Tiffany Scharschmidt, MD

Associate Professor

Layilin Anchors Regulatory T Cells in Skin.

Journal of immunology (Baltimore, Md. : 1950)

Mehta P, Gouirand V, Boda DP, Zhang J, Gearty SV, Zirak B, Lowe MM, Clancy S, Boothby I, Mahuron KM, Fries A, Krummel MF, Mankoo P, Chang HW, Liu J, Moreau JM, Scharschmidt TC, Daud A, Kim E, Neuhaus IM, Harris HW, Liao W, Rosenblum MD

Regulatory T cells promote innate inflammation after skin barrier breach via TGF-ß activation.

Science immunology

Moreau JM, Dhariwala MO, Gouirand V, Boda DP, Boothby IC, Lowe MM, Cohen JN, Macon CE, Leech JM, Kalekar LA, Scharschmidt TC, Rosenblum MD

Hair of the mouse: A skin bacteria "cocktail" gets follicles back on their feet.

Cell host & microbe

Gonzalez JR, Merana GR, Scharschmidt TC

Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature.

Cell reports. Medicine

Dhariwala MO, Karthikeyan D, Vasquez KS, Farhat S, Weckel A, Taravati K, Leitner EG, Clancy S, Pauli M, Piper ML, Cohen JN, Ashouri JF, Lowe MM, Rosenblum MD, Scharschmidt TC

Atlas of atopic dermatitis.

The Journal of allergy and clinical immunology

Boothby IC, Gonzalez JR, Scharschmidt TC

Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues.

JCI insight

Lowe MM, Boothby I, Clancy S, Ahn RS, Liao W, Nguyen DN, Schumann K, Marson A, Mahuron KM, Kingsbury GA, Liu Z, Munoz Sandoval P, Rodriguez RS, Pauli ML, Taravati K, Arron ST, Neuhaus IM, Harris HW, Kim EA, Shin US, Krummel MF, Daud A, Scharschmidt TC, Rosenblum MD

Toxin-Triggered Interleukin-1 Receptor Signaling Enables Early-Life Discrimination of Pathogenic versus Commensal Skin Bacteria.

Cell host & microbe

Leech JM, Dhariwala MO, Lowe MM, Chu K, Merana GR, Cornuot C, Weckel A, Ma JM, Leitner EG, Gonzalez JR, Vasquez KS, Diep BA, Scharschmidt TC

MAIT cells are imprinted by the microbiota in early life and promote tissue repair.

Science (New York, N.Y.)

Constantinides MG, Link VM, Tamoutounour S, Wong AC, Perez-Chaparro PJ, Han SJ, Chen YE, Li K, Farhat S, Weckel A, Krishnamurthy SR, Vujkovic-Cvijin I, Linehan JL, Bouladoux N, Merrill ED, Roy S, Cua DJ, Adams EJ, Bhandoola A, Scharschmidt TC, Aubé J, Fischbach MA, Belkaid Y

The TNFRSF members CD27 and OX40 coordinately limit TH17 differentiation in regulatory T cells.

Science immunology

Remedios KA, Zirak B, Sandoval PM, Lowe MM, Boda D, Henley E, Bhattrai S, Scharschmidt TC, Liao W, Naik HB, Rosenblum MD

The microbiome in patients with atopic dermatitis.

The Journal of allergy and clinical immunology

Paller AS, Kong HH, Seed P, Naik S, Scharschmidt TC, Gallo RL, Luger T, Irvine AD

Alteration of the cutaneous microbiome in psoriasis and potential role in Th17 polarization.


Chang HW, Yan D, Singh R, Liu J, Lu X, Ucmak D, Lee K, Afifi L, Fadrosh D, Leech J, Vasquez KS, Lowe MM, Rosenblum MD, Scharschmidt TC, Lynch SV, Liao W

Skin Commensal Antigens: Taking the Road Less Traveled.

Trends in immunology

Dhariwala MO, Scharschmidt TC

Fighting staph: Not child’s play.

Science translational medicine

Tiffany C. Scharschmidt

Successful treatment of mucous membrane pemphigoid with bortezomib.

JAAD case reports

Saeed L, Schmidt TH, Gensler LS, Gross AJ, Fox LP, Scharschmidt TC, Gaensler K, Naik H, Rosenblum MA, Shinkai K

S. aureus induces IL-36 to start the itch.

Science translational medicine

Tiffany C. Scharschmidt

Growing good bugs with mom’s milk.

Science translational medicine

Tiffany C. Scharschmidt

ILC regs : The new kid in class.

Science translational medicine

Tiffany C. Scharschmidt

Interferon with antitumor immunity.

Science translational medicine

Tiffany C. Scharschmidt

Skin Dysbiosis Goes "Off-Leish".

