Scott Zamvil, MD, PhD

Professor
Neurology
[email protected]
+1 415 502-7395

Dr. Scott Zamvil is a neurologist and immunologist who specializes in treating multiple sclerosis and neuromyelitis optica. His research focuses on developing novel treatments for these autoimmune diseases.

Zamvil earned his medical degree and a doctorate in microbiology and immunology from Stanford University. He then completed a residency in internal medicine at Stanford University and a residency in neurology at Brigham and Women's Hospital. Before coming to UCSF, he was a neurologist at Brigham and Women's Hospital.

Zamvil is a board member of the International Society of Neuroimmunology. He is also an adviser for America's Committee for Treatment and Research in Multiple Sclerosis. He serves as deputy editor of the journal Neurology: Neuroimmunology & Neuroinflammation.

Publications: 

Programming tissue-sensing T cells that deliver therapies to the brain.

Science (New York, N.Y.)

Simic MS, Watchmaker PB, Gupta S, Wang Y, Sagan SA, Duecker J, Shepherd C, Diebold D, Pineo-Cavanaugh P, Haegelin J, Zhu R, Ng B, Yu W, Tonai Y, Cardarelli L, Reddy NR, Sidhu SS, Troyanskaya O, Hauser SL, Wilson MR, Zamvil SS, Okada H, Lim WA

Antigen-specificity of clonally-enriched CD8+ T cells in multiple sclerosis.

bioRxiv : the preprint server for biology

Mittl K, Hayashi F, Dandekar R, Schubert RD, Gerdts J, Oshiro L, Loudermilk R, Greenfield A, Augusto DG, Ramesh A, Tran E, Koshal K, Kizer K, Dreux J, Cagalingan A, Schustek F, Flood L, Moore T, Kirkemo LL, Cooper T, Harms M, Gomez R, University of California, San Francisco MS-EPIC Team, Sibener L, Cree BAC, Hauser SL, Hollenbach JA, Gee M, Wilson MR, Zamvil SS, Sabatino JJ

High-yield production of recombinant human myelin oligodendrocyte glycoprotein in SHuffle bacteria without a refolding step.

Journal of immunological methods

Wu W, Gupta S, Sagan SA, Moseley CE, Zamvil SS, Pak JE

A 79-Year-Old Woman With Worsening Headaches and Pachymeningeal Enhancement: A Case Report From the National Multiple Sclerosis Society Case Conference Proceedings.

Neurology(R) neuroimmunology & neuroinflammation

Sheth MS, Hale DE, Mcarthur JC, Zamvil SS, Goldman MD, Riley C, Chitnis T

HLA-transgenic mouse models to study autoimmune central nervous system diseases.

Autoimmunity

Pressley KR, Schwegman L, Montes De Oca Arena M, Chase Huizar C, Zamvil SS, Forsthuber TG

Should We Measure CSF Complement Levels in Patients With MOGAD?

Neurology(R) neuroimmunology & neuroinflammation

Moseley CE, Zamvil SS

MOG CNS Autoimmunity and MOGAD.

Neurology(R) neuroimmunology & neuroinflammation

Moseley CE, Virupakshaiah A, Forsthuber TG, Steinman L, Waubant E, Zamvil SS

Predictors of a relapsing course in myelin oligodendrocyte glycoprotein antibody-associated disease.

Journal of neurology, neurosurgery, and psychiatry

Virupakshaiah A, Schoeps VA, Race J, Waltz M, Sharayah S, Nasr Z, Moseley CE, Zamvil SS, Gaudioso C, Schuette A, Casper TC, Rose J, Flanagan EP, Rodriguez M, Tillema JM, Chitnis T, Gorman MP, Graves JS, Benson LA, Rensel M, Abrams A, Krupp L, Lotze TE, Aaen G, Wheeler Y, Schreiner T, Waldman A, Chong J, Mar S, Waubant E

An autoantibody signature predictive for multiple sclerosis.

Nature medicine

Zamecnik CR, Sowa GM, Abdelhak A, Dandekar R, Bair RD, Wade KJ, Bartley CM, Kizer K, Augusto DG, Tubati A, Gomez R, Fouassier C, Gerungan C, Caspar CM, Alexander J, Wapniarski AE, Loudermilk RP, Eggers EL, Zorn KC, Ananth K, Jabassini N, Mann SA, Ragan NR, Santaniello A, Henry RG, Baranzini SE, Zamvil SS, Sabatino JJ, Bove RM, Guo CY, Gelfand JM, Cuneo R, von Büdingen HC, Oksenberg JR, Cree BAC, Hollenbach JA, Green AJ, Hauser SL, Wallin MT, DeRisi JL, Wilson MR

Life-Threatening MOG Antibody-Associated Hemorrhagic ADEM With Elevated CSF IL-6.

Neurology(R) neuroimmunology & neuroinflammation

Virupakshaiah A, Moseley CE, Elicegui S, Gerwitz LM, Spencer CM, George E, Shah M, Cree BAC, Waubant E, Zamvil SS

Progressive Encephalomyelopathy in an Older Man: A Case Report From the National Multiple Sclerosis Society Case Conference Proceedings.

Neurology(R) neuroimmunology & neuroinflammation

Ross LA, Lee J, Carlson AK, Conway DS, Cohen JA, Graves J, Zamvil SS, Newsome SD, Kunchok A

A 42-Year-Old Woman With Rapidly Expanding White Matter Lesions: From the National Multiple Sclerosis Society Case Conference Proceedings.

Neurology(R) neuroimmunology & neuroinflammation

Amiola TO, Oh U, Richard H, Newsome SD, Graves J, Zamvil SS, Goldman MD

Relapsing White Matter Disease and Subclinical Optic Neuropathy.

Neurology(R) neuroimmunology & neuroinflammation

O'Neill KA, Dugue A, Abreu NJ, Balcer LJ, Branche M, Galetta S, Graves J, Kister I, Magro C, Miller C, Newsome SD, Pappas J, Rucker J, Steigerwald C, William CM, Zamvil SS, Grossman SN, Krupp LB

Teenager With Recurrent Ataxia, Ophthalmoplegia, and Encephalopathy Associated With Demyelination.

Neurology(R) neuroimmunology & neuroinflammation

Poisson KE, Newsome SD, Graves J, Zamvil SS, Marcus LR

Tuberculous Meningitis or Neurosarcoidosis-a Diagnostic Quandary.

Neurology(R) neuroimmunology & neuroinflammation

Lin J, Pulst-Korenberg J, Zamvil SS, Graves J, Newsome SD, Amezcua L

Targeting PGLYRP1 in cancer and autoimmunity.

Nature immunology

Moseley CE, Zamvil SS

Susceptibility-based imaging aids accurate distinction of pediatric-onset MS from myelin oligodendrocyte glycoprotein antibody-associated disease.

Multiple sclerosis (Houndmills, Basingstoke, England)

Sacco S, Virupakshaiah A, Papinutto N, Schoeps VA, Akula A, Zhao H, Arona J, Stern WA, Chong J, Hart J, Zamvil SS, Sati P, Henry RG, Waubant E

A 28-Year-Old Woman With Left-Sided Weakness and Atypical MRI Lesions: From the National Multiple Sclerosis Society Case Conference Proceedings.

Neurology(R) neuroimmunology & neuroinflammation

Safadi AL, Osborne B, Chitnis T, Graves JS, Newsome SD, Zamvil SS, Solomon IH, Shin RK

T cell deletional tolerance restricts AQP4 but not MOG CNS autoimmunity.

Proceedings of the National Academy of Sciences of the United States of America

Sagan SA, Moinfar Z, Moseley CE, Dandekar R, Spencer CM, Verkman AS, Ottersen OP, Sobel RA, Sidney J, Sette A, Anderson MS, Steinman L, Wilson MR, Sabatino JJ, Zamvil SS

Defining blood-induced microglia functions in neurodegeneration through multiomic profiling.

