Our lab's goal is to understand the genetic circuits that control human immune cell function in health and disease. We have begun to identify how genetic risk variants for autoimmune diseases disrupt immune cell circuits (Farh and Marson et al., Nature 2015; Simeonov et al., Nature, 2017), and how pathogenic circuits may be targeted with novel therapeutics (Xiao et al., Immunity 2014). My lab has developed new tools for efficient CRISPR genome engineering in primary human T cells (Schumann et al., PNAS 2015; Roth et al., Nature 2018; Nguyen et al. Nature Biotech 2020).

Pam Murnane is an Assistant Professor in the department of Epidemiology & Biostatistics at UCSF. Her research focusses on biological, behavioral, and structural factors that influence maternal and child health outcomes in the context of HIV in resource limited settings. She has expertise in adherence measurement, risk prediction, and implementation science.