Suzanne Noble, MD, PhD

Associate Professor
Microbiology and Immunology
Publications: 

Peptide YY: A Paneth cell antimicrobial peptide that maintains Candida gut commensalism.

Science (New York, N.Y.)

Pierre JF, Peters BM, La Torre D, Sidebottom AM, Tao Y, Zhu X, Cham CM, Wang L, Kambal A, Harris KG, Silva JF, Zaborina O, Alverdy JC, Herzog H, Witchley J, Noble SM, Leone VA, Chang EB

Multifactor transcriptional control of alternative oxidase induction integrates diverse environmental inputs to enable fungal virulence.

Nature communications

Liu Z, Basso P, Hossain S, Liston SD, Robbins N, Whitesell L, Noble SM, Cowen LE

Deep tissue infection by an invasive human fungal pathogen requires lipid-based suppression of the IL-17 response.

Cell host & microbe

Basso P, Dang EV, Urisman A, Cowen LE, Madhani HD, Noble SM

Christine Guthrie (1945-2022).

Science (New York, N.Y.)

Noble S, Burgess SM, Strauss E

Candida albicans oscillating UME6 expression during intestinal colonization primes systemic Th17 protective immunity.

Cell reports

Shao TY, Kakade P, Witchley JN, Frazer C, Murray KL, Ene IV, Haslam DB, Hagan T, Noble SM, Bennett RJ, Way SS

Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets.

Nature communications

Fu C, Zhang X, Veri AO, Iyer KR, Lash E, Xue A, Yan H, Revie NM, Wong C, Lin ZY, Polvi EJ, Liston SD, VanderSluis B, Hou J, Yashiroda Y, Gingras AC, Boone C, O'Meara TR, O'Meara MJ, Noble S, Robbins N, Myers CL, Cowen LE

Adaptive immunity induces mutualism between commensal eukaryotes.

Nature

Ost KS, O'Meara TR, Stephens WZ, Chiaro T, Zhou H, Penman J, Bell R, Catanzaro JR, Song D, Singh S, Call DH, Hwang-Wong E, Hanson KE, Valentine JF, Christensen KA, O'Connell RM, Cormack B, Ibrahim AS, Palm NW, Noble SM, Round JL

Visualization of Candida albicans in the Murine Gastrointestinal Tract Using Fluorescent In Situ Hybridization.

Journal of visualized experiments : JoVE

Witchley JN, Penumetcha PM, Noble SM

A natural histone H2A variant lacking the Bub1 phosphorylation site and regulated depletion of centromeric histone CENP-A foster evolvability in Candida albicans.

PLoS biology

Brimacombe CA, Burke JE, Parsa JY, Catania S, O'Meara TR, Witchley JN, Burrack LS, Madhani HD, Noble SM

Candida albicans Morphogenesis Programs Control the Balance between Gut Commensalism and Invasive Infection.

Cell host & microbe

Witchley JN, Penumetcha P, Abon NV, Woolford CA, Mitchell AP, Noble SM

High-Throughput Screening Identifies Genes Required for Candida albicans Induction of Macrophage Pyroptosis.

mBio

O'Meara TR, Duah K, Guo CX, Maxson ME, Gaudet RG, Koselny K, Wellington M, Powers ME, MacAlpine J, O'Meara MJ, Veri AO, Grinstein S, Noble SM, Krysan D, Gray-Owen SD, Cowen LE

Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections.

Nature communications

Tian C, Hromatka BS, Kiefer AK, Eriksson N, Noble SM, Tung JY, Hinds DA

Candida albicans cell-type switching and functional plasticity in the mammalian host.

Nature reviews. Microbiology

Noble SM, Gianetti BA, Witchley JN

Impact of a transposon insertion in phzF2 on the specialized metabolite production and interkingdom interactions of Pseudomonas aeruginosa.

Journal of bacteriology

Phelan VV, Moree WJ, Aguilar J, Cornett DS, Koumoutsi A, Noble SM, Pogliano K, Guerrero CA, Dorrestein PC

Genetics and molecular biology in Candida albicans.

Methods in enzymology

Hernday AD, Noble SM, Mitrovich QM, Johnson AD

A phenotypic profile of the Candida albicans regulatory network.

PLoS genetics

Homann OR, Dea J, Noble SM, Johnson AD

An RNA transport system in Candida albicans regulates hyphal morphology and invasive growth.

PLoS genetics

Elson SL, Noble SM, Solis NV, Filler SG, Johnson AD

Genetics of Candida albicans, a diploid human fungal pathogen.

Annual review of genetics

Noble SM, Johnson AD

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