Nature immunology

Mendiola AS, Yan Z, Dixit K, Johnson JR, Bouhaddou M, Meyer-Franke A, Shin MG, Yong Y, Agrawal A, MacDonald E, Muthukumar G, Pearce C, Arun N, Cabriga B, Meza-Acevedo R, Alzamora MDPS, Zamvil SS, Pico AR, Ryu JK, Krogan NJ, Akassoglou K

A Predictive Autoantibody Signature in Multiple Sclerosis.

medRxiv : the preprint server for health sciences

Zamecnik CR, Sowa GM, Abdelhak A, Dandekar R, Bair RD, Wade KJ, Bartley CM, Tubati A, Gomez R, Fouassier C, Gerungan C, Alexander J, Wapniarski AE, Loudermilk RP, Eggers EL, Zorn KC, Ananth K, Jabassini N, Mann SA, Ragan NR, Santaniello A, Henry RG, Baranzini SE, Zamvil SS, Bove RM, Guo CY, Gelfand JM, Cuneo R, von Büdingen HC, Oksenberg JR, Cree BA, Hollenbach JA, Green AJ, Hauser SL, Wallin MT, DeRisi JL, Wilson MR

Low protection from breakthrough SARS-CoV-2 infection and mild disease course in ocrelizumab-treated patients with multiple sclerosis after three mRNA vaccine doses.

Journal of neurology, neurosurgery, and psychiatry

Novak F, Bajwa HM, Coia JE, Nilsson AC, Nielsen C, Holm DK, Østergaard K, Hvidt MVM, Byg KE, Johansen IS, Mittl K, Rowles W, Zamvil SS, Bove R, Sabatino JJ, Sejbaek T

Relapsing Encephalomyelitis After COVID-19 Infection and Vaccination: From the National MS Society Case Conference Proceedings.

Neurology(R) neuroimmunology & neuroinflammation

Roy S, Barreras P, Pardo CA, Graves JS, Zamvil SS, Newsome SD

SAkuraBONSAI: Protocol design of a novel, prospective study to explore clinical, imaging, and biomarker outcomes in patients with AQP4-IgG-seropositive neuromyelitis optica spectrum disorder receiving open-label satralizumab.

Frontiers in neurology

Bennett JL, Fujihara K, Kim HJ, Marignier R, O'Connor KC, Sergott RC, Traboulsee A, Wiendl H, Wuerfel J, Zamvil SS, Anania VG, Buffels R, K?nzel T, Lekkerkerker AN, Lennon-Chrimes S, Pittock SJ

CAR-T Cell-Mediated B-Cell Depletion in Central Nervous System Autoimmunity.

Neurology(R) neuroimmunology & neuroinflammation

Gupta S, Simic M, Sagan SA, Shepherd C, Duecker J, Sobel RA, Dandekar R, Wu GF, Wu W, Pak JE, Hauser SL, Lim W, Wilson MR, Zamvil SS

N2 Year in Review.

Neurology(R) neuroimmunology & neuroinflammation

Dalmau J, Dalakas MC, Kolson DL, Paul F, S?nchez-Valle R, Zamvil SS

Longitudinal adaptive immune responses following sequential SARS-CoV-2 vaccinations in MS patients on anti-CD20 therapies and sphingosine-1-phosphate receptor modulators.

Multiple sclerosis and related disorders

Sabatino JJ, Mittl K, Rowles W, Zamecnik CR, Loudermilk RP, Gerungan C, Spencer CM, Sagan SA, Alexander J, Mcpolin K, Chen P, Deshpande C, Wyse K, Maiese EM, Wilson MR, Zamvil SS, Bove R

MOG Antibody-Associated Disease and Thymic Hyperplasia: From the National Multiple Sclerosis Society Case Conference Proceedings.

Neurology(R) neuroimmunology & neuroinflammation

Hurtubise B, Frohman EM, Galetta S, Balcer LJ, Frohman TC, Lisak RP, Newsome SD, Graves JS, Zamvil SS, Amezcua L

Recurrent Optic Neuritis and Perineuritis Followed by an Unexpected Discovery: From the National Multiple Sclerosis Society Case Conference Proceedings.

Neurology(R) neuroimmunology & neuroinflammation

Pimentel Maldonado DA, Lisak R, Galetta S, Balcer L, Varkey T, Goodman A, Graves J, Racke M, Zamvil SS, Newsome S, Frohman EM, Frohman TC

Multiple Sclerosis Followed by Neuromyelitis Optica Spectrum Disorder: From the National Multiple Sclerosis Society Case Conference Proceedings.

Neurology(R) neuroimmunology & neuroinflammation

Goldschmidt C, Galetta SL, Lisak RP, Balcer LJ, Hellman A, Racke MK, Lovett-Racke AE, Cruz R, Parsons MS, Sattarnezhad N, Steinman L, Zamvil SS, Frohman EM, Frohman TC

Reply to "Spinal cord atrophy is a preclinical marker of progressive MS".

Annals of neurology

Bischof A, Papinutto N, Keshavan A, Rajesh A, Kirkish G, Zhang X, Mallott JM, Asteggiano C, Sacco S, Gundel TJ, Zhao C, Stern WA, Caverzasi E, Zhou Y, Gomez R, Ragan NR, Santaniello A, Zhu AH, Juwono J, Bevan CJ, Bove RM, Crabtree E, Gelfand JM, Goodin DS, Graves JS, Green AJ, Oksenberg JR, Waubant E, Wilson MR, Zamvil SS, University of CaliforniaSan Francisco MS-EPIC Team, Cree BA, Hauser SL, Henry RG

A hormonal therapy for menopausal women with MS: A phase Ib/IIa randomized controlled trial.

Multiple sclerosis and related disorders

Bove R, Anderson A, Rowles W, Rankin KA, Hills NK, Carleton M, Cooper J, Cree BAC, Gelfand JM, Graves JS, Henry RG, Krysko KM, Rush G, Zamvil SS, Joffe H, Chan JR, Green AJ

Persistently reduced humoral and sustained cellular immune response from first to third SARS-CoV-2 mRNA vaccination in anti-CD20-treated multiple sclerosis patients.

Multiple sclerosis and related disorders

Bajwa HM, Novak F, Nilsson AC, Nielsen C, Holm DK, Østergaard K, Witt AH, Byg KE, Johansen IS, Mittl K, Rowles W, Zamvil SS, Bove R, Sabatino JJ, Sejbaek T

Multiple sclerosis therapies differentially affect SARS-CoV-2 vaccine-induced antibody and T cell immunity and function.

JCI insight

Sabatino JJ, Mittl K, Rowles WM, McPolin K, Rajan JV, Laurie MT, Zamecnik CR, Dandekar R, Alvarenga BD, Loudermilk RP, Gerungan C, Spencer CM, Sagan SA, Augusto DG, Alexander JR, DeRisi JL, Hollenbach JA, Wilson MR, Zamvil SS, Bove R

Spinal cord atrophy predicts progressive disease in relapsing multiple sclerosis.

Annals of neurology

Bischof A, Papinutto N, Keshavan A, Rajesh A, Kirkish G, Zhang X, Mallott JM, Asteggiano C, Sacco S, Gundel TJ, Zhao C, Stern WA, Caverzasi E, Zhou Y, Gomez R, Ragan NR, Santaniello A, Zhu AH, Juwono J, Bevan CJ, Bove RM, Crabtree E, Gelfand JM, Goodin DS, Graves JS, Green AJ, Oksenberg JR, Waubant E, Wilson MR, Zamvil SS, University of California, San Francisco MS-EPIC Team, Cree BA, Hauser SL, Henry RG

Lymph node-resident dendritic cells drive TH2 cell development involving MARCH1.

Science immunology

Castellanos CA, Ren X, Gonzalez SL, Li HK, Schroeder AW, Liang HE, Laidlaw BJ, Hu D, Mak ACY, Eng C, Rodríguez-Santana JR, LeNoir M, Yan Q, Celedón JC, Burchard EG, Zamvil SS, Ishido S, Locksley RM, Cyster JG, Huang X, Shin JS

SARS-CoV-2 spike protein induces abnormal inflammatory blood clots neutralized by fibrin immunotherapy.

bioRxiv : the preprint server for biology

Ryu JK, Sozmen EG, Dixit K, Montano M, Matsui Y, Liu Y, Helmy E, Deerinck TJ, Yan Z, Schuck R, Acevedo RM, Spencer CM, Thomas R, Pico AR, Zamvil SS, Lynch KL, Ellisman MH, Greene WC, Akassoglou K

Impact of multiple sclerosis disease-modifying therapies on SARS-CoV-2 vaccine-induced antibody and T cell immunity.

medRxiv : the preprint server for health sciences

Sabatino JJ, Mittl K, Rowles W, Mcpolin K, Rajan JV, Zamecnik CR, Dandekar R, Alvarenga BD, Loudermilk RP, Gerungan C, Spencer CM, Sagan SA, Augusto DG, Alexander J, Hollenbach JA, Wilson MR, Zamvil SS, Bove R

Humoral immune response following SARS-CoV-2 mRNA vaccination concomitant to anti-CD20 therapy in multiple sclerosis.

