Professor
Orofacial Sciences
+1 415 502-4683
Publications
Nisin lantibiotic prevents NAFLD liver steatosis and mitochondrial oxidative stress following periodontal disease by abrogating oral, gut and liver dysbiosis.
NPJ biofilms and microbiomes
Biological biomarkers of oral cancer.
Periodontology 2000
Geroscience: Aging and Oral Health Research.
Advances in dental research
Nisin a probiotic bacteriocin mitigates brain microbiome dysbiosis and Alzheimer's disease-like neuroinflammation triggered by periodontal disease.
Journal of neuroinflammation
EVIDENCE SUPPORTS SHORT-TERM CLINICAL BENEFITS OF ADJUNCTIVE ORAL PROBIOTICS FOLLOWING SCALING AND ROOT PLANING TREATMENT.
The journal of evidence-based dental practice
Reparative dentin formation following dental pulp capping is mediated by TNFR1 in vivo.
Journal of endodontics
Periodontal treatment and microbiome-targeted therapy in management of periodontitis-related nonalcoholic fatty liver disease with oral and gut dysbiosis.
World journal of gastroenterology
Stimulation of Human Periodontal Ligament Fibroblasts Using Purified Dentilisin Extracted from Treponema denticola.
Bio-protocol
Association between oral health markers and decline in muscle strength and physical performance in later life: longitudinal analyses of two prospective cohorts from the UK and the USA.
The lancet. Healthy longevity
Use of the Probiotic Bifidobacterium animalis subsp. lactis HN019 in Oral Diseases.
International journal of molecular sciences
Nisin probiotic prevents inflammatory bone loss while promoting reparative proliferation and a healthy microbiome.
NPJ biofilms and microbiomes
Cellular Mechanisms of Inflammaging and Periodontal Disease.
Frontiers in dental medicine
Incision Free, Coronally Advanced Flap with Subepithelial Connective Tissue Graft Placed by the Molar or Canine Access (MOCA) Technique: 13 Case series.
Clinical advances in periodontics
Solid Lipid Nanoparticles Loaded with Nisin (SLN-Nisin) are More Effective Than Free Nisin as Antimicrobial, Antibiofilm, and Anticancer Agents.
Journal of biomedical nanotechnology
Periodontal Disease: The Good, The Bad, and The Unknown.
Frontiers in cellular and infection microbiology
Functional Adaptation of LPS-affected Dentoalveolar Fibrous Joints in Rats.
Journal of periodontal research
A Commentary on strategic extraction.
Journal of periodontology
Clinical study showing a lower abundance of Neisseria in the oral microbiome aligns with low birth weight pregnancy outcomes.
Clinical oral investigations
Association between metabolic syndrome and periodontitis: The role of lipids, inflammatory cytokines, altered host response, and the microbiome.
Periodontology 2000
Dental informed consent challenges and considerations for cognitively impaired patients.
Periodontology 2000
Eating disorders through the periodontal lens.
Periodontology 2000
Oral microbiome shifts during pregnancy and adverse pregnancy outcomes: Hormonal and Immunologic changes at play.
Periodontology 2000
Paradigm shift in the pathogenesis and treatment of oral cancer and other cancers focused on the oralome and antimicrobial-based therapeutics.
Periodontology 2000
Periodontal disease-related nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: An emerging concept of oral-liver axis.
Periodontology 2000
Probiotics for periodontal health-Current molecular findings.
Periodontology 2000
The human oral virome: Shedding light on the dark matter.
Periodontology 2000
The oral microbiome: Role of key organisms and complex networks in oral health and disease.
Periodontology 2000
The psychobiological links between chronic stress-related diseases, periodontal/peri-implant diseases, and wound healing.
Periodontology 2000
Treatment planning considerations in the older adult with periodontal disease.
Periodontology 2000
Connective Tissue Graft with or without Enamel Matrix Derivative for Treating Gingival Recession Defects: A Systematic Review and Meta-Analysis.
The journal of evidence-based dental practice
Survival Versus Success.
Journal of the American Dental Association (1939)
Phosphatidylserine-Gold Nanoparticles (PS-AuNP) Induce Prostate and Breast Cancer Cell Apoptosis.