Cell host & microbe

Scharschmidt TC

A vitamin to D-crease sunburn.

Science translational medicine

Scharschmidt TC

Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation.


Ali N, Zirak B, Rodriguez RS, Pauli ML, Truong HA, Lai K, Ahn R, Corbin K, Lowe MM, Scharschmidt TC, Taravati K, Tan MR, Ricardo-Gonzalez RR, Nosbaum A, Bertolini M, Liao W, Nestle FO, Paus R, Cotsarelis G, Abbas AK, Rosenblum MD

Measuring inflammation in IBD with an OSM-ostat.

Science translational medicine

Scharschmidt TC

Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin.

Cell host & microbe

Scharschmidt TC, Vasquez KS, Pauli ML, Leitner EG, Chu K, Truong HA, Lowe MM, Sanchez Rodriguez R, Ali N, Laszik ZG, Sonnenburg JL, Millar SE, Rosenblum MD

When TLRs fail, IgG has your back.

Science translational medicine

Scharschmidt TC

014 Commensal microbes augment expression of the hair follicle chemokine Ccl20 to facilitate accumulation of Tregs in neonatal skin.

Journal of Investigative Dermatology

T.C. Scharschmidt, K.S. Vasquez, M.L. Pauli, H. Truong, J.L. Sonnenburg, S.E. Millar, M.D. Rosenblum

Cutting Edge: Regulatory T Cells Facilitate Cutaneous Wound Healing.

Journal of immunology (Baltimore, Md. : 1950)

Nosbaum A, Prevel N, Truong HA, Mehta P, Ettinger M, Scharschmidt TC, Ali NH, Pauli ML, Abbas AK, Rosenblum MD

A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes.


Scharschmidt TC, Vasquez KS, Truong HA, Gearty SV, Pauli ML, Nosbaum A, Gratz IK, Otto M, Moon JJ, Liese J, Abbas AK, Fischbach MA, Rosenblum MD

Paradoxical benefits of psychological stress in inflammatory dermatoses models are glucocorticoid mediated.

The Journal of investigative dermatology

Lin TK, Man MQ, Santiago JL, Scharschmidt TC, Hupe M, Martin-Ezquerra G, Youm JK, Zhai Y, Trullas C, Feingold KR, Elias PM

What Lives On Our Skin: Ecology, Genomics and Therapeutic Opportunities Of the Skin Microbiome.

Drug discovery today. Disease mechanisms

Scharschmidt TC, Fischbach MA

Immune reconstitution reactions in human immunodeficiency virus-negative patients: report of a case and review of the literature.

JAMA dermatology

Scharschmidt TC, Amerson EH, Rosenberg OS, Jacobs RA, McCalmont TH, Shinkai K

Neurogenic rosacea: a distinct clinical subtype requiring a modified approach to treatment.

Archives of dermatology

Scharschmidt TC, Yost JM, Truong SV, Steinhoff M, Wang KC, Berger TG

Epidermal barrier dysfunction in non-atopic HIV: evidence for an "inside-to-outside" pathogenesis.

The Journal of investigative dermatology

Gunathilake R, Schmuth M, Scharschmidt TC, Gruber R, Grabher D, Leslie KS, Maurer TA, Mauro TM, Elias PM

Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens.

The Journal of allergy and clinical immunology

Scharschmidt TC, Man MQ, Hatano Y, Crumrine D, Gunathilake R, Sundberg JP, Silva KA, Mauro TM, Hupe M, Cho S, Wu Y, Celli A, Schmuth M, Feingold KR, Elias PM

Matriptase-deficient mice exhibit ichthyotic skin with a selective shift in skin microbiota.

The Journal of investigative dermatology

Scharschmidt TC, List K, Grice EA, Szabo R, Renaud G, Lee CC, Wolfsberg TG, Bugge TH, Segre JA

Maintenance of an acidic stratum corneum prevents emergence of murine atopic dermatitis.

The Journal of investigative dermatology

Hatano Y, Man MQ, Uchida Y, Crumrine D, Scharschmidt TC, Kim EG, Mauro TM, Feingold KR, Elias PM, Holleran WM

Modeling atopic dermatitis with increasingly complex mouse models.

The Journal of investigative dermatology

Scharschmidt TC, Segre JA

Autosomal ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is phenocopied in ST14 hypomorphic mice.

The Journal of biological chemistry

List K, Currie B, Scharschmidt TC, Szabo R, Shireman J, Molinolo A, Cravatt BF, Segre J, Bugge TH

Estrogen receptor beta-selective transcriptional activity and recruitment of coregulators by phytoestrogens.

The Journal of biological chemistry

An J, Tzagarakis-Foster C, Scharschmidt TC, Lomri N, Leitman DC

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