji A, DeUgarte DA, Gibbons MM, Alam HB, Scott J, Kao LS, Self WH, Winchell RJ, Villegas CM, Talan DA, Kessler LG, Lavallee DC, Krishnadasan A, Lawrence SO, Comstock B, Fannon E, Flum DR, Heagerty PJ

A new trauma frontier: Exploratory pilot study of platelet transcriptomics in trauma patients.

The journal of trauma and acute care surgery

Fields AT, Lee MC, Mayer F, Santos YA, Bainton CMV, Matthay ZA, Callcut RA, Mayer N, Cuschieri J, Kober KM, Bainton RJ, Kornblith LZ

Utility and Outcome of Angioembolization for High-Grade Renal Trauma Management in a Large Hospital-Based Trauma Registry.

The Journal of urology

Hakam N, Amend GM, Nabavizadeh B, Allen IE, Shaw NM, Cuschieri J, Wilson MW, Stein DM, Breyer BN

Respiratory events after intensive care unit discharge in trauma patients: Epidemiology, outcomes, and risk factors.

The journal of trauma and acute care surgery

Rosen JE, Bulger EM, Cuschieri J

Antibiotics versus Appendectomy for Acute Appendicitis - Longer-Term Outcomes.

The New England journal of medicine

CODA Collaborative, Davidson GH, Flum DR, Monsell SE, Kao LS, Voldal EC, Heagerty PJ, Fannon E, Lavallee DC, Bizzell B, Lawrence SO, Comstock BA, Krishnadasan A, Winchell RJ, Self WH, Thompson CM, Farjah F, Park PK, Alam HB, Saltzman D, Moran GJ, Kaji AH, DeUgarte DA, Salzberg M, Ferrigno L, Mandell KA, Price TP, Siparsky N, Glaser J, Ayoung-Chee P, Chiang W, Victory J, Chung B, Carter DW, Kutcher ME, Jones A, Holihan J, Liang MK, Faine BA, Cuschieri J, Evans HL, Johnson J, Patton JH, Coleman N, Fischkoff K, Drake FT, Sanchez SE, Parsons C, Odom SR, Kessler LG, Talan DA

Chronic critical illness after hypothermia in trauma patients.

Trauma surgery & acute care open

Miranda D, Maine R, Cook M, Brakenridge S, Moldawer L, Arbabi S, O'Keefe G, Robinson B, Bulger EM, Maier R, Cuschieri J

Multi-center validation of the Bowel Injury Predictive Score (BIPS) for the early identification of need to operate in blunt bowel and mesenteric injuries.

Injury

Wandling M, Cuschieri J, Kozar R, O'Meara L, Celii A, Starr W, Burlew CC, Todd SR, de Leon A, McIntyre RC, Urban S, Biffl WL, Bayat D, Dunn J, Peck K, Rooney AS, Kornblith LZ, Callcut RA, Lollar DI, Ambroz E, Leichtle SW, Aboutanos MB, Schroeppel T, Hennessy EA, Russo R, McNutt M

The Covid-19 Pandemic: Lessons Learned for Sustained Trauma Preparedness and Responses.

Annals of surgery

Cuschieri J, Robinson B, Lynch J, Mitchell S, Arbabi S, Bryson C, Sayre M, Maier RV, Bulger E

Aspirin versus anticoagulation for stroke prophylaxis in blunt cerebrovascular injury: a propensity-matched retrospective cohort study.

Journal of neurosurgery

Bonow RH, Witt CE, Mossa-Basha M, Cuschieri J, Arbabi S, Vavilala MS, Rivara FP, Chesnut RM

PREVENTion of CLots in Orthopaedic Trauma (PREVENT CLOT): a randomised pragmatic trial protocol comparing aspirin versus low-molecular-weight heparin for blood clot prevention in orthopaedic trauma patients.

BMJ open

O'Toole RV, Stein DM, Frey KP, O'Hara NN, Scharfstein DO, Slobogean GP, Taylor TJ, Haac BE, Carlini AR, Manson TT, Sudini K, Mullins CD, Wegener ST, Firoozabadi R, Haut ER, Bosse MJ, Seymour RB, Holden MB, Gitajn IL, Goldhaber SZ, Eastman AL, Jurkovich GJ, Vallier HA, Gary JL, Kleweno CP, Cuschieri J, Marvel D, Castillo RC, METRC

Venous thromboembolism prophylaxis in the trauma intensive care unit: an American Association for the Surgery of Trauma Critical Care Committee Clinical Consensus Document.

Trauma surgery & acute care open

Rappold JF, Sheppard FR, Carmichael Ii SP, Cuschieri J, Ley E, Rangel E, Seshadri AJ, Michetti CP

Distinct immunologic endotypes are associated with clinical trajectory after severe blunt trauma and hemorrhagic shock.

The journal of trauma and acute care surgery

Brakenridge SC, Wang Z, Cox M, Raymond S, Hawkins R, Darden D, Ghita G, Brumback B, Cuschieri J, Maier RV, Moore FA, Mohr AM, Efron PA, Moldawer LL

Persistent metabolomic alterations characterize chronic critical illness after severe trauma.

The journal of trauma and acute care surgery

Horn DL, Bettcher LF, Navarro SL, Pascua V, Neto FC, Cuschieri J, Raftery D, O'Keefe GE

Changes in error patterns in unanticipated trauma deaths during 20 years: In pursuit of zero preventable deaths.

The journal of trauma and acute care surgery

LaGrone LN, McIntyre L, Riggle A, Robinson BRH, Maier RV, Bulger E, Cuschieri J

A Randomized Trial Comparing Antibiotics with Appendectomy for Appendicitis.

The New England journal of medicine

CODA Collaborative, Flum DR, Davidson GH, Monsell SE, Shapiro NI, Odom SR, Sanchez SE, Drake FT, Fischkoff K, Johnson J, Patton JH, Evans H, Cuschieri J, Sabbatini AK, Faine BA, Skeete DA, Liang MK, Sohn V, McGrane K, Kutcher ME, Chung B, Carter DW, Ayoung-Chee P, Chiang W, Rushing A, Steinberg S, Foster CS, Schaetzel SM, Price TP, Mandell KA, Ferrigno L, Salzberg M, DeUgarte DA, Kaji AH, Moran GJ, Saltzman D, Alam HB, Park PK, Kao LS, Thompson CM, Self WH, Yu JT, Wiebusch A, Winchell RJ, Clark S, Krishnadasan A, Fannon E, Lavallee DC, Comstock BA, Bizzell B, Heagerty PJ, Kessler LG, Talan DA

Society of Interventional Radiology Clinical Practice Guideline for Inferior Vena Cava Filters in the Treatment of Patients with Venous Thromboembolic Disease: Developed in collaboration with the American College of Cardiology, American College of Chest P

Journal of vascular and interventional radiology : JVIR

Kaufman JA, Barnes GD, Chaer RA, Cuschieri J, Eberhardt RT, Johnson MS, Kuo WT, Murin S, Patel S, Rajasekhar A, Weinberg I, Gillespie DL

Authors' reply: Understanding state-level Medicaid expansion in the context of nationwide data.

