eLife

Functional and structural segregation of overlapping helices in HIV-1.

eLife

Safari M, Jayaraman B, Yang S, Smith C, Fernandes JD, Frankel AD

Robust T cell activation requires an eIF3-driven burst in T cell receptor translation.

eLife

De Silva D, Ferguson L, Chin GH, Smith BE, Apathy RA, Roth TL, Blaeschke F, Kudla M, Marson A, Ingolia NT, Cate JH

Allosteric mechanism of signal transduction in the two-component system histidine kinase PhoQ.

eLife

Mensa B, Polizzi NF, Molnar KS, Natale AM, Lemmin T, DeGrado WF

Modeling the ACVR1R206H mutation in human skeletal muscle stem cells.

eLife

Barruet E, Garcia SM, Wu J, Morales BM, Tamaki S, Moody T, Pomerantz JH, Hsiao EC

The East Asian gut microbiome is distinct from colocalized white subjects and connected to metabolic health.

eLife

Ang QY, Alba DL, Upadhyay V, Bisanz JE, Cai J, Lee HL, Barajas E, Wei G, Noecker C, Patterson AD, Koliwad SK, Turnbaugh PJ

A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons.

eLife

Kim GJ, Mo H, Liu H, Wu Z, Chen S, Zheng J, Zhao X, Nucum D, Shortland J, Peng L, Elepano M, Tang B, Olson S, Paras N, Li H, Renslo AR, Arkin MR, Huang B, Lu B, Sirota M, Guo S

RNA splicing programs define tissue compartments and cell types at single-cell resolution.

eLife

Olivieri JE, Dehghannasiri R, Wang PL, Jang S, de Morree A, Tan SY, Ming J, Ruohao Wu A, Tabula Sapiens Consortium, Quake SR, Krasnow MA, Salzman J

Single cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree.

eLife

Hendley AM, Rao AA, Leonhardt L, Ashe S, Smith JA, Giacometti S, Peng XL, Jiang H, Berrios D, Pawlak M, Li LY, Lee J, Collisson EA, Anderson MS, Fragiadakis GK, Yeh JJ, Chun JY, Kim GE, Weaver VM, Hebrok M

Protomer alignment modulates specificity of RNA substrate recognition by Ire1.

eLife

Li W, Crotty K, Garrido Ruiz D, Voorhies M, Rivera C, Sil A, Mullins RD, Jacobson MP, Peschek J, Walter P

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