Multiple sclerosis and related disorders

Novak F, Nilsson AC, Nielsen C, Holm DK, Østergaard K, Bystrup A, Byg KE, Johansen IS, Mittl K, Rowles W, Mcpolin K, Spencer C, Sagan S, Gerungan C, Wilson MR, Zamvil SS, Bove R, Sabatino JJ, Sejbaek T

Encephalitis and Myelitis in a Young Woman: Overlap Syndrome, Thyroiditis, and Occult Tumor From the National Multiple Sclerosis Society Case Conference Proceedings.

Neurology(R) neuroimmunology & neuroinflammation

Zarghami Esfanhani N, Wundes A, Varkey T, Lisak RP, Goodman A, Graves J, Zamvil SS, Frohman EM, Frohman TC, Newsome SD

Can Systemic Anti-CD20 B Cell-Depleting Antibodies Eliminate Meningeal Follicles in Multiple Sclerosis?

Neurology(R) neuroimmunology & neuroinflammation

Gupta S, Zamvil SS

Application of an evidence-based, out-patient treatment strategy for COVID-19: Multidisciplinary medical practice principles to prevent severe disease.

Journal of the neurological sciences

Frohman EM, Villemarette-Pittman NR, Rodriguez A, Glanzman R, Rugheimer S, Komogortsev O, Zamvil SS, Cruz RA, Varkey TC, Frohman AN, Frohman AR, Parsons MS, Konkle EH, Frohman TC

CNS Autoimmune Responses in BCMA-Deficient Mice Provide Insight for the Failure of Atacicept in MS.

Neurology(R) neuroimmunology & neuroinflammation

Kumar G, Maria Z, Kohli U, Agasing A, Quinn JL, Ko RM, Zamvil SS, Axtell RC

Antigen Presentation by B Cells in Multiple Sclerosis.

The New England journal of medicine

Zamvil SS, Hauser SL

A CD8+ NK cell transcriptomic signature associated with clinical outcome in relapsing remitting multiple sclerosis.

Nature communications

McKinney EF, Cuthbertson I, Harris KM, Smilek DE, Connor C, Manferrari G, Carr EJ, Zamvil SS, Smith KGC

N2 year in review.

Neurology(R) neuroimmunology & neuroinflammation

Dalmau J, Dalakas MC, Kolson DL, Paul F, Zamvil SS

Targeting B Cells to Modify MS, NMOSD, and MOGAD: Part 1.

Neurology(R) neuroimmunology & neuroinflammation

Graf J, Mares J, Barnett M, Aktas O, Albrecht P, Zamvil SS, Hartung HP

Targeting B cells to modify MS, NMOSD, and MOGAD: Part 2.

Neurology(R) neuroimmunology & neuroinflammation

Graf J, Mares J, Barnett M, Aktas O, Albrecht P, Zamvil SS, Hartung HP

Treating MS after surviving PML: Discrete strategies for rescue, remission, and recovery patient 1: From the National Multiple Sclerosis Society Case Conference Proceedings.

Neurology(R) neuroimmunology & neuroinflammation

Anadani N, Hyland M, Cruz RA, Lisak R, Costello K, Major EO, Jassam Y, Meltzer E, Varkey TC, Parsons MS, Goodman AD, Graves JS, Newsome S, Zamvil SS, Frohman EM, Frohman TC

Treating MS after surviving PML: Discrete strategies for rescue, remission, and recovery patient 2: From the National Multiple Sclerosis Society Case Conference Proceedings.

Neurology(R) neuroimmunology & neuroinflammation

Cruz RA, Hogan N, Sconzert J, Sconzert M, Major EO, Lisak RP, Melamed E, Varkey TC, Meltzer E, Goodman A, Komogortsev O, Parsons MS, Costello K, Graves JS, Newsome S, Zamvil SS, Frohman EM, Frohman TC

Neurite Orientation Dispersion and Density Imaging for Assessing Acute Inflammation and Lesion Evolution in MS.

AJNR. American journal of neuroradiology

Sacco S, Caverzasi E, Papinutto N, Cordano C, Bischof A, Gundel T, Cheng S, Asteggiano C, Kirkish G, Mallot J, Stern WA, Bastianello S, Bove RM, Gelfand JM, Goodin DS, Green AJ, Waubant E, Wilson MR, Zamvil SS, Cree BA, Hauser SL, Henry RG

The immune signatures of multiple sclerosis: Lessons from twin studies.

Proceedings of the National Academy of Sciences of the United States of America

Villoslada P, Zamvil SS

Ataxin-1 regulates B cell function and the severity of autoimmune experimental encephalomyelitis.

Proceedings of the National Academy of Sciences of the United States of America

Didonna A, Canto Puig E, Ma Q, Matsunaga A, Ho B, Caillier SJ, Shams H, Lee N, Hauser SL, Tan Q, Zamvil SS, Oksenberg JR

Author Correction: Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation.

Nature immunology

Mendiola AS, Ryu JK, Bardehle S, Meyer-Franke A, Ang KK, Wilson C, Baeten KM, Hanspers K, Merlini M, Thomas S, Petersen MA, Williams A, Thomas R, Rafalski VA, Meza-Acevedo R, Tognatta R, Yan Z, Pfaff SJ, Machado MR, Bedard C, Coronado PER, Jiang X, Wang J, Pleiss MA, Green AJ, Zamvil SS, Pico AR, Bruneau BG, Arkin MR, Akassoglou K

A pathogenic and clonally expanded B cell transcriptome in active multiple sclerosis.

Proceedings of the National Academy of Sciences of the United States of America

Ramesh A, Schubert RD, Greenfield AL, Dandekar R, Loudermilk R, Sabatino JJ, Koelzer MT, Tran EB, Koshal K, Kim K, Pröbstel AK, Banerji D

Mitigating alemtuzumab-associated autoimmunity in MS: A "whack-a-mole" B-cell depletion strategy.

Neurology(R) neuroimmunology & neuroinflammation

Meltzer E, Campbell S, Ehrenfeld B, Cruz RA, Steinman L, Parsons MS, Zamvil SS, Frohman EM, Frohman TC

Microglia complement astrocytes in neuromyelitis optica.

The Journal of clinical investigation

Moinfar Z, Zamvil SS

Effect of the sphingosine-1-phosphate receptor modulator ozanimod on leukocyte subtypes in relapsing MS.

Neurology(R) neuroimmunology & neuroinflammation

Harris S, Tran JQ, Southworth H, Spencer CM, Cree BAC, Zamvil SS

Should interferons take front stage as an essential MS disease-modifying therapy in the era of coronavirus disease 2019?

Neurology(R) neuroimmunology & neuroinflammation

Maguire C, Frohman T, Zamvil SS, Frohman E, Melamed E

Part I. SARS-CoV-2 triggered 'PANIC' attack in severe COVID-19.

Journal of the neurological sciences

Frohman EM, Villemarette-Pittman NR, Melamed E, Cruz RA, Longmuir R, Varkey TC, Steinman L, Zamvil SS, Frohman TC

Part II. high-dose methotrexate with leucovorin rescue for severe COVID-19: An immune stabilization strategy for SARS-CoV-2 induced 'PANIC' attack.

Journal of the neurological sciences

Frohman EM, Villemarette-Pittman NR, Cruz RA, Longmuir R, Rowe V, Rowe ES, Varkey TC, Steinman L, Zamvil SS, Frohman TC

Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation.

Nature immunology

Mendiola AS, Ryu JK, Bardehle S, Meyer-Franke A, Ang KK, Wilson C, Baeten KM, Hanspers K, Merlini M, Thomas S, Petersen MA, Williams A, Thomas R, Rafalski VA, Meza-Acevedo R, Tognatta R, Yan Z, Pfaff SJ, Machado MR, Bedard C, Rios Coronado PE, Jiang X, Wang J, Pleiss MA, Green AJ, Zamvil SS, Pico AR, Bruneau BG, Arkin MR, Akassoglou K

Glatiramer acetate immune modulates B-cell antigen presentation in treatment of MS.

