Yvonne Kapila, DDS, PhD

Professor
Orofacial Sciences
+1 415 502-4683
Publications: 

Nisin lantibiotic prevents NAFLD liver steatosis and mitochondrial oxidative stress following periodontal disease by abrogating oral, gut and liver dysbiosis.

NPJ biofilms and microbiomes

Kuraji R, Ye C, Zhao C, Gao L, Martinez A, Miyashita Y, Radaic A, Kamarajan P, Le C, Zhan L, Range H, Sunohara M, Numabe Y, Kapila YL

Biological biomarkers of oral cancer.

Periodontology 2000

Radaic A, Kamarajan P, Cho A, Wang S, Hung GC, Najarzadegan F, Wong DT, Ton-That H, Wang CY, Kapila YL

Geroscience: Aging and Oral Health Research.

Advances in dental research

Weintraub JA, Kaeberlein M, Perissinotto C, Atchison KA, Chen X, D'Souza RN, Feine JS, Ghezzi EM, Kirkwood KL, Ryder M, Slashcheva LD, Touger-Decker R, Wu B, Kapila Y

Nisin a probiotic bacteriocin mitigates brain microbiome dysbiosis and Alzheimer's disease-like neuroinflammation triggered by periodontal disease.

Journal of neuroinflammation

Zhao C, Kuraji R, Ye C, Gao L, Radaic A, Kamarajan P, Taketani Y, Kapila YL

Reparative dentin formation following dental pulp capping is mediated by TNFR1 in vivo.

Journal of endodontics

Aparecido de Almeida-Junior L, Curcino Araujo LD, Chaves Lamarque GC, Manfrin Arnez MF, Kapila YL, Bezerra da Silva LA, Garcia de Paula-Silva FW

Association between oral health markers and decline in muscle strength and physical performance in later life: longitudinal analyses of two prospective cohorts from the UK and the USA.

The lancet. Healthy longevity

Kimble R, McLellan G, Lennon LT, Papacosta AO, Weyant RJ, Kapila Y, Mathers JC, Wannamathee SG, Whincup PH, Ramsay SE

Use of the Probiotic Bifidobacterium animalis subsp. lactis HN019 in Oral Diseases.

International journal of molecular sciences

Araujo LDC, Furlaneto FAC, da Silva LAB, Kapila YL

Nisin probiotic prevents inflammatory bone loss while promoting reparative proliferation and a healthy microbiome.

NPJ biofilms and microbiomes

Gao L, Kuraji R, Zhang MJ, Martinez A, Radaic A, Kamarajan P, Le C, Zhan L, Ye C, Rangé H, Sailani MR, Kapila YL

Cellular Mechanisms of Inflammaging and Periodontal Disease.

Frontiers in dental medicine

Clark D, Radaic A, Kapila Y

Incision Free, Coronally Advanced Flap with Subepithelial Connective Tissue Graft Placed by the Molar or Canine Access (MOCA) Technique: 13 Case series.

Clinical advances in periodontics

Kashani H, Vora MV, Kuraji R, Fathi-Kelly H, Nguyen T, Tamraz B, Tran C, Kapila YL

Periodontal Disease: The Good, The Bad, and The Unknown.

Frontiers in cellular and infection microbiology

Sedghi LM, Bacino M, Kapila YL

Functional Adaptation of LPS-affected Dentoalveolar Fibrous Joints in Rats.

Journal of periodontal research

Wang B, Ustriyana P, Tam CS, Lin JD, Srirangapatanam S, Kapila Y, Ryder MI, Webb S, Seo Y, Ho SP

A Commentary on strategic extraction.

Journal of periodontology

Kao RT, Lin GH, Kapila Y, Sadowsky S, Curtis DA

Clinical study showing a lower abundance of Neisseria in the oral microbiome aligns with low birth weight pregnancy outcomes.

Clinical oral investigations

Ye C, You M, Huang P, Xia Z, Radaic A, Tang J, Wu W, Wu Y, Kapila Y

Association between metabolic syndrome and periodontitis: The role of lipids, inflammatory cytokines, altered host response, and the microbiome.

Periodontology 2000

Pirih FQ, Monajemzadeh S, Singh N, Sinacola RS, Shin JM, Chen T, Fenno JC, Kamarajan P, Rickard AH, Travan S, Paster BJ, Kapila Y

Dental informed consent challenges and considerations for cognitively impaired patients.

