JCI insight

Fgl2 regulates Fc?RIIB+CD8+ T cell responses during infection.

JCI insight

Morris AB, Adelman MW, Bennion KB, Martinez CD, McCook KM, Woodworth MH, Langelier CR, Rouphael N, Scharer CD, Maier CL, Kraft CS, Ford ML

Single-cell RNA-seq analysis reveals cell subsets and gene signatures associated with Rheumatoid Arthritis Disease Activity.

JCI insight

Binvignat M, Miao BY, Wibrand C, Yang MM, Rychkov D, Flynn E, Nititham J, Tamaki W, Khan U, Carvidi A, Krueger M, Niemi EC, Sun Y, Fragiadakis GK, Sellam J, Mariotti-Ferrandiz E, Klatzmann D, Gross AJ, Ye CJ, Butte AJ, Criswell LA, Nakamura MC, Sirota M

Coordinated immune dysregulation in juvenile dermatomyositis revealed by single-cell genomics.

JCI insight

Rabadam G, Wibrand C, Flynn E, Hartoularos GC, Sun Y, Madubata C, Fragiadakis GK, Ye CJ, Kim S, Gartner ZJ, Sirota M, Neely J

Enhancing CAR-T cell metabolism to overcome hypoxic conditions in the brain tumor microenvironment.

JCI insight

Hatae R, Kyewalabye K, Yamamichi A, Chen T, Phyu S, Chuntova P, Nejo T, Levine LS, Spitzer MH, Okada H

Tertiary lymphoid structures sustain cutaneous B cell activity in hidradenitis suppurativa.

JCI insight

Lowe MM, Cohen JN, Moss MI, Clancy S, Adler JP, Yates AE, Naik HB, Yadav R, Pauli M, Taylor I, McKay A, Harris H, Kim E, Hansen SL, Rosenblum MD, Moreau JM

Homeostatic cytokines reciprocally modulate the emergence of prenatal effector PLZF+CD4+ T cells in humans.

JCI insight

Locher V, Park S, Bunis DG, Makredes S, Mayer M, Burt TD, Fragiadakis GK, Halkias J

EPIREGULIN creates a developmental niche for spatially organized human intestinal enteroids.

JCI insight

Childs CJ, Holloway EM, Sweet CW, Tsai YH, Wu A, Vallie A, Eiken MK, Capeling MM, Zwick RK, Palikuqi B, Trentesaux C, Wu JH, Pellon-Cardenas O, Zhang CJ, Glass IA, Loebel C, Yu Q, Camp JG, Sexton JZ, Klein OD, Verzi MP, Spence JR

NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes.

JCI insight

Calabrese DR, Tsao T, Magnen M, Valet C, Gao Y, Mallavia B, Tian JJ, Aminian EA, Wang KM, Shemesh A, Punzalan EB, Sarma A, Calfee CS, Christenson SA, Langelier CR, Hays SR, Golden JA, Leard LE, Kleinhenz ME, Kolaitis NA, Shah RJ, Venado A, Lanier LL, Greenland JR, Sayah DM, Ardehali A, Kukreja J, Weigt SS, Belperio JA, Singer JP, Looney MR

Immunopathogenesis of hidradenitis suppurativa and response to anti-TNF-a?? therapy.

JCI insight

Lowe MM, Naik HB, Clancy S, Pauli M, Smith KM, Bi Y, Dunstan R, Gudjonsson JE, Paul M, Harris H, Kim E, Shin US, Ahn R, Liao W, Hansen SL, Rosenblum MD

IL-13-programmed airway tuft cells produce PGE2, which promotes CFTR-dependent mucociliary function.

JCI insight

Kotas ME, Moore CM, Gurrola Ii JG, Pletcher SD, Goldberg AN, Alvarez R, Yamato S, Bratcher PE, Shaughnessy CA, Zeitlin PL, Zhang IH, Li Y, Montgomery MT, Lee K, Cope EK, Locksley RM, Seibold MA, Gordon ED

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