Pharmaceutics
Treponema denticola-Induced RASA4 Upregulation Mediates Cytoskeletal Dysfunction and MMP-2 Activity in Periodontal Fibroblasts.
Frontiers in cellular and infection microbiology
Therapeutic Prognosis System for Root Coverage Procedures.
The International journal of periodontics & restorative dentistry
The Contribution of Macrophages in Old Mice to Periodontal Disease.
Journal of dental research
The oralome and its dysbiosis: New insights into oral microbiome-host interactions.
Computational and structural biotechnology journal
Poor oral health and inflammatory, haemostatic and cardiac biomarkers in older age: Results from two studies in the UK and USA.
The journals of gerontology. Series A, Biological sciences and medical sciences
Periodontal inflammation triggers a site-specific and wide radius of calcium metabolic effects on alveolar bone.
Journal of periodontal research
Analyzing the predictability of the Kwok and Caton periodontal prognosis system: A retrospective study.
Journal of periodontology
Unculturable and culturable periodontal-related bacteria are associated with periodontal inflammation during pregnancy and with preterm low birth weight delivery.
Scientific reports
Modulation of pathogenic oral biofilms towards health with nisin probiotic.
Journal of oral microbiology
Rebuilding the Interproximal Papilla: Description of "Tube" Technique and Two Case Reports.
Clinical advances in periodontics
Oxidative Stress, NE and IGFBP7 Levels in Patients with Oropharyngeal Cancer and Chronic Periodontitis.
Oral diseases
Innovative application of nested PCR for detection of Porphyromonas gingivalis in human highly calcified atherothrombotic plaques.
Journal of oral microbiology
Temporal and dynamic changes in gingival blood flow during progression of ligature-induced periodontitis.
Oral diseases
Polymicrobial periodontal disease triggers a wide radius of effect and unique virome.
NPJ biofilms and microbiomes
Bacterial anti-microbial peptides and nano-sized drug delivery systems: The state of the art toward improved bacteriocins.
Journal of controlled release : official journal of the Controlled Release Society
Host-microbe interactions: Profiles in the transcriptome, the proteome, and the metabolome.
Periodontology 2000
Probiotics, including nisin-based probiotics, improve clinical and microbial outcomes relevant to oral and systemic diseases.
Periodontology 2000
Inflammasomes and their regulation in periodontal disease: A review.
Journal of periodontal research
High serum ferritin levels are associated with a reduced periodontium in women with anorexia nervosa.
Eating and weight disorders : EWD
The significance of surgically modifying soft tissue phenotype around fixed dental prostheses: An American Academy of Periodontology best evidence review.
Journal of periodontology
Differential expression of inflammasome regulatory transcripts in periodontal disease.
Journal of periodontology
Antibiotic prescribing practices in periodontal surgeries with and without bone grafting.
Journal of periodontology
Patient-Centered Risk Assessment in Implant Treatment Planning.
The International journal of oral & maxillofacial implants
The role of caspase-8, caspase-9, and apoptosis inducing factor in periodontal disease.
Journal of periodontology
Applications of sensory and physiological measurement in oral-facial dental pain.
Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Journal of clinical periodontology
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Journal of periodontology
Effect of membrane exposure on guided bone regeneration: A systematic review and meta-analysis.
Clinical oral implants research
Treponema denticola increases MMP-2 expression and activation in the periodontium via reversible DNA and histone modifications.
Cellular microbiology
Increased Variance in Oral and Gastric Microbiome Correlates With Esophagectomy Anastomotic Leak.
The Annals of thoracic surgery
Parameters to Define Peri-Implantitis: A Review and a Proposed Multi-Domain Scale.
The Journal of oral implantology
Microbial Communities Associated with Primary and Metastatic Head and Neck Squamous Cell Carcinoma - A High Fusobacterial and Low Streptococcal Signature.
Scientific reports
High-purity Nisin Alone or in Combination with Sodium Hypochlorite Is Effective against Planktonic and Biofilm Populations of Enterococcus faecalis.
Journal of endodontics
Head and Neck Squamous Cell Carcinoma Metabolism Draws on Glutaminolysis, and Stemness Is Specifically Regulated by Glutaminolysis via Aldehyde Dehydrogenase.