Periodontology 2000

Alsaleh A, Kapila A, Shahriar I, Kapila YL

Eating disorders through the periodontal lens.

Periodontology 2000

Rangé H, Colon P, Godart N, Kapila Y, Bouchard P

Probiotics for periodontal health-Current molecular findings.

Periodontology 2000

Nguyen T, Brody H, Radaic A, Kapila Y

The human oral virome: Shedding light on the dark matter.

Periodontology 2000

Martínez A, Kuraji R, Kapila YL

The oral microbiome: Role of key organisms and complex networks in oral health and disease.

Periodontology 2000

Sedghi L, DiMassa V, Harrington A, Lynch SV, Kapila YL

Treatment planning considerations in the older adult with periodontal disease.

Periodontology 2000

Curtis DA, Lin GH, Rajendran Y, Gessese T, Suryadevara J, Kapila YL

Connective Tissue Graft with or without Enamel Matrix Derivative for Treating Gingival Recession Defects: A Systematic Review and Meta-Analysis.

The journal of evidence-based dental practice

Dubey P, Narasimhan M, Sehgal NK, Yanni P, Kim JW, Kapila YL, Lin GH

Survival Versus Success.

Journal of the American Dental Association (1939)

Curtis DA, Sadowsky SJ, Daubert DM, Kapila Y

Phosphatidylserine-Gold Nanoparticles (PS-AuNP) Induce Prostate and Breast Cancer Cell Apoptosis.

Pharmaceutics

Radaic A, Joo NE, Jeong SH, Yoo SI, Kotov N, Kapila YL

Treponema denticola dentilisin triggered TLR2/MyD88 activation upregulates a tissue destructive program involving MMPs via Sp1 in human oral cells.

PLoS pathogens

Ganther S, Radaic A, Malone E, Kamarajan P, Chang NN, Tafolla C, Zhan L, Fenno JC, Kapila YL

Treponema denticola-Induced RASA4 Upregulation Mediates Cytoskeletal Dysfunction and MMP-2 Activity in Periodontal Fibroblasts.

Frontiers in cellular and infection microbiology

Malone ET, Ganther S, Mena N, Radaic A, Shariati K, Kindberg A, Tafolla C, Kamarajan P, Fenno JC, Zhan L, Kapila YL

Therapeutic Prognosis System for Root Coverage Procedures.

The International journal of periodontics & restorative dentistry

Nguyen T, Lee KJ, Chen JL, Xenoudi P, Kapila YL, Kao RT, Lin GH

Poor oral health and inflammatory, haemostatic and cardiac biomarkers in older age: Results from two studies in the UK and USA.

The journals of gerontology. Series A, Biological sciences and medical sciences

Kotronia E, Wannamethee SG, Papacosta AO, Whincup PH, Lennon LT, Visser M, Kapila YL, Weyant RJ, Ramsay SE

Periodontal inflammation triggers a site-specific and wide radius of calcium metabolic effects on alveolar bone.

Journal of periodontal research

Kuraji R, Wu YH, Hashimoto S, Miyashita Y, Mishiro S, Ito H, Kamarajan P, Kapila Y, Numabe Y

Analyzing the predictability of the Kwok and Caton periodontal prognosis system: A retrospective study.

Journal of periodontology

Nguyen L, Krish G, Alsaleh A, Mailoa J, Kapila Y, Kao RT, Lin GH

Modulation of pathogenic oral biofilms towards health with nisin probiotic.

Journal of oral microbiology

Radaic A, Ye C, Parks B, Gao L, Kuraji R, Malone E, Kamarajan P, Zhan L, Kapila YL

Rebuilding the Interproximal Papilla: Description of "Tube" Technique and Two Case Reports.

Clinical advances in periodontics

Kashani H, Vora MV, Kuraji R, Brody H, Kapila YL

Innovative application of nested PCR for detection of Porphyromonas gingivalis in human highly calcified atherothrombotic plaques.

Journal of oral microbiology

Brun A, Rangé H, Prouvost B, Mazighi M, Kapila Y, Bouchard P, Michel JB

Temporal and dynamic changes in gingival blood flow during progression of ligature-induced periodontitis.

Oral diseases

Kuraji R, Wu YH, Hashimoto S, Mishiro S, Maeda Y, Miyashita Y, Ito H, Miwa Y, Sunohara M, Kapila Y, Numabe Y

Polymicrobial periodontal disease triggers a wide radius of effect and unique virome.

