Michael Kattah, MD, PhD

Assistant Professor
Medicine
+1 415 502-4444
Kattah Lab

As an Assistant Professor in the Division of GI at UCSF, I am interested in the molecular underpinnings of intestinal inflammation and Inflammatory Bowel Disease (IBD). We employ a variety of tools to study intestinal epithelial cells and death signaling pathways in mouse models, patient-derived biopsies, and organoids.

Publications: 

Single-cell spatial transcriptomics of fixed, paraffin-embedded biopsies reveals colitis-associated cell networks.

bioRxiv : the preprint server for biology

Mennillo E, Lotstein ML, Lee G, Johri V, Ekstrand C, Tsui J, Hou J, Leet DE, He JY, Mahadevan U, Eckalbar W, Oh DY, Fragiadakis GK, Kattah MG, Combes AJ

Symptomatic and Sonographic Improvement of Immune Checkpoint Inhibitor Enterocolitis With Risankizumab.

Inflammatory bowel diseases

Mei R, Pepe E, Oh DY, Tsai KK, Chugh R, Kattah MG

Tu1756 TWO SPATIAL TRANSCRIPTOMIC PLATFORMS IDENTIFIED POTENTIAL PATHWAYS LINKED TO VEDOLIZUMAB RESPONSIVENESS IN ULCERATIVE COLITIS.

Gastroenterology

Elvira Mennillo, Gyehyun Lee, Madison Lotstein, Jessica Tsui, Uma Mahadevan, Gabriela K. Fragiadakis, Alexis Combes, Michael Kattah

Dysregulation of CD4+ and CD8+ resident memory T, myeloid, and stromal cells in steroid-experienced, checkpoint inhibitor colitis.

Journal for immunotherapy of cancer

He JY, Kim YJ, Mennillo E, Rusu I, Bain J, Rao AA, Andersen C, Law K, Yang H, Tsui J, Shen A, Davidson B, Kushnoor D, Shi Y, Fan F, Cheung A, Zhang L, Fong L, Combes AJ, Pisco AO, Kattah MG, Oh DY

Single-cell and spatial multi-omics highlight effects of anti-integrin therapy across cellular compartments in ulcerative colitis.

Nature communications

Mennillo E, Kim YJ, Lee G, Rusu I, Patel RK, Dorman LC, Flynn E, Li S, Bain JL, Andersen C, Rao A, Tamaki S, Tsui J, Shen A, Lotstein ML, Rahim M, Naser M, Bernard-Vazquez F, Eckalbar W, Cho SJ, Beck K, El-Nachef N, Lewin S, Selvig DR, Terdiman JP, Mahadevan U, Oh DY, Fragiadakis GK, Pisco A, Combes AJ, Kattah MG

VEDOLIZUMAB RESPONSE AND NON-RESPONSE IN ULCERATIVE COLITIS: INSIGHTS FROM SPATIAL TRANSCRIPTOMICS.

Gastroenterology

Elvira Mennillo, Gyehyun Lee, Madison Lotstein, Jessica Tsui, Uma Mahadevan, Gabriela Fragiadakis, Alexis Combes, Michael Kattah

VEDOLIZUMAB RESPONSE AND NON-RESPONSE IN ULCERATIVE COLITIS: INSIGHTS FROM SPATIAL TRANSCRIPTOMICS.

Inflammatory bowel diseases

Elvira Mennillo, Gyehyun Lee, Madison Lotstein, Jessica Tsui, Uma Mahadevan, Gabriela Fragiadakis, Alexis Combes, Michael Kattah

Single-cell and spatial multi-omics identify innate and stromal modules targeted by anti-integrin therapy in ulcerative colitis.

bioRxiv : the preprint server for biology

Mennillo E, Kim YJ, Rusu I, Lee G, Dorman LC, Bernard-Vazquez F, Bain JL, Patel R, Andersen C, Rao A, Tamaki S, Tsui J, Shen A, Naser M, Eckalbar W, Cho SJ, Beck K, El-Nachef N, Lewin S, Selvig DR, Terdiman JP, Mahadevan U, Oh DY, Fragiadakis GK, Pisco A, Combes AJ, Kattah MG

630 SINGLE-CELL AND SPATIAL MULTI-OMICS IDENTIFY INNATE AND STROMAL MODULES TARGETED BY ANTI-INTEGRIN THERAPY IN ULCERATIVE COLITIS.

