Suzanne Noble, MD, PhD

Functional genomic analysis of genes important for Candida albicans fitness in diverse environmental conditions.

Cell reports

Xiong EH, Zhang X, Yan H, Ward HN, Lin ZY, Wong CJ, Fu C, Gingras AC, Noble SM, Robbins N, Myers CL, Cowen LE

Peptide YY: A Paneth cell antimicrobial peptide that maintains Candida gut commensalism.

Science (New York, N.Y.)

Pierre JF, Peters BM, La Torre D, Sidebottom AM, Tao Y, Zhu X, Cham CM, Wang L, Kambal A, Harris KG, Silva JF, Zaborina O, Alverdy JC, Herzog H, Witchley J, Noble SM, Leone VA, Chang EB

Multifactor transcriptional control of alternative oxidase induction integrates diverse environmental inputs to enable fungal virulence.

Nature communications

Liu Z, Basso P, Hossain S, Liston SD, Robbins N, Whitesell L, Noble SM, Cowen LE

Ent2 Governs Morphogenesis and Virulence in Part through Regulation of the Cdc42 Signaling Cascade in the Fungal Pathogen Candida albicans.

mBio

Lash E, Prudent V, Stogios PJ, Savchenko A, Noble SM, Robbins N, Cowen LE

Deep tissue infection by an invasive human fungal pathogen requires lipid-based suppression of the IL-17 response.

Cell host & microbe

Basso P, Dang EV, Urisman A, Cowen LE, Madhani HD, Noble SM

Christine Guthrie (1945-2022).

Science (New York, N.Y.)

Noble S, Burgess SM, Strauss E

Candida albicans oscillating UME6 expression during intestinal colonization primes systemic Th17 protective immunity.

Cell reports

Shao TY, Kakade P, Witchley JN, Frazer C, Murray KL, Ene IV, Haslam DB, Hagan T, Noble SM, Bennett RJ, Way SS

Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets.

Nature communications

Fu C, Zhang X, Veri AO, Iyer KR, Lash E, Xue A, Yan H, Revie NM, Wong C, Lin ZY, Polvi EJ, Liston SD, VanderSluis B, Hou J, Yashiroda Y, Gingras AC, Boone C, O'Meara TR, O'Meara MJ, Noble S, Robbins N, Myers CL, Cowen LE

Adaptive immunity induces mutualism between commensal eukaryotes.

Nature

Ost KS, O'Meara TR, Stephens WZ, Chiaro T, Zhou H, Penman J, Bell R, Catanzaro JR, Song D, Singh S, Call DH, Hwang-Wong E, Hanson KE, Valentine JF, Christensen KA, O'Connell RM, Cormack B, Ibrahim AS, Palm NW, Noble SM, Round JL

Recording of DNA-binding events reveals the importance of a repurposed Candida albicans regulatory network for gut commensalism.

Cell host & microbe

Visualization of Candida albicans in the Murine Gastrointestinal Tract Using Fluorescent In Situ Hybridization.

Journal of visualized experiments : JoVE

Witchley JN, Penumetcha PM, Noble SM

A natural histone H2A variant lacking the Bub1 phosphorylation site and regulated depletion of centromeric histone CENP-A foster evolvability in Candida albicans.

PLoS biology

Brimacombe CA, Burke JE, Parsa JY, Catania S, O'Meara TR, Witchley JN, Burrack LS, Madhani HD, Noble SM

Impact of a transposon insertion in phzF2 on the specialized metabolite production and interkingdom interactions of Pseudomonas aeruginosa.

Journal of bacteriology

Phelan VV, Moree WJ, Aguilar J, Cornett DS, Koumoutsi A, Noble SM, Pogliano K, Guerrero CA, Dorrestein PC

Candida albicans specializations for iron homeostasis: from commensalism to virulence.

Current opinion in microbiology

Noble SM

Passage through the mammalian gut triggers a phenotypic switch that promotes Candida albicans commensalism.

