Roberto Ricardo Gonzalez, MD, PhD

Assistant Professor
Dermatology
Publications: 

Innate type 2 immunity controls hair follicle commensalism by Demodex mites.

Immunity

Ricardo-Gonzalez RR, Kotas ME, O'Leary CE, Singh K, Damsky W, Liao C, Arouge E, Tenvooren I, Marquez DM, Schroeder AW, Cohen JN, Fassett MS, Lee J, Daniel SG, Bittinger K, Díaz RE, Fraser JS, Ali N, Ansel KM, Spitzer MH, Liang HE, Locksley RM

012 Tissue-specific manipulation of regulatory T cells reveals the skin to be a site of immune tolerance.

Journal of Investigative Dermatology

J. Cohen, J. Moreau, V. Gouirand, C. Macon, I. Boothby, I. Gratz, A. Stoecklinger, C. Weaver, A. Sharpe, R. Ricardo-Gonzalez, M. Rosenblum

Classification of human chronic inflammatory skin disease based on single-cell immune profiling.

Science immunology

Liu Y, Wang H, Taylor M, Cook C, Martínez-Berdeja A, North JP, Harirchian P, Hailer AA, Zhao Z, Ghadially R, Ricardo-Gonzalez RR, Grekin RC, Mauro TM, Kim E, Choi J, Purdom E, Cho RJ, Cheng JB

Bile acid-sensitive tuft cells regulate biliary neutrophil influx.

Science immunology

O'Leary CE, Sbierski-Kind J, Kotas ME, Wagner JC, Liang HE, Schroeder AW, de Tenorio JC, von Moltke J, Ricardo-Gonzalez RR, Eckalbar WL, Molofsky AB, Schneider C, Locksley RM

ILC2s - development, divergence, dispersal.

Current opinion in immunology

Ricardo-Gonzalez RR, Molofsky AB, Locksley RM

CISH constrains the tuft-ILC2 circuit to set epithelial and immune tone.

Mucosal immunology

Kotas ME, Mroz NM, Koga S, Liang HE, Schroeder AW, Ricardo-Gonzalez RR, Schneider C, Locksley RM

A role for IL-33-activated ILC2s in eosinophilic vasculitis.

JCI insight

Kotas ME, Dion J, Van Dyken S, Ricardo-Gonzalez RR, Danel CJ, Taillé C, Mouthon L, Locksley RM, Terrier B

Skin-resident innate lymphoid cells converge on a pathogenic effector state.

Nature

Bielecki P, Riesenfeld SJ, Hütter JC, Torlai Triglia E, Kowalczyk MS, Ricardo-Gonzalez RR, Lian M, Amezcua Vesely MC, Kroehling L, Xu H, Slyper M, Muus C, Ludwig LS, Christian E, Tao L, Kedaigle AJ, Steach HR, York AG, Skadow MH, Yaghoubi P, Dionne D, Jarret A, McGee HM, Porter CBM, Licona-Limón P, Bailis W, Jackson R, Gagliani N, Gasteiger G, Locksley RM, Regev A, Flavell RA

Single-Cell Profiling Reveals Divergent, Globally Patterned Immune Responses in Murine Skin Inflammation.

iScience

Liu Y, Cook C, Sedgewick AJ, Zhang S, Fassett MS, Ricardo-Gonzalez RR, Harirchian P, Kashem SW, Hanakawa S, Leistico JR, North JP, Taylor MA, Zhang W, Man MQ, Charruyer A, Beliakova-Bethell N, Benz SC, Ghadially R, Mauro TM, Kaplan DH, Kabashima K, Choi J, Song JS, Cho RJ, Cheng JB

095 Single-cell Profiling Reveals a Highly Specific, Compartmentalized Functional Response in the Cutaneous Immune System.

Journal of Investigative Dermatology

Y. Liu, C. Cook, P. Haririchian, R. Ricardo-Gonzalez, J.P. North, A. Charruyer, R. Ghadially, R.J. Cho, J.B. Cheng

716 Supporting diversity in skin science: Development of a summer curriculum for underrepresented minority medical students.

Journal of Investigative Dermatology

M. Paul, J. Lester, R. Ricardo-Gonzalez, H. Naik

Tissue-specific pathways extrude activated ILC2s to disseminate type 2 immunity.

The Journal of experimental medicine

Ricardo-Gonzalez RR, Schneider C, Liao C, Lee J, Liang HE, Locksley RM

Skin-Resident Innate Lymphoid Cells - Cutaneous Innate Guardians and Regulators.