Neurology(R) neuroimmunology & neuroinflammation

Häusler D, Hajiyeva Z, Traub JW, Zamvil SS, Lalive PH, Brück W, Weber MS

New cases of vasculitis after alemtuzumab.

Multiple sclerosis (Houndmills, Basingstoke, England)

Azevedo CJ, Zamvil SS

Intrathecal B-cell activation in LGI1 antibody encephalitis.

Neurology(R) neuroimmunology & neuroinflammation

Lehmann-Horn K, Irani SR, Wang S, Palanichamy A, Jahn S, Greenfield AL, Dandekar R, Lepennetier G, Michael S, Gelfand JM, Geschwind MD, Wilson MR, Zamvil SS, von Büdingen HC

Reply: Neither human nor mouse is hypercalcaemic with 250 nmol/l 25-hydroxyvitamin D.

Brain : a journal of neurology

Häusler D, Torke S, Peelen E, Bertsch T, Weber M, Heilmann M, Djukic M, Nau R, Larochelle C, Zamvil SS, Brück W, Weber MS

Publisher Correction: B cells in autoimmune and neurodegenerative central nervous system diseases.

Nature reviews. Neuroscience

Sabatino JJ, Pröbstel AK, Zamvil SS

N2 year in review.

Neurology(R) neuroimmunology & neuroinflammation

Dalmau J, Dalakas MC, Kolson DL, Paul F, Zamvil SS

Reply: Hypercalcaemia rather than high dose vitamin D3 supplements could exacerbate multiple sclerosis.

Brain : a journal of neurology

Häusler D, Torke S, Peelen E, Bertsch T, Djukic M, Nau R, Larochelle C, Zamvil SS, Brück W, Weber MS

Anti-CD20 therapy depletes activated myelin-specific CD8+ T cells in multiple sclerosis.

Proceedings of the National Academy of Sciences of the United States of America

Sabatino JJ, Wilson MR, Calabresi PA, Hauser SL, Schneck JP, Zamvil SS

B cells in autoimmune and neurodegenerative central nervous system diseases.

Nature reviews. Neuroscience

Sabatino JJ, Pröbstel AK, Zamvil SS

Monitoring retinal changes with optical coherence tomography predicts neuronal loss in experimental autoimmune encephalomyelitis.

Journal of neuroinflammation

Cruz-Herranz A, Dietrich M, Hilla AM, Yiu HH, Levin MH, Hecker C, Issberner A, Hallenberger A, Cordano C, Lehmann-Horn K, Balk LJ, Aktas O, Ingwersen J, von Gall C, Hartung HP, Zamvil SS, Fischer D, Albrecht P, Green AJ

High dose vitamin D exacerbates central nervous system autoimmunity by raising T-cell excitatory calcium.

Brain : a journal of neurology

Häusler D, Torke S, Peelen E, Bertsch T, Djukic M, Nau R, Larochelle C, Zamvil SS, Brück W, Weber MS

Cataclysmically disseminating neurologic presentation in an immunosuppressed lupus patient: From the National Multiple Sclerosis Society Case Conference Proceedings.

Neurology(R) neuroimmunology & neuroinflammation

Perrone CM, Lisak RP, Meltzer EI, Sguigna P, Tizazu E, Jacobs D, Melamed E, Lucas A, Freeman L, Pardo G, Goodman A, Fox EJ, Costello K, Parsons MS, Zamvil SS, Frohman EM, Frohman TC

Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10.

Cell

Rojas OL, Pröbstel AK, Porfilio EA, Wang AA, Charabati M, Sun T, Lee DSW, Galicia G, Ramaglia V, Ward LA, Leung LYT, Najafi G, Khaleghi K, Garcillán B, Li A, Besla R, Naouar I, Cao EY, Chiaranunt P, Burrows K, Robinson HG, Allanach JR, Yam J, Luck H, Campbell DJ, Allman D, Brooks DG, Tomura M, Baumann R, Zamvil SS, Bar-Or A, Horwitz MS, Winer DA, Mortha A, Mackay F, Prat A, Osborne LC, Robbins C, Baranzini SE, Gommerman JL

Silent progression in disease activity-free relapsing multiple sclerosis.

Annals of neurology

Cree BAC, Hollenbach JA, Bove R, Kirkish G, Sacco S, Caverzasi E, Bischof A, Gundel T, Zhu AH, Papinutto N, Stern WA, Bevan C, Romeo A, Goodin DS, Gelfand JM, Graves J, Green AJ, Wilson MR, Zamvil SS, Zhao C, Gomez R, Ragan NR, Rush GQ, Barba P, Santaniello A, Baranzini SE, Oksenberg JR, Henry RG, Hauser SL

Cerebellar syndrome in a man treated with natalizumab: From the National Multiple Sclerosis Society Case Conference Proceedings.

Neurology(R) neuroimmunology & neuroinflammation

Lapides DA, Batchala PP, Donahue JH, Lisak RP, Meltzer EI, Narayan RN, Nath A, Frohman TC, Costello K, Goldman MD, Zamvil SS, Frohman EM

B-Cell Therapies in Multiple Sclerosis.

Cold Spring Harbor perspectives in medicine

Sabatino JJ, Zamvil SS, Hauser SL

The Evolving Mechanisms of Action of Glatiramer Acetate.

Cold Spring Harbor perspectives in medicine

Prod'homme T, Zamvil SS

Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10.

Cell

Rojas OL, Pröbstel AK, Porfilio EA, Wang AA, Charabati M, Sun T, Lee DSW, Galicia G, Ramaglia V, Ward LA, Leung LYT, Najafi G, Khaleghi K, Garcillán B, Li A, Besla R, Naouar I, Cao EY, Chiaranunt P, Burrows K, Robinson HG, Allanach JR, Yam J, Luck H, Campbell DJ, Allman D, Brooks DG, Tomura M, Baumann R, Zamvil SS, Bar-Or A, Horwitz MS, Winer DA, Mortha A, Mackay F, Prat A, Osborne LC, Robbins C, Baranzini SE, Gommerman JL

A young man in "double-trouble": Hallucinations and cranial nerve palsies: From the National Multiple Sclerosis Society Case Conference Proceedings.

Neurology(R) neuroimmunology & neuroinflammation

Bradshaw MJ, Lisak RP, Meltzer E, Melamed E, Lucas A, Freeman L, Frohman TC, Costello K, Balcer L, Galetta S, Chitnis T, Zamvil SS, Frohman EM

N2 year in review and message from the editor to our reviewers.

Neurology(R) neuroimmunology & neuroinflammation

Dalmau J, Kolson DL, Paul F, Zamvil SS

Multiple Sclerosis-Associated Changes in the Composition and Immune Functions of Spore-Forming Bacteria.

mSystems

Cekanaviciute E, Pröbstel AK, Thomann A, Runia TF, Casaccia P, Katz Sand I, Crabtree E, Singh S, Morrissey J, Barba P, Gomez R, Knight R, Mazmanian S, Graves J, Cree BAC, Zamvil SS, Baranzini SE

A young man with numbness in arms and legs: From the National Multiple Sclerosis Society Case Conference Proceedings.

Neurology(R) neuroimmunology & neuroinflammation

Romeo AR, Lisak RP, Meltzer E, Fox EJ, Melamed E, Lucas A, Freeman L, Frohman TC, Costello K, Zamvil SS, Frohman EM, Gelfand JM

Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration.

Nature immunology

Ryu JK, Rafalski VA, Meyer-Franke A, Adams RA, Poda SB, Rios Coronado PE, Pedersen LØ, Menon V, Baeten KM, Sikorski SL, Bedard C, Hanspers K, Bardehle S, Mendiola AS, Davalos D, Machado MR, Chan JP, Plastira I, Petersen MA, Pfaff SJ, Ang KK, Hallenbeck KK, Syme C, Hakozaki H, Ellisman MH, Swanson RA, Zamvil SS, Arkin MR, Zorn SH, Pico AR, Mucke L, Freedman SB, Stavenhagen JB, Nelson RB, Akassoglou K

T cells take aim at a ubiquitous autoantigen in multiple sclerosis.