NPJ biofilms and microbiomes

Gao L, Kang M, Zhang MJ, Reza Sailani M, Kuraji R, Martinez A, Ye C, Kamarajan P, Le C, Zhan L, Rangé H, Ho SP, Kapila YL

Bacterial anti-microbial peptides and nano-sized drug delivery systems: The state of the art toward improved bacteriocins.

Journal of controlled release : official journal of the Controlled Release Society

Radaic A, de Jesus MB, Kapila YL

Host-microbe interactions: Profiles in the transcriptome, the proteome, and the metabolome.

Periodontology 2000

Nguyen T, Sedghi L, Ganther S, Malone E, Kamarajan P, Kapila YL

Probiotics, including nisin-based probiotics, improve clinical and microbial outcomes relevant to oral and systemic diseases.

Periodontology 2000

Nguyen T, Brody H, Lin GH, Rangé H, Kuraji R, Ye C, Kamarajan P, Radaic A, Gao L, Kapila Y

Inflammasomes and their regulation in periodontal disease: A review.

Journal of periodontal research

Aral K, Milward MR, Kapila Y, Berdeli A, Cooper PR

High serum ferritin levels are associated with a reduced periodontium in women with anorexia nervosa.

Eating and weight disorders : EWD

Boillot A, Ringuenet D, Kapila Y, Pallier A, Colon P, Bouchard P, Rangé H

The significance of surgically modifying soft tissue phenotype around fixed dental prostheses: An American Academy of Periodontology best evidence review.

Journal of periodontology

Lin GH, Curtis DA, Kapila Y, Velasquez D, Kan JYK, Tahir P, Avila-Ortiz G, Kao RT

Differential expression of inflammasome regulatory transcripts in periodontal disease.

Journal of periodontology

Aral K, Berdeli E, Cooper PR, Milward MR, Kapila Y, Berdeli A, Aral CA, Karadede Ünal B

Antibiotic prescribing practices in periodontal surgeries with and without bone grafting.

Journal of periodontology

Hai JH, Lee C, Kapila YL, Chaffee BW, Armitage GC

Patient-Centered Risk Assessment in Implant Treatment Planning.

The International journal of oral & maxillofacial implants

Curtis DA, Lin GH, Fishman A, Sadowsky SJ, Daubert DM, Kapila Y, Sharma AB, Conte GJ, Yonemura CY, Marinello CP, Kao R

Applications of sensory and physiological measurement in oral-facial dental pain.

Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry

Dabiri D, Harper DE, Kapila Y, Kruger GH, Clauw DJ, Harte S

Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

Journal of clinical periodontology

Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H

Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

Journal of periodontology

Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H

Effect of membrane exposure on guided bone regeneration: A systematic review and meta-analysis.

Clinical oral implants research

Garcia J, Dodge A, Luepke P, Wang HL, Kapila Y, Lin GH

Treponema denticola increases MMP-2 expression and activation in the periodontium via reversible DNA and histone modifications.

Cellular microbiology

Ateia IM, Sutthiboonyapan P, Kamarajan P, Jin T, Godovikova V, Kapila YL, Fenno JC

Increased Variance in Oral and Gastric Microbiome Correlates With Esophagectomy Anastomotic Leak.

The Annals of thoracic surgery

Reddy RM, Weir WB, Barnett S, Heiden BT, Orringer MB, Lin J, Chang AC, Carrott PW, Lynch WR, Beer DG, Fenno JC, Kapila Y

Parameters to Define Peri-Implantitis: A Review and a Proposed Multi-Domain Scale.

The Journal of oral implantology

Lin GH, Kapila Y, Wang HL

Dental implants and grafting success remain high despite large variations in maxillary sinus mucosal thickening.

International journal of implant dentistry

Maska B, Lin GH, Othman A, Behdin S, Travan S, Benavides E, Kapila Y

Metabolomics of Head and Neck Cancer: A Mini-Review.

Frontiers in physiology

Shin JM, Kamarajan P, Fenno JC, Rickard AH, Kapila YL

The Role of Apoptotic Factors in Assessing Progression of Periodontal Disease.

International journal of dentistry and oral science

Dabiri D, Halubai S, Layher M, Klausner C, Makhoul H, Lin GH, Eckert G, Abuhussein H, Kamarajan P, Kapila Y

Incidental Findings From Cone-Beam Computed Tomography During Implant Therapy.

Clinical advances in periodontics

Maska B, Othman A, Behdin S, Benavides E, Kapila Y

Community-based assessment and intervention for early childhood caries in rural El Salvador.