Trends in immunology

Kobayashi T, Ricardo-Gonzalez RR, Moro K

ILC2s chew the fat.

The Journal of experimental medicine

Ricardo-Gonzalez RR, Locksley RM

Tissue-Resident Group 2 Innate Lymphoid Cells Differentiate by Layered Ontogeny and In Situ Perinatal Priming.

Immunity

Schneider C, Lee J, Koga S, Ricardo-Gonzalez RR, Nussbaum JC, Smith LK, Villeda SA, Liang HE, Locksley RM

Tissue signals imprint ILC2 identity with anticipatory function.

Nature immunology

Ricardo-Gonzalez RR, Van Dyken SJ, Schneider C, Lee J, Nussbaum JC, Liang HE, Vaka D, Eckalbar WL, Molofsky AB, Erle DJ, Locksley RM

1021 Origin of type 2 innate lymphoid cells in the skin.

Journal of Investigative Dermatology

J. Lee, C. Schneider, H. Liang, R. Ricardo-Gonzalez, J. Nussbaum, L. Smith, S. Villeda, R. Locksley

940 ILC2s and Type 2 immunity influence hair follicle stem cell proliferation and skin homeostasis.

Journal of Investigative Dermatology

R. Ricardo-Gonzalez, S. Van Dyken, R. Locksley

LB973 Characterization of tissue-resident ILC2 heterogeneity in homeostasis.

Journal of Investigative Dermatology

R. Ricardo-Gonzalez, S. Van Dyken, A. Molofsky, J. Nussbaum, J. Lee, R. Locksley

Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation.

Cell

Ali N, Zirak B, Rodriguez RS, Pauli ML, Truong HA, Lai K, Ahn R, Corbin K, Lowe MM, Scharschmidt TC, Taravati K, Tan MR, Ricardo-Gonzalez RR, Nosbaum A, Bertolini M, Liao W, Nestle FO, Paus R, Cotsarelis G, Abbas AK, Rosenblum MD

Neutrophil-rich subcutaneous fat necrosis of the newborn: A potential mimic of infection.

Journal of the American Academy of Dermatology

Ricardo-Gonzalez RR, Lin JR, Mathes EF, McCalmont TH, Pincus LB

A case of Wong-type dermatomyositis with concomitant anti-MDA5 features.

Journal of the American Academy of Dermatology

Canavan T, Sidorsky T, Doan LT, Ricardo-Gonzalez RR, Shen G, Rosenblum MD

Plasmacytoid carcinoma of the bladder: a urothelial carcinoma variant with a predilection for intraperitoneal spread.

The Journal of urology

Ricardo-Gonzalez RR, Nguyen M, Gokden N, Sangoi AR, Presti JC, McKenney JK

Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis.

Science (New York, N.Y.)

Wu D, Molofsky AB, Liang HE, Ricardo-Gonzalez RR, Jouihan HA, Bando JK, Chawla A, Locksley RM

IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity.

Proceedings of the National Academy of Sciences of the United States of America

Ricardo-Gonzalez RR, Red Eagle A, Odegaard JI, Jouihan H, Morel CR, Heredia JE, Mukundan L, Wu D, Locksley RM, Chawla A

PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance.

Nature medicine

Mukundan L, Odegaard JI, Morel CR, Heredia JE, Mwangi JW, Ricardo-Gonzalez RR, Goh YP, Eagle AR, Dunn SE, Awakuni JU, Nguyen KD, Steinman L, Michie SA, Chawla A

Regulation of macrophage activation and function by PPARs.

Cytokine

Justin Odegaard, Lata Mukundan, Roberto Ricardo-Gonzalez, Christine Morel, Ajay Chawla

Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance.

Cell metabolism

Odegaard JI, Ricardo-Gonzalez RR, Red Eagle A, Vats D, Morel CR, Goforth MH, Subramanian V, Mukundan L, Ferrante AW, Chawla A

Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance.

Nature

Odegaard JI, Ricardo-Gonzalez RR, Goforth MH, Morel CR, Subramanian V, Mukundan L, Red Eagle A, Vats D, Brombacher F, Ferrante AW, Chawla A

Quantitative expansion of ES cell-derived myeloid progenitors capable of differentiating into macrophages.

Journal of leukocyte biology

Odegaard JI, Vats D, Zhang L, Ricardo-Gonzalez R, Smith KL, Sykes DB, Kamps MP, Chawla A

Custom People Group: 
UCSF Microbiome Researchers