Science translational medicine

Sabatino JJ, Zamvil SS

Functional characterization of reappearing B cells after anti-CD20 treatment of CNS autoimmune disease.

Proceedings of the National Academy of Sciences of the United States of America

Häusler D, Häusser-Kinzel S, Feldmann L, Torke S, Lepennetier G, Bernard CCA, Zamvil SS, Brück W, Lehmann-Horn K, Weber MS

Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2a.

Nature communications

Wang Q, He Z, Huang M, Liu T, Wang Y, Xu H, Duan H, Ma P, Zhang L, Zamvil SS, Hidalgo J, Zhang Z, O'Rourke DM, Dahmane N, Brem S, Mou Y, Gong Y, Fan Y

The Gut Microbiome in Neuromyelitis Optica.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Zamvil SS, Spencer CM, Baranzini SE, Cree BAC

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4.

Journal of visualized experiments : JoVE

Sagan SA, Cruz-Herranz A, Spencer CM, Ho PP, Steinman L, Green AJ, Sobel RA, Zamvil SS

Aryl hydrocarbon receptor activity may serve as a surrogate marker for MS disease activity.

Neurology(R) neuroimmunology & neuroinflammation

Sabatino JJ, Zamvil SS

Acute liver injury in a Glatopa-treated patient with MS.

Neurology(R) neuroimmunology & neuroinflammation

Sabatino JJ, Mehta NJ, Kakar S, Zamvil SS, Cree BAC

T cells targeting neuromyelitis optica autoantigen aquaporin-4 cause paralysis and visual system injury.

Journal of nature and science

Cruz-Herranz A, Sagan SA, Sobel RA, Green AJ, Zamvil SS

B cell repertoire expansion occurs in meningeal ectopic lymphoid tissue.

JCI insight

Lehmann-Horn K, Wang SZ, Sagan SA, Zamvil SS, von Büdingen HC

Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4.

Proceedings of the National Academy of Sciences of the United States of America

Sagan SA, Winger RC, Cruz-Herranz A, Nelson PA, Hagberg S, Miller CN, Spencer CM, Ho PP, Bennett JL, Levy M, Levin MH, Verkman AS, Steinman L, Green AJ, Anderson MS, Sobel RA, Zamvil SS

Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery.

eLife

Mei F, Lehmann-Horn K, Shen YA, Rankin KA, Stebbins KJ, Lorrain DS, Pekarek K, A Sagan S, Xiao L, Teuscher C, von Büdingen HC, Wess J, Lawrence JJ, Green AJ, Fancy SP, Zamvil SS, Chan JR

Associations between the gut microbiota and host immune markers in pediatric multiple sclerosis and controls.

BMC neurology

Tremlett H, Fadrosh DW, Faruqi AA, Hart J, Roalstad S, Graves J, Spencer CM, Lynch SV, Zamvil SS, Waubant E

Treatment of spontaneous EAE by laquinimod reduces Tfh, B cell aggregates, and disease progression.

Neurology(R) neuroimmunology & neuroinflammation

Varrin-Doyer M, Pekarek KL, Spencer CM, Bernard CC, Sobel RA, Cree BA, Schulze-Topphoff U, Zamvil SS

Restoring immune tolerance in neuromyelitis optica: Part I.

Neurology(R) neuroimmunology & neuroinflammation

Steinman L, Bar-Or A, Behne JM, Benitez-Ribas D, Chin PS, Clare-Salzler M, Healey D, Kim JI, Kranz DM, Lutterotti A, Martin R, Schippling S, Villoslada P, Wei CH, Weiner HL, Zamvil SS, Yeaman MR, Smith TJ

Restoring immune tolerance in neuromyelitis optica: Part II.

Neurology(R) neuroimmunology & neuroinflammation

Bar-Or A, Steinman L, Behne JM, Benitez-Ribas D, Chin PS, Clare-Salzler M, Healey D, Kim JI, Kranz DM, Lutterotti A, Martin R, Schippling S, Villoslada P, Wei CH, Weiner HL, Zamvil SS, Smith TJ, Yeaman MR

Long-term evolution of multiple sclerosis disability in the treatment era.

Annals of neurology

Cree BA, Gourraud PA, Oksenberg JR, Bevan C, Crabtree-Hartman E, Gelfand JM, Goodin DS, Graves J, Green AJ, Mowry E, Okuda DT, Pelletier D, von Büdingen HC, Zamvil SS, Agrawal A, Caillier S, Ciocca C, Gomez R, Kanner R, Lincoln R, Lizee A, Qualley P, Santaniello A, Suleiman L, Bucci M, Panara V, Papinutto N, Stern WA, Zhu AH, Cutter GR, Baranzini S, Henry RG, Hauser SL

Gut microbiome analysis in neuromyelitis optica reveals overabundance of Clostridium perfringens.

Annals of neurology

Cree BA, Spencer CM, Varrin-Doyer M, Baranzini SE, Zamvil SS

Your nose knows how to target brain inflammation.

Brain : a journal of neurology

Winger RC, Zamvil SS

Antibodies in multiple sclerosis oligoclonal bands target debris.

Proceedings of the National Academy of Sciences of the United States of America

Winger RC, Zamvil SS

Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2.

Proceedings of the National Academy of Sciences of the United States of America

Schulze-Topphoff U, Varrin-Doyer M, Pekarek K, Spencer CM, Shetty A, Sagan SA, Cree BA, Sobel RA, Wipke BT, Steinman L, Scannevin RH, Zamvil SS

CNS accumulation of regulatory B cells is VLA-4-dependent.

Neurology(R) neuroimmunology & neuroinflammation

Lehmann-Horn K, Sagan SA, Winger RC, Spencer CM, Bernard CC, Sobel RA, Zamvil SS

Glatiramer acetate treatment negatively regulates type I interferon signaling.

Neurology(R) neuroimmunology & neuroinflammation

Molnarfi N, Prod'homme T, Schulze-Topphoff U, Spencer CM, Weber MS, Patarroyo JC, Lalive PH, Zamvil SS

Vitamin D in clinically isolated syndrome: evidence for possible neuroprotection.

European journal of neurology

Mowry EM, Pelletier D, Gao Z, Howell MD, Zamvil SS, Waubant E

Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation.

Nature communications

Ryu JK, Petersen MA, Murray SG, Baeten KM, Meyer-Franke A, Chan JP, Vagena E, Bedard C, Machado MR, Rios Coronado PE, Prod'homme T, Charo IF, Lassmann H, Degen JL, Zamvil SS, Akassoglou K

Unique invariant CD8(+) T cell population persists in MS.

Neurology(R) neuroimmunology & neuroinflammation

Sabatino JJ, Zamvil SS

Update on biomarkers in neuromyelitis optica.

Neurology(R) neuroimmunology & neuroinflammation

Melamed E, Levy M, Waters PJ, Sato DK, Bennett JL, John GR, Hooper DC, Saiz A, Bar-Or A, Kim HJ, Pandit L, Leite MI, Asgari N, Kissani N, Hintzen R, Marignier R, Jarius S, Marcelletti J, Smith TJ, Yeaman MR, Han MH, Aktas O, Apiwattanakul M, Banwell B, Bichuetti D, Broadley S, Cabre P, Chitnis T, De Seze J, Fujihara K, Greenberg B, Hellwig K, Iorio R, Jarius S, Klawiter E, Kleiter I, Lana-Peixoto M, O'Connor K, Palace J, Paul F, Prayoonwiwat N, Ruprecht K, Stuve O, Tedder T, Tenembaum S, Garrahan JP, Aires B, van Herle K, van Pelt D, Villoslada P, Waubant E, Weinshenker B, Wingerchuk D, Würfel J, Zamvil S

Erratum: The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis.

Nature immunology

Onizawa M, Oshima S, Schulze-Topphoff U, Oses-Prieto JA, Lu T, Tavares R, Prodhomme T, Duong B, Whang MI, Advincula R, Agelidis A, Barrera J, Wu H, Burlingame A, Malynn BA, Zamvil SS, Ma A

Use of Advanced Magnetic Resonance Imaging Techniques in Neuromyelitis Optica Spectrum Disorder.