Journal of proteome research
Dental implants and grafting success remain high despite large variations in maxillary sinus mucosal thickening.
International journal of implant dentistry
Metabolomics of Head and Neck Cancer: A Mini-Review.
Frontiers in physiology
The Role of Apoptotic Factors in Assessing Progression of Periodontal Disease.
International journal of dentistry and oral science
Incidental Findings From Cone-Beam Computed Tomography During Implant Therapy.
Clinical advances in periodontics
Community-based assessment and intervention for early childhood caries in rural El Salvador.
International dental journal
Biomedical applications of nisin.
Journal of applied microbiology
Oral Health Status of Adults in Rural Meru, Kenya
Oral Health Dent Manag
A Novel Sirtuin-3 Inhibitor, LC-0296, Inhibits Cell Survival and Proliferation, and Promotes Apoptosis of Head and Neck Cancer Cells.
Anticancer research
A Modified Shuttle Plasmid Facilitates Expression of a Flavin Mononucleotide-Based Fluorescent Protein in Treponema denticola ATCC 35405.
Applied and environmental microbiology
To Brazil and Back: An International Dental Student Exchange Program.
The Journal of the Michigan Dental Association
Antimicrobial nisin acts against saliva derived multi-species biofilms without cytotoxicity to human oral cells.
Frontiers in microbiology
Oral health status of children in rural schools in Kithoka, Kenya
Oral Health and Dental Management
Shedding of NG2 by MMP-13 attenuates anoikis.
DNA and cell biology
Treponema denticola upregulates MMP-2 activation in periodontal ligament cells: interplay between epigenetics and periodontal infection.
Archives of oral biology
The student perspective: international exchange programs.
The Journal of the Michigan Dental Association
Implant success remains high despite grafting voids in the maxillary sinus.
Clinical oral implants research
The role of factors associated with apoptosis in assessing periodontal disease status.
Journal of periodontology
ADAM17-mediated CD44 cleavage promotes orasphere formation or stemness and tumorigenesis in HNSCC.
Cancer medicine
Sirtuin-3 (SIRT3) and the Hallmarks of Cancer.
Genes & cancer
Apoptotic activity of gingival crevicular fluid from localized aggressive periodontitis.
Journal of the International Academy of Periodontology
Nisin, an apoptogenic bacteriocin and food preservative, attenuates HNSCC tumorigenesis via CHAC1.
Cancer medicine
Delineating metabolic signatures of head and neck squamous cell carcinoma: phospholipase A2, a potential therapeutic target.
The international journal of biochemistry & cell biology
Magic angle spinning NMR-based metabolic profiling of head and neck squamous cell carcinoma tissues.
Journal of proteome research
SIRT3 and cancer: tumor promoter or suppressor?
Biochimica et biophysica acta
Divergent upstream osteogenic events contribute to the differential modulation of MG63 cell osteoblast differentiation by MMP-1 (collagenase-1) and MMP-13 (collagenase-3).
Matrix biology : journal of the International Society for Matrix Biology
Implications of cultured periodontal ligament cells for the clinical and experimental setting: a review.
Archives of oral biology
Capturing the regenerative potential of periodontal ligament fibroblasts.
Journal of stem cells & regenerative medicine
Anoikis mediators in oral squamous cell carcinoma.
Oral diseases
The Treponema denticola chymotrypsin-like protease dentilisin induces matrix metalloproteinase-2-dependent fibronectin fragmentation in periodontal ligament cells.
Infection and immunity
Anoikis triggers Mdm2-dependent p53 degradation.
Molecular and cellular biochemistry
Calcium hydroxide promotes cementogenesis and induces cementoblastic differentiation of mesenchymal periodontal ligament cells in a CEMP1- and ERK-dependent manner.
Calcified tissue international
Proapoptotic fibronectin fragment induces the degradation of ubiquitinated p53 via proteasomes in periodontal ligament cells.
Journal of periodontal research
Matrix metalloproteinase expression in teeth with apical periodontitis is differentially modulated by the modality of root canal treatment.