Gastroenterology

Elvira Mennillo, Yang Joon Kim, Iulia Rusu, Gyehyun Lee, Leah Dorman, Faviola Bernard-Vazquez, Jared Bain, Ravi K. Patel, Christopher Andersen, Stanley Tamaki, Jessica Tsui, Kendall Beck, Najwa El-Nachef, Sara M. Lewin, Daniel Selvig, Jonathan P. Terdiman, Uma Mahadevan, David Oh, Gabriela K. Fragiadakis, Angela O. Pisco, Alexis Combes, Michael Kattah

A20 Restricts NOS2 Expression and Intestinal Tumorigenesis in a Mouse Model of Colitis-Associated Cancer.

Gastro Hep Advances

Basta DW, Vong M, Beshimova A, Nakamura BN, Rusu I, Kattah MG, Shao L

Vedolizumab Antagonizes MAdCAM-1-Dependent Human Placental Cytotrophoblast Adhesion and Invasion In Vitro.

Inflammatory bowel diseases

Blaisdell A, Zhou Y, Kattah MG, Fisher SJ, Mahadevan U

Intestinal inflammation alters the antigen-specific immune response to a skin commensal.

Cell reports

Merana GR, Dwyer LR, Dhariwala MO, Weckel A, Gonzalez JR, Okoro JN, Cohen JN, Tamaki CM, Han J, Tasoff P, Palacios-Calderon Y, Ha CWY, Lynch SV, Segre JA, Kong HH, Kattah MG, Ma A, Scharschmidt TC

Tu1517: MICROBIAL SIGNALS, MYD88, AND LYMPHOTOXIN DRIVE TNFINDEPENDENT DEATH OF A20 AND ABIN-1 DEFICIENT EPITHELIUM.

Gastroenterology

Iulia Rusu, Elvira Mennillo, Jared L. Bain, Zhongmei Li, Xiaofei Sun, Kimberly Ly, Yenny Y. Rosli, Mohammad Naser, Zunqiu Wang, Rommel Advincula, Philip Achacoso, Ling Shao, Bahram Razani, Ophir D. Klein, Alexander Marson, Jessie A. Turnbaugh, Peter J. Turnbaugh, Barbara Malynn, Averil Ma, Michael Kattah

Microbial signals, MyD88, and lymphotoxin drive TNF-independent intestinal epithelial tissue damage.

The Journal of clinical investigation

Rusu I, Mennillo E, Bain JL, Li Z, Sun X, Ly KM, Rosli YY, Naser M, Wang Z, Advincula R, Achacoso P, Shao L, Razani B, Klein OD, Marson A, Turnbaugh JA, Turnbaugh PJ, Malynn BA, Ma A, Kattah MG

Importance of Not MSing Cerebral White Matter Disease in Patients with Inflammatory Bowel Disease.

Digestive diseases and sciences

Regner EH, Green AJ, Bain JL, Kattah MG, Mahadevan U

A20 in dendritic cells restrains intestinal anti-bacterial peptide expression and preserves commensal homeostasis.

PloS one

Talpin A, Kattah MG, Advincula R, Fadrosh D, Lynch K, LaMere B, Fujimura KE, Nagalingam NA, Malynn BA, Lynch SV, Ma A

Balancing the Checkpoint: Managing Colitis Associated with Dual Checkpoint Inhibitors and High-Dose Aspirin.

Digestive diseases and sciences

Hammami MB, Gill R, Thiruvengadam N, Oh DY, Beck K, Mahadevan U, Kattah MG

Correction: Anti-TNF and thiopurine therapy in pregnant IBD patients does not significantly alter a panel of B-cell and T-cell subsets in 1-year-old infants.