JAMA neurology

Kremer S, Renard F, Achard S, Lana-Peixoto MA, Palace J, Asgari N, Klawiter EC, Tenembaum SN, Banwell B, Greenberg BM, Bennett JL, Levy M, Villoslada P, Saiz A, Fujihara K, Chan KH, Schippling S, Paul F, Kim HJ, de Seze J, Wuerfel JT, Cabre P, Marignier R, Tedder T, van Pelt D, Broadley S, Chitnis T, Wingerchuk D, Pandit L, Leite MI, Apiwattanakul M, Kleiter I, Prayoonwiwat N, Han M, Hellwig K, van Herle K, John G, Hooper DC, Nakashima I, Sato D, Yeaman MR, Waubant E, Zamvil S, Stüve O, Aktas O, Smith TJ, Jacob A, O'Connor K

B lymphocytes in neuromyelitis optica.

Neurology(R) neuroimmunology & neuroinflammation

Bennett JL, O'Connor KC, Bar-Or A, Zamvil SS, Hemmer B, Tedder TF, von Büdingen HC, Stuve O, Yeaman MR, Smith TJ, Stadelmann C

The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis.

Nature immunology

Onizawa M, Oshima S, Schulze-Topphoff U, Oses-Prieto JA, Lu T, Tavares R, Prodhomme T, Duong B, Whang MI, Advincula R, Agelidis A, Barrera J, Wu H, Burlingame A, Malynn BA, Zamvil SS, Ma A

Update on the autoimmune pathology of multiple sclerosis: B-cells as disease-drivers and therapeutic targets.

European neurology

von Büdingen HC, Palanichamy A, Lehmann-Horn K, Michel BA, Zamvil SS

Reduction of CD8(+) T lymphocytes in multiple sclerosis patients treated with dimethyl fumarate.

Neurology(R) neuroimmunology & neuroinflammation

Spencer CM, Crabtree-Hartman EC, Lehmann-Horn K, Cree BA, Zamvil SS

Precision medicine in chronic disease management: The multiple sclerosis BioScreen.

Annals of neurology

Gourraud PA, Henry RG, Cree BA, Crane JC, Lizee A, Olson MP, Santaniello AV, Datta E, Zhu AH, Bevan CJ, Gelfand JM, Graves JS, Goodin DS, Green AJ, von Büdingen HC, Waubant E, Zamvil SS, Crabtree-Hartman E, Nelson S, Baranzini SE, Hauser SL

Immunodominant T-cell epitopes of MOG reside in its transmembrane and cytoplasmic domains in EAE.

Neurology(R) neuroimmunology & neuroinflammation

Shetty A, Gupta SG, Varrin-Doyer M, Weber MS, Prod'homme T, Molnarfi N, Ji N, Nelson PA, Patarroyo JC, Schulze-Topphoff U, Fogal SE, Forsthuber T, Sobel RA, Bernard CC, Slavin AJ, Zamvil SS

MOG transmembrane and cytoplasmic domains contain highly stimulatory T-cell epitopes in MS.

Neurology(R) neuroimmunology & neuroinflammation

Varrin-Doyer M, Shetty A, Spencer CM, Schulze-Topphoff U, Weber MS, Bernard CC, Forsthuber T, Cree BA, Slavin AJ, Zamvil SS

Laquinimod, an up-and-coming immunomodulatory agent for treatment of multiple sclerosis.

Experimental neurology

Varrin-Doyer M, Zamvil SS, Schulze-Topphoff U

MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies.

The Journal of experimental medicine

Molnarfi N, Schulze-Topphoff U, Weber MS, Patarroyo JC, Prod'homme T, Varrin-Doyer M, Shetty A, Linington C, Slavin AJ, Hidalgo J, Jenne DE, Wekerle H, Sobel RA, Bernard CC, Shlomchik MJ, Zamvil SS

Therapeutic decisions in multiple sclerosis: moving beyond efficacy.

JAMA neurology

Brück W, Gold R, Lund BT, Oreja-Guevara C, Prat A, Spencer CM, Steinman L, Tintoré M, Vollmer TL, Weber MS, Weiner LP, Ziemssen T, Zamvil SS

Tob1 plays a critical role in the activation of encephalitogenic T cells in CNS autoimmunity.

The Journal of experimental medicine

Schulze-Topphoff U, Casazza S, Varrin-Doyer M, Pekarek K, Sobel RA, Hauser SL, Oksenberg JR, Zamvil SS, Baranzini SE

Developmental maturation of innate immune cell function correlates with susceptibility to central nervous system autoimmunity.

European journal of immunology

Hertzenberg D, Lehmann-Horn K, Kinzel S, Husterer V, Cravens PD, Kieseier BC, Hemmer B, Brück W, Zamvil SS, Stüve O, Weber MS

The neonatal CNS is not conducive for encephalitogenic Th1 T cells and B cells during experimental autoimmune encephalomyelitis.

Journal of neuroinflammation

Cravens PD, Kieseier BC, Hussain R, Herndon E, Arellano B, Ben LH, Timmons BC, Castro-Rojas C, Hartung HP, Hemmer B, Weber MS, Zamvil SS, Stüve O

Aquaporin 4-specific T cells in neuromyelitis optica exhibit a Th17 bias and recognize Clostridium ABC transporter.

Annals of neurology

Varrin-Doyer M, Spencer CM, Schulze-Topphoff U, Nelson PA, Stroud RM, Cree BA, Zamvil SS

K+ channel alterations in the progression of experimental autoimmune encephalomyelitis.

Neurobiology of disease

Jukkola PI, Lovett-Racke AE, Zamvil SS, Gu C

Laquinimod, a quinoline-3-carboxamide, induces type II myeloid cells that modulate central nervous system autoimmunity.

PloS one

Schulze-Topphoff U, Shetty A, Varrin-Doyer M, Molnarfi N, Sagan SA, Sobel RA, Nelson PA, Zamvil SS

Randomized controlled trial of atorvastatin in clinically isolated syndrome: the STAyCIS study.

Neurology

Waubant E, Pelletier D, Mass M, Cohen JA, Kita M, Cross A, Bar-Or A, Vollmer T, Racke M, Stüve O, Schwid S, Goodman A, Kachuck N, Preiningerova J, Weinstock-Guttman B, Calabresi PA, Miller A, Mokhtarani M, Iklé D, Murphy S, Kopetskie H, Ding L, Rosenberg E, Spencer C, Zamvil SS

B cells in multiple sclerosis: connecting the dots.

Current opinion in immunology

von Büdingen HC, Bar-Or A, Zamvil SS

Lymph node-derived donor encephalitogenic CD4+ T cells in C57BL/6 mice adoptive transfer experimental autoimmune encephalomyelitis highly express GM-CSF and T-bet.

Journal of neuroinflammation

Cravens PD, Hussain RZ, Zacharias TE, Ben LH, Herndon E, Vinnakota R, Lambracht-Washington D, Nessler S, Zamvil SS, Eagar TN, Stüve O

Accelerated central nervous system autoimmunity in BAFF-receptor-deficient mice.

Journal of the neurological sciences

Kim SS, Richman DP, Zamvil SS, Agius MA

Glatiramer acetate in the treatment of multiple sclerosis: emerging concepts regarding its mechanism of action.

CNS drugs

Lalive PH, Neuhaus O, Benkhoucha M, Burger D, Hohlfeld R, Zamvil SS, Weber MS

Switching multiple sclerosis patients with breakthrough disease to second-line therapy.

PloS one

Castillo-Trivino T, Mowry EM, Gajofatto A, Chabas D, Crabtree-Hartman E, Cree BA, Goodin DS, Green AJ, Okuda DT, Pelletier D, Zamvil SS, Vittinghoff E, Waubant E

Proinflammatory role of aquaporin-4 in autoimmune neuroinflammation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Li L, Zhang H, Varrin-Doyer M, Zamvil SS, Verkman AS

Repetitive pertussis toxin promotes development of regulatory T cells and prevents central nervous system autoimmune disease.

PloS one

Weber MS, Benkhoucha M, Lehmann-Horn K, Hertzenberg D, Sellner J, Santiago-Raber ML, Chofflon M, Hemmer B, Zamvil SS, Lalive PH

Immunodominant T cell determinants of aquaporin-4, the autoantigen associated with neuromyelitis optica.

PloS one

Nelson PA, Khodadoust M, Prodhomme T, Spencer C, Patarroyo JC, Varrin-Doyer M, Ho JD, Stroud RM, Zamvil SS

B-cell activation influences T-cell polarization and outcome of anti-CD20 B-cell depletion in central nervous system autoimmunity.