The journal of trauma and acute care surgery

Scott JW, Shrime MG, Stewart BT, Arbabi S, Bulger EM, Cuschieri J, Maier RV, Robinson BRH

Splenic artery angioembolization for high-grade splenic injury: Are we wasting money?

American journal of surgery

Senekjian L, Cuschieri J, Robinson BRH

Predictors of mortality, limb loss, and discharge disposition at admission among patients with necrotizing skin and soft tissue infections.

The journal of trauma and acute care surgery

Horn DL, Shen J, Roberts E, Wang TN, Li KS, O'Keefe GE, Cuschieri J, Bulger EM, Robinson BRH

Prospective Validation of a Transcriptomic Metric in Severe Trauma.

Annals of surgery

Raymond SL, Hawkins RB, Wang Z, Mira JC, Stortz JA, Han F, Lanz JD, Hennessy LV, Brumback BA, Baker HV, Efron PA, Brakenridge SC, Xiao W, Tompkins RG, Cuschieri J, Moore FA, Maier RV, Moldawer LL

Proceedings from the Consensus Conference on Trauma Patient-Reported Outcome Measures.

Journal of the American College of Surgeons

Sakran JV, Ezzeddine H, Schwab CW, Bonne S, Brasel KJ, Burd RS, Cuschieri J, Ficke J, Gaines BA, Giacino JT, Gibran NS, Haider A, Hall EC, Herrera-Escobar JP, Joseph B, Kao L, Kurowski BG, Livingston D, Mandell SP, Nehra D, Sarani B, Seamon M, Yonclas P, Zarzaur B, Stewart R, Bulger E, Nathens AB, Patient Reported Outcome Consortium

Contemporary hemodynamic monitoring, fluid responsiveness, volume optimization, and endpoints of resuscitation: an AAST critical care committee clinical consensus.

Trauma surgery & acute care open

Martin ND, Codner P, Greene W, Brasel K, Michetti C, AAST Critical Care Committee

Lifting the burden: State Medicaid expansion reduces financial risk for the injured.

The journal of trauma and acute care surgery

Scott JW, Shrime MG, Stewart BT, Arbabi S, Bulger EM, Cuschieri J, Maier RV, Robinson BRH

Cell-free nuclear, but not mitochondrial, DNA concentrations correlate with the early host inflammatory response after severe trauma.

Scientific reports

Stortz JA, Hawkins RB, Holden DC, Raymond SL, Wang Z, Brakenridge SC, Cuschieri J, Moore FA, Maier RV, Moldawer LL, Efron PA

Ventilator-associated events, not ventilator-associated pneumonia, is associated with higher mortality in trauma patients.

The journal of trauma and acute care surgery

Meagher AD, Lind M, Senekjian L, Iwuchukwu C, Lynch JB, Cuschieri J, Robinson BRH

Authors Response to Commentary on our Manuscript.

The journal of trauma and acute care surgery

Cook MR, Cuschieri J

Trauma Surgeon and Palliative Care Physician Attitudes Regarding Goals-of-Care Delineation for Injured Geriatric Patients.

The American journal of hospice & palliative care

Cunningham HB, Scielzo SA, Nakonezny PA, Bruns BR, Brasel KJ, Inaba K, Brakenridge SC, Kerby JD, Joseph BA, Mohler MJ, Cuschieri J, Paulk ME, Ekeh AP, Madni TD, Taveras LR, Imran JB, Wolf SE, Phelan HA

Burn Surgeon and Palliative Care Physician Attitudes Regarding Goals of Care Delineation for Burned Geriatric Patients.

Journal of burn care & research : official publication of the American Burn Association

Cunningham HB, Scielzo SA, Nakonezny PA, Bruns BR, Brasel KJ, Inaba K, Brakenridge SC, Kerby JD, Joseph BA, Mohler MJ, Cuschieri J, Paulk ME, Ekeh AP, Madni TD, Taveras LR, Imran JB, Wolf SE, Phelan HA

Decreased Risk of Delirium With Use of Regional Analgesia in Geriatric Trauma Patients With Multiple Rib Fractures.

Annals of surgery

O'Connell KM, Quistberg DA, Tessler R, Robinson BRH, Cuschieri J, Maier RV, Rivara FP, Vavilala MS, Bhalla PI, Arbabi S

Unique Uses of Cooling Strategies.

Therapeutic hypothermia and temperature management

Lyden P, Paul J, Yokobori S, Cuschieri J

Duration of Respiratory Failure After Trauma Is Not Associated With Increased Long-Term Mortality.

Critical care medicine

Cook MR, O'Connell K, Qiu Q, Riggle AJ, Shoultz TH, Maine RG, Arbabi S, O'Keefe GE, Cuschieri J, Maier RV, Robinson BRH

Effect of Standardized Handoff Curriculum on Improved Clinician Preparedness in the Intensive Care Unit: A Stepped-Wedge Cluster Randomized Clinical Trial.

JAMA surgery

Parent B, LaGrone LN, Albirair MT, Serina PT, Keller JM, Cuschieri J, Addison EJ, Choe L, Delossantos GB, Gaskill CE, Moon SD, MacDonald JT, Stolzberg MJ, Van Eaton EG, Zech JM, Kritek PA

Fellowship training in extracorporeal life support: Characterization and educational needs assessment.

Journal of critical care

Cook MR, Badulak J, Çoruh B, Kiraly LN, Zonies D, Cuschieri J, Bulger EM

Short-Course Antimicrobial Therapy Does Not Increase Treatment Failure Rate in Patients with Intra-Abdominal Infection Involving Fungal Organisms.

Surgical infections

Elwood NR, Guidry CA, Duane TM, Cuschieri J, Cook CH, O'Neill PJ, Askari R, Napolitano LM, Namias N, Dellinger EP, Watson CM, Banton KL, Blake DP, Hassinger TE, Sawyer RG

A cohort study of blunt cerebrovascular injury screening in children: Are they just little adults?

The journal of trauma and acute care surgery

Cook MR, Witt CE, Bonow RH, Bulger EM, Linnau KF, Arbabi S, Robinson BRH, Cuschieri J

The Epidemiology of Chronic Critical Illness After Severe Traumatic Injury at Two Level-One Trauma Centers.

Critical care medicine

Mira JC, Cuschieri J, Ozrazgat-Baslanti T, Wang Z, Ghita GL, Loftus TJ, Stortz JA, Raymond SL, Lanz JD, Hennessy LV, Brumback B, Efron PA, Baker HV, Moore FA, Maier RV, Moldawer LL, Brakenridge SC

Novel Method Suggests Global Superiority of Short-Duration Antibiotics for Intra-abdominal Infections.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Celestin AR, Odom SR, Angelidou K, Evans SR, Coimbra R, Guidry CA, Cuschieri J, Banton KL, O'Neill PJ, Askari R, Namias N, Duane TM, Claridge JA, Dellinger EP, Sawyer RA, Cook CH

Does Isolation of Enterococcus Affect Outcomes in Intra-Abdominal Infections?