Clinical and translational gastroenterology

Kattah MG, Milush JM, Burt T, McCabe RP, Whang MI, Ma A, Mahadevan U

A20 and ABIN-1 synergistically preserve intestinal epithelial cell survival.

The Journal of experimental medicine

Kattah MG, Shao L, Rosli YY, Shimizu H, Whang MI, Advincula R, Achacoso P, Shah S, Duong BH, Onizawa M, Tanbun P, Malynn BA, Ma A

Effect of I-scan Electronic Chromoendoscopy on Detection of Adenomas During Colonoscopy.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Kidambi TD, Terdiman JP, El-Nachef N, Singh A, Kattah MG, Lee JK

A20 regulates canonical wnt-signaling through an interaction with RIPK4.

PloS one

Nakamura BN, Glazier A, Kattah MG, Duong B, Jia Y, Campo D, Shao L

Anti-TNF and thiopurine therapy in pregnant IBD patients does not significantly alter a panel of B-cell and T-cell subsets in 1-year-old infants.

Clinical and translational gastroenterology

Kattah MG, Milush JM, Burt T, McCabe RP, Whang MI, Ma A, Mahadevan U

A20 upregulation during treated HIV disease is associated with intestinal epithelial cell recovery and function.

PLoS pathogens

Chitre AS, Kattah MG, Rosli YY, Pao M, Deswal M, Deeks SG, Hunt PW, Abdel-Mohsen M, Montaner LJ, Kim CC, Ma A, Somsouk M, McCune JM

Ubiquitin-Modifying Enzymes and Regulation of the Inflammasome.

Journal of molecular biology

Kattah MG, Malynn BA, Ma A

The Ubiquitin Binding Protein TAX1BP1 Mediates Autophagasome Induction and the Metabolic Transition of Activated T Cells.

Immunity

Whang MI, Tavares RM, Benjamin DI, Kattah MG, Advincula R, Nomura DK, Debnath J, Malynn BA, Ma A

P-285 A20 and ABIN-1 Cooperate to Preserve Intestinal Epithelial Homeostasis.

Inflammatory bowel diseases

Michael Kattah, Ling Shao, Yenny Rosli, Michael Whang, Rommel Advincula, Barbara Malynn, Averil Ma

Effect of Intense Exercise on Inflammatory Bowel Disease Activity.

The American journal of gastroenterology

Benjamin Hassid, Brandon Lamere, Michael Kattah, Uma Mahadevan

245 A20 and ABIN-1 Cooperate to Restrict Intestinal Epithelial Cell Death and Maintain Mucosal Immune Homeostasis.

Gastroenterology

Ling Shao, Michael G. Kattah, Michael Whang, Bao Duong, Michio Onizawa, Sadeea Abbasi, Yenny Rosli, Joseph Callahan, Mihir Pendse, Julio Barrera, Alison Glazier, Rommel Advincula, Barbara Malynn, Averil Ma

Tetramers reveal IL-17-secreting CD4+ T cells that are specific for U1-70 in lupus and mixed connective tissue disease.

Proceedings of the National Academy of Sciences of the United States of America

Kattah NH, Newell EW, Jarrell JA, Chu AD, Xie J, Kattah MG, Goldberger O, Ye J, Chakravarty EF, Davis MM, Utz PJ

Measurement of mast cell surface molecules by high-throughput immunophenotyping using transcription (HIT).

Methods in molecular biology (Clifton, N.J.)

Haddon DJ, Jarrell JA, Hughes MR, Snyder K, McNagny KM, Kattah MG, Utz PJ

Antigen Specific T Cells in Lupus Recognize U1-70 and Produce IL-17 by Tetramer Staining.

Clinical Immunology

Nicole Kattah, Evan Newell, Alvina Chu, Michael Kattah, Mark Davis

Naive CD4 t cell proliferation is controlled by mammalian target of rapamycin regulation of GRAIL expression.