Annals of neurology

Weber MS, Prod'homme T, Patarroyo JC, Molnarfi N, Karnezis T, Lehmann-Horn K, Danilenko DM, Eastham-Anderson J, Slavin AJ, Linington C, Bernard CC, Martin F, Zamvil SS

Natalizumab and progressive multifocal leukoencephalopathy: what are the causal factors and can it be avoided?

Archives of neurology

Warnke C, Menge T, Hartung HP, Racke MK, Cravens PD, Bennett JL, Frohman EM, Greenberg BM, Zamvil SS, Gold R, Hemmer B, Kieseier BC, Stüve O

TLR-mediated B cell activation results in ectopic CLIP expression that promotes B cell-dependent inflammation.

Journal of leukocyte biology

Newell MK, Tobin RP, Cabrera JH, Sorensen MB, Huckstep A, Villalobos-Menuey EM, Burnett M, McCrea E, Harvey CP, Buddiga A, Bar-Or A, Freedman MS, Nalbantoglu J, Arbour N, Zamvil SS, Antel JP

Translational research in neurology and neuroscience 2010: multiple sclerosis.

Archives of neurology

Stüve O, Kieseier BC, Hemmer B, Hartung HP, Awad A, Frohman EM, Greenberg BM, Racke MK, Zamvil SS, Phillips JT, Gold R, Chan A, Zettl U, Milo R, Marder E, Khan O, Eagar TN

Depletion of B lymphocytes from cerebral perivascular spaces by rituximab.

Archives of neurology

Martin Mdel P, Cravens PD, Winger R, Kieseier BC, Cepok S, Eagar TN, Zamvil SS, Weber MS, Frohman EM, Kleinschmidt-Demasters BK, Montine TJ, Hemmer B, Marra CM, Stüve O

Glatiramer acetate increases IL-1 receptor antagonist but decreases T cell-induced IL-1beta in human monocytes and multiple sclerosis.

Proceedings of the National Academy of Sciences of the United States of America

Burger D, Molnarfi N, Weber MS, Brandt KJ, Benkhoucha M, Gruaz L, Chofflon M, Zamvil SS, Lalive PH

Genotype-Phenotype correlations in multiple sclerosis: HLA genes influence disease severity inferred by 1HMR spectroscopy and MRI measures.

Brain : a journal of neurology

Okuda DT, Srinivasan R, Oksenberg JR, Goodin DS, Baranzini SE, Beheshtian A, Waubant E, Zamvil SS, Leppert D, Qualley P, Lincoln R, Gomez R, Caillier S, George M, Wang J, Nelson SJ, Cree BA, Hauser SL, Pelletier D

Decrease in the numbers of dendritic cells and CD4+ T cells in cerebral perivascular spaces due to natalizumab.

Archives of neurology

del Pilar Martin M, Cravens PD, Winger R, Frohman EM, Racke MK, Eagar TN, Zamvil SS, Weber MS, Hemmer B, Karandikar NJ, Kleinschmidt-DeMasters BK, Stüve O

Glatiramer acetate treatment does not modify the clinical course of (NZB x BXSB)F1 lupus murine model.

International immunology

Borel P, Benkhoucha M, Weber MS, Zamvil SS, Santiago-Raber ML, Lalive PH

Disease-modifying agents for multiple sclerosis: recent advances and future prospects.

Drugs

Menge T, Weber MS, Hemmer B, Kieseier BC, von Büdingen HC, Warnke C, Zamvil SS, Boster A, Khan O, Hartung HP, Stüve O

Pharmacological treatment of early multiple sclerosis.

Drugs

Stüve O, Bennett JL, Hemmer B, Wiendl H, Racke MK, Bar-Or A, Hu W, Zivadinov R, Weber MS, Zamvil SS, Pacheco MF, Menge T, Hartung HP, Kieseier BC, Frohman EM

Statins and demyelination.

Current topics in microbiology and immunology

Weber MS, Zamvil SS

Mechanism of action of glatiramer acetate in treatment of multiple sclerosis.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Weber MS, Hohlfeld R, Zamvil SS

Neuroimmunotherapeutics comes of age.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Ransohoff RM, Zamvil SS

Statins--treatment option for central nervous system autoimmune disease?

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Weber MS, Steinman L, Zamvil SS

Spotlight on statins.

International MS journal

Weber MS, Stuve O, Neuhaus O, Hartung HP, Zamvil SS

Type II monocytes modulate T cell-mediated central nervous system autoimmune disease.

Nature medicine

Weber MS, Prod'homme T, Youssef S, Dunn SE, Rundle CD, Lee L, Patarroyo JC, Stüve O, Sobel RA, Steinman L, Zamvil SS

Combination therapies for multiple sclerosis: scientific rationale, clinical trials, and clinical practice.

Current opinion in neurology

Costello F, Stüve O, Weber MS, Zamvil SS, Frohman E

T effectors outfox T regulators in autoimmunity.

Nature medicine

Prod'homme T, Weber MS, Zamvil SS

Inhibition of naive Th1 CD4+ T cells by glatiramer acetate in multiple sclerosis.

Journal of neuroimmunology

Kantengwa S, Weber MS, Juillard C, Benkhoucha M, Fellay B, Zamvil SS, Gougeon ML, Chofflon M, Lalive PH

Simvastatin regulates oligodendroglial process dynamics and survival.

Glia

Miron VE, Rajasekharan S, Jarjour AA, Zamvil SS, Kennedy TE, Antel JP

Statins in the treatment of central nervous system autoimmune disease.

Journal of neuroimmunology

Weber MS, Youssef S, Dunn SE, Prod'homme T, Neuhaus O, Stuve O, Greenwood J, Steinman L, Zamvil SS

Statin therapy and autoimmune disease: from protein prenylation to immunomodulation.

Nature reviews. Immunology

Greenwood J, Steinman L, Zamvil SS

Immunomodulatory synergy by combination of atorvastatin and glatiramer acetate in treatment of CNS autoimmunity.

The Journal of clinical investigation

Stüve O, Youssef S, Weber MS, Nessler S, von Büdingen HC, Hemmer B, Prod'homme T, Sobel RA, Steinman L, Zamvil SS

A neuropeptide in immune-mediated inflammation, Y?

Trends in immunology

Prod'homme T, Weber MS, Steinman L, Zamvil SS

Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin.

The Journal of experimental medicine

Dunn SE, Youssef S, Goldstein MJ, Prod'homme T, Weber MS, Zamvil SS, Steinman L

Drug Insight: using statins to treat neuroinflammatory disease.

Nature clinical practice. Neurology

Weber MS, Prod'homme T, Steinman L, Zamvil SS

Therapeutic considerations for disease progression in multiple sclerosis: evidence, experience, and future expectations.

Archives of neurology

Frohman EM, Stüve O, Havrdova E, Corboy J, Achiron A, Zivadinov R, Sorensen PS, Phillips JT, Weinshenker B, Hawker K, Hartung HP, Steinman L, Zamvil S, Cree BA, Hauser S, Weiner H, Racke MK, Filippi M

[Statins for treatment of CNS diseases. Status report from research and clinical practice].

Der Nervenarzt

Menge T, von Büdingen HC, Zamvil SS, Hartung HP, Kieseier BC, Stüve O

Are statins a treatment option for multiple sclerosis?

The Lancet. Neurology

Neuhaus O, Stüve O, Zamvil SS, Hartung HP

Mitoxantrone as a potential therapy for primary progressive multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England)

Stüve O, Kita M, Pelletier D, Fox RJ, Stone J, Goodkin DE, Zamvil SS

Statins as potential therapeutic agents in multiple sclerosis.

Current neurology and neuroscience reports

Stüve O, Prod'homme T, Youssef S, Dunn S, Neuhaus O, Weber M, Hartung HP, Steinman L, Zamvil SS

The potential therapeutic role of statins in central nervous system autoimmune disorders.

Cellular and molecular life sciences : CMLS

Stüve O, Youssef S, Dunn S, Slavin AJ, Steinman L, Zamvil SS

Statins and their potential targets in multiple sclerosis therapy.

Expert opinion on therapeutic targets

Stüve O, Prod'homme T, Slavin A, Youssef S, Dunn S, Steinman L, Zamvil SS

MRI lesion volume heterogeneity in primary progressive MS in relation with axonal damage and brain atrophy.