International dental journal

Dabiri D, Fontana M, Kapila Y, Eckert G, Sokal-Gutierrez K

Biomedical applications of nisin.

Journal of applied microbiology

Shin JM, Gwak JW, Kamarajan P, Fenno JC, Rickard AH, Kapila YL

Oral Health Status of Adults in Rural Meru, Kenya

Oral Health Dent Manag

Crouch, SDzingle, JTyus, JKapila, SEber, RNdege, PKKapila, Y

A Modified Shuttle Plasmid Facilitates Expression of a Flavin Mononucleotide-Based Fluorescent Protein in Treponema denticola ATCC 35405.

Applied and environmental microbiology

Godovikova V, Goetting-Minesky MP, Shin JM, Kapila YL, Rickard AH, Fenno JC

Nisin ZP, a Bacteriocin and Food Preservative, Inhibits Head and Neck Cancer Tumorigenesis and Prolongs Survival.

PloS one

Kamarajan P, Hayami T, Matte B, Liu Y, Danciu T, Ramamoorthy A, Worden F, Kapila S, Kapila Y

To Brazil and Back: An International Dental Student Exchange Program.

The Journal of the Michigan Dental Association

Crouch S, Farkash J, Branch A, Vasconcellos L, Veronesi G, Kapila YL

Antimicrobial nisin acts against saliva derived multi-species biofilms without cytotoxicity to human oral cells.

Frontiers in microbiology

Shin JM, Ateia I, Paulus JR, Liu H, Fenno JC, Rickard AH, Kapila YL

Oral health status of children in rural schools in Kithoka, Kenya

Oral Health and Dental Management

Fujawa, DTyus, JCooper, JDzingle, JKapila, SEber, RGonzalez-Cabezas, CNdege, PKPeck, MPeck, SKapila, Y

Shedding of NG2 by MMP-13 attenuates anoikis.

DNA and cell biology

Joo NE, Miao D, Bermúdez M, Stallcup WB, Kapila YL

Treponema denticola upregulates MMP-2 activation in periodontal ligament cells: interplay between epigenetics and periodontal infection.

Archives of oral biology

Miao D, Godovikova V, Qian X, Seshadrinathan S, Kapila YL, Fenno JC

The student perspective: international exchange programs.

The Journal of the Michigan Dental Association

Lesch A, Pisano J, Kapila YL

Implant success remains high despite grafting voids in the maxillary sinus.

Clinical oral implants research

Tsai CY, Garaicoa-Pazmino C, Mori K, Benavides E, Kaigler D, Kapila Y

The role of factors associated with apoptosis in assessing periodontal disease status.

Journal of periodontology

Abuhussein H, Bashutski JD, Dabiri D, Halubai S, Layher M, Klausner C, Makhoul H, Kapila Y

ADAM17-mediated CD44 cleavage promotes orasphere formation or stemness and tumorigenesis in HNSCC.

Cancer medicine

Kamarajan P, Shin JM, Qian X, Matte B, Zhu JY, Kapila YL

Sirtuin-3 (SIRT3) and the Hallmarks of Cancer.

Genes & cancer

Alhazzazi TY, Kamarajan P, Verdin E, Kapila YL

Apoptotic activity of gingival crevicular fluid from localized aggressive periodontitis.

Journal of the International Academy of Periodontology

Makhoul H, Bashutski J, Halubai S, Dabiri D, Benavides E, Kapila YL

Nisin, an apoptogenic bacteriocin and food preservative, attenuates HNSCC tumorigenesis via CHAC1.

Cancer medicine

Joo NE, Ritchie K, Kamarajan P, Miao D, Kapila YL

Delineating metabolic signatures of head and neck squamous cell carcinoma: phospholipase A2, a potential therapeutic target.

The international journal of biochemistry & cell biology

Tripathi P, Kamarajan P, Somashekar BS, MacKinnon N, Chinnaiyan AM, Kapila YL, Rajendiran TM, Ramamoorthy A

Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis.

Cancer

Kamarajan P, Alhazzazi TY, Danciu T, D'silva NJ, Verdin E, Kapila YL

Magic angle spinning NMR-based metabolic profiling of head and neck squamous cell carcinoma tissues.

Journal of proteome research

Somashekar BS, Kamarajan P, Danciu T, Kapila YL, Chinnaiyan AM, Rajendiran TM, Ramamoorthy A

SIRT3 and cancer: tumor promoter or suppressor?