Journal of endodontics
Disease-associated extracellular matrix suppresses osteoblastic differentiation of human periodontal ligament cells via MMP-1.
Calcified tissue international
Receptor-interacting protein shuttles between cell death and survival signaling pathways.
Molecular biology of the cell
Comments on atrophic lingual papillae and candidiasis in Sjögren syndrome.
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
High matrix metalloproteinase activity is a hallmark of periapical granulomas.
Journal of endodontics
Multiple differentiation capacity of STRO-1+/CD146+ PDL mesenchymal progenitor cells.
Stem cells and development
TNF-alpha promotes an odontoblastic phenotype in dental pulp cells.
Journal of dental research
Porphyromonas gingivalis, gamma interferon, and a proapoptotic fibronectin matrix form a synergistic trio that induces c-Jun N-terminal kinase 1-mediated nitric oxide generation and cell death.
Infection and immunity
MMP-1 (collagenase-1) and MMP-13 (collagenase-3) differentially regulate markers of osteoblastic differentiation in osteogenic cells.
Matrix biology : journal of the International Society for Matrix Biology
NG2, a novel proapoptotic receptor, opposes integrin alpha4 to mediate anoikis through PKCalpha-dependent suppression of FAK phosphorylation.
Cell death and differentiation
An altered fibronectin matrix induces anoikis of human squamous cell carcinoma cells by suppressing integrin alpha v levels and phosphorylation of FAK and ERK.
Apoptosis : an international journal on programmed cell death
Disease-associated fibronectin matrix fragments trigger anoikis of human primary ligament cells: p53 and c-myc are suppressed.
Apoptosis : an international journal on programmed cell death
JNK1 and JNK2 oppositely regulate p53 in signaling linked to apoptosis triggered by an altered fibronectin matrix: JNK links FAK and p53.
The Journal of biological chemistry
Application of laser capture microdissection to phage display peptide library screening.
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
Squamous cell carcinoma cell aggregates escape suspension-induced, p53-mediated anoikis: fibronectin and integrin alphav mediate survival signals through focal adhesion kinase.
The Journal of biological chemistry
Functional differences between integrin alpha4 and integrins alpha5/alphav in modulating the motility of human oral squamous carcinoma cells in response to the V region and heparin-binding domain of fibronectin.
Experimental cell research
Specific pro-apoptotic fibronectin fragments modulate proteinase expression in periodontal ligament cells.
Journal of periodontology
The effect of high sugar intake on the development of periradicular lesions in rats with type 2 diabetes.
Journal of dental research
Ascorbic acid induces collagenase-1 in human periodontal ligament cells but not in MC3T3-E1 osteoblast-like cells: potential association between collagenase expression and changes in alkaline phosphatase phenotype.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Specific fibronectin fragments as markers of periodontal disease status.
Journal of periodontology
The heparin-binding domain and V region of fibronectin regulate apoptosis by suppression of p53 and c-myc in human primary cells.
The Journal of biological chemistry
Three-dimensional structural analysis of fibronectin heparin-binding domain mutations.
Journal of cellular biochemistry. Supplement
Coordinate induction of collagenase-1, stromelysin-1 and urokinase plasminogen activator (uPA) by the 120-kDa cell-binding fibronectin fragment in fibrocartilaginous cells: uPA contributes to activation of procollagenase-1.
Matrix biology : journal of the International Society for Matrix Biology
Mutations in the heparin binding domain of fibronectin in cooperation with the V region induce decreases in pp125(FAK) levels plus proteoglycan-mediated apoptosis via caspases.
The Journal of biological chemistry
The response of periodontal ligament cells to fibronectin.
Journal of periodontology
The high affinity heparin-binding domain and the V region of fibronectin mediate invasion of human oral squamous cell carcinoma cells in vitro.
The Journal of biological chemistry
Cocaine-associated rapid gingival recession and dental erosion. A case report.
Journal of periodontology
Fibronectin and fibronectin fragments modulate the expression of proteinases and proteinase inhibitors in human periodontal ligament cells.
Matrix biology : journal of the International Society for Matrix Biology
Oral candidiasis in Sjögren's syndrome: prevalence, clinical correlations, and treatment.
Oral surgery, oral medicine, and oral pathology