Journal of neurology, neurosurgery, and psychiatry

Pelletier D, Nelson SJ, Oh J, Antel JP, Kita M, Zamvil SS, Goodkin DE

Statins as potential therapeutic agents in neuroinflammatory disorders.

Current opinion in neurology

Stüve O, Youssef S, Steinman L, Zamvil SS

Transcriptional analysis of targets in multiple sclerosis.

Nature reviews. Immunology

Steinman L, Zamvil S

The role of the MHC class II transactivator in class II expression and antigen presentation by astrocytes and in susceptibility to central nervous system autoimmune disease.

Journal of immunology (Baltimore, Md. : 1950)

Stüve O, Youssef S, Slavin AJ, King CL, Patarroyo JC, Hirschberg DL, Brickey WJ, Soos JM, Piskurich JF, Chapman HA, Zamvil SS

The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease.

Nature

Youssef S, Stüve O, Patarroyo JC, Ruiz PJ, Radosevich JL, Hur EM, Bravo M, Mitchell DJ, Sobel RA, Steinman L, Zamvil SS

Approved and future pharmacotherapy for multiple sclerosis.

The neurologist

Stüve O, Cree BC, von Büdingen HC, Yousef S, Bowen JD, Genain CP, Hauser SL, Steinman L, Zamvil SS

Cutting edge: oral type I IFN-tau promotes a Th2 bias and enhances suppression of autoimmune encephalomyelitis by oral glatiramer acetate.

Journal of immunology (Baltimore, Md. : 1950)

Soos JM, Stüve O, Youssef S, Bravo M, Johnson HM, Weiner HL, Zamvil SS

Single nucleotide polymorphisms in MHC2TA, the gene encoding the MHC class II transactivator (CIITA).

Genes and immunity

Patarroyo JC, Stuve O, Piskurich JF, Hauser SL, Oksenberg JR, Zamvil SS

Requirement for endocytic antigen processing and influence of invariant chain and H-2M deficiencies in CNS autoimmunity.

The Journal of clinical investigation

Slavin AJ, Soos JM, Stuve O, Patarroyo JC, Weiner HL, Fontana A, Bikoff EK, Zamvil SS

Specific immunotherapy: one size does not fit all.

Nature medicine

Genain CP, Zamvil SS

Differential expression of B7 co-stimulatory molecules by astrocytes correlates with T cell activation and cytokine production.

International immunology

Soos JM, Ashley TA, Morrow J, Patarroyo JC, Szente BE, Zamvil SS

Highlights from the Fifth International Congress of the International Society of Neuroimmunology.

Journal of neuroimmunology

Freedman MS, Ransohoff R, Talbot PJ, Zamvil SS

Astrocytes express elements of the class II endocytic pathway and process central nervous system autoantigen for presentation to encephalitogenic T cells.

Journal of immunology (Baltimore, Md. : 1950)

Soos JM, Morrow J, Ashley TA, Szente BE, Bikoff EK, Zamvil SS

Pathogenesis and treatment of central nervous system demyelinating disease.

Revue neurologique

Zamvil SS, Soos JM, Weiner HL

Effect of oral beta interferon on subsequent immune responsiveness.

Annals of the New York Academy of Sciences

Nelson PA, Akselband Y, Dearborn SM, Al-Sabbagh A, Tian ZJ, Gonnella PA, Zamvil SS, Chen Y, Weiner HL

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy.

Cell

Kuchroo VK, Das MP, Brown JA, Ranger AM, Zamvil SS, Sobel RA, Weiner HL, Nabavi N, Glimcher LH

Reciprocal expression of co-stimulatory molecules, B7-1 and B7-2, on murine T cells following activation.

European journal of immunology

Prabhu Das MR, Zamvil SS, Borriello F, Weiner HL, Sharpe AH, Kuchroo VK

T cell receptor (TCR) usage determines disease susceptibility in experimental autoimmune encephalomyelitis: studies with TCR V beta 8.2 transgenic mice.

The Journal of experimental medicine

Kuchroo VK, Collins M, al-Sabbagh A, Sobel RA, Whitters MJ, Zamvil SS, Dorf ME, Hafler DA, Seidman JG, Weiner HL

'Lupus-prone' mice are susceptible to organ-specific autoimmune disease, experimental allergic encephalomyelitis.

Pathobiology : journal of immunopathology, molecular and cellular biology

Zamvil SS, al-Sabbagh A, Nelson PA, Kaul D, Charles MS, Mitchell DJ, Steinman L, Weiner HL, Kuchroo VK

Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity.

International immunology

Powell MB, Mitchell D, Lederman J, Buckmeier J, Zamvil SS, Graham M, Ruddle NH, Steinman L

The T lymphocyte in experimental allergic encephalomyelitis.

Annual review of immunology

Zamvil SS, Steinman L

Prevention of experimental encephalomyelitis with peptides that block interaction of T cells with major histocompatibility complex proteins.

Proceedings of the National Academy of Sciences of the United States of America

Sakai K, Zamvil SS, Mitchell DJ, Hodgkinson S, Rothbard JB, Steinman L

Polymorphic residues on the I-A beta chain modulate the stimulation of T cell clones specific for the N-terminal peptide of the autoantigen myelin basic protein.

Journal of immunology (Baltimore, Md. : 1950)

Davis CB, Mitchell DJ, Wraith DC, Todd JA, Zamvil SS, McDevitt HO, Steinman L, Jones PP

Autoimmune demyelinating disease.

The Western journal of medicine

Zamvil SS, Steinman L

Involvement of distinct murine T-cell receptors in the autoimmune encephalitogenic response to nested epitopes of myelin basic protein.

Proceedings of the National Academy of Sciences of the United States of America

Sakai K, Sinha AA, Mitchell DJ, Zamvil SS, Rothbard JB, McDevitt HO, Steinman L

Multiple discrete encephalitogenic epitopes of the autoantigen myelin basic protein include a determinant for I-E class II-restricted T cells.

The Journal of experimental medicine

Zamvil SS, Mitchell DJ, Powell MB, Sakai K, Rothbard JB, Steinman L

Characterization of a major encephalitogenic T cell epitope in SJL/J mice with synthetic oligopeptides of myelin basic protein.

Journal of neuroimmunology

Sakai K, Zamvil SS, Mitchell DJ, Lim M, Rothbard JB, Steinman L

Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention.

Cell

Acha-Orbea H, Mitchell DJ, Timmermann L, Wraith DC, Tausch GS, Waldor MK, Zamvil SS, McDevitt HO, Steinman L

Predominant expression of a T cell receptor V beta gene subfamily in autoimmune encephalomyelitis.

The Journal of experimental medicine

Zamvil SS, Mitchell DJ, Lee NE, Moore AC, Waldor MK, Sakai K, Rothbard JB, McDevitt HO, Steinman L, Acha-Orbea H

T cell specificity for class II (I-A) and the encephalitogenic N-terminal epitope of the autoantigen myelin basic protein.

Journal of immunology (Baltimore, Md. : 1950)

Zamvil SS, Mitchell DJ, Moore AC, Schwarz AJ, Stiefel W, Nelson PA, Rothbard JB, Steinman L

T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis.

Nature

Zamvil SS, Mitchell DJ, Moore AC, Kitamura K, Steinman L, Rothbard JB

Therapy of autoimmune diseases with antibody to immune response gene products or to T-cell surface markers.

Annals of the New York Academy of Sciences

Steinman L, Waldor MK, Zamvil SS, Lim M, Herzenberg L, Herzenberg L, McDevitt HO, Mitchell D, Sriram S

Encephalitogenic T cell clones specific for myelin basic protein. An unusual bias in antigen recognition.

The Journal of experimental medicine

Zamvil SS, Nelson PA, Mitchell DJ, Knobler RL, Fritz RB, Steinman L

T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination.

Nature

Zamvil S, Nelson P, Trotter J, Mitchell D, Knobler R, Fritz R, Steinman L

Murine model for pertussis vaccine encephalopathy: linkage to H-2.

Nature

Steinman L, Sriram S, Adelman NE, Zamvil S, McDevitt HO, Urich H

Maturation of potassium-stimulated respiration in rat cerebral cortical slices.

Journal of neurochemistry

Holtzman D, Olson J, Zamvil S, Nguyen H

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