Nature genetics

Pande K, Chen C, Noble SM

Post-transcriptional regulation of the Sef1 transcription factor controls the virulence of Candida albicans in its mammalian host.

PLoS pathogens

Chen C, Noble SM

Transcriptional response of Candida albicans to nitric oxide and the role of the YHB1 gene in nitrosative stress and virulence.

Molecular biology of the cell

Hromatka BS, Noble SM, Johnson AD

Strains and strategies for large-scale gene deletion studies of the diploid human fungal pathogen Candida albicans.

Eukaryotic cell

Noble SM, Johnson AD

Essential yeast protein with unexpected similarity to subunits of mammalian cleavage and polyadenylation specificity factor (CPSF).

Science (New York, N.Y.)

Chanfreau G, Noble SM, Guthrie C

Transcriptional pulse-chase analysis reveals a role for a novel snRNP-associated protein in the manufacture of spliceosomal snRNPs.

The EMBO journal

Noble SM, Guthrie C

Identification of novel genes required for yeast pre-mRNA splicing by means of cold-sensitive mutations.

Genetics

Noble SM, Guthrie C

The Benioff Center for Microbiome Medicine

Suzanne Noble, MD, PhD

Functional genomic analysis of genes important for Candida albicans fitness in diverse environmental conditions.

Peptide YY: A Paneth cell antimicrobial peptide that maintains Candida gut commensalism.

Multifactor transcriptional control of alternative oxidase induction integrates diverse environmental inputs to enable fungal virulence.

Ent2 Governs Morphogenesis and Virulence in Part through Regulation of the Cdc42 Signaling Cascade in the Fungal Pathogen Candida albicans.

Deep tissue infection by an invasive human fungal pathogen requires lipid-based suppression of the IL-17 response.

Christine Guthrie (1945-2022).

Candida albicans oscillating UME6 expression during intestinal colonization primes systemic Th17 protective immunity.

Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets.

Adaptive immunity induces mutualism between commensal eukaryotes.

Recording of DNA-binding events reveals the importance of a repurposed Candida albicans regulatory network for gut commensalism.

Visualization of Candida albicans in the Murine Gastrointestinal Tract Using Fluorescent In Situ Hybridization.

A natural histone H2A variant lacking the Bub1 phosphorylation site and regulated depletion of centromeric histone CENP-A foster evolvability in Candida albicans.

Candida albicans Morphogenesis Programs Control the Balance between Gut Commensalism and Invasive Infection.

High-Throughput Screening Identifies Genes Required for Candida albicans Induction of Macrophage Pyroptosis.

Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections.

Candida albicans cell-type switching and functional plasticity in the mammalian host.

Impact of a transposon insertion in phzF2 on the specialized metabolite production and interkingdom interactions of Pseudomonas aeruginosa.

Candida albicans specializations for iron homeostasis: from commensalism to virulence.

Passage through the mammalian gut triggers a phenotypic switch that promotes Candida albicans commensalism.

Post-transcriptional regulation of the Sef1 transcription factor controls the virulence of Candida albicans in its mammalian host.

An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis.

Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity.

Genetics and molecular biology in Candida albicans.

A phenotypic profile of the Candida albicans regulatory network.

An RNA transport system in Candida albicans regulates hyphal morphology and invasive growth.

Systematic genetic analysis of virulence in the human fungal pathogen Cryptococcus neoformans.

Genetics of Candida albicans, a diploid human fungal pathogen.

Transcriptional response of Candida albicans to nitric oxide and the role of the YHB1 gene in nitrosative stress and virulence.

Strains and strategies for large-scale gene deletion studies of the diploid human fungal pathogen Candida albicans.

Essential yeast protein with unexpected similarity to subunits of mammalian cleavage and polyadenylation specificity factor (CPSF).

Transcriptional pulse-chase analysis reveals a role for a novel snRNP-associated protein in the manufacture of spliceosomal snRNPs.

Identification of novel genes required for yeast pre-mRNA splicing by means of cold-sensitive mutations.

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Suzanne Noble, MD, PhD