Surgical infections

Sanders JM, Tessier JM, Sawyer R, Dellinger EP, Miller PR, Namias N, West MA, Cook CH, O'Neill PJ, Napolitano L, Rattan R, Cuschieri J, Claridge JA, Guidry CA, Askari R, Banton K, Rotstein O, Moore BJ, Duane TM

Transcranial Doppler Microemboli Monitoring for Stroke Risk Stratification in Blunt Cerebrovascular Injury.

Critical care medicine

Bonow RH, Witt CE, Mosher BP, Mossa-Basha M, Vavilala MS, Rivara FP, Cuschieri J, Arbabi S, Chesnut RM

Effect of Ganciclovir on IL-6 Levels Among Cytomegalovirus-Seropositive Adults With Critical Illness: A Randomized Clinical Trial.

JAMA

Limaye AP, Stapleton RD, Peng L, Gunn SR, Kimball LE, Hyzy R, Exline MC, Files DC, Morris PE, Frankel SK, Mikkelsen ME, Hite D, Enfield KB, Steingrub J, O'Brien J, Parsons PE, Cuschieri J, Wunderink RG, Hotchkin DL, Chen YQ, Rubenfeld GD, Boeckh M

Validation of a Geriatric Trauma Prognosis Calculator: A P.A.L.Li.A.T.E. Consortium Study.

Journal of the American Geriatrics Society

Cook AC, Joseph B, Mohler MJ, Inaba K, Bruns BR, Nakonezny PA, Kerby JD, Brasel KJ, Wolf SE, Cuschieri J, Paulk ME, Rhodes RL, Brakenridge SC, Ekeh AP, Phelan HA

A comparison of prognosis calculators for geriatric trauma: A Prognostic Assessment of Life and Limitations After Trauma in the Elderly consortium study.

The journal of trauma and acute care surgery

Madni TD, Ekeh AP, Brakenridge SC, Brasel KJ, Joseph B, Inaba K, Bruns BR, Kerby JD, Cuschieri J, Mohler MJ, Nakonezny PA, Clark A, Imran J, Wolf SE, Paulk ME, Rhodes RL, Phelan HA

Longer-Duration Antimicrobial Therapy Does Not Prevent Treatment Failure in High-Risk Patients with Complicated Intra-Abdominal Infections.

Surgical infections

Hassinger TE, Guidry CA, Rotstein OD, Duane TM, Evans HL, Cook CH, O'Neill PJ, Mazuski JE, Askari R, Napolitano LM, Namias N, Miller PR, Dellinger EP, Coimbra R, Cocanour CS, Banton KL, Cuschieri J, Popovsky K, Sawyer RG

Age and Its Impact on Outcomes with Intra-Abdominal Infection.

Surgical infections

Farmer D, Tessier JM, Sanders JM, Sawyer RG, Rotstein OD, Dellinger EP, Lipsett PA, Cuschieri J, Miller P, Cook CH, Guidry CA, Askari R, Moore BJ, Duane TM

Preventing hospital-acquired venous thromboembolism: Improving patient safety with interdisciplinary teamwork, quality improvement analytics, and data transparency.

Journal of hospital medicine

Schleyer AM, Robinson E, Dumitru R, Taylor M, Hayes K, Pergamit R, Beingessner DM, Zaros MC, Cuschieri J

Acute Rehabilitation after Trauma: Does it Really Matter?

Journal of the American College of Surgeons

Nehra D, Nixon ZA, Lengenfelder C, Bulger EM, Cuschieri J, Maier RV, Arbabi S

Patients with Risk Factors for Complications Do Not Require Longer Antimicrobial Therapy for Complicated Intra-Abdominal Infection.

The American surgeon

Rattan R, Allen CJ, Sawyer RG, Mazuski J, Duane TM, Askari R, Banton KL, Claridge JA, Coimbra R, Cuschieri J, Dellinger EP, Evans HL, Guidry CA, Miller PR, O'Neill PJ, Rotstein OD, West MA, Popovsky K, Namias N

Sex-based differences in the genomic response, innate immunity, organ dysfunction, and clinical outcomes after severe blunt traumatic injury and hemorrhagic shock.

The journal of trauma and acute care surgery

Lopez MC, Efron PA, Ozrazgat-Baslanti T, Zhang J, Cuschieri J, Maier RV, Minei JP, Baker HV, Moore FA, Moldawer LL, Brakenridge SC

Inclusion of Vancomycin as Part of Broad-Spectrum Coverage Does Not Improve Outcomes in Patients with Intra-Abdominal Infections: A Post Hoc Analysis.

Surgical infections

Sanders JM, Tessier JM, Sawyer RG, Lipsett PA, Miller PR, Namias N, O'Neill PJ, Dellinger EP, Coimbra R, Guidry CA, Cuschieri J, Banton KL, Cook CH, Moore BJ, Duane TM

Multicenter external validation of the Geriatric Trauma Outcome Score: A study by the Prognostic Assessment of Life and Limitations After Trauma in the Elderly (PALLIATE) consortium.

The journal of trauma and acute care surgery

Cook AC, Joseph B, Inaba K, Nakonezny PA, Bruns BR, Kerby JD, Brasel KJ, Wolf SE, Cuschieri J, Paulk ME, Rhodes RL, Brakenridge SC, Phelan HA

Patients with Complicated Intra-Abdominal Infection Presenting with Sepsis Do Not Require Longer Duration of Antimicrobial Therapy.

Journal of the American College of Surgeons

Rattan R, Allen CJ, Sawyer RG, Askari R, Banton KL, Claridge JA, Cocanour CS, Coimbra R, Cook CH, Cuschieri J, Dellinger EP, Duane TM, Evans HL, Lipsett PA, Mazuski JE, Miller PR, O'Neill PJ, Rotstein OD, Namias N

The Role of Lipopolysaccharide Structure in Monocyte Activation and Cytokine Secretion.

Shock (Augusta, Ga.)

Plevin RE, Knoll M, McKay M, Arbabi S, Cuschieri J

Prehospital Resuscitation of Traumatic Hemorrhagic Shock with Hypertonic Solutions Worsens Hypocoagulation and Hyperfibrinolysis.

Shock (Augusta, Ga.)

Delano MJ, Rizoli SB, Rhind SG, Cuschieri J, Junger W, Baker AJ, Dubick MA, Hoyt DB, Bulger EM

Trial of short-course antimicrobial therapy for intraabdominal infection.

The New England journal of medicine

Sawyer RG, Claridge JA, Nathens AB, Rotstein OD, Duane TM, Evans HL, Cook CH, O'Neill PJ, Mazuski JE, Askari R, Wilson MA, Napolitano LM, Namias N, Miller PR, Dellinger EP, Watson CM, Coimbra R, Dent DL, Lowry SF, Cocanour CS, West MA, Banton KL, Cheadle WG, Lipsett PA, Guidry CA, Popovsky K, STOP-IT Trial Investigators

Pretrauma center red blood cell transfusion is associated with reduced mortality and coagulopathy in severely injured patients with blunt trauma.

Annals of surgery

Brown JB, Cohen MJ, Minei JP, Maier RV, West MA, Billiar TR, Peitzman AB, Moore EE, Cuschieri J, Sperry JL, Inflammation and the Host Response to Injury Investigators

Morbidity and survival probability in burn patients in modern burn care.

Critical care medicine

Jeschke MG, Pinto R, Kraft R, Nathens AB, Finnerty CC, Gamelli RL, Gibran NS, Klein MB, Arnoldo BD, Tompkins RG, Herndon DN, Inflammation and the Host Response to Injury Collaborative Research Program

Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock.

Critical care (London, England)

Vanzant EL, Hilton RE, Lopez CM, Zhang J, Ungaro RF, Gentile LF, Szpila BE, Maier RV, Cuschieri J, Bihorac A, Leeuwenburgh C, Moore FA, Baker HV, Moldawer LL, Brakenridge SC, Efron PA, Inflammation and Host Response to Injury Investigators

Evolving beyond the vicious triad: Differential mediation of traumatic coagulopathy by injury, shock, and resuscitation.

The journal of trauma and acute care surgery

Kutcher ME, Howard BM, Sperry JL, Hubbard AE, Decker AL, Cuschieri J, Minei JP, Moore EE, Brownstein BH, Maier RV, Cohen MJ

Prehospital use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with a reduced incidence of trauma-induced coagulopathy.

Annals of surgery

Neal MD, Brown JB, Moore EE, Cuschieri J, Maier RV, Minei JP, Billiar TR, Peitzman AB, Cohen MJ, Sperry JL, Inflammation and Host Response to Injury Investigators

Pre-hospital aspiration is associated with increased pulmonary complications.

Surgical infections

Fawcett VJ, Warner KJ, Cuschieri J, Copass M, Grabinsky A, Kwok H, Rea T, Evans HL

A better understanding of why murine models of trauma do not recapitulate the human syndrome.

Critical care medicine

Gentile LF, Nacionales DC, Lopez MC, Vanzant E, Cuenca A, Cuenca AG, Ungaro R, Baslanti TO, McKinley BA, Bihorac A, Cuschieri J, Maier RV, Moore FA, Leeuwenburgh C, Baker HV, Moldawer LL, Efron PA

Benchmarking outcomes in the critically injured burn patient.

Annals of surgery

Klein MB, Goverman J, Hayden DL, Fagan SP, McDonald-Smith GP, Alexander AK, Gamelli RL, Gibran NS, Finnerty CC, Jeschke MG, Arnoldo B, Wispelwey B, Mindrinos MN, Xiao W, Honari SE, Mason PH, Schoenfeld DA, Herndon DN, Tompkins RG, Inflammation and Host Response to Injury, and Large-Scale Collaborative Research Program

Delayed topical p38 MAPK inhibition attenuates full-thickness burn wound inflammatory signaling.

Journal of burn care & research : official publication of the American Burn Association

Carter D, Warsen A, Mandell K, Cuschieri J, Maier RV, Arbabi S

Differences in end-of-life care in the ICU across patients cared for by medicine, surgery, neurology, and neurosurgery physicians.

Chest

Kross EK, Engelberg RA, Downey L, Cuschieri J, Hallman MR, Longstreth WT, Tirschwell DL, Curtis JR

Determining a core curriculum in surgical infections for fellowship training in acute care surgery using the Delphi technique.

Surgical infections

May AK, Cuschieri J, Johnson JL, Duane TM, Cherry-Bukowiec JR, Rosengart MR

Upper extremity deep vein thrombosis in hospitalized patients: a descriptive study.

Journal of hospital medicine

Schleyer AM, Jarman KM, Calver P, Cuschieri J, Robinson E, Goss JR

Prehospital hypertonic saline resuscitation attenuates the activation and promotes apoptosis of neutrophils in patients with severe traumatic brain injury.

Shock (Augusta, Ga.)

Junger WG, Rhind SG, Rizoli SB, Cuschieri J, Baker AJ, Shek PN, Hoyt DB, Bulger EM

Determination of burn patient outcome by large-scale quantitative discovery proteomics.

Critical care medicine

Finnerty CC, Jeschke MG, Qian WJ, Kaushal A, Xiao W, Liu T, Gritsenko MA, Moore RJ, Camp DG, Moldawer LL, Elson C, Schoenfeld D, Gamelli R, Gibran N, Klein M, Arnoldo B, Remick D, Smith RD, Davis R, Tompkins RG, Herndon DN, Investigators of the Inflammation and the Host Response Glue Grant

Trauma-associated human neutrophil alterations revealed by comparative proteomics profiling.

Proteomics. Clinical applications

Zhou JY, Krovvidi RK, Gao Y, Gao H, Petritis BO, De AK, Miller-Graziano CL, Bankey PE, Petyuk VA, Nicora CD, Clauss TR, Moore RJ, Shi T, Brown JN, Kaushal A, Xiao W, Davis RW, Maier RV, Tompkins RG, Qian WJ, Camp DG, Smith RD, Inflammation and the Host Response to Injury Large Scale Collaborative Research Program

Comparing clinical predictors of deep venous thrombosis versus pulmonary embolus after severe injury: a new paradigm for posttraumatic venous thromboembolism?

The journal of trauma and acute care surgery

Brakenridge SC, Henley SS, Kashner TM, Golden RM, Paik DH, Phelan HA, Cohen MJ, Sperry JL, Moore EE, Minei JP, Maier RV, Cuschieri J, Inflammation and the Host Response to Injury Investigators

Development of a genomic metric that can be rapidly used to predict clinical outcome in severely injured trauma patients.

Critical care medicine

Cuenca AG, Gentile LF, Lopez MC, Ungaro R, Liu H, Xiao W, Seok J, Mindrinos MN, Ang D, Baslanti TO, Bihorac A, Efron PA, Cuschieri J, Warren HS, Tompkins RG, Maier RV, Baker HV, Moldawer LL, Inflammation and Host Response to Injury Collaborative Research Program

Goal-directed resuscitation in the prehospital setting: a propensity-adjusted analysis.

The journal of trauma and acute care surgery

Brown JB, Cohen MJ, Minei JP, Maier RV, West MA, Billiar TR, Peitzman AB, Moore EE, Cuschieri J, Sperry JL, Inflammation and the Host Response to Injury Investigators

Genomic responses in mouse models poorly mimic human inflammatory diseases.

Proceedings of the National Academy of Sciences of the United States of America

Seok J, Warren HS, Cuenca AG, Mindrinos MN, Baker HV, Xu W, Richards DR, McDonald-Smith GP, Gao H, Hennessy L, Finnerty CC, López CM, Honari S, Moore EE, Minei JP, Cuschieri J, Bankey PE, Johnson JL, Sperry J, Nathens AB, Billiar TR, West MA, Jeschke MG, Klein MB, Gamelli RL, Gibran NS, Brownstein BH, Miller-Graziano C, Calvano SE, Mason PH, Cobb JP, Rahme LG, Lowry SF, Maier RV, Moldawer LL, Herndon DN, Davis RW, Xiao W, Tompkins RG, Inflammation and Host Response to Injury, Large Scale Collaborative Research Program

Antiplatelet therapy is associated with decreased transfusion-associated risk of lung dysfunction, multiple organ failure, and mortality in trauma patients.

Critical care medicine

Harr JN, Moore EE, Johnson J, Chin TL, Wohlauer MV, Maier R, Cuschieri J, Sperry J, Banerjee A, Silliman CC, Sauaia A

Characterization of acute coagulopathy and sexual dimorphism after injury: females and coagulopathy just do not mix.

The journal of trauma and acute care surgery

Brown JB, Cohen MJ, Minei JP, Maier RV, West MA, Billiar TR, Peitzman AB, Moore EE, Cuschieri J, Sperry JL, Inflammation and the Host Response to Injury Investigators

Who should we feed? Western Trauma Association multi-institutional study of enteral nutrition in the open abdomen after injury.

The journal of trauma and acute care surgery

Burlew CC, Moore EE, Cuschieri J, Jurkovich GJ, Codner P, Nirula R, Millar D, Cohen MJ, Kutcher ME, Haan J, MacNew HG, Ochsner G, Rowell SE, Truitt MS, Moore FO, Pieracci FM, Kaups KL, WTA Study Group

Resuscitation of traumatic hemorrhagic shock patients with hypertonic saline-without dextran-inhibits neutrophil and endothelial cell activation.

Shock (Augusta, Ga.)

Junger WG, Rhind SG, Rizoli SB, Cuschieri J, Shiu MY, Baker AJ, Li L, Shek PN, Hoyt DB, Bulger EM

Acute respiratory distress syndrome after trauma: development and validation of a predictive model.

Critical care medicine

Watkins TR, Nathens AB, Cooke CR, Psaty BM, Maier RV, Cuschieri J, Rubenfeld GD

Hypothermia in massive transfusion: have we been paying enough attention to it?

The journal of trauma and acute care surgery

Reynolds BR, Forsythe RM, Harbrecht BG, Cuschieri J, Minei JP, Maier RV, Moore EE, Billiar EE, Peitzman AB, Sperry JL, Inflammation and Host Response to Injury Investigators

The role and value of surgical critical care, an essential component of Acute Care Surgery, in the Affordable Care Act: a report from the Critical Care Committee and Board of Managers of the American Association for the Surgery of Trauma.

The journal of trauma and acute care surgery

Frankel HL, Butler KL, Cuschieri J, Friese RS, Huynh T, Mohr AM, Schinco MA, Napolitano LM, Britt LD, Coimbra R, Croce MA, Davis JW, Jurkovich GJ, Moore EE, Morris JA, Peitzman AB, Pruitt BA, Rozycki GS, Scalea TM, Meredith JW

Active surveillance cultures of methicillin-resistant Staphylococcus aureus as a tool to predict methicillin-resistant S. aureus ventilator-associated pneumonia.

Critical care medicine

Chan JD, Dellit TH, Choudhuri JA, McNamara E, Melius EJ, Evans HL, Cuschieri J, Arbabi S, Lynch JB

Benchmarking outcomes in the critically injured trauma patient and the effect of implementing standard operating procedures.

Annals of surgery

Cuschieri J, Johnson JL, Sperry J, West MA, Moore EE, Minei JP, Bankey PE, Nathens AB, Cuenca AG, Efron PA, Hennessy L, Xiao W, Mindrinos MN, McDonald-Smith GP, Mason PH, Billiar TR, Schoenfeld DA, Warren HS, Cobb JP, Moldawer LL, Davis RW, Maier RV, Tompkins RG, Inflammation and Host Response to Injury, Large Scale Collaborative Research Program

Ventilator-associated pneumonia rates at major trauma centers compared with a national benchmark: a multi-institutional study of the AAST.

The journal of trauma and acute care surgery

Michetti CP, Fakhry SM, Ferguson PL, Cook A, Moore FO, Gross R, AAST Ventilator-Associated Pneumonia Investigators

Crystalloid to packed red blood cell transfusion ratio in the massively transfused patient: when a little goes a long way.

The journal of trauma and acute care surgery

Neal MD, Hoffman MK, Cuschieri J, Minei JP, Maier RV, Harbrecht BG, Billiar TR, Peitzman AB, Moore EE, Cohen MJ, Sperry JL

The changing pattern and implications of multiple organ failure after blunt injury with hemorrhagic shock.

Critical care medicine

Minei JP, Cuschieri J, Sperry J, Moore EE, West MA, Harbrecht BG, O'Keefe GE, Cohen MJ, Moldawer LL, Tompkins RG, Maier RV, Inflammation and the Host Response to Injury Collaborative Research Program

Obese patients show a depressed cytokine profile following severe blunt injury.

Shock (Augusta, Ga.)

Winfield RD, Delano MJ, Cuenca AG, Cendan JC, Lottenberg L, Efron PA, Maier RV, Remick DG, Moldawer LL, Cuschieri J

Ventilator-associated pneumonia: bacteremia and death after traumatic injury.

The journal of trauma and acute care surgery

O'Keefe GE, Caldwell E, Cuschieri J, Wurfel MM, Evans HL

Changes in massive transfusion over time: an early shift in the right direction?

The journal of trauma and acute care surgery

Kautza BC, Cohen MJ, Cuschieri J, Minei JP, Brackenridge SC, Maier RV, Harbrecht BG, Moore EE, Billiar TR, Peitzman AB, Sperry JL, Inflammation and the Host Response to Injury Investigators

A genomic storm in critically injured humans.

The Journal of experimental medicine

Xiao W, Mindrinos MN, Seok J, Cuschieri J, Cuenca AG, Gao H, Hayden DL, Hennessy L, Moore EE, Minei JP, Bankey PE, Johnson JL, Sperry J, Nathens AB, Billiar TR, West MA, Brownstein BH, Mason PH, Baker HV, Finnerty CC, Jeschke MG, López MC, Klein MB, Gamelli RL, Gibran NS, Arnoldo B, Xu W, Zhang Y, Calvano SE, McDonald-Smith GP, Schoenfeld DA, Storey JD, Cobb JP, Warren HS, Moldawer LL, Herndon DN, Lowry SF, Maier RV, Davis RW, Tompkins RG, Inflammation and Host Response to Injury Large-Scale Collaborative Research Program

Increased neutrophil adenosine a3 receptor expression is associated with hemorrhagic shock and injury severity in trauma patients.

Shock (Augusta, Ga.)

Bulger EM, Tower CM, Warner KJ, Garland T, Cuschieri J, Rizoli S, Rhind S, Junger WG

Pre-hospital intubation factors and pneumonia in trauma patients.

Surgical infections

Evans HL, Warner K, Bulger EM, Sharar SR, Maier RV, Cuschieri J

Dissecting inflammatory complications in critically injured patients by within-patient gene expression changes: a longitudinal clinical genomics study.

PLoS medicine

Desai KH, Tan CS, Leek JT, Maier RV, Tompkins RG, Storey JD, Inflammation and the Host Response to Injury Large-Scale Collaborative Research Program

The Glue Grant experience: characterizing the post injury genomic response.

European journal of trauma and emergency surgery : official publication of the European Trauma Society

Cuenca AG, Maier RV, Cuschieri J, Moore EE, Moldawer LL, Tompkins RG, Inflammation and Host Response to Injury, Large Scale Collaborative Research Program

Early blood product and crystalloid volume resuscitation: risk association with multiple organ dysfunction after severe blunt traumatic injury.

The Journal of trauma

Brakenridge SC, Phelan HA, Henley SS, Golden RM, Kashner TM, Eastman AE, Sperry JL, Harbrecht BG, Moore EE, Cuschieri J, Maier RV, Minei JP, Inflammation and the Host Response to Injury Investigators

Clinical outcomes of linezolid vs vancomycin in methicillin-resistant Staphylococcus aureus ventilator-associated pneumonia: retrospective analysis.

Journal of intensive care medicine

Chan JD, Pham TN, Wong J, Hessel M, Cuschieri J, Neff M, Dellit TH

Human transcriptome array for high-throughput clinical studies.

Proceedings of the National Academy of Sciences of the United States of America

Xu W, Seok J, Mindrinos MN, Schweitzer AC, Jiang H, Wilhelmy J, Clark TA, Kapur K, Xing Y, Faham M, Storey JD, Moldawer LL, Maier RV, Tompkins RG, Wong WH, Davis RW, Xiao W, Inflammation and Host Response to Injury Large-Scale Collaborative Research Program

Body adipose content is independently associated with a higher risk of organ failure and nosocomial infection in the nonobese patient postinjury.

The Journal of trauma

Edmonds RD, Cuschieri J, Minei JP, Rosengart MR, Maier RV, Harbrecht BG, Billiar TR, Peitzman AB, Moore EE, Sperry JL, Inflammation the Host Response to Injury Investigators

Sew it up! A Western Trauma Association multi-institutional study of enteric injury management in the postinjury open abdomen.

The Journal of trauma

Burlew CC, Moore EE, Cuschieri J, Jurkovich GJ, Codner P, Crowell K, Nirula R, Haan J, Rowell SE, Kato CM, MacNew H, Ochsner MG, Harrison PB, Fusco C, Sauaia A, Kaups KL, WTA Study Group

The association between the transfusion of older blood and outcomes after trauma.

Shock (Augusta, Ga.)

Hassan M, Pham TN, Cuschieri J, Warner KJ, Nester T, Maier RV, Shalhub S, O'Keefe GE

Identification and interpretation of longitudinal gene expression changes in trauma.

PloS one

Rajicic N, Cuschieri J, Finkelstein DM, Miller-Graziano CL, Hayden D, Moldawer LL, Moore E, O'Keefe G, Pelik K, Warren HS, Schoenfeld DA, Inflammation and the Host Response to Injury Large Scale Collaborative Research Program

Timing of intubation and ventilator-associated pneumonia following injury.

Archives of surgery (Chicago, Ill. : 1960)

Evans HL, Zonies DH, Warner KJ, Bulger EM, Sharar SR, Maier RV, Cuschieri J

Early elevation in random plasma IL-6 after severe injury is associated with development of organ failure.

Shock (Augusta, Ga.)

Cuschieri J, Bulger E, Schaeffer V, Sakr S, Nathens AB, Hennessy L, Minei J, Moore EE, O'Keefe G, Sperry J, Remick D, Tompkins R, Maier RV, Inflammation and the Host Response to Injury Collaborative Research Program

Plasma proteome response to severe burn injury revealed by 18O-labeled "universal" reference-based quantitative proteomics.

Journal of proteome research

Qian WJ, Petritis BO, Kaushal A, Finnerty CC, Jeschke MG, Monroe ME, Moore RJ, Schepmoes AA, Xiao W, Moldawer LL, Davis RW, Tompkins RG, Herndon DN, Camp DG, Smith RD, Inflammation and the Host Response to Injury Large Scale Collaborative Research Program

Clinical microfluidics for neutrophil genomics and proteomics.

Nature medicine

Kotz KT, Xiao W, Miller-Graziano C, Qian WJ, Russom A, Warner EA, Moldawer LL, De A, Bankey PE, Petritis BO, Camp DG, Rosenbach AE, Goverman J, Fagan SP, Brownstein BH, Irimia D, Xu W, Wilhelmy J, Mindrinos MN, Smith RD, Davis RW, Tompkins RG, Toner M, Inflammation and the Host Response to Injury Collaborative Research Program

Role of the mTOR pathway in LPS-activated monocytes: influence of hypertonic saline.

The Journal of surgical research

Schaeffer V, Arbabi S, Garcia IA, Knoll ML, Cuschieri J, Bulger EM, Maier RV

Analysis of factorial time-course microarrays with application to a clinical study of burn injury.

Proceedings of the National Academy of Sciences of the United States of America

Zhou B, Xu W, Herndon D, Tompkins R, Davis R, Xiao W, Wong WH, Inflammation and Host Response to Injury Program, Toner M, Warren HS, Schoenfeld DA, Rahme L, McDonald-Smith GP, Hayden D, Mason P, Fagan S, Yu YM, Cobb JP, Remick DG, Mannick JA, Lederer JA, Gamelli RL, Silver GM, West MA, Shapiro MB, Smith R, Camp DG, Qian W, Storey J, Mindrinos M, Tibshirani R, Lowry S, Calvano S, Chaudry I, West MA, Cohen M, Moore EE, Johnson J, Moldawer LL, Baker HV, Efron PA, Balis UG, Billiar TR, Ochoa JB, Sperry JL, Miller-Graziano CL, De AK, Bankey PE, Finnerty CC, Jeschke MG, Minei JP, Arnoldo BD, Hunt JL, Horton J, Cobb JP, Brownstein B, Freeman B, Maier RV, Nathens AB, Cuschieri J, Gibran N, Klein M, O'Keefe G

Effect of chlorhexidine whole-body bathing on hospital-acquired infections among trauma patients.

Archives of surgery (Chicago, Ill. : 1960)

Evans HL, Dellit TH, Chan J, Nathens AB, Maier RV, Cuschieri J

Traditional resuscitative practices fail to resolve metabolic acidosis in morbidly obese patients after severe blunt trauma.

The Journal of trauma

Winfield RD, Delano MJ, Lottenberg L, Cendan JC, Moldawer LL, Maier RV, Cuschieri J

Differences in outcome between obese and nonobese patients following severe blunt trauma are not consistent with an early inflammatory genomic response.

Critical care medicine

Winfield RD, Delano MJ, Dixon DJ, Schierding WS, Cendan JC, Lottenberg L, Lopez MC, Baker HV, Cobb JP, Moldawer LL, Maier RV, Cuschieri J

Oxidant alterations in CD16 expression are cytoskeletal induced.

Shock (Augusta, Ga.)

Cuschieri J, Sakr S, Bulger E, Knoll M, Arbabi S, Maier RV

Validation of the riboleukogram to detect ventilator-associated pneumonia after severe injury.

Annals of surgery

Cobb JP, Moore EE, Hayden DL, Minei JP, Cuschieri J, Yang J, Li Q, Lin N, Brownstein BH, Hennessy L, Mason PH, Schierding WS, Dixon DJ, Tompkins RG, Warren HS, Schoenfeld DA, Maier RV

Analysis of the relationship between longitudinal gene expressions and ordered categorical event data.

Statistics in medicine

Rajicic N, Finkelstein DM, Schoenfeld DA, Inflammation and Host Response to Injury Research Program Investigators

Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndrome.

The Journal of trauma

Watson GA, Sperry JL, Rosengart MR, Minei JP, Harbrecht BG, Moore EE, Cuschieri J, Maier RV, Billiar TR, Peitzman AB, Inflammation and Host Response to Injury Investigators

Inflammation and the host response to injury, a Large-Scale Collaborative Project: patient-oriented research core standard operating procedures for clinical care IX. Definitions for complications of clinical care of critically injured patients.

The Journal of trauma

Evans HL, Cuschieri J, Moore EE, Shapiro MB, Nathens AB, Johnson JL, Harbrecht BG, Minei JP, Bankey PE, Maier RV, West MA, Inflammation and Host Response to Injury Investigators

Single-dose etomidate for rapid sequence intubation may impact outcome after severe injury.

The Journal of trauma

Warner KJ, Cuschieri J, Jurkovich GJ, Bulger EM

Assessing statistical significance in microarray experiments using the distance between microarrays.

PloS one

Hayden D, Lazar P, Schoenfeld D, Inflammation and the Host Response to Injury Investigators

A genomic score prognostic of outcome in trauma patients.

Molecular medicine (Cambridge, Mass.)

Warren HS, Elson CM, Hayden DL, Schoenfeld DA, Cobb JP, Maier RV, Moldawer LL, Moore EE, Harbrecht BG, Pelak K, Cuschieri J, Herndon DN, Jeschke MG, Finnerty CC, Brownstein BH, Hennessy L, Mason PH, Tompkins RG, Inflammation and Host Response to Injury Large Scale Collaborative Research Program

Characterization of persistent hyperglycemia: what does it mean postinjury?

The Journal of trauma

Sperry JL, Frankel HL, Nathens AB, O'keefe GE, Cuschieri J, Moore EE, Maier RV, Minei JP, Inflammation and the Host Response to Injury Investigators

Assessment of functional limitation after necrotizing soft tissue infection.

Journal of burn care & research : official publication of the American Burn Association

Pham TN, Moore ML, Costa BA, Cuschieri J, Klein MB

The utility of early end-tidal capnography in monitoring ventilation status after severe injury.

The Journal of trauma

Warner KJ, Cuschieri J, Garland B, Carlbom D, Baker D, Copass MK, Jurkovich GJ, Bulger EM

The evolution of the diagnostic work-up for stab wounds to the back and flank.

Injury

Pham TN, Heinberg E, Cuschieri J, Bulger EM, O'Keefe GE, Gross JA, Jurkovich GJ

Inflammation and the host response to injury, a large-scale collaborative project: patient-oriented research core--standard operating procedures for clinical care VII--Guidelines for antibiotic administration in severely injured patients.

The Journal of trauma

West MA, Moore EE, Shapiro MB, Nathens AB, Cuschieri J, Johnson JL, Harbrecht BG, Minei JP, Bankey PE, Maier RV, Inflammation and the Host Response to Injury Collaborative Research Program

Inflammation and the host response to injury, a large-scale collaborative project: patient-oriented research core--standard operating procedures for clinical care VIII--Nutritional support of the trauma patient.

The Journal of trauma

O'Keefe GE, Shelton M, Cuschieri J, Moore EE, Lowry SF, Harbrecht BG, Maier RV, Inflammation and the Host Response to Injury Collaborative Research Program

Necrotizing soft tissue infection.

Surgical infections

Cuschieri J

An FFP:PRBC transfusion ratio >/=1:1.5 is associated with a lower risk of mortality after massive transfusion.

The Journal of trauma

Sperry JL, Ochoa JB, Gunn SR, Alarcon LH, Minei JP, Cuschieri J, Rosengart MR, Maier RV, Billiar TR, Peitzman AB, Moore EE, Inflammation the Host Response to Injury Investigators

Inflammation and the host response to injury a large-scale collaborative project: patient-oriented research core standard operating procedure for clinical care X. Guidelines for venous thromboembolism prophylaxis in the trauma patient.

The Journal of trauma

Cuschieri J, Freeman B, O'Keefe G, Harbrecht BG, Bankey P, Johnson JL, Minei JP, Sperry J, West M, Nathens A, Moore EE, Maier RV, Inflammation and the Host Response to Injury Collaborative Research Program

Negative appendectomy and imaging accuracy in the Washington State Surgical Care and Outcomes Assessment Program.

Annals of surgery

SCOAP Collaborative, Cuschieri J, Florence M, Flum DR, Jurkovich GJ, Lin P, Steele SR, Symons RG, Thirlby R

Effect of immediate enteral feeding on trauma patients with an open abdomen: protection from nosocomial infections.

Journal of the American College of Surgeons

Dissanaike S, Pham T, Shalhub S, Warner K, Hennessy L, Moore EE, Maier RV, O'Keefe GE, Cuschieri J

Early supplemental parenteral nutrition is associated with increased infectious complications in critically ill trauma patients.

Journal of the American College of Surgeons

Sena MJ, Utter GH, Cuschieri J, Maier RV, Tompkins RG, Harbrecht BG, Moore EE, O'Keefe GE

Male gender is associated with excessive IL-6 expression following severe injury.

The Journal of trauma

Sperry JL, Friese RS, Frankel HL, West MA, Cuschieri J, Moore EE, Harbrecht BG, Peitzman AB, Billiar TR, Maier RV, Remick DG, Minei JP, Inflammation and the Host Response to Injury Investigators

Emergency department ventilation effects outcome in severe traumatic brain injury.

The Journal of trauma

Warner KJ, Cuschieri J, Copass MK, Jurkovich GJ, Bulger EM

Insulin regulates macrophage activation through activin A.

Shock (Augusta, Ga.)

Cuschieri J, Bulger E, Grinsell R, Garcia I, Maier RV

Mechanistic analysis of macrophage response to IRAK-1 gene knockdown by a smart polymer-antisense oligonucleotide therapeutic.

Journal of biomaterials science. Polymer edition

Johns RE, El-Sayed ME, Bulmus V, Cuschieri J, Maier R, Hoffman AS, Stayton PS

Inflammation and the host response to injury, a large-scale collaborative project: patient-oriented research core-standard operating procedures for clinical care: VI. Blood glucose control in the critically ill trauma patient.

The Journal of trauma

Harbrecht BG, Minei JP, Shapiro MB, Nathens AB, Moore EE, West MA, Bankey PE, Cuschieri J, Johnson JL, Maier RV, Inflammation and the Host Response to Injury Scale Collaborative Research Project

Oxidative stress, lipid rafts, and macrophage reprogramming.

Antioxidants & redox signaling

Cuschieri J, Maier RV

The impact of prehospital ventilation on outcome after severe traumatic brain injury.

The Journal of trauma

Warner KJ, Cuschieri J, Copass MK, Jurkovich GJ, Bulger EM

The priming effect of C5a on monocytes is predominantly mediated by the p38 MAPK pathway.

Shock (Augusta, Ga.)

Schaeffer V, Cuschieri J, Garcia I, Knoll M, Billgren J, Jelacic S, Bulger E, Maier R

The practice of venous thromboembolism prophylaxis in the major trauma patient.

The Journal of trauma

Nathens AB, McMurray MK, Cuschieri J, Durr EA, Moore EE, Bankey PE, Freeman B, Harbrecht BG, Johnson JL, Minei JP, McKinley BA, Moore FA, Shapiro MB, West MA, Tompkins RG, Maier RV

Acid sphingomyelinase is required for lipid Raft TLR4 complex formation.

Surgical infections

Cuschieri J, Bulger E, Billgrin J, Garcia I, Maier RV

Vitamin E inhibits endotoxin-mediated transport of phosphatases to lipid rafts.

Shock (Augusta, Ga.)

Cuschieri J, Bulger E, Biligren J, Garcia I, Maier RV

Surgical management of acute necrotizing lung infections.

Canadian respiratory journal

Reimel BA, Krishnadasen B, Cuschieri J, Klein MB, Gross J, Karmy-Jones R

Mitogen-activated protein kinase (MAPK).

Critical care medicine

Cuschieri J, Maier RV

Accidental self-inflicted nail gun injury to the heart

Injury Extra

Pritts TA
Knight D
Davis BR
Promebka D
Cuschieri J

Central venous-arterial carbon dioxide difference as an indicator of cardiac index.

Intensive care medicine

Cuschieri J, Rivers EP, Donnino MW, Katilius M, Jacobsen G, Nguyen HB, Pamukov N, Horst HM

Calcium/calmodulin-dependent kinase II is required for platelet-activating factor priming.

Shock (Augusta, Ga.)

Cuschieri J, Bulger E, Garcia I, Jelacic S, Maier RV

The role of repeat angiography in the management of pelvic fractures.

The Journal of trauma

Shapiro M, McDonald AA, Knight D, Johannigman JA, Cuschieri J

PKC-zeta is essential for endotoxin-induced macrophage activation.

The Journal of surgical research

Cuschieri J, Umanskiy K, Solomkin J

Implications of proteasome inhibition: an enhanced macrophage phenotype.

Cellular immunology

Cuschieri J, Gourlay D, Garcia I, Jelacic S, Maier RV

Modulation of macrophage responsiveness to lipopolysaccharide by IRAK-1 manipulation.

Shock (Augusta, Ga.)

Cuschieri J, Bulmus V, Gourlay D, Garcia I, Hoffman A, Stayton P, Maier RV

Modulation of endotoxin-induced endothelial function by calcium/calmodulin-dependent protein kinase.

Shock (Augusta, Ga.)

Cuschieri J, Gourlay D, Garcia I, Jelacic S, Maier RV

NADPH oxidase activation in fibronectin adherent human neutrophils: A potential role for beta1 integrin ligation.

Surgery

Umanskiy K, Robinson C, Cave C, Williams MA, Lentsch AB, Cuschieri J, Solomkin JS

Platelet-activating factor acetylhydrolase inhibits alveolar macrophage activation in vivo.

Shock (Augusta, Ga.)

Bulger EM, Gourlay D, Cuschieri J, Jelacic S, Staudenmeyer K, Garcia I, Maier RV

Modulation of endotoxin-induced endothelial activity by microtubule depolymerization.

The Journal of trauma

Cuschieri J, Gourlay D, Garcia I, Jelacic S, Maier RV

Stress-Induced Endothelial Cell Proinflammatory Phenotypic Differentiation Requires Stress Fiber Polymerization

Shock. 2003:19(5):433-439.

Cuschieri J, Gourlay D, Garcia I, Jelacic S, Maier RV.

Accidental self-inflicted nail gun injury to the heart

Injury Extra

Pritts TA, Knight D, Davis BR, Promebka D, Cuschieri J

Platelet-activating factor priming of inflammatory cell activity requires cellular adherence.

Surgery

Cuschieri J, Gourlay D, Bulger E, Garcia I, Jelacic S, Maier RV

Slow channel calcium inhibition blocks proinflammatory gene signaling and reduces macrophage responsiveness.

The Journal of trauma

Cuschieri J, Gourlay D, Garcia I, Jelacic S, Maier RV

Hypertonic preconditioning inhibits macrophage responsiveness to endotoxin.

Journal of immunology (Baltimore, Md. : 1950)

Cuschieri J, Gourlay D, Garcia I, Jelacic S, Maier RV

Role of bronchoscopy in massive hemoptysis.

Chest surgery clinics of North America

Karmy-Jones R, Cuschieri J, Vallières E

Endotoxin Tolerance in Endothelial Cells is Reversed by Phosphatase Inhibition

Surgical Forum, Vol LII

Cuschieri J, Gourlay D, Garcia I, Jelacic S, Maier RV.

Clearing the cervical spine in victims of blunt assault to the head and neck: what is necessary?

The American surgeon

Patton JH, Kralovich KA, Cuschieri J, Gasparri M

Anterior mediastinal abscess after closed sternal fracture.

The Journal of trauma

Cuschieri J, Kralovich KA, Patton JH, Horst HM, Obeid FN, Karmy-Jones R

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