Sakeen Kashem, MD, PhD

Postdoc
Dermatology
Publications: 

Discovery of a CCR2-targeting pepducin therapy for chronic pain.

Pharmacological research

Midavaine É, Brouillette RL, Théberge E, Mona CE, Kashem SW, Côté J, Zeugin V, Besserer-Offroy É, Longpré JM, Marsault É, Sarret P

Regulatory T cell-derived enkephalin imparts pregnancy-induced analgesia.

bioRxiv : the preprint server for biology

Midavaine É, Moraes BC, Benitez J, Rodriguez SR, Braz JM, Kochhar NP, Eckalbar WL, Domingos AI, Pintar JE, Basbaum AI, Kashem SW

Neuropeptide substance P alters stem cell fate to aid wound healing and promote epidermal stratification through asymmetric stem cell divisions.

Stem cells (Dayton, Ohio)

Khalifa A, Xiao T, Abegaze B, Weisenberger T, Charruyer A, Sanad S, AbuElnasr T, Kashem SW, Fassett M, Ghadially R

Tetracycline transactivator overexpression in keratinocytes triggers a TRPV1 primary sensory neuron-dependent neuropathic itch

bioRxiv

Crowther AJ, Kashem SW, Jewell ME, Chang HL, Casillas MR, Midavaine E, Rodriguez S, Braz JM, Kania A, Basbaum AI

Local IL-23 is required for proliferation and retention of skin-resident memory TH17 cells.

Science immunology

Whitley SK, Li M, Kashem SW, Hirai T, Igyártó BZ, Knizner K, Ho J, Ferris LK, Weaver CT, Cua DJ, McGeachy MJ, Kaplan DH

A single-cell transcriptional gradient in human cutaneous memory T cells restricts Th17/Tc17 identity.

Cell reports. Medicine

Cook CP, Taylor M, Liu Y, Schmidt R, Sedgewick A, Kim E, Hailer A, North JP, Harirchian P, Wang H, Kashem SW, Shou Y, McCalmont TC, Benz SC, Choi J, Purdom E, Marson A, Ramos SBV, Cheng JB, Cho RJ

Association of Facial Pustular Neutrophilic Eruption With Messenger RNA-1273 SARS-CoV-2 Vaccine.

JAMA dermatology

Merrill ED, Kashem SW, Amerson EH, Pincus LB, Lang UE, Shinkai K, Chang AY

Single-Cell Profiling Reveals Divergent, Globally Patterned Immune Responses in Murine Skin Inflammation.

iScience

Liu Y, Cook C, Sedgewick AJ, Zhang S, Fassett MS, Ricardo-Gonzalez RR, Harirchian P, Kashem SW, Hanakawa S, Leistico JR, North JP, Taylor MA, Zhang W, Man MQ, Charruyer A, Beliakova-Bethell N, Benz SC, Ghadially R, Mauro TM, Kaplan DH, Kabashima K, Choi J, Song JS, Cho RJ, Cheng JB

Inflammatory arthritis in pediatric patients with morphea.

Journal of the American Academy of Dermatology

Kashem SW, Correll CK, Vehe RK, Hobday PM, Binstadt BA, Maguiness SM

Antigen-Presenting Cells in the Skin.

Annual review of immunology

Kashem SW, Haniffa M, Kaplan DH

Different Lymphocyte Populations Direct Dichotomous Eosinophil or Neutrophil Responses to Pulmonary Cryptococcus Infection.

Journal of immunology (Baltimore, Md. : 1950)

Wiesner DL, Smith KD, Kashem SW, Bohjanen PR, Nielsen K

Brief Report: Arthritis in KRN T Cell Receptor-Transgenic Mice Does Not Require Interleukin-17 or Th17 Cells.

Arthritis & rheumatology (Hoboken, N.J.)

Auger JL, Cowan HM, Engelson BJ, Kashem SW, Prinz I, Binstadt BA

Skin Immunity to Candida albicans.

Trends in immunology

Kashem SW, Kaplan DH

Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β.

Nature immunology

Mohammed J, Beura LK, Bobr A, Astry B, Chicoine B, Kashem SW, Welty NE, Igyártó BZ, Wijeyesinghe S, Thompson EA, Matte C, Bartholin L, Kaplan A, Sheppard D, Bridges AG, Shlomchik WD, Masopust D, Kaplan DH

Generation of Th17 cells in response to intranasal infection requires TGF-β1 from dendritic cells and IL-6 from CD301b+ dendritic cells.

Proceedings of the National Academy of Sciences of the United States of America

Linehan JL, Dileepan T, Kashem SW, Kaplan DH, Cleary P, Jenkins MK

Candida albicans morphology and dendritic cell subsets determine T helper cell differentiation.

Immunity

Kashem SW, Igyarto BZ, Gerami-Nejad M, Kumamoto Y, Mohammed JA, Jarrett E, Drummond RA, Zurawski SM, Zurawski G, Berman J, Iwasaki A, Brown GD, Kaplan DH

Alterations in antigen-specific naive CD4 T cell precursors after sepsis impairs their responsiveness to pathogen challenge.

Journal of immunology (Baltimore, Md. : 1950)

Cabrera-Perez J, Condotta SA, James BR, Kashem SW, Brincks EL, Rai D, Kucaba TA, Badovinac VP, Griffith TS

Langerhans cells require MyD88-dependent signals for Candida albicans response but not for contact hypersensitivity or migration.

Journal of immunology (Baltimore, Md. : 1950)

Haley K, Igyártó BZ, Ortner D, Bobr A, Kashem S, Schenten D, Kaplan DH

G protein coupled receptor specificity for C3a and compound 48/80-induced degranulation in human mast cells: roles of Mas-related genes MrgX1 and MrgX2.

European journal of pharmacology

Kashem SW, Subramanian H, Collington SJ, Magotti P, Lambris JD, Ali H

PMX-53 as a dual CD88 antagonist and an agonist for Mas-related gene 2 (MrgX2) in human mast cells.

Molecular pharmacology

Subramanian H, Kashem SW, Collington SJ, Qu H, Lambris JD, Ali H

Antithrombotic activity of kininogen is mediated by inhibitory effects of domain 3 during arterial injury in vivo.

American journal of physiology. Heart and circulatory physiology

Hassan S, Sainz IM, Khan MM, Bradford HN, Isordia-Salas I, Kashem SW, Sartor RB, Colman RW

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