Journal of immunology (Baltimore, Md. : 1950)

Lin JT, Lineberry NB, Kattah MG, Su LL, Utz PJ, Fathman CG, Wu L

OR.85. Regulation of GRAIL Expression by mTOR Controls Naive CD4 T Cell Proliferation.

Clinical Immunology

Jack Lin, Neil Lineberry, Michael Kattah, Leon Su, Paul Utz, C. Garrison Fathman

Differential regulation of chemokines by IL-17 in colonic epithelial cells.

Journal of immunology (Baltimore, Md. : 1950)

Lee JW, Wang P, Kattah MG, Youssef S, Steinman L, DeFea K, Straus DS

Protein microarrays with carbon nanotubes as multicolor Raman labels.

Nature biotechnology

Chen Z, Tabakman SM, Goodwin AP, Kattah MG, Daranciang D, Wang X, Zhang G, Li X, Liu Z, Utz PJ, Jiang K, Fan S, Dai H

Protein microarrays address the elephant in the room.

Clinical chemistry

Kattah MG, Utz PJ, Balboni I

OR.40. Cytokines Secreted in Response to TLR-ligand Stimulation Modulate Human Th17 Differentiation.

Clinical Immunology

Michael Kattah, Michael Wong, Matthew Yocum, Paul Utz

Sa.12. Profiling Epigenetic Biomarkers for the Study and Treatment of Lupus.

Clinical Immunology

Chih Long Liu, Michael Kattah, Alex Kuo, Xiaobing Shi, Imelda Balboni, Paul Utz, Or Gozani

Sa.95. HIT: A Novel Protein Array Platform Identifies Down-regulation of CD26 on Regulatory T Cell Subsets.

Clinical Immunology

Michael Kattah, John Coller, Regina Cheung, Neekaan Oshidary, Paul Utz

Free-solution oligonucleotide separation in nanoscale channels.

Analytical chemistry

Pennathur S, Baldessari F, Santiago JG, Kattah MG, Steinman JB, Utz PJ

Antibody-oligo Arrays for Multiplex Surface Marker Profiling of Immune Cells Subsets.

Clinical Immunology

Michael Kattah, John Coller, Golnaz Alemi, Neekaan Oshidary, Paul J. Utz

A new two-color Fab labeling method for autoantigen protein microarrays.

Nature methods

Kattah MG, Alemi GR, Thibault DL, Balboni I, Utz PJ

Medicine on a need-to-know basis.

Nature immunology

Busch R, Byrne B, Gandrud L, Sears D, Meyer E, Kattah M, Kurihara C, Haertel E, Parnes JR, Mellins ED

Multiplexed protein array platforms for analysis of autoimmune diseases.

Annual review of immunology

Balboni I, Chan SM, Kattah M, Tenenbaum JD, Butte AJ, Utz PJ

Sa.127. A Novel Two-Color Fab Labeling Method for Autoantigen Protein Microarrays.

Clinical Immunology

Michael Kattah, Golnaz Alemi, Donna Thibault, Paul Utz

Structure-based discovery of nonpeptidic small organic compounds to block the T cell response to myelin basic protein.

Journal of medicinal chemistry

Koehler NK, Yang CY, Varady J, Lu Y, Wu XW, Liu M, Yin D, Bartels M, Xu BY, Roller PP, Long YQ, Li P, Kattah M, Cohn ML, Moran K, Tilley E, Richert JR, Wang S

Crystal structure of the human myeloid cell activating receptor TREM-1.

Structure (London, England : 1993)

Radaev S, Kattah M, Rostro B, Colonna M, Sun PD

Making sense of the diverse ligand recognition by NKG2D.

Journal of immunology (Baltimore, Md. : 1950)

Radaev S, Kattah M, Zou Z, Colonna M, Sun PD

Generating isomorphous heavy-atom derivatives by a quick-soak method. Part I: test cases.

Acta crystallographica. Section D, Biological crystallography

Sun PD, Radaev S, Kattah M

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