Biochimica et biophysica acta

Alhazzazi TY, Kamarajan P, Verdin E, Kapila YL

Implications of cultured periodontal ligament cells for the clinical and experimental setting: a review.

Archives of oral biology

Marchesan JT, Scanlon CS, Soehren S, Matsuo M, Kapila YL

Capturing the regenerative potential of periodontal ligament fibroblasts.

Journal of stem cells & regenerative medicine

Scanlon C, Marchesan J, Soehren S, Matsuo M, Kapila Y

Anoikis mediators in oral squamous cell carcinoma.

Oral diseases

Bunek J, Kamarajan P, Kapila YL

Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer.

Cancer

Alhazzazi TY, Kamarajan P, Joo N, Huang JY, Verdin E, D'Silva NJ, Kapila YL

Parathyroid hormone mediates hematopoietic cell expansion through interleukin-6.

PloS one

Pirih FQ, Michalski MN, Cho SW, Koh AJ, Berry JE, Ghaname E, Kamarajan P, Bonnelye E, Ross CW, Kapila YL, Jurdic P, McCauley LK

Anoikis triggers Mdm2-dependent p53 degradation.

Molecular and cellular biochemistry

Ghosh A, Chen TC, Kapila YL

Receptor-interacting protein shuttles between cell death and survival signaling pathways.

Molecular biology of the cell

Kamarajan P, Bunek J, Lin Y, Nunez G, Kapila YL

Comments on atrophic lingual papillae and candidiasis in Sjögren syndrome.

Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics

Daniels TE, Kapila YL

High matrix metalloproteinase activity is a hallmark of periapical granulomas.

Journal of endodontics

de Paula-Silva FW, D'Silva NJ, da Silva LA, Kapila YL

Multiple differentiation capacity of STRO-1+/CD146+ PDL mesenchymal progenitor cells.

Stem cells and development

Xu J, Wang W, Kapila Y, Lotz J, Kapila S

TNF-alpha promotes an odontoblastic phenotype in dental pulp cells.

Journal of dental research

Paula-Silva FW, Ghosh A, Silva LA, Kapila YL

MMP-1 (collagenase-1) and MMP-13 (collagenase-3) differentially regulate markers of osteoblastic differentiation in osteogenic cells.

Matrix biology : journal of the International Society for Matrix Biology

Hayami T, Kapila YL, Kapila S

NG2, a novel proapoptotic receptor, opposes integrin alpha4 to mediate anoikis through PKCalpha-dependent suppression of FAK phosphorylation.

Cell death and differentiation

Joo NE, Watanabe T, Chen C, Chekenya M, Stallcup WB, Kapila YL

Disease-associated fibronectin matrix fragments trigger anoikis of human primary ligament cells: p53 and c-myc are suppressed.

Apoptosis : an international journal on programmed cell death

Dai R, Iwama A, Wang S, Kapila YL

Application of laser capture microdissection to phage display peptide library screening.

Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics

Lu H, Jin D, Kapila YL

The effect of high sugar intake on the development of periradicular lesions in rats with type 2 diabetes.

Journal of dental research

Iwama A, Nishigaki N, Nakamura K, Imaizumi I, Shibata N, Yamasaki M, Nakamura H, Kameyama Y, Kapila Y

Ascorbic acid induces collagenase-1 in human periodontal ligament cells but not in MC3T3-E1 osteoblast-like cells: potential association between collagenase expression and changes in alkaline phosphatase phenotype.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Shiga M, Kapila YL, Zhang Q, Hayami T, Kapila S

Specific fibronectin fragments as markers of periodontal disease status.

Journal of periodontology

Huynh QN, Wang S, Tafolla E, Gansky SA, Kapila S, Armitage GC, Kapila YL

Three-dimensional structural analysis of fibronectin heparin-binding domain mutations.

Journal of cellular biochemistry. Supplement

Kapila Y, Doan D, Tafolla E, Fletterick R

The response of periodontal ligament cells to fibronectin.

Journal of periodontology

Kapila YL, Lancero H, Johnson PW

Fibronectin and fibronectin fragments modulate the expression of proteinases and proteinase inhibitors in human periodontal ligament cells.

Matrix biology : journal of the International Society for Matrix Biology

Kapila YL, Kapila S, Johnson PW

Oral candidiasis in Sjögren's syndrome: prevalence, clinical correlations, and treatment.

Oral surgery, oral medicine, and oral pathology

Hernandez YL